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Inhibitory effect of medicinal plant extracts on xanthine oxidase activity

약용식물 추출물의 xanthine oxidase 활성 저해 효과

  • Received : 2019.07.30
  • Accepted : 2019.08.26
  • Published : 2019.09.30

Abstract

This study was performed to certify the inhibitory effect of aqueous extracts from sixty-seven medicinal plants on the activity of xanthine oxidase in vitro. Among the sixty-seven medicinal plants, Scutellaria baicalensis Georgi, Citrus aurantium L., Polygonum multiflorum Thunb., Pueraria thunbergiana (Sieb. et Zucc.) Benth., Citrus unshiu Marcor., Rubus coreanus Miquel, Camellia sinensis L., and Poncirus trifoliata Raf. were regarded as effective anti-gout sources. The active substances of P. multiflorum root extract were very stable at pH 2.0 and high temperatures. Xanthine oxidase activity was proportionally inhibited when concentrations of P. multiflorum extract increased. The aqueous extract from P. multiflorum root at a concentration of 2.0 mg/0.1 mL inhibited xanthine oxidase by 73.8%.

Acknowledgement

Supported by : 청운대학교

References

  1. Harrold L (2013) New developments in gout. Curr Opin Rheumatol 25:304-309 https://doi.org/10.1097/BOR.0b013e32835fd5e5
  2. Shin YJ, Hwang JM, Lee SC (2013) Antioxidant and xanthine oxidase inhibitory activities of hot water extracts of medicinal herbs. J Korean Soc Food Sci Nutr 42: 1712-1716 https://doi.org/10.3746/jkfn.2013.42.10.1712
  3. Duke EJ, Joyce P, Ryan JP (1973) Characterization of alternative molecular forms of xanthine oxidase in the mouse. J Biochem 131: 187-190 https://doi.org/10.1042/bj1310187
  4. Yu TF, Gutman AB (1967) Uric acid nephrolithiasis in gout. Ann Int Med 67: 1133-1148 https://doi.org/10.7326/0003-4819-67-6-1133
  5. Lee MH, Graham GG, Williams KM, Day RO (2008) A benefit-risk assessment of benzbromarone in the treatment of gout. Was its withdrawal from the market in the best interest of patients?. Drug Saf 31:643-665 https://doi.org/10.2165/00002018-200831080-00002
  6. Pacher P, Nivorozhkin A, Szabo C (2006) Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 58: 87-114 https://doi.org/10.1124/pr.58.1.6
  7. Zanabaatar B, Song JH, Seo GS, Noh HJ, Yoo YB, Lee JS (2010) Screening of anti-gout xanthine oxidase inhibitor from mushrooms. Kor J Mycol 38: 85-87 https://doi.org/10.4489/KJM.2010.38.1.085
  8. Yeo SG, Park YB, Kim IS, Kim SB, Park YH (1995) Inhibition of xanthine oxidase by tea extracts from green tea, oolong tea and black tea. J Korean Soc Food Nutr 24: 154-159
  9. Lee YS, Yoon HG, Kim NW (2010) The physiological activities of ripe fruit of Poncirus trifoliate. Korean J Food Preserv 17: 698-705
  10. Lee EH, Park HJ, Kim NH, Hong EJ, Park MJ, Lee SH, Kim MU, An BJ, Cho YJ (2016) Biological activities of Aster scaber extracts. Korean J Food Preserv 23: 393-401 https://doi.org/10.11002/kjfp.2016.23.3.393
  11. An BJ, Kim WK, Choi JY, Kwon IB, Choi C (1992) Structure and isolation of xanthine oxidase inhibitor from oolong tea. Kor J Food Sci Technol 24: 558-562
  12. Moon SH, Lee MK, Chae KS (2001) Inhibitory effects of the solvent fractions from persimmon leaves on xanthine oxidase activity. Kor J Food Nutr 14: 120-125
  13. Ra KS, Chung SH, Suh HJ, Son JY, Lee HK (1998) Inhibitor of xanthine oxidase from onion skin. Kor J Food Sci Technol 30: 697-701
  14. Stripe F, Della CE (1969) The regulation of rat xanthine oxidase. Conversion in vitro of enzyme activity from dehydrogenase (type D) to oxidase (type O). J Biol Chem 244: 3855-3863
  15. Nagao A, Seki M, Kobayashi H (1999) Inhibition of xanthine oxidase by flavonoids. Biosci Biotechnol Biochem 63: 1787-1790 https://doi.org/10.1271/bbb.63.1787
  16. Do J, Gwak J, Rho JJ, Lee K, Irfan M, Rhee MH, Kim DC (2018) Aqueous extract of taegeuk ginseng inhibits platelet aggregation and thrombus formation. J Med Food 21: 1137-1144 https://doi.org/10.1089/jmf.2017.4145
  17. Kim SI, Moon JY, Kim KS, Kim DH, Nam KS, Lim JK (1997) Antioxidative effects of Scutellariae radix aquaacupuncture solution on lipid peroxidation induced by free radicals. Kor J Oriental Preventive Medical Society 1: 48-54
  18. Kim SC, Ahn KS, Park CK, Jeon BS, Lee JT, Park WJ (2006) Isolation of antioxidative compound from Scutellaria baicalensis G. Korean J Medicinal Crop Sci 14: 212-216
  19. Huang Y, Tsang SY, Yao X, Chen ZY (2005) Biological properties of baicalein in cardiovascular system. Curr Drug Targets Cardiovasc Haematol Disord 5: 177-184 https://doi.org/10.2174/1568006043586206
  20. Liu K, Wang W, Guo BH, Gao H, Liu Y, Liu XH, Yao HL, Cheng K (2016) Chemical evidence for potent xanthine oxidase inhibitory activity of ethyl acetate extract of Citrus aurantium L. dried immature fruits. Molecules 21: 302 https://doi.org/10.3390/molecules21030302
  21. Son E, Yoon JM, An BJ, Lee YM, Cha J, Chi GY, Kim DS (2019) Comparison among activities and isoflavonoids from Pueraria thunbergiana aerial parts and root. Molecules 24: 912 https://doi.org/10.3390/molecules24050912
  22. Hurh J, Simu SY, Han Y, Ahn JC, Yang DC (2018) Dendropanax morbifera and Rubus coreanus Miq. extracts inhibit the formation of uric acid crystal by reducing xanthine oxidase activity. Proceedings of the Plant Resources Society of Korea Conference, 95
  23. Lin HT, Nah SL, Huang YY, Wu SC (2010) Potential antioxidant components and characteristics of fresh Polygonum multiflorum. J Food Drug Anal 18: 120-127
  24. Huang WY, Cai YZ, Xing J, Corke H, Sun M (2008) Comparative analysis of bioactivities of four Polygonum species. Planta Med 74: 43-49 https://doi.org/10.1055/s-2007-993759
  25. Kim DC, Chae HJ, In MJ (2004) Existence of stable fibrin-clotting inhibitor in salt-fermented anchovy sauce. J Food Comp Anal 17: 113-118 https://doi.org/10.1016/S0889-1575(03)00106-6
  26. Radi R, Tan S, Prodanov E, Evans RA, Parks DA (1992) Inhibition of xanthine oxidase by uric acid and its influence on superoxide radical production. BBA-Protein Struct M 122: 178-182
  27. Pirouzpanah S, Rashidi MR, Delazar A, Razavieh SV, Hamidi AA (2009) Inhibitory effect of Ruta graveolens L. extract on guinea pig liver and bovine milk xanthine oxidase. Iran J Pharm Sci 5: 163-170
  28. Zhang HJ, Hu YJ, Xu P, Liang WQ, Zhou J, Liu PG, Cheng L, Pu JB (2016) Screening of potential xanthine oxidase inhibitors in Gnaphalium hypoleucum DC. by immobilized metal affinity chromatography and ultrafiltration-ultra performance liquid chromatography-mass spectrometry. Molecules 21: 1242 https://doi.org/10.3390/molecules21091242