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Simultaneous Occurrence of Melanotic Macule and Melanoma in the Oral Cavity: A Case Report

  • Kim, Su-Hyun (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Byun, Jin-Seok (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Jung, Jae-Kwang (Department of Oral Medicine, School of Dentistry, Kyungpook National University) ;
  • Choi, Jae-Kap (Department of Oral Medicine, School of Dentistry, Kyungpook National University)
  • Received : 2020.09.07
  • Accepted : 2020.09.15
  • Published : 2020.09.30

Abstract

While oral melanotic macule is regarded as the most frequent oral pigmented lesion without any harmful symptom, oral melanoma is a very rare and life-threatening disease among oral pigmented lesions. Oral melanotic macule has previously been described as benign, with no malignant potential. However, a few case reports have raised the question of malignant potential of oral melanotic macule. In this case report, we present a case of coexistence of oral melanotic macule and oral melanoma. A 66-year-old man with a chief complaint of black pigmentation on gingiva showed the lesion spread out on the right palatal gingiva, the right maxillary buccal gingiva and the right buccal mucosa, appearing to merge with one another. Biopsies were performed on the right palatal gingiva and the right buccal mucosa. While the lesion on the right palatal gingiva was diagnosed as an oral melanotic macule, the other lesion on the right buccal mucosa was diagnosed as an oral melanoma. The present case implied the possibility of malignant potential of oral melanotic macule. Therefore, oral melanotic macule needs careful periodic observation for early detection and prompt treatment of the transformed oral melanoma.

References

  1. Buchner A, Merrell PW, Carpenter WM. Relative frequency of solitary melanocytic lesions of the oral mucosa. J Oral Pathol Med 2004;33:550-557.
  2. Weathers DR, Corio RL, Crawford BE, Giansanti JS, Page LR. The labial melanotic macule. Oral Surg Oral Med Oral Pathol 1976;42:196-205.
  3. Shen ZY, Liu W, Bao ZX, Zhou ZT, Wang LZ. Oral melanotic macule and primary oral malignant melanoma: epidemiology, location involved, and clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011;112:e21-e25.
  4. Rapini RP, Golitz LE, Greer RO Jr, Krekorian EA, Poulson T. Primary malignant melanoma of the oral cavity. A review of 177 cases. Cancer 1985;55:1543-1551.
  5. Takagi M, Ishikawa G, Mori W. Primary malignant melanoma of the oral cavity in Japan. With special reference to mucosal melanosis. Cancer 1974;34:358-370.
  6. Hicks MJ, Flaitz CM. Oral mucosal melanoma: epidemiology and pathobiology. Oral Oncol 2000;36:152-169.
  7. Macintyre DR, Briggs JC. Primary oral malignant melanoma. Int J Oral Surg 1984;13:160-165.
  8. Kauzman A, Pavone M, Blanas N, Bradley G. Pigmented lesions of the oral cavity: review, differential diagnosis, and case presentations. J Can Dent Assoc 2004;70:682-683.
  9. Taylor CO, Lewis JS. Histologically documented transformation of benign oral melanosis into malignant melanoma: a case report. J Oral Maxillofac Surg 1990;48:732-734.
  10. Umeda M, Komatsubara H, Shibuya Y, Yokoo S, Komori T. Premalignant melanocytic dysplasia and malignant melanoma of the oral mucosa. Oral Oncol 2002;38:714-722.
  11. Kahn MA, Weathers DR, Hoffman JG. Transformation of a benign oral pigmentation to primary oral melanoma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;100:454-459.
  12. Kaehler KC, Russo PA, Egberts F, Warnke PH, Cerroni L, Hauschild A. Metastatic melanoma of the tongue arising from oral melanosis. Arch Dermatol 2008;144:558-560.
  13. Meleti M, Mooi WJ, van der Waal I. Melanotic pigmentation of palatal salivary glands as a possible precursor to malignant melanoma: report of an unusual case. J Oral Maxillofac Surg 2010;68:867-869.
  14. Patel PB, Wright JM, Kang DR, Cheng YL. Longitudinal clinicopathologic data of the progression of oral mucosal melanomareport of 2 cases and literature review. Oral Surg Oral Med Oral Pathol Oral Radiol 2018;126:e21-e30.
  15. Mellouli N, Sioud S, Garma M, Chokri A, Hamdi H, Selmi J. Oral malignant melanoma: History of malignant degeneration of a pigmented lesion. J Oral Med Oral Surg 2019;25:19.
  16. Allen AC, Spitz S. Malignant melanoma; a clinicopathological analysis of the criteria for diagnosis and prognosis. Cancer 1953;6:1-45.
  17. Femiano F, Lanza A, Buonaiuto C, Gombos F, Di Spirito F, Cirillo N. Oral malignant melanoma: a review of the literature. J Oral Pathol Med 2008;37:383-388.
  18. Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. Cancer 1998;83:1664-1678.
  19. Ascierto PA, Accorona R, Botti G, et al. Mucosal melanoma of the head and neck. Crit Rev Oncol Hematol 2017;112:136-152.
  20. Ostman J, Anneroth G, Gustafsson H, Tavelin B. Malignant oral tumours in Sweden 1960-1989: an epidemiological study. Eur J Cancer B Oral Oncol 1995;31B:106-112.
  21. Chaudhry AP, Hampel A, Gorlin RJ. Primary malignant melanoma of the oral cavity: a review of 105 cases. Cancer 1958;11:923-928.
  22. Liversedge RL. Oral malignant melanoma. Br J Oral Surg 1975;13:40-55.
  23. Kaugars GE, Heise AP, Riley WT, Abbey LM, Svirsky JA. Oral melanotic macules: a review of 353 cases. Oral Surg Oral Med Oral Pathol 1993;76:59-61.
  24. Gupta G, Williams RE, Mackie RM. The labial melanotic macule: a review of 79 cases. Br J Dermatol 1997;136:772-775.
  25. Buchner A, Hansen LS. Melanotic macule of the oral mucosa. A clinicopathologic study of 105 cases. Oral Surg Oral Med Oral Pathol 1979;48:244-249.
  26. Ho KK, Dervan P, O'Loughlin S, Powell FC. Labial melanotic macule: a clinical, histopathologic, and ultrastructural study. J Am Acad Dermatol 1993;28:33-39.
  27. Thomas L, Tranchand P, Berard F, Secchi T, Colin C, Moulin G. Semiological value of ABCDE criteria in the diagnosis of cutaneous pigmented tumors. Dermatology 1998;197:11-17.
  28. Buery RR, Siar CH, Katase N, et al. Clinico-pathological evaluation of oral melanotic macule, oral pigmented nevus and oral mucosal melanoma. J Hard Tissue Biol 2010;19:57-64.
  29. Patrick RJ, Fenske NA, Messina JL. Primary mucosal melanoma. J Am Acad Dermatol 2007;56:828-834.
  30. Meleti M, Leemans CR, Mooi WJ, Vescovi P, van der Waal I. Oral malignant melanoma: a review of the literature. Oral Oncol 2007;43:116-121.
  31. Tanaka N, Mimura M, Ogi K, Amagasa T. Primary malignant melanoma of the oral cavity: assessment of outcome from the clinical records of 35 patients. Int J Oral Maxillofac Surg 2004;33:761-765.
  32. Patel SG, Prasad ML, Escrig M, et al. Primary mucosal malignant melanoma of the head and neck. Head Neck 2002;24:247-257.