- Volume 46 Issue 2
DOI QR Code
Analysis of Treatment Response in Patients with Oral Lichen Planus
- Ju, Hye-Min (Department of Oral Medicine, Pusan National University Dental Hospital, Dental Research Institute) ;
- Kim, Kyung-Hee (Department of Oral Medicine, Inje University Busan Paik Hospital) ;
- Jeon, Hye-Mi (Dental Clinic Center, Pusan National University Hospital) ;
- Ahn, Yong-Woo (Department of Oral Medicine, Pusan National University, School of Dentistry, Dental Research Institute, Dental and Life Science Institute) ;
- Ok, Soo-Min (Department of Oral Medicine, Pusan National University, School of Dentistry, Dental Research Institute, Dental and Life Science Institute) ;
- Jeong, Sung-Hee (Department of Oral Medicine, Pusan National University, School of Dentistry, Dental Research Institute, Dental and Life Science Institute)
- Received : 2021.05.28
- Accepted : 2021.06.16
- Published : 2021.06.30
Purpose: To evaluate compliance by analyzing and comparing treatment duration, degree of improvement after treatment and treatment response of oral lichen planus (OLP) patients according to characteristics of them and the severity of the lesion. Methods: According to treatment process, 132 subjects with OLP who first visited the Department of Oral Medicine at the Pusan National University Dental Hospital from January 2017 to December 2020were classified into three groups: Treatment completed (CT) group, Under treatment (UT) group, and Dropped out during follow-up (DT) group. The reticulation/keratosis, erythema, and ulceration (REU) scoring system was used to assess the severity of OLP. The degree of improvement after treatment was evaluated in CT group. Results: There were 53 (40.15%) CT, 27 (20.45%) UT and 52 (39.39%) DT. In CT group, according to initial REU score there was a statistical difference in the degree of improvement, but not in the length of time to complete treatment. There was no statistical difference between the days it took for patients to feel symptom relief, and the days of entire treatment among three groups. However, there was a positive correlation between the REU score of gingiva and duration of treatment in DT group. In the CT and DT groups, there was a correlation between the length of time taken to relieve symptoms and the duration of treatment. Conclusions: The severity of the gingival lesion and the initial response to treatment have a large effect on the entire treatment period and prognosis, so it should be considered when explaining the disease prognosis and treatment period to patients, and the clinician needs to focus on initial symptom relief.
- Stoopler ET, Sollecito TP. Oral mucosal diseases: evaluation and management. Med Clin North Am 2014;98:1323-1352. https://doi.org/10.1016/j.mcna.2014.08.006
- Gonzalez-Moles MA, Bravo M, Gonzalez-Ruiz L, Ramos P, GilMontoya JA. Outcomes of oral lichen planus and oral lichenoid lesions treated with topical corticosteroid. Oral Dis 2018;24:573-579. https://doi.org/10.1111/odi.12803
- Sciubba JJ. Autoimmune oral mucosal diseases: clinical, etiologic, diagnostic, and treatment considerations. Dent Clin North Am 2011;55:89-103.
- Chainani-Wu N, Silverman S Jr, Lozada-Nur F, Mayer P, Watson JJ. Oral lichen planus: patient profile, disease progression and treatment responses. J Am Dent Assoc 2001;132:901-909. https://doi.org/10.14219/jada.archive.2001.0302
- Sugerman PB, Savage NW. Oral lichen planus: causes, diagnosis and management. Aust Dent J 2002;47:290-297. https://doi.org/10.1111/j.1834-7819.2002.tb00540.x
- Park HK, Hurwitz S, Woo SB. Oral lichen planus: REU scoring system correlates with pain. Oral Surg Oral Med Oral Pathol Oral Radiol 2012;114:75-82. https://doi.org/10.1016/j.oooo.2012.02.013
- Shirasuna K. Oral lichen planus: malignant potential and diagnosis. Oral Sci Int 2014;11:1-7. https://doi.org/10.1016/S1348-8643(13)00030-X
- Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M. Interventions for treating oral lichen planus: corticosteroid therapies. Cochrane Database Syst Rev 2020;2:CD001168.
- Piboonniyom SO, Treister N, Pitiphat W, Woo SB. Scoring system for monitoring oral lichenoid lesions: a preliminary study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2005;99:696-703. https://doi.org/10.1016/j.tripleo.2004.07.013
- Kwatra G, Mukhopadhyay S. Topical corticosteroids: pharmacology. In: Lahiri K, ed. A treatise on topical corticosteroids in dermatology. Singapore: Springer; 2018. pp. 11-22.
- Liu J, Zeng X, Chen Q, et al. An evaluation on the efficacy and safety of amlexanox oral adhesive tablets in the treatment of recurrent minor aphthous ulceration in a Chinese cohort: a randomized, double-blind, vehicle-controlled, unparallel multicenter clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006;102:475-481. https://doi.org/10.1016/j.tripleo.2005.12.014
- Lavanya N, Jayanthi P, Rao UK, Ranganathan K. Oral lichen planus: an update on pathogenesis and treatment. J Oral Maxillofac Pathol 2011;15:127-132. https://doi.org/10.4103/0973-029X.84474
- Ahmed I, Nasreen S, Jehangir U, Wahid Z. Frequency of oral lichen planus in patients with noninsulin dependent diabetes mellitus. J Pak Assoc Dermatol 2012;22:30-34.
- Romero MA, Seoane J, Varela-Centelles P, Diz-Dios P, GarciaPola MJ. Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathological characteristics. Med Oral 2002;7:121-129.
- Otero Rey EM, Yanez-Busto A, Rosa Henriques IF, Lopez-Lopez J, Blanco-Carrion A. Lichen planus and diabetes mellitus: systematic review and meta-analysis. Oral Dis 2019;25:1253-1264. https://doi.org/10.1111/odi.12977
- Kim SA, Park WS, Ohrr HC, et al. Prevalence and management status of diabetes mellitus in Korea. Korean J Med 2005;68:10-17.
- Bagewadi A, Bhoweer AK. Oral lichen planus and its association with diabetes mellitus and hypertension. J Indian Acad Oral Med Radiol 2011;23:300-303.
- Edwards PC, Kelsch R. Oral lichen planus: clinical presentation and management. J Can Dent Assoc 2002;68:494-499.
- Fernandez-Gonzalez F, Vazquez-Alvarez R, Reboiras-Lopez D, Gandara-Vila P, Garcia-Garcia A, Gandara-Rey JM. Histopathological findings in oral lichen planus and their correlation with the clinical manifestations. Med Oral Patol Oral Cir Bucal 2011;16:e641-e646.
- Osipoff A, Carpenter MD, Noll JL, Valdez JA, Gormsen M, Brennan MT. Predictors of symptomatic oral lichen planus. Oral Surg Oral Med Oral Pathol Oral Radiol 2020;129:468-477. https://doi.org/10.1016/j.oooo.2019.12.019
- Graber AL, Davidson P, Brown AW, McRae JR, Woolridge K. Dropout and relapse during diabetes care. Diabetes Care 1992;15:1477-1483. https://doi.org/10.2337/diacare.15.11.1477
- Boorghani M, Gholizadeh N, Taghavi Zenouz A, Vatankhah M, Mehdipour M. Oral lichen planus: clinical features, etiology, treatment and management; a review of literature. J Dent Res Dent Clin Dent Prospects 2010;4:3-9.