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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Analytical Science and Technology
Journal Basic Information
Journal DOI :
The Korean Society of Analytical Science
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Volume & Issues
Volume 21, Issue 6 - Dec 2008
Volume 21, Issue 4 - Oct 2008
Volume 21, Issue 5 - Oct 2008
Volume 21, Issue 3 - Aug 2008
Volume 21, Issue 2 - Jun 2008
Volume 21, Issue 1 - Feb 2008
Selecting the target year
Process analytical technology (PAT): new paradigm for the state-of-the-art analytical technology
Kim, Jong-Yun ; Park, Yong Joon ; Yeon, Jei-Won ; Woo, Young-Ah ; Kim, Hyo-Jin ; Song, Kyuseok ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 345~363
Process analytics has been already widely utilized in a large-scale continuous production line such as petroleum industries for several decades. Although the process analytics has a long history, a concept of "Process Analytical Technology (PAT)" has been rapidly adopted as a new paradigm for the process monitoring in the production process of various industries. In this review, current status and recent developments of PAT in various research bodies have been introduced, including the introduction of various types of analytical instruments, chemometrics tools, and perspectives and future applications of PAT as well as the fundamentals on PAT such as terminology and its historical background.
Measurement of heavy metals in antarctic soil at the king sejong station: application of isotope dilution inductively coupled plasma mass spectrometry
Suh, Jung-Ki ; Hwang, Euijin ; Min, Hyung Sik ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 364~374
Antarctic Environmental Monitoring Handbook' was published by COMNAP/SCAR in 2000. The standardized method described in this handbook is recommended for monitoring of antarctic environment. High pressure bomb technique in this guide was used to decompose soil samples. In compliance with this guide book, high pressure bomb technique was applied to decompose the antarctic soil sampled at the King Sejong Station. An Isotope Dilution-Inductively Coupled Plasma-Mass Spectrometry (ID-ICP-MS) was applied to determine mass concentrations of Pb, Cu and Zn in the soil. The accuracy in this method was verified by the analysis of certified reference materials (CRM) of NIST 2702 (marine sediment). The analytical results agreed with certified value within the range from 99.5~100.8%. Matrix separation was necessitated for the determination of Cu and Zn by Chelex 100 ion exchange resin. As a result, the average mass concentrations of Pb, Cu and Zn which are suspected to be caused by anthropogenic pollution were 332.9 mg/kg, 95.6 mg/kg and 115.3 mg/kg, respectively. Those for the metals sampled in the soils of the remote regions from the station were 28.1 mg/kg, 101.8 mg/kg and 115.6 mg/kg, respectively.
The study of relationship between the concentrations of Bisphenol A and DEHP in human plasma and precocious puberty
Han, Eunjung ; Yim, Okkyoung ; Chung, Jaeyeon ; Baek, Sunyoung ; Kim, Yunje ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 375~382
Bisphenol A (BPA) and di-2-ethyhexyl phthalate (DEHP) is the considerably hazardous materials, endocrine disrupting chemicals (EDCs), which is accumulated to the human's fat and tissue. We studied the relationship between the concentrations of BPA and DEHP in the precocious puberty and the normal controls using GC/MSD. BPA concentrations of the precocious puberty are lower than that of normal controls. But DEHP concentrations of the precocious puberty are higher than that of normal controls. From these results, BPA is not related to the precocious puberty. Otherwise, DEHP is somewhat related to the precocious puberty and the concentrations of the precocious puberty are approximately 45% higher than that of normal controls.
Monitoring and risk assessment of 1,4-Dioxane in Nakdong river
Lee, Ji-Young ; Kim, Joung-Hwa ; Kim, Hyun-Koo ; Choi, Jong-Ho ; Kim, Seungki ; Pyo, Heesoo ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 383~391
International Agency for Research on Cancer (IARC) has classified it as a possible carcinogen and World Health Organization (WHO) has suggested 50 ng/mL as a guideline value for 1,4-dioxane. Considering the toxicity of 1,4-dioxane and ingestion rate of drinking water, the monitoring of 1,4-dioxane in drinking water in Nakdong river is very important. We analyzed 1,4-dioxane four times per year for the 12 samples of treated water and 4 samples of raw water in Nakdong river in Korea from 2000 to 2007 and surveyed the trend of concentrations of 1,4-dioxane. As a results of analysis, 1,4-dioxane was detected from 0.24 to 240.2 ng/mL in treated water and from 0.39 to 81.9 ng/mL in raw water from 2000 to 2007. The average concentrations are 22.68 ng/mL and 19.15 ng/mL in treated water and raw water, respectively. The detected concentrations was decreased but frequency of detection was not changed since establishment of regulation in 2004. Results of comparison of 95 percentile excessive cancer risk of 1,4-dioxane in treated and raw water were each
before 2004 and
after 2004. Also, comparing the detected concentration and frequency for each season, these were more detected the concentration and frequency for 1,4-dioxane in treated and raw water from winter to spring.
Removal of toxic compounds from Acer tegmentosum using supercritical fluid extraction
Pyo, Dongjin ; Jin, Jungeun ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 392~396
Acer tegmentosum is a tree used to treat various liver diseases in Korea. There have been some concern regarding the safety of Acer tegmentosum due to some toxic chemical compounds in its stems. Supercritical fluid extraction (SFE) was employed to develop a removing method of toxic compounds from Acer tegmentosum. The toxic compounds were effectively extracted with ethanol modified supercritical fluid
. The optimum condition of SFE was 100 bar of pressure,
of extraction temperature, 3 mL/min of
flow rate, 0.2 mL/min of modifier (ethanol) flow rate.
Determination of Trace Silicon in Uranium Dioxide by UV-VIS Spectrophometry
Choi, Kwang-Soon ; Joe, Kihsoo ; Han, Sun-Ho ; Song, Kyuseok ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 397~402
Uranium dioxide was dissolved with nitric acid and a trace amount of HF. The analytical conditions of a spectrophotometer were investigated to determine a trace amount of silicon in the uranium matrices without a separation process. The effects of a trace amount of HF on the determination of silicon were examined. Boric acid was used to eliminate HF the interference in the colorimetric process. The recovery of silicon in the presence of a trace amount of HF in uranium solutions with or without saturated boric acid was
, respectively. The amount of saturated boric acid did not affect the recovery of the silicon. Therefore it was possible for this procedure to measure a trace amount of silicon in a uranium matrix without a separation by a UV-VIS spectrophotometry.
Synthesis of DMDBTDMA and determination of radiolysis products by GC/MS
Yang, Han-Beom ; Lee, Eil-Hee ; Park, Gyo-Beom ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 403~411
Dimethyldibutyltetradecylmalonamide (DMDBTDMA) extractant was used in a solvent extraction process for a radioactive liquid waste treatment. For the study of radiolysis phenomena, DMDBTDMA was synthesized and the degradation compounds (n-methylbutylamine, tetradecane, 1-tetradecanol) in the DMDBTDMA extractant, irradiated with
gamma ray, were identified and determined as radiolysis products by a Fourier transform infrared (FT-IR), gas chromatograph/mass spectrometer (GC/MS) analysis and GC/MS with selected ion monitoring (SIM) mode. Retention behavior of n-methylbutylamine, n-dodecane, tetradecane and 1-tetradecanol in the total ion chromatogram with the standard materials and n-dodecane as the internal standard (ISTD) were 2.35 min., 8.83 min., 10.68 min. and 12.75 min., respectively. In the case of tetradecane, there was a linear relationship between the concentration of the tetradecane and the absorbed dose of the
-ray irradiated DMDBTDMA.
Optimization of solid-phase extraction for the liquid chromatography-tandem mass spectrometry analysis of basic drugs in equine urine
Shin, Hyun Du ; Yang, Ji Suk ; Jung, Mihye ; Kim, Hyung-Seung ; Youm, Jeong-Rok ; Hu, Man Bae ; Kim, Sung Jean ; Han, Sang Beom ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 412~423
A procedure based on solid-phase extraction (SPE) followed by liquid chromatography-tandem mass spectrometry has been developed for the simultaneous analysis of 55 basic drugs in equine urine. The test scope covers diversified classes of drugs including some
-agonists, antihypotensives, CNS stimulants, sedatives, tranquilizers, antidepressants, antihypertensives and so on. LC-MS/MS separation and quantification was carried out in positive electrospray ionization and multiple reaction monitoring (MRM) mode. Four different brands of mixed mode cation exchange SPE sorbents; UCT XTRACT
XRDAH, Supelco DSC-MCAX
, Varian Bond Elut Certify
and Waters Oasis
MCX were compared. The UCT XTRACT
XRDAH sorbent provided the best results in the preconcentration of samples, yielding relative recoveries higher than 80% except for terbutaline (41.3%), salbutamol (71.5%), heptaminol (70.7%), phenylpropanolamine (66.3%). Detection limits of the target drugs provided by the proposed analytical procedure were between 0.2~8.3 ng/mL.
Analysis of streptomycin in honey by LC-MS/MS
Shim, Young-Eun ; Myung, Seung-Woon ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 424~431
Streptomycin, which is one of aminoglycoside antibiotics, has been widely used in the rearing of food-producing animals to prevent and treat diseases in cattle, pigs and poultry. Although not licensed in South Korea, streptomycin has also been used for the treatment of bacterial honeybee disease, such as European foulbrood in Third World countries. A reliable and effective method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the determination of streptomycin in honey. A established method was optimized the clean-up and extraction procedure for the trace determination, good precision and accuracy. And the chromatographic and tandem mass spectrometric parameters were also optimized. The precision (RSD) and accuracy (bias) in the concentration range of 5.0~50.0 ug/kg were 5.5~14% and -10.0~8.0%, respectively. Limit of detection was 0.75 ug/kg and recovery of streptomycin spiked at level of 10 ug/kg in honey was 74%. The established and validated method was applied to determine streptomycin in honey which was on the market.
The reaction rate of polysilanes prepared by electroreduction with different monomers and additives
Zhang, Feng-Jun ; Chen, Ming-Liang ; Oh, Won-Chun ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 432~437
In this study, polysilanes were synthesized by electroreduction with different monomers such as
by Mg electrodes under ultrasonic radiation. The effects of monomers and additives (p-dibromobenzene (DBB), naphthalene (NAPH) and anthracene (ANTH)) on the reaction rate were investigated. Polymerization of
among the four monomers showed the highest rate. p-dibromobenzene (DBB) was proved the most effective additive. Based on the observations, some possible reaction mechanisms of the polymerization were proposed.
Quantitative analysis of phosphorus by HERETIC-NMR method
Lim, Heon-Sung ; Park, Chan-Jo ; Lee, Sueg-Geun ;
Analytical Science and Technology, volume 21, issue 5, 2008, Pages 438~441
We have developed an alternative to the internal chemical reference based on a calibrated reference signal which is not a real NMR line but an electronically produced signal (HERETIC) and determined the phosphorus concentration using this method. The area ratio of HERETIC and sample peaks obtained from the standard samples was used to measure the concentrations of different samples directly. The analysis of phosphorus by this method showed the excellent linear regression coefficient (
) for the concentration range from 20 ppm to 500 ppm with HERETIC peak as reference.