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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Analytical Science and Technology
Journal Basic Information
Journal DOI :
The Korean Society of Analytical Science
Editor in Chief :
Volume & Issues
Volume 22, Issue 6 - Dec 2009
Volume 22, Issue 5 - Oct 2009
Volume 22, Issue 4 - Aug 2009
Volume 22, Issue 3 - Jun 2009
Volume 22, Issue 2 - Apr 2009
Volume 22, Issue 1 - Feb 2009
Selecting the target year
Process analytical technology (PAT): field applications and current status in pharmaceutical industries
Woo, Young-Ah ; Kim, Jong-Yun ; Park, Yong Joon ; Yeon, Jei-Won ; Song, Kyuseok ; Kim, Hyo-Jin ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 35~43
The goal of PAT (Process Analytical Technology) is to build quality into products through better understanding and control of manufacturing processes, rather than merely testing the quality of the end product. Pharmaceutical manufacturers are trying to develop and implement new technologies in pharmaceutical production and quality control for real-time measurements of critical product and process parameters. Characterization of manufacturing process through experimental design, for evaluation of the effect of product and process variables, represents an integral part of the PAT framework. However, the publications regarding real PAT application to pharmaceutical process are very limited and the technologies are confidential as well. In this review, the case studies related to PAT are shown with real applications from a pharmaceutical company. Additionally, various applications of PAT on the developing stage are introduced with high analytical technologies for the improvement of quality control on manufacturing process.
Analysis of mercury and methylmercury in river sediment samples
Lee, Jung-Sub ; Park, Jae-Sung ; Kang, Hak-Gu ; Cho, Jae-Seok ; Hong, Eun-Jin ; Jeong, Gi-Taeg ; Cha, Jun-Seok ; Jung, Kwang-Yong ; Kim, Young-Hee ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 44~50
In this study, the use of purge & trap GC-MS technique for determination of methylmercury in sediment samples was described. The method detection limit of the method was determined as 0.06 ng/g and the recovery of the method was
, with precisions better than 11.2%. The method was validated by analysis of CRMs such as ERM CC580 (estuarine sediment) and IAEA 405 (sediment). Additionally, the performance of the method was tested on river sediment samples and the analytical results were compared with those of the GC-CVAFS, which has been widely used for methylmercury analysis.
Age comparisons of coastal sand dune stratum in Chollipo, Korea by altering preheat and cut-heat, and grain size distributions by OSL dating
Bang, Jun-Hwan ; Kim, Ki-Dong ; Eum, Chul-Hun ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 51~56
The samples from coastal sand dune stratum in Chollipo were dated by Optically Stimulated Luminescence (OSL) with modified Single Aliquots Regeneration (SAR) method. It is possible to choose the OSL signals by thermal treatments such as preheat and cut-heat in SAR procedure. Preheat and cut-heat of
for 10 sec
for 0 sec, and
for 10 sec
for 10 sec were applied for estimation of equivalent dose of the samples. The OSL signals from different thermal treatment were used for OSL dating. Equivalent dose were estimated with 4 fractionated grain distributions with
sieves with above heating treatments. Consequently, the estimated dose were differently valued in sample sizes and applied heating treatments, different stratum ages were calculated. The ages from radiocarbon dating were compared with the OSL ages. The ages varying with grain sizes produce that the site sampled were formed with mixed soil sources.
Development of a building materials database; Volatile organic compounds, formaldehyde emission rates and chemical compositions
Yu, Young-Jae ; Lee, Chul-Won ; Kim, Man-Goo ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 57~64
A material database has been developed for VOCs and formaldehyde emitted from building materials in this study. New classification system has been made by correlating the classification methods used in Korean Air Cleaning and Environmental Protection Agency. The developed databases include emission rates of TVOC, 5VOC and formaldehyde emitted from each building material. In addition, the databases can be used as an input variable to estimate indoor air quality (IAQ) using computer simulation since they also contain chemical component and general imformation. Box plot was used to do statistical analysis for emission rates of formaldehyde and TVOCs from different types of building materials. Also we confirmed the building materials worsening IAQ by categorizing the emission characteristic of different types of pollutants.
The analysis of the urushiol congeners from the extracts of lacquer trees
Cho, Yumi ; Jung, Yu-Kyung ; Kim, Jinsan ; Lee, Joonbae ; Paeng, Ki-Jung ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 65~74
Active components of lacquer tree referred to as urushiol congeners, which are catechol derivatives with various alkyl or alkenyl substituents. The olefin side chains typically have one, two or three double bonds. In this study, the each congener's ratio analysis of extracts from korean lacquer tree are compared to the one from other asian lacquer tree. Extraction was performed using liquid-liquid extraction (LLE) method with soxhlet system from tree's bark and sap. Extracts were analyzed by reverse phase liquid chromatography and on-line electro spray ionization mass spectrometry (LC-MS/MS).
Study on the size-based separation of nano to micron particles in natural water and soil using flow and sedimentaion Field-flow fractionation
Eum, Chul Hun ; Kang, Dong Young ; Lee, Tae Woo ; Lee, Seungho ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 75~81
A flow and sedimentation field-flow fractionation method has been used to characterize colloidal particles in environmental samples. The opposed flow sample concentration (OFSC) method was employed. The OFSC procedure was optimized for the analysis of particles in ground water with respect to various experimental parameters including sample introduction time, flow rates, etc. The effectiveness in low concentration and characterization of the OFSC-FlFFF was demonstrated with GW-1 and GW-2 ground water samples. Ground water of upto 100 mL has been successfully loaded, concentrated, and characterized by OFSC-FlFFF. The OFSC technique allow the application of FlFFF possible for the separation and characterization of colloidal particles in very low concentrations. The results show FFF provides a simplified alternative to existing off-line concentration procedures, and shows a high potential for the applications to the analysis of dilute colloidal particles in the environmental samples.
Preparation and evaluation of limestone reference material for a proficiency test
Jung, Choong-Ho ; Park, Deok-Won ; Kim, Sung-Min ; Yu, Eung-Chul ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 82~91
Preparation and evaluation of the limestone samples for a proficiency test using domestic limestone have been performed. We have used statistical method for evaluation of the XRF and instrumental analysis results. We have found that there were some outliers from XRF and ICP-OES instrumental analysis results for each sample. After removal of 5 outliers among the 50 samples we could obtain the homogeneous samples which have within a reliability of 95% from a statistical analysis result.
Adsorption of uranium(VI), calcium(II), and samarium(III) ions on synthetic resin adsorbent with styrene hazardous materials
Kim, Joon-Tae ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 92~100
Azacrown resins were synthesized by mixing 1-aza-12-crown-4 macrocyclic ligand into styrene (2th petroleum in 4th class hazardous materials) divinylbenzene (DVB) copolymer with crosslinkage of 1%, 2%, 5% and 10% by substitution reaction. The synthesis of these resins was confirmed by content of chlorine, element analysis, thermogravimetric analysis (TGA), surface area (BET), and IR-spectroscopy. The effects of pH, time, crosslinkage of resins and dielectric constant of solvent on adsorption of metal ions by resin adsorbent were investigated. Metal ions showed a great adsorption over pH 3 and adsorption equilibrium of metal ions was about two hours. In addition, adsorptive selectivity of metals on the resin in ethanol solvent was increased in the order of
ion and adsorption of uranium ion was decreased with increase of crosslinkage such as 1%, 2%, 5% and 10% and was inversely proportional to the order of dielectric constant of solvents.
Bioequivalence of pioglitazone tablet to Actos
tablet (Pioglitazone 30 mg)
Yeom, Hyesun ; Lee, Tae Ho ; Youm, Jeong-Rok ; Song, Jin-Ho ; Han, Sang Beom ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 101~108
The bioequivalence of two pioglitazone tablets, Actos
tablet (Takeda Chemical Industries, reference drug) and Pioglitazone tablet (Boryung Company, test drug) was evaluated according to the guidelines of Korea Food and Drug Administration. Twenty-eight healthy male Korean volunteers received each medicine (pioglitazone dose of 30 mg) in a
crossover study with one week washout interval. After drug administration, blood samples were collected at specific time intervals from 0-36 hours. The plasma concentrations of pioglitazone were determined by high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS). The total chromatographic run time was 5 min and calibration curves were linear over the concentration range of 5-2000 ng/mL for pioglitazone. The method was validated for selectivity, sensitivity, linearity, accuracy and precision. The pharmacokinetic parameters were determined from the plasma concentration-time profiles of both formulations. The primary calculated pharmacokinetic parameters were compared statistically to evaluate bioequivalence between the two preparations. The 90% confidence intervals of the
ratio and the
ratio for Pioglitazone tablet and Actos
tablet were log0.9422~log1.1040 and log0.9200~log1.1556, respectively. Based on the statistical considerations, we can conclude that the test drug, Pioglitazone tablet was bioequivalent to the reference drug, Actos
Analysis of polycyclic aromatic hydrocarbons in cooked fish and shellfish
Hu, Soojung ; Park, Sungkuk ; Jin, Sunhee ; Choi, Dongmi ;
Analytical Science and Technology, volume 22, issue 1, 2009, Pages 109~117
The following concentrations of some PAHs were investigated; [benzo(a)anthracene, chrysene, benzo (b)fluoranthene, benzo(k)fluoranthene, benzo(a)pyrene, dibenzo(a,h)anthracene, benzo(g, h, i)perylene, indeno (1,2,3-c,d)pyrene] in fish(n=168) and shellfish(n=40). The methodology involved saponification and extraction with n-hexane, clean-up on Sep-Pak Florisil Cartridges and determination by HPLC/FLD (High Performance Liquid Chromatograph/Fluorescence Detector). Overall method recoveries for 8 PAHs spiked into these products ranged from 88 to 112%. The mean level of benzo(a)anthracene, chrysene, benzo(b)fluoranthene, benzo(k) fluoranthene, benzo(a)pyrene, dibenzo(a,h)anthracene, benzo(g,h,i)perylene and indeno(1,2,3-c,d)pyrene in cooked fish was ND, ND, 0.0009, ND, 0.01, ND, ND, ND and in cooked shellfish was 1.84, 3.51, 0.81, 0.38, 0.39, 0.04, 0.20, ND, respectively.