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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 23, Issue 4 - Nov 2010
Volume 23, Issue 3 - Aug 2010
Volume 23, Issue 2 - May 2010
Volume 23, Issue 1 - Feb 2010
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Effects of Gaeullijin-Tang on the Progression of the Estradiol Valerate-induced Polycystic Ovaries in Rats
Yun, Mun-Hui ; Lee, Dong-Nyung ; Seo, Il-Bock ; Kim, Hyung-Jun ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 1~19
Purpose: This study was designed to investigate the effects of Gaeullijin-Tang(GIT) on the progression of the estradiol valerate(EV)-induced polycystic ovaries(PCO) in rats. Methods: PCO was induced by single intramuscular injection with estradiol valerate(EV)(4mg) in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for sixty days. PCO control group (n=8) were injected with EV and orally administrated distilled water for sixty days. GIT treated group(n=8) were injected with EV and orally administrated GIT for same duration. At the end day of experiment, we measured weights of body, ovaries, adrenal glands, uterus and contents of serum androsternedione (ADD) and total estrogen. The histomorphometrical changes of ovaries were also evaluated. And we observed the NGF and CRF expression by immunohistochemistry. Results: The results were as follows - The weights(mg) of ovaries in GIT treated group(
) were significantly increased(p<0.001) compared with PCO control group(
). - The numbers of mature follicles in GIT treated group(
) were significantly increased(p<0.05) compared with PCO control group(
). - The numbers of corpora lutea in GIT treated group(
) were significantly increased(p<0.05) compared with PCO control group(
). Conclusion: From the above results, we concluded that Gaeullijin-Tang(GIT) contributes to stimulating normally ovulation by decreasesing ovarian NGF concentrations.
Antibacterial Effects of Sasangjasaebang Aqueous Extracts Against Gardnerella Vaginalis ATCC14018, and Combination Effects with Metronidazole
Sung, Hyun-Ah ; Park, Young-Sun ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 20~37
Purpose: The objective of this study was to observe the antibacterial effects of Sasangjasaebang (SSJSB) aqueous extracts, traditionally used for treating various gynecological diseases including vaginitis in Korea and their individual components - Cnidi Fructus(CF), Zanthoxyli Fructus(ZF) and Alumen(AL) against Gardnerella vaginalis ATCC14018, and combination effects of SSJSB extracts and Metronidazole were also monitored in this study. Methods: Antibacterial activities against Gardnerella vaginalis ATCC14018 of SSJSB (CF : ZF : AL = 10 : 3 : 3) aqueous extracts and their individual components were detected using standard agar microdilution methods. In addition, the effects on the bacterial growth curve were also monitored at MIC and
levels. The combination effects of SSJSB aqueous extracts and Metronidazole were observed by Checkboard Microtiter Assay and effects on bacterial growth curve treated with SSJSB aqueous extracts MIC + Metronidazole MIC, 1/2MIC and 1/4MIC, respectively. In the present study, Gardnerella vaginalis ATCC14018 were incubated under
, 10% CO2 and bacterial growth curves were calculated at 24, 48, 72, 96 and 120 hrs after incubations. Results: MIC of CF aqueous extracts, ZF aqueous extracts, AL powders and SSJSB aqueous extracts against Gardnerella vaginalis ATCC14018 were detected as
, respectively. MIC of Metronidazole was detected as
at same conditions. In addition, Metronidazole, CF aqueous extracts, ZF aqueous extracts, AL powders, and SSJSB aqueous extracts showed marked dosage-dependent inhibition of bacterial growth, and more dramatical inhibitions were detected in Metronidazole 1/2 MIC + SSJSB aqueous extracts MIC treatment as compared with each of single Metronidazole MIC and SSJSB aqueous extracts MIC treatments, respectively. Especially, quite similar inhibitory effects on bacterial growth were detected in Metronidazole 1/4 MIC + SSJSB aqueous extracts MIC treatment as compared with single Metronidazole MIC treatment in the present study. FIC index were detected as
(0.375~0.625) at Checkboard Microtiter Assay. Conclusion: The results obtained in this study suggest that CF aqueous extracts, ZF aqueous extracts, AL powders, and SSJSB aqueous extracts showed antibacterial effects against Gardnerella vaginalis ATCC14018, and they also showed dosage-dependent inhibitory effects on the bacterial growth. More potent antibacterial effects were detected in SSJSB aqueous extract as compared with individual components, respectively. In addition, combination treatment of SSJSB aqueous extract and Metronidazole showed more potent inhibitory effects on the growth of Gardnerella vaginalis with FIC index
(0.375~0.625). According to these results, the combination of SSJSB aqueous extract and Metronidazole is synergistic, and it is expected that effective dosages of Metronidazole could be reduced to 1/4 levels in combination with SSJSB extracts. And it might be needed to make further studies to seek the herbs which have antibacterial effects on the Gardnerella vaginalis ATCC14018.
Effect of Foeniculi Fructus on the Ovarian Function and Gene Expression of Caspase-3, MAPK and MPG in Female Mice
Jeon, Mi-Hye ; Park, Young-Sun ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 38~56
Purpose: This study was designed to evaluate the effect of administration of Foeniculi Fructus on ovarian functions and differential gene expressions related cell viability such as caspase-3, MAPK and MPG in female mice. Methods: We administered the Foeniculi Fructus to 6-week-old female CF-1 mice for 4, 8, 12 days. After administration of Foeniculi Fructus with 0.1, 1, 10,
concentration in the comparison of control group with
, we observed the mean number of total ovulated oocytes and the number of morphologically normal oocytes. After entosomatic fertilization, we observed the rate of fertilized 2-cell embryos to blastocyst stage in vitro. Also we chose the caspase-3 for cell apoptosis, MAPK and MPG genes for cell viability and DNA repair by RT-PCR. Results: 1. In case of 4, 8, 12day administration of Foeniculi Fructus with 0.1, 1, 10,
, the mean number of total ovulated oocytes and the number of morphologically normal oocytes were increased in the comparison of control group. 2. In case of 4, 8, 12day administration of Foeniculi Fructus with 0.1, 1, 10,
, the rates of blastocyst formation from 2-cell stages were increased in the comparison of control group. 3. In case of 4, 8, 12day administration of Foeniculi Fructus with 0.1, 1, 10,
, the gene expression of caspase-3, MAPK, MPG didn't show significant result in the comparison of control group. Conclusion: This study shows that Foeniculi Fructus has significant effects on the increase of the function on ovulation and embryonic development of female mice. But this results have nothing to do with caspase-3, MAPK and MPG genes. So we need a further study for which genes are related to the activation of reproductive functions of Foeniculi Fructus.
Study of Gidaebang on the T cells activation using dendritic cells
Kim, Ji-Ryang ; Jeong, Ji-Hye ; Cheong, Hyun-Cheol ; Choe, Chang-Min ; Cho, Han-Baek ; Kim, Song-Baeg ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 57~70
Purpose: In this study, we investigated the effects of GDB(Gidaebang) on the immune response to establish the treatment mechanism of vaginitis. Methods: We examined the effects of GDB on the DCs(Dendritic cells) phenotypic and functional maturation. iDCs were cultured in the presence of GM-CSF and the generated iDCs were respectively stimulated by GDB or LPS as the control group for 24 hours. To evaluate the DCs phenotypic and functional maturation, we used flow cytometric analysis, RT-PCR and ELISA. Results: 1. GDB upregulated the expression of class II MHC and CD40 on DCs. 2. GDB upregulated the expression of CD80 and CD86 on DCs. 3. GDB induced cytokine IL-12 production and mRNA expression in DCs. Conclusion: These results suggest that GDB is able to improve the antigen-presenting capacity of DCs through the upregulation of their maturation, and might induce proliferation of T cells. In conclusion, this immunomodulatory properties of GDB may be useful in the treatment of vaginitis.
Effects of Gleditsiae Spina(GS) on the Polycystic Ovary Induced by Estradiol Valerate in Rats
Gu, Hee-Jun ; Cho, Sung-Hee ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 71~84
Purpose: In the theory of traditional medicine, Glenditsia spina(GS) can resolve carbuncle, relive swelling, dispel wind and destroy parasites. This study was designed to investigate the effects of GS on gene expression of ovarian tissue in polycystic ovary syndrome(PCOS) rats. Methods: In this experiment, female rats injected with a single dose of 2 mg estradiol valerate(EV) and GS was given for 5 weeks. The genetic profile for the effects on ovarian tissue in PCOS rats was measured using microarray technique, and the functional analysis on these genes was conducted. Results: 985 genes were increased in control and restored to normal level in GS group. (B), 733 genes were decreased in control group and restored to normal level in GS group. (F). Metabolic pathways related in B group genes were Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Small cell lung cancer, Type I diabetes mellitus. Metabolic pathways related in F group genes were Antigen processing and present, Adipocytokine signalling pathway, Focal adhesion, ECM-receptor interaction, Pancreatic cancer, Notch signalling pathway, Tight junction. The network of total protein interactions was measured using cytoscape program, and some key molecules, such as c-Fos, c-Myc, ABL1 related in B group, MAPK8, RASA1, CALR related in F group that can be used for elucidation of therapeutical mechanism of medicine in future were identified. Conclusion: These results suggest possibility of GS as anti-cancer and anti-hyperplasia drug in PCOS. In addition, the present author also suggests that related mechanisms are involved in suppression of proto-oncogene such as c-Fos, c-Myc and ABL1, and in regulation of cell cycle such as RASA1.
Coo-Sun activity a man of mind rule and its effect on the quality of life of female cancer patients suffering from anxiety and depression
Nam, Ho-Young ; Jeong, Tae-Young ; Yoo, Hwa-Seung ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 85~94
Purpose: This study aimed to investigate a clinical effect of Coo-Sun activity focusing on improvement of quality of life in female cancer patients. Methods: The subject of study consisted of 5 female cancer patients at the East-West Cancer Center of OO Oriental hospital. The survey methods of this study are Functional Assessment of Cancer Therapy-General (FACT-G) and State-Trait Anxiety Inventory (STAI). Patients performed Coo-Sun activity 6 times a week and filled out FACT-G and STAI questionnaire after every 3 times training. Results: In FACT-G questionnaire, physical well-being and emotional wellbeing was improved significantly after Coo-Sun activity. And change of social/family well-being and functional well-being score were not significant statistically. In STAI questionnaire, STAI1 was improved significantly after Coo-Sun activity. And change of STAI2 score was not significant statistically. Conclusion: After Coo-Sun activity, quality of life (QOL) in female cancer patients was improved and anxiety was decreased. But this study have limitation to prove effects of Coo-Sun activity completely in female cancer patients. So well designed prospective cohort study will be needed to prove its benefits.
A Study on the Severity of Dysmenorrhea, Digestive Power according to the Shift Rotation
Yang, Na-Rae ; Cho, Jung-Hoon ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 95~105
Purpose: The purpose of this study was to find out the correlation among Shift Rotation, dysmenorrhea and digestion function. Methods: We conducted a questionnaire survey of 161 nurses about their menstruation and digestion function from several hospitals from Oct to Nov in 2009. Using chi-square test and pearson correlation, statistical analysis was made by SPSS 12.0. We significance level p-value was determined as 0.05. Results: 1. There was no significant correlation between Shift Rotation and the severity of dysmenorrhea. 2. There was statistically mild correlation between Shift Rotation and digestion power. 3. There was statistically mild correlation between dyspepsia and the severity of menstruation. Conclusion: From above results, we could conclude that Shift Rotation, dyspepsia had mild relation to menstruation.
Assessment of Maternal and Neonatal Risk Factors for Postpartum Depression
Choi, Jin-Young ; Lee, Jin-Moo ; Cho, Jung-Hoon ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 106~115
Purpose: The purposes of this study were in understanding maternal and neonatal risk factors for postpartum depression using Edinburgh Postnatal Depression Scale(EPDS). Methods: Among 788 women, who had delivery include cesarean section in the department of obstetrics and gynecology at OO medical center from May 28th 2008 to October 6st 2009, 72 women filled out EPDS questionnaire sheets. Additional aspects included for the analysis are maternal factors including age, number of children, parity, delivery method, and hemoglobin; and neonatal factors such as weight, sex, gestational age, apgar score, and neonatal intensive care unit admission. Comparison was performed between the women with EPDS score equal or less than 8 and the women with EPDS score equal to or higher than 9 using statistical methods of student t-test for linear variables and chi-square test for non-linear variables. SPSS version 13.0 for windows was used for analysis. Results: Thirty women(41.7%) were included in the postpartum depression risk group (EPDS score
). Statistically significant difference(P<0.05) was found in gestational ages of the risk group(
weeks) and the non-risk group (
weeks). Identified statistically significant risk factors(P<0.05) include cesarean section (OR=3.304 [1.121-9.744]), low birth weight infant(OR =6.500 [1.606-26.314]), preterm delivery(OR=2.857[1.071-7.621]), low apgar score (1minute) after delivery (OR=14.909 [1.750-127.025]). There was no statistically significant difference in maternal age, number of children, parity, hemoglobin, neonatal sex, apgar score (5minutes), NICU admission. Conclusions: Through the results showed, gestational age, delivery method, neonatal weight, apgar score(1minute) were identified as risk factors for postpartum depression. To prevent or minimize postpartum depression, oriental medical intervention is recommended for pregnant women through early detection.
A Study on Digital Infrared Thermographic Imaging Characters of Women Suffering from Postpartum Disease
Park, Kyoung-Sun ; Lee, Yoon-Jae ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Cho, Jung-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 116~123
Purpose: During Postpartum period many women complain multiple pain, cold hypersensitivity, hot flush, sweating and so on. We call the postpartum disease as San Hu Pung. We studied DITI Characters of women suffering from Postpartum disease. Methods: We studied 74 postpartum women visiting OOhospital from February 2006 to December 2009. The subjects were categorized in two groups, symptom group and no symptom group. We measured the temperatures of abdomen, upper and lower limb and back. We studied the difference of DITI between two groups by Student T-test using SPSS for windows(version 17.0). Results: The general characteristics were not different statistically. Temperatures of abdomen and back of two groups were not different statistically. Temperatures of both LR3 of symptom group were statistically higher than no symptom group. The difference of both PC8 and LU4, both LR3 and ST32 of symptom group were statistically higher than no symptom group. Conclusion: The results suggest that women suffering from Postpartum disease shows high temperatures on hand and foot. It seems that postpartum disease patients tend to have blood deficiency. DITI can be useful to diagnose San Hu Pung. More studies to diagnose San Hu Pung would be needed.
Effects of Menstrual Cycle on Heart Rate Variability in Dysmenorrhea Patients
Kim, Eun-Sook ; Moon, Seung-Joon ; Cho, Han-Baek ; Lim, Eun-Mee ; Ko, Seong-Gyu ; Cho, Jung-Hoon ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 124~130
Purpose: The aim of the study was to investigate menstrual cycle phase differences in Heart Rate Variability(HRV) in dysmenorrhea patients. Methods: 16 dysmenorrhea patients were enrolled. The severity of dysmenorrhea was measured by Visual Analog Scale(VAS). Recordings for HRV analysis were obtained during the two phases of the menstrual cycle (follicular phase 4~10 days and luteal phase 18~23 days from the start of bleeding). Results: No measure of HRV was significantly different between two menstrual cycle phases. Conclusion: We concluded that menstrual cycle was not significantly associated with changes in autonomic nervous system as measured by HRV in dysmenorrhea patients.
The Study to Investigate the Recognition on Postpartum Symptom among Korean, Korean resident in America and American
Bae, Geung-Mee ; Lee, In-Sun ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 131~144
Purpose: There has not been decisional consensus in the concepts and the ways of postpartum cares between Western and non-Western cultures though the importance of postpartum period has been emphasized by the multitude of health professionals. In this study, we investigated the differences in recognition concerning postpartum care among Koreans, Korean residents in America, and Americans (hereafter, K, KA, A). Methods: We used questionnaire of women who had given birth from last 6 weeks to less than 13 years. The women consisted of three groups;104 K, 44 KA, and 44 A. Results: In the perception survey concerning postpartum care, every three group thought that postpartum care was important. However, there were differences in understanding how it would affect women's health, and what they did in the period. K significantly agreed with the content and the importance of postpartum care. The investigation concerning seven categories of postpartum care showed that K group performed the 6 categories except consuming medication beneficial for the postpartum care. KA group performed in a low rate and A group performed two categories in a significantly low rate two categories; avoiding cold stimulation and keeping the body warm. Conclusion: Based on this study, it should be suggested that there were common points and differences among the recognition concerning postnatal care in three groups. Therefore, health professionals make efforts in understanding diversities on postnatal care and providing the adequate services reflecting each mother's needs and recognition.
A Case of Sjogren's Syndrome
Yeo, Eun-Ju ; Gu, Hee-Jun ; Yang, Dong-Seon ; Jo, Sung-Hee ; Yang, Seung-Jung ; Park, Kyung-Mi ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 145~153
Purpose: Sjogren's syndrome is a type of autoimmune disease and characterized by the keratoconjunctivitis sicca, xerostomia, dryness of mouth & eyes and rheumatoid arthritis or another connective tissue disease. In the Traditional Korean Medicine, there is few report to diagnose and treat Sjogren's syndrome. Methods: The subject was a typical Sjogren's syndrome in 48-year old women whose complaints were dryness of mouth and eyes, severe general myalgia. The author treated her with acupuncture and herbal medicine therapy, then evaluated with MMQ score, XQS grade and VAS score on a regular basis. Results: After treatment, clinical symptoms were improved, MMQ score and XQS grade were decreased. Conclusion: The Traditional Korean Medical Therapy combined acupuncture with herbal medicine relieves the symptom of Sjogren's syndrome.
A Case Report of a Woman in Menopausal Transition by Using Hormone Assay
Kang, Jung-Ah ; Kim, Hae-Jung ; Ryu, Ik-Han ; Kim, Song-Baeg ; Choe, Chang-Min ; Cho, Han-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 23, issue 2, 2010, Pages 154~160
Purpose: This study was done to report the progress of treatment with oriental medicine on a woman who complained of irregular menstruation in menopausal transition. Methods: The patient in this case was treated with Chokyungjongoktanggamibang, acupuncture and moxibustion. And to assess the effectiveness of this treatment, we evaluated the ovarian function by using hormone assay. Results: During treatment period the patient had three times of uterine bleeding, two of the three seemed like normal menstrual bleeding. And analyzing the hormone assay, estraiol level was increased and FSH, LH levels were decreased significantly. However a month after treatment end, estradiol level was decreased and FSH, LH levels were incresead as the levels in menopausal transition or menopause state. And the patient had no more uterine bleeding since last one according to follow up by phone-call. Conclusion: In this study, the progress of ovarian function was specified with hormonal changes after treatment of oriental medicine during menopausal transition. And further studies are needed to find the more appropriate clinical approach for women in menopausal transition.