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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 25, Issue 4 - Nov 2012
Volume 25, Issue 3 - Aug 2012
Volume 25, Issue 2 - May 2012
Volume 25, Issue 1 - Feb 2012
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A Study on Inhibitory Mechanism of Melia Fructus Extract on Osteoclast Differentiation
Yun, Young-Jin ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 1~11
Objectives: This study was conducted to evaluate the inhibitory effect of Melia Fructus extract on osteoclast differentiation. Methods: MTT-assay was performed to estimate cytotoxicity of Melia Fructus extract in BMMs stimulated with M-CSF. TRAP staining, TRAP activity and Real-time PCR were performed to know the inhibitory effect on osteoclast differentiation. Actin ring formation were analysed to observe the effect of Melia Fructus extract. Results: Melia Fructus extract decreased the number of TRAP positive cells and the expression of NFATc1 gene, c-Fos gene, TRAP and OSCAR in BMMs stimulated with RANKL. Melia Fructus extract has no cytotoxicity at the concentration used in this study. Melia Fructus extract restrained the formation of actin ring. Melia Fructus inhibited NF-
activity by inducing degradation of p-
. Conclusions: Melia Fructus has the inhibitory effect of osteocalst differentiation and bone resorption. Further studies are needed to treat osteoporosis by herbal medicine containing Melia Fructus.
Immune Enhancing Effect of Houttuyniae Herba on Mouse Macrophage
Kim, Jeong-Hyun ; Kim, Yoon-Sang ; Lim, Eun-Mee ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 12~22
Objectives: The aim of this study is to investigate immune enhancing effect of Houttuyniae Herba water extract(HW) on RAW 264.7 cell of mouse macrophages. Methods: Effects of HW on productions of nitric oxide(NO) and hydrogen peroxide(
) in RAW 264.7 mouse macrophages were measured. Effect of HW on production of cytokines such as interleukin(IL)-
, IL-6, and tumor necrosis factor(TNF)-
in RAW 264.7 cells was accessed by a multiplex bead array assay based on xMAP technology. All of results were represented P<0.05 compared to the normal. Results: 1. After 24 hr incubation, HW increased significantly NO production in RAW 264.7 cells at the concentrations of 25, 50, 100 and 200
/mL. 2. After 24 hr incubation, HW increased significantly hydrogen peroxide production in RAW 264.7 cells at the concentrations of 25, 50, 100 and 200
/mL. 3. After 24 hr incubation, HW increased significantly IL-
production in RAW 264.7 cells at the concentrations of 100 and 200
/mL. 4. After 24 hr incubation, HW increased significantly IL-6 production in RAW 264.7 cells at the concentrations of 100 and 200
/mL. 5. After 24 hr incubation, HW increased significantly TNF-
production in RAW 264.7 cells at the concentrations of 50, 100, and 200
/mL. Conclusions: These results suggest that HW has immune enhancing activity related with its increasement of NO, hydrogen peroxide, IL-
, IL-6, and TNF-
Effects of Samkieumgamibang Extract on Osteoclast Differentiation and Osteoblast Function
Park, Sun-Min ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 23~42
Objectives: This study was performed to evaluate the effect of Samkieumgamibang (SKG) on osteoporosis. Methods: The osteoclastogenesis and gene expression were determined in RANKL-stimulated RAW 264.7 cell. And, osteoblastogenesis was also determined in rat calvarial cell. Results: SKG decreased the number of TRAP positive cell in osteoclast. It also decreased the expression of Cathepsin K, MMP-9, TRAP, c-fos, NAFTc1 and JNK1 in osteoclast. SKG increased the expression of iNOS in RANKL-stimulated in osteoclast. Otherwise, SKG inhibited TRAP activity in osteoclast. SKG increased cell proliferation, ALP activity, bone martix protein, collagen and nodule in osteoblast. Conclusions: It is concluded that SKG might decrease the bone resorption resulted from decrease of osteoclast differentiation and it's related gene expression. And, SKG might increase the bone formation resulted from increase of osteoblast function.
Effects of Hyeolbuchukeo-tang on the Estradiol Valerate-induced Polycystic Ovaries and the Conception of Rats
Bae, Sang-Jin ; Kim, Hyung-Jun ; Lee, Dong-Nyung ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 43~65
Objectives: This study was designed to investigate the effects of Hyeolbuchukeotang( HCT) on the Estradiol Valerate(EV) induced Polycystic Ovaries and the Implantation of rats. Methods: PCO was induced by single intramuscular(IM) injection with EV in female rats. Normal group(n=8) were injected with sesame oil and orally administrated distilled water for 60 days. Control group(n=8) were injected with EV and orally administrated distilled water for 60 days. HCT treated group(n=8) were injected with EV and orally administrated HCT for 60 days. At the end day of experiment, we measured weights of body, ovaries, adrenal glands, uterus and contents of serum LH, FSH, ADD. The histomorphometrical changes of ovaries were also evaluated. And we observed the NGF and CRF expression by immunohistochemistry. Also we observed the mating and count the number of implantation. Results: - The weights(mg) of ovaries in HCT treated group(
) were significantly increased (p<0.01) compared with control group (
). - The number of mature follicles in HCT treated group(
) was significantly increased (p<0.01) compared with control group(
). - The number of cystic follicles in HCT treated group(
) was significantly decreased (p<0.01) compared with control group(
). - The value of serum FSH(mIU/ml) in HCT treated group(
) was significantly decreased(p<0.05) compared with control group(
). - The expression of NGF-immunoreactive cells in the ovarian cells in HCT treated group was lesser observed than control group. - The number of implantation in HCT treated group(
) was significantly increased (p<0.05) compared with control group(
). Conclusions: Hyeolbuchukeo-tang(HCT) is effect on polycystic ovaries and the implantation of rats by EV-induced.
Effects of Pinelliae Rhizoma(PR) on Ovarian Tissue in Polycystic Ovary Syndrome(PCOS) Rats
Yeo, Eun-Ju ; Jo, Sung-Hee ; Yang, Seung-Jung ; Park, Kyung-Mi ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 66~77
Objectives: This study was designed to investigate the effects of PR on ovarian tissue in PCOS rats through measurement of morphological and histo-pathological observations, ovarian size. In addition, effects on expression levels of Insulin like Growth Factor Receptor(IGFR) were also investigated to elucidate related mechanisms. Methods: PCOS was induced by single intermuscular injection with
-Estradiol 17-Valerate(EV) in female rats. Normal group(NOR, n=8) were injected with sesame oil and administrated hard food for five weeks. Control group(CTL, n=8) were injected with EV and administrated hard food for five weeks. CR group(n=8) were injected with EV and administrated hard food mixed CR for five weeks. Then, we measured weights of body and ovary, uptakes of food and water. And we observed morphological and histo-pathological changes of ovary, levels of IGFR. Results: In this experiments, single injection of Estradiol Valerate(EV) induced suppression of weight gain, formation of cysts, increase of IGFR expression. Oral administration of PR prevent decrease of ovarian size significantly. Further more, formation of cystic follicles induced by EV injection is suppressed by PR treatment. Conclusions: These results suggest PR can be used for patients with PCOS to prevent formation of cystic follicles and malfunction of ovary.
Antioxidant Effect of Paeonia Japonica Extracts on Mouse Embryonic Fibroblast Cells
Yoon, Hee-Jung ; Go, Eun-Bi ; Choi, Min-Sun ; Kim, Dong-Il ; Sung, Jung-Suk ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 78~88
Objectives: Paeonia japonica has been widely used for gynecopathy and analgesic effects in Korean Traditional Medicine. The aim of the present study is to determine the antioxidant effect of Paeonia japonica extracts(PJE) by using mouse embryonic fibroblast cells(MEF cells). Methods: We evaluated Radical Scavenging Activity of PJE by the DPPH assay. Protective effect of the PJE on the hydrogen peroxide(
) induced oxidative damage of MEF cells was analyzed by the MTT assay. The Morphological changes of MEF cells induced by P. japonica,
and P. japonica+
was evaluated by DAPI staining. And effect of PJE on the rate of apoptosis in MEF cells was measured using flow cytometry with Annexin V-FITC and PI double staining. Results: We observed that PJE contain significant DPPH radical scavenging activity. Cell viability of oxidative damaged cells treated with various concentrations of
was increased by treatment with PJE. Flow cytometric analysis of the cells treated with
in the absence or presence of PJE showed that the crumbled G1 peak was accumulated by the treatment with
alone, but restored by addition of PJE. Portion of cells that undergo apoptosis mediated by oxidative stress was decreased by treatment of PJE. The nuclear fragmentation occurred in the oxidative damaged MEF cells was also decreased by PJE treatment. Conclusions: Taken together, our results suggest that PJE exhibits significant antioxidant activity and functions to inhibit cell death mediated by oxidative damage induced apoptotic pathways.
Evaluation of Anti-Inflammatory Effects of Yukmijihwangtang and Individual Drug Substances Based on the Extraction Methods
Lee, Gui-Hee ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 89~107
Objectives: This study was performed to develop therapeutic prescription that is more significant than existing ones through extraction method and formulation changes. Methods: Yukmijihwangtang(YMJHT) was extracted in 80% ethanol, and their relative anti-oxidant activities as well as anti-inflammatory effects through immune modulation were measured. Results: Both water and ethanol extracted YMJHT showed does-dependent DPPH elimination activities. ROS inhibition activity was greater in water extracted YMJHT except for Moutan Cortex. NO inhibition assay results indicated that all groups showed higher NO inhibition activities in RAW 264.7 cells in dose dependent manner. Water extracted group showed higher NO inhibition activity than that of ethanol extracted group. TNF-
secretion inhibition assay using RAW 264.7 cells, water extracted YMJHT showed higher activity than ethanol extracts. Growth rate of spleen cells was greater in all tested groups, with higher rate in YMJHT-EtOH than YMJHT-DW. Suppression of gene expression of IFN-r in spleen cells stimulated by Con A was higher in YMJHT-EtOH than YMJHT-DW. Suppression of gene expression of IL-10 in spleen cells stimulated by Con A was highest in YMJHT-DW with 40%. Suppression of gene expression of IL-4 in spleen cells stimulated by Con A were significant with 90% or higher in all groups and that of IL-12p35 were also higher than 90% in all cases. Conclusions: From the results, it shows that YMJHT has anti-inflammatory effects through immune modulation. However, the difference between YMJHT-EtOH and YMJHT-DW was not that significant. Further studies are needed to find out effective extraction methods of herbal medicine.
The Compositional Differences of Sipjeondaebo-tang(Siquandabu-tang) Decoctions Extracted by Different Extraction Method and Extraction Time
Kim, Jung-Hoon ; Seo, Chang-Seob ; Jeon, Woo-Young ; Shin, Hyeun-Kyoo ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 108~119
Objectives: This study was performed to compare the differences between decoctions extracted by different extraction method and extraction time. Methods: Decoctions were prepared with pressurized or non-pressurized extraction for 60, 120 and 180min. The yield of extract, total soluble solid content, hydrogen ion concentration(pH) and the content of reference compound in Sipjeondaebo-tang (Siquandabu-tang) were investigated. Results: While yields and the total soluble solid of decoction were higher in pressurized method proportional to extraction time, pH values were lower in pressurized method and showed decreasing values with increasing extraction time. Albilflorin, ferulic acid, nodakenin, coumarin, cinnamaldehyde and glycyrrhizin were contained in decoctions by pressurized extraction method more than non-pressurized method whereas the content of coumarin was higher in decoctions by non-pressurized extraction method. In addition, coumarin was extracted increasingly with extraction time in decoctions by pressurized method, however, nine compounds except cinnamaldehyde showed the tendency of increasing proportional to extraction time. Conclusions: The results show that extraction methods including pressurized or non-pressurized extraction, and extraction time could affect the physicochemical characteristic or composition of Sipjeondaebo-tang(Siquandabu-tang) decoction.
A Report of the Symptoms Accompanied with Acne and Heart Rate Variability Analysis of Acne Patients
Heo, Su-Jeong ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Lee, Kyung-Sub ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 120~130
Objectives: The purpose of this study is to investigate the symptoms accompanied with acne and HRV pattern of the acne patients. Methods: We reviewed 60 acne patients(age 15-38) who visited
hospital from January 2010 to October 2011. We investigated the symptoms accompanied with acne of 60 patients and evaluated HRV of 41 acne patients. The data were analyzed by Mann-Whitney test using SPSS/PC ver 13.0 program. Results: 1. Prevalence of female post-adolescent acne was 66.7% in this study. The symptoms accompanied with acne were dischezia(35%), gastric discomfort(28.3%) in all patients and dysmenorrhea(40%), leukorrhea(38%), irregular menstrual period (24%) in female patients. 2. SDNN, RMSSD, VLF and HF of female were significantly lower than male. 3. SDNN, TP and VLF of un-dysmenorrhea group were significantly lower than dysmenorrhea group. 4. PSI of under 6 months group was significantly higer than over 6 months group. 5. In postadolescent acne patients SDNN, RMSSD, TP, LF and HF were significantly lower and PSI was significantly higher than adolescent acne patients. Conclusions: There are many female post-adolescent acne pateints and the assessment of the symptoms accompanied with acne and stress degree is helpful in treating acne. The further research and development about the diagnostic and therapeutic methods of acne are needed in oriental obstetrics and gynecology field.
Study of the Efficacy and Safety of "adenophorae radix extract" in the Obese Patients or Overweight
Kim, Gi-Tae ; Go, Heung ; Shin, Seon-Mi ; Kim, Hyung-Jun ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 131~141
Objectives: The purpose of this study is to evaluate the efficacy and biosafety of Adenophorae Radix(AR) extract in obesity or overweight patient. Methods: This study is double-blind, randomized, placebo-controlled intervention Study. 30 patients with BMI
and 30> were allotted into two groups at random. In 0,
week, we had checked body weight, waist line, hip line, body fat and abdominal CT scan. In 0,
week, we also had checked lipid metabolism and biosafety with blood test. Results: AR treatment had a significant effect on suppressing body wight gain (p<0.01) and BMI index(p<0.01). AR treatment reduced plasma TG level but we couldn't find statistical significance. AR treatment had produced no adverse reactions. Conclusions: This study shows that Adenophorae Radix(AR) extract can reduce the weight, BMI. Adenophorae Radix(AR) extract can be used in obesity or overweight patient.
A Clinical Study on the Effect of Dysmenorrhea Clinic for Female College Students
Kim, Hyeon-Ju ; Sohn, Young-Joo ; Lee, Yong-Hyun ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 142~153
Objectives: The purpose of this study is to identify the clinical effects of korean medicine treatment of dysmenorrhea patients. Methods: We studied twenty-six patients who visited Oriental Hospital of
University from September 2011 to December 2011. Women with organic disease such as endometriosis, uterine myoma and pelvic inflammatory disease were excluded from this study. We treated them with herb, acupuncture and moxibustion for one menstrual cycle. The severity of dysmenorrhea was measured by VAS(Visual analog scale) and MVRS(Multidimensional Verbal Rating scale). Results: The mean
Standard Error of mean(S.E) of VAS on after treatment was decreased significantly compared with that of before(p=0.00). The mean
S.E of MVRS on after treatment was decreased significantly compared with that of before(p=0.00). Conclusions: This study shows that korean medicine treatment such as herb, acupuncture and moxibustion has remarkable effects on dysmenorrhea patients. Further study will be needed.
The Effect of Dance Movement Therapy on Anxiety, Depression, and the Quality of Life in Climacteric Women
So, Sun-Hee ; Kim, Hyung-Jun ; Ha, Hun-Yong ; Kim, Nam-Song ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 154~173
Objectives: The aim of this study is to find out the effects of dance movement therapy(DMT) on anxiety, depression, and life quality by applying DMT program to climacteric women. Methods: The subjects of the research are climacteric women between the ages of 45 and 55 who located in the city of oo in Chollabukdo. The program was conducted with the subjects of a total of 27 women less than one year after menopause, 14 in the experiment group and 13 in the comparison group, 90 minutes a session, once a week, for 15 weeks. Results: The results show that the points of anxiety and depression decreased significantly in the experiment group which participated in the DMT program (p<0.05). The points of life increased significantly in physical & mental wellbeing, competence, and stability (p<0.05). Vitality points increased, but not significantly. Conclusions: This means that DMT decreases anxiety and depression of climacteric women, has positive effects on life quality related to health, and can help increase physical, mental, and emotional wellbeing of climacteric women.
Short-term Clinical Observation of the Early Postpartum Low Back Pain in the Korean Medical Hospital
Lee, Eun-Hee ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 174~184
Objectives: The purpose of this study was to observe the early postpartum low back pain and pelvic girdle pain in the Korean medical hospital for 2-weeks. Methods: Fifty-one postpartum women who admitted for postpartum care in Korean hospital from December 3rd, 2011 to January 31st, 2012 had written out pain measurement questionnaires(SF-MPQ, VAS, ODI) three times for 2-weeks. SPSS 18.0 for Windows was used to analyse the data and the independent samples t-test, paired T-test were used to verify the results. Results: 1. Evaluation of low back pain within the first week after birth was as follows: SF-MPQ sensory area was
points; SF-MPQ emotional areas was
points; VAS mean was
points; and ODI mean was
. 2. Early postpartum low back pain and pelvic girdle pain were significantly decreased in SF-MPQ, VAS, and ODI after 2-weeks(p < 0.01). 3. Age, birth type, parity, weight, and BMI increased during pregnancy does not affect the postpartum low back pain and pelvic girdle pain. Conclusions: The top 10% of postpartum low back pain scale was 10.8 points or more in the sensory area of SF-MPQ, and 3 points or more in the affective area of SF-MPQ. In the case of VAS, it was more than 7 points, and ODI was more than 21.8 points. Postpartum back pain with oriental medical treatment was significantly improved.
Review on the Treatment Methods of Korean Oriental Medicine for PMS
Jang, Su-Hee ; Lee, Eun-Sol ; Kim, Dong-Il ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 185~199
Objectives: This study aimed to review the effects and treatment of Korean, Oriental, Chinese medicine for premenstrual syndrome(PMS) as preceding research in order to further research the effective Korean Medicine treatment for PMS. Methods: Databases from Jan., 2002 through Feb., 2012 were searched through Pubmed for international journals; Korean studies information service system(KISS), National Discovery for Science Leaders(NDSL), Journal of Korean Acumoxa, J of Oriental Obstetrics and Gynecology, J of Meridian and Acupoint, and J of Korean Oriental Medicine for Korean journals were searched for national journals. The following search terms were used: acupuncture premenstrual syndrome, alternative medicine premenstrual syndrome, traditional Chinese medicine(TCM), premenstrual syndrome for Pubmed, premenstrual syndrome(in Korean and English) for the remaining search. Results: Twenty four studies were included in this review. Conclusions: Alternative medicinal intervention such as acupuncture and herb medicine may be effective treatment method in controlling premenstrual syndrome and premenstrual dysphoric disorder(PMDD).
A Case Report of Preterm Labor Patient at High Risk for Preterm Delivery Treated by Combination of Herbal Medicine and Conventional Treatment
Jo, Jun-Young ; Park, Kyoung-Sun ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 200~206
Objectives: The purpose of this study is to report the effect of combination of herbal medicine and conventional treatment on preterm labor patient at high risk for preterm delivery. Methods: The patient in this case was 33-year-old female with gravid 3, para 2, abortus 1. She experienced 1 preterm birth 5 years ago. She visited our clinic with lower abdominal pain at 14th gestational week. We treated her by herbal medicine. She also take vaginal progesterone from 19th gestational week to 34th gestational week. Results: She maintained her pregnancy until giving a birth by cesarean section at 38th gestational week. No adverse effects were not observed among mother or infant. Conclusions: Combination of herbal medicine and conventional treatment is effective on preterm labor patient at high risk for preterm delivery.
A Case Report of Adenomyosis Treated with Gamiseokhong-jeon Gamibang
Shim, Gye-Seon ; Cho, Seung-Hee ; Seo, Eun-Bi ; Jung, Young-Min ; Choi, Chang-Min ; Kim, Song-Baek ; Seo, Yun-Jung ; Cho, Han-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 2, 2012, Pages 207~214
Objectives: The most common symptom of adenomyosis is dysmenorrhea and menorrhagia. Therefore, final treatment of this disease is hysterectomy. If dysmenorrhea and menorrhagia can be controlled, It doesn't need the surgical treatment. so, this case study was designed to evaluate the effect of Gamiseokhong-jeon on dysmenorrhea, menorrhagia due to adenomyosis. Methods: A 45-year-old female patient who was diagnosed with adenomyosis has been troubled by dysmenorrhea and menorrhagia. She was taken Korean herbal medicine(Gamiseokhong-jeon gamibang) about 3 months. Results: During this treatment period, dysmenorrhea and menorrhagia were relieved. Also after all treatment, the effect has been continuing. Conclusions: Gamiseokhong-jeon gamibang relieve dysmenorrhea and menorrhagia due to adenomyosis.