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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 25, Issue 4 - Nov 2012
Volume 25, Issue 3 - Aug 2012
Volume 25, Issue 2 - May 2012
Volume 25, Issue 1 - Feb 2012
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The Antiinflammatory Effects of Chaenomelis Fructus Herba Water Extract on Mouse RAW 264.7 Cell
Ryu, Hahn-Woo ; Kim, Yoon-Sang ; Lim, Eun-Mee ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 1~15
Objectives: The purpose of this study was to investigate the effects of Chaenomelis Fructus Herba Water Extract(CF) on the production of inflammatory mediators in RAW 264.7 cell mouse macrophages stimulated with LPS. Methods: We have not examined effect of CF on the cell viability of RAW 264.7 cell until we investigated effects of CF on LPS-induced productions of NO, Ca and various cytokines in RAW 264.7 cell. And when p-value is below 0.05, it is judged to have the significant difference statistically(P<0.05). Results: 1. CF increased the cell viability in the RAW 264.7 cell at the density of 25, 50, 100 and 200
. 2. CF inhibited significantly increasing the production of NO in LPS-induced RAW 264.7 cell at the density of 25, 50, 100 and 200
. 3. CF inhibited significantly increasing the production of Intracellular Ca in LPS-induced RAW 264.7 cell at the density of 25, 50, 100 and 200
. 4. CF inhibited significantly the IL-2, IL-10, IL-12p70, TNF-
, GM-CSF, M-CSF, LIF and VEGF of the RAW 264.7 cell induced by LPS at the density of 25, 50, 100 and 200
. 5. CF inhibited significantly the IL-4 at the density of 25, 50
, the IL-5, IL-15 and MIG at the density of 25, 50 and 200
at the density of 25, 100
respectively in the RAW 264.7 cell increased by LPS. Conclusions: CF inhibited significantly increasing IL-2, IL-10, IL-12p70, TNF-
, GM-CSF, M-CSF, LIF, VEGF, NO and Ca in LPS-induced RAW 264.7 cell at the density of more than 25
without causing the toxicity. These results signify that CF has antiinflammatory effect on controlling the over inflammatory reaction by the RAW 264.7 cell.
Effects of Cordyceps militaris(CM) on Osteoclastogenesis and Gene Expression
Choi, Kyung-Hee ; Yoo, Jeong-Eun ; Hwang, Gwi-Seo ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 16~26
Objectives: This study was performed to evaluate effects of Cordyceps militaris(CM) on osteoclast differentiation and its related gene expression. Methods: We used mouse myeloid cells RAW 264.7 stimulated by receptor activator of nuclear factor kappa-B ligand(RANKL) to induce osteoclast differentiation. There are four groups of which RAW 264.7 cells are not stimulated by RANKL (Normal), stimulated by RANKL without CM(Control), stimulated by RANKL with 0.1
of CM(CM 0.1), stimulated by RANKL with 1
of CM(CM 1). Osteoclastogenesis was measured by counting Tartrate-resistant acid phosphatase-positive multinucleated cells [TRAP(+) MNC]. RT-PCR was performed to evaluate the inhibitory effect of CM on gene expression(TRAP, AKT1, JNK1, NFATc1, c-Fos, MITF). Results: 1. CM decreased the number of TRAP(+) osteoclast in RANKL-stimulated RAW 264.7 cell at the concentration of 0.1
. 2. CM decreased the expression of TRAP in osteoclast at the concentration of 1
. 3. CM decreased the expression of AKT1, JNK1 in osteoclast at the concentration of 1
. 4. CM didn't affect the expression of NFATc1, c-Fos, MITF in osteoclast. Conclusions: Cordyceps militaris has inhibitory effects on osteoclast differentiation and its related gene expression. These results suggest that Cordyceps militaris has a potential as a treatment of osteoporosis.
In Vitro Antibacterial Effects of Tunong-san and Kwaruwoobang-tang Aqueous Extracts against Staphylococcus aureus
Jang, Se-Ran ; Park, Young-Sun ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 27~39
Objectives: Recently Ciprofloxacin, used in the treatment of mastitis, showed many serious side effects. The object of this study was to recognize whether TNS and KWT can be used in the treatment of mastitis by observing the in vitro antibacterial effects of TNS and KWT aqueous herbal extracts against S. aureus. Methods: Antibacterial activities of TNS and KWT aqueous extracts against S. aureus ATCC 25923 were detected using standard agar microdilution methods. In addition, the effects on the bacterial growth curve were monitored at MIC and
levels. The effects on the intracellular killing and bacterial invasion of individual test materials were also observed using Raw 264.6 and MCF-7. The results were compared with Ciprofloxacin, a second generation of quinolone antibiotics in the present study. Results: MIC of aqueous extracts of TNS and KWT against S. aureus were detected as (
) and (
) mg/ml, respectively. MIC of Ciprofloxacin was detected as (
at same conditions. In addition, TNS, KWT aqueous herbal extracts and Ciprofloxacin were also showed marked dosage-dependent inhibition of bacterial growth, and dramatical inhibitions on the both intracellular killing assays and bacterial invasion using Raw 264.6 and MCF-7 cells were detected. Conclusions: The results obtained in this study suggest that TNS and KWT aqueous herbal extracts showed antibacterial effects against S. aureus, and they also showed dosage-dependent inhibitory effects on the bacterial growth. And they showed the significant intracellular killing and bacterial invasion effects. It means, KWT and TNS may show more potent anti-infectious effects against S. aureus in vivo.
Shipyeukmiyeugi-eum Extracts Suppressed Tumor Growth through Immunomodulatory Effects on MCF-7
Jung, Yeon-Chul ; Park, Young-Sun ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 40~60
Objectives: The object of this study was to observe antitumor, anticachexia and immunomodulatory effects of Shipyeukmiyeugi-eum(SYM) on human breast cancer cell, MCF-7, xenograft Balb/c nu-nu nude mice. Methods: Three different dosages of SYM-125, 250 and 500 mg/kg were orally administered once a day for 28 days from 11 days after tumor cell inoculation, and the changes on the body weights, tumor volume and weights, weights of spleen and popliteal lymph node and epididymal fat, serum IL-6 and IFN-
levels, NK cell and peritoneal macrophage activities, splenic TNF-
and IL-10 contents were observed. In addition, histopathological observations of apoptotic cell, spleen, popliteal lymph node and cervical brown adipose were also detected. The results were compared with a potent cytotoxic estrogen receptor antagonist, Tamoxifen 20 mg/kg treated mice. Results: Tumor volumes and weights were decreased without cytotoxic effects on the both MCF-7 and MCF-10A cells as results of all three different dosages of SYM treatment. And weights of body, spleen, popliteal lymph node, epididymal fat, serum IFN-
, NK cell, peritoneal macrophage activities, splenic TNF-
and IL-10 contents were increased with decrease of serum IL-6. At histopathological observations, apoptotic tumor cells, spleen, popliteal lymph node and cervical brown adipose tissue were increased. That means tumor-related immunosuppress and cachexia were markedly inhibited by SYM treatment as compared with tumor-bearing mice. On the other hand, Tamoxifen showed marked cytotoxic effects against MCF-7 and MCF-10A, decreases of tumor volume and weights, and increases of apoptotic tumor cells and related decreases of tumor cell volumes, but tamoxifen markedly deteriorated the tumor-related immune-suppress and cachexia. Conclusions: The results obtained in this study suggest that SYM showed favorable anticancer effects and anticachexic effects on the MCF-7 cell xenograft through immunomodulatory effects. SYM did not induce any cytotoxic effects against both normal and cancer cells.
The Effects of Cinnamomum loureirii on Osteoblast in Murine Rat Calvarial Cells
Kim, Duck-Gu ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 61~70
Objectives: In this study, the author aimed to evaluate the effect of BuOH fraction(YK) from Cinnamomum loureirii on osteoblast proliferation in murine rat calvarial cells. Methods: The osteoblast separated from murine calvariae was cultivated for 10 days and evaluated the cell function. After the addition of YK on the culture medium, we determined the effect of YK on the cell proliferation, alkaline phosphatase activity, apoptosis of the cultivated osteoblast, protein synthesis and collagen synthesis. Results: YK increased the proliferation of rat calvarial osteoblast. YK increased ALP activity of rat calvarial osteoblast. YK did not change the survival rate of rat calvarial osteoblast. YK increased protein synthesis of rat calvarial osteoblast. YK increased collagen synthesis of rat calvarial osteoblast. Conclusions: This study suggests that YK might improve the osteoporosis resulted from augumentation of osteoblast proliferation.
Effects of Pueraria lobata on Body Weight and Gene Expression in Obese Rats Muscle with Estrogen Deficiency
Shin, Hee-Jong ; Yoo, Jeong-Eun ; Jung, Eun-Hye ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 71~84
Objectives: GG is the EtOH fraction of extract of Pueraria lobata. In this study, we aimed to elucidate a possibility that GG reduce obesity and obesity-derived complications such as cardiovascular and metabolic disease. Methods: The effects of GG on the estrogen-deficient obese rats and the level of gene expression in muscle of rats were investigated. Results: GG decreased body weight in obese rats with estrogen deficiency. GG increased leptin gene expression in obese rats with estrogen deficiency. GG decreased TNFa gene expression in obese rats with estrogen deficiency. And GG increased PPAR-gamma, PGC-1a, Prdx6, FDFT1, and ACC gene expression of those in obese rats. Conclusions: We conclude GG might reduce body weight and regulate gene expression of muscle in obese rats.
A Study for the Syndrome Differentiation of Retroverted Uterus Using Ultrasound
Hwang, Deok-Sang ; Lee, Jae-Sung ; Jeong, Eun-Jeong ; Lee, Yoon-Jae ; Lee, Kyung-Sub ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 85~94
Objectives: We have studied the syndrome differentiation of ultrasound of retroverted uterus(RU) as the inspection in traditional Korean medicine. Methods: Eighty-four patients, who visited H clinic for infertility treatment, were recruited and evaluated by questionnaires and ultrasound, from April, 2012 to May, 2012. We used ultrasound(Logiq C3; GE Health care) for examination of RU. For statistics, we used Fisher's extract test to evaluate the RU and symptoms, and Chi-square test to evaluated the RU and syndrome differentiations, and Student T-test for the relationship between RU and each score of syndrome differentiation, using PASW Statistics(version 18.0.0) and GraphPad Prism(version 5.01). Results: 1. RU was correlated with moderate or severe dysmenorrhea and premenstrual lower abdominal pain. 2. In syndrome differentiation, blood stasis questionnaire was correlated with RU. 3. RU was related with dysmenorrhea, mass of low abdomen, pressure pain, clod of menstrual blood, dyspareunia. Conclusions: The ultrasound of RU might be related with the syndrome of blood stasis.
The Cut Off Values for Diagnosing Cold Hypersensitivity of Hands by Using Digital Infrared Thermographic Imaging
Jo, Jun-Young ; Park, Kyoung-Sun ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 95~102
Purpose: The purpose of this study is to define the cut off values of cold hypersensitivity of hands by using digital infrared thermographic imaging(DITI). Methods: Thermographic images of 130 patients with cold hypersensitivity of hands(CHHG, n=65) and non-cold hypersensitivity of hands(NCHHG, n=65) were retrospectively reviewed. We used the temperature difference the palm(PC8) and the upper arm(LU4) for diagnosing cold hypersensitivity of hands. The temperature differences of between two groups were analysed using independent samples t-tests. The cut off values were calculated by ROC curve analysis. Analyses were undertaken using SPSS version 17.0. P value of < 0.05 was considered significant. Results: The temperature difference the palm(PC8) and the upper arm(LU4) were significantly different between groups(p < 0.001). Using receiver operating characteristic curve analysis, the sensitivity, specificity, and area under the curve were 70.8%, 73.8%, respectively both hands. The AUC was 0.822 on right hand and 0.818 on left hand. The optimum cut-off value was defined as
. Conclusions: These results suggest that DITI is a reliable instrument for estimating the cold hypersensitivity of hands.
The Research of Oriental Obstetrical & Gynecological Point of View on Woman's Breast Disease
Kim, Yoon-Sang ; Lim, Eun-Mee ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 103~116
Objectives: The aim of this study is to differentiate women from men on breast diseases. Methods: We have searched antique books, texts and references of oriental obstetric & gynecology and checked into present conditions of oriental medicine hospitals in republic of Korea. Results: In physiological, pathological and epidemiological viewpoint of both oriental and western medicine, it was accepted that women were different with men on breast disease. Among references published in the Journal of Oriental Obstetrics and Gynecology from 1987, the number of references concerned breast disease was fifty divided into 29 original articles(58%) in types and 26 breast cancer(52%), 13 postpartum lactation(26%) in categorizations. and woman's breast disease and cancer taken charge on oriental obstetrics and gynecology in oriental medicine hospitals were 25(86%) and 19(66%) respectively. Conclusions: We could not realize that woman's breast disease already were accepted woman's particularity in various aspects until conducting our study. Accordingly, it is suggested that more researches would be conducted on the needs of female patients with breast disease through questionnaire or research and on the association reproductive factor and breast disease of women.
Clinical Study on the Effect of Chuna Manupulation in Treating Postpartum Patients with Low Back Pain and Pelvic Girdle Pain
Lee, Sung-Cheul ; Bae, Sang-Eun ; Kim, Hee-Jeong ; Kim, In-Joong ; Shin, Joon-Sik ; Kim, Chul-Soo ; Ahn, Young-Tae ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 117~131
Objectives: This study was designed to observe the effect of chuna manupulation in alleviating the symptoms of postpartum patients with low back pain and pelvic girdle pain. Methods: Targeted by outpatient 30 postpartum patients, A group was patients who were treated with acupuncture, traditional Korean medicine, physical therapy, B group was patients who were treated with acupuncture, traditional Korean medicine, physical therapy, and chuna manupulation. After 2-months, the progress of symptoms was evaluated by visual analogue scale(VAS) and Oswestry Disability Index(ODI) and Pain drawing. Results: 1. Group A and B were analyzed for general characteristics, with an average age of both groups, average weeks at admission after delivery, parity and method of delivery, weight gain and BMI during pregnancy were no significant differences in. 2. VNRS improvement in the rate of group A was
, VNRS improvement in the rate of group B was
. Between the two groups was statistically significant. 3. ODI improvement rate in group A was
, ODI improvement rate in Group B was
. Between the two groups was statistically significant. 4. Patients who received acupuncture, traditional Korean medicine, physical therapy, and chuna manupulation. in group B compared pubis, thighs, buttocks showing more effective in pain relief than group A, who received only acupuncture, traditional Korean medicine, physical therapy. Conclusions: In case of postpartum patients with low back pain and pelvic girdle pain, it is more effective to treat with Integrated traditional Korean therapy and chuna manupulation than to treat with only integrated traditional Korean therapy.
A Study on the Management and Effect of Dysmenorrhea Care Program by Korean Traditional Medicine
Jeong, Da-Un ; Kim, Myung-Jae ; Mo, Seung-Hee ; Kim, Eun-Young ; Lee, Kyoung-Sim ; Park, Sung-Hee ; Yu, Kyung-Soon ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 132~148
Objectives: The aim of this study was to evaluate the effectiveness of dysmenorrhea care program by Korean traditional medicine on dysmenorrhiec juveniles. Methods: 47 adolescent dysmenorrhiec patients in local girls' high school took part in dysmenorrhea care program by Korean traditional medicine. The subjects were treated by acupuncture, ear-acupuncture, acupressure education, herbal extract medication and qigong exercise. The results were investigated by visual analogue scale(VAS), multidimensional verbal rating scale(MVRS) and verbal rating scale (VRS). Data was collected every three months from March, 2011 to March, 2012. Additionally satisfaction survey was conducted. Results: VAS score was reduced after treatment, but rebounded back to baseline after 6 months of discontinued dysmenorrhea care program. There was no significant difference of time and group interaction in linear mixed model analysis. MVRS and VRS outcomes showed similar pattern. Conclusions: Dysmenorrhea care program by Korean traditional medicine is effective in juveniles with dysmenorrhea for several months but not for long as nine months after treatment. However, the effect can last for three months at the very least.
A Case Report of Pruritus Gravidarum Diagnosed as Tae-eumin Exterior-Cold-Disease by Cold in the Esophagus
Choi, Yu-Jeong ; Kang, Yu-Jeong ; Lee, In-Seon ; Cho, Hye-Sook ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 149~156
Objectives: This case study described a process of the pruritus gravidarum patient diagnosed as Tae-eumin Exterior-Cold-Disease by Cold in the Esophagus. Methods: We experienced one patient who had been suffering from itching and plaque during pregnancy. We diagnosed her case as Tae-eumin Exterior-Cold-Disease by Cold in the Esophagus and treated with Jowiseuncheong-tang and Jiyang-go. Results: She was treated with herbal therapy, and her symptoms were remarkably alleviated. Also after all treatment, there were no adverse effects such as a recurrence of severe itching or fetal problems. Conclusions: This clinical case indicates that Jowiseuncheong-tang is effective in treatment of Tae-eumin Exterior-Cold-Disease by Cold in the Esophagus type of pruritus gravidarum.
A Clinical Study on 3 Cases of Pregnancy of Uterine Myoma Patients by Short Term Oriental Medicine
Jang, Se-Ran ; Park, Young-Sun ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 25, issue 3, 2012, Pages 157~167
Objectives: It is not yet clear wheather myomectomy for uterine myomas raises the pregnancy rate or not. And myomectomy has the risk of side effects and reducing pregnancy rate by causing tubal disorders, pelvic adhesions, endometriosis and so on. Therefore less invasive treatment to patients with uterine myoma who want to be pregnant is necessary. Methods: In this study, the patients who had uterin myoma were treated by oriental medical treatments such as herbal medication, acupuncture and moxibustion therapy. Results: After oriental medical treatments, their menstrual condition was improved and size of their myoma was decreased. And they were pregnant within two to five months. Conclusions: This case report shows that the oriental medical treatment is less invasive for uterine myoma and that is effective for patients with uterine myoma who want to be pregnant.