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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 26, Issue 4 - Nov 2013
Volume 26, Issue 3 - Aug 2013
Volume 26, Issue 2 - May 2013
Volume 26, Issue 1 - Feb 2013
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The Effect of Samul-tanggahyangbuja on Depression and Learning on Repeated Stress in Ovariectomized Rats
Lee, Soon-Yee ; Kim, Song-Baek ; Seo, Yun-Jung ; Choi, Chang-Min ; Cho, Han-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 1~17
DOI : 10.15204/jkobgy.2013.26.3.001
Objectives: In this research, the effect of samul-tanggahyangbuja on depression and learning in ovariectomized rats subjected to repetitive stress were assessed. Samul-tanggahyangbuja is the prescription consisting of Samul-tang and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After being orally medicated with samul-tanggahyangbuja (100 or 400 mg/kg), rats performed the Morris water maze test and forced swimming test, and social exploration was assessed in a behavior test. As well, sucrose intake was measured and measurements of blood serum corticosterone and the change of interleukin-
) and tumor necrosis factor-
) in blood samples were made. Results: 1. In the Morris water maze test, rats medicated with 100 mg samul-tanggahyangbuja mastered the maze in a shorter time on the 4th day in comparison with the control group, while rats medicated with 400 mg samul-tanggahyangbuja mastered the maze more quickly (p<0.05 on the 3rd day ; p<0.01 on the 4th day, as compared to control). 2. Immobility time in the forced swimming test was significantly decreased in rats receiving 400 mg samul-tanggahyangbuja compared with the control group (p<0.05). 3. Sucrose intake and active social behavior of rats receiving 400 mg samul-tanggahyangbuja were markedly increased in comparison with the control group (p<0.01). 4. Blood serum corticosterone measurements revealed decreased blood serum corticosterone level after medicating with samul-tanggahyangbuja. But it was not statistically significant. 5. Treatment with either dose of samul-tanggahyangbuja significantly reduced IL-
(p<0.05). Conclusions: These results suggest that samul-tanggahyangbuja possesses the anti-depressant and cognitive-enhancing activities related to menopause.
The Effect of Gyogam-dan on Depression and Immunity on Repeated Stress in Ovariectomized Rats
Cheong, Hyun-Cheol ; Kim, Song-Baek ; Seo, Yun-Jung ; Cho, Han-Baek ; Choi, Chang-Min ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 18~32
DOI : 10.15204/jkobgy.2013.26.3.018
Objectives: In this research, the effect of Gyogam-dan (GGD) on depression and immunity were assessed in ovariectomized rats subjected to repetitive stress. GGD is the prescription consisting of Poria cocos and Cyperi Rhizoma. Methods: Ovariectomized rats were repeatedly stressed over a 2-week period. After GGD (100 or 400 mg/kg) were orally administered, Elevated Plus Maze (EPM) and forced swimming test (FST) were performed to evaluate depressive and anxiety response. As well, the change of corticosterone (CORT) and the change of interleukin-
) and interleukin-4 (IL-4) in blood serum and in brain were mesured. Results: 1. In the EPM, there were no statistically significant differences among the groups. 2. In the FST, immobility time significantly decreased in rats of each experiment group compared with the control group (p<0.01). 3. Serum CORT level were decreased in 400 mg GGD group (p<0.05). 4. On IL-
and IL-4 measurement in the serum and brain, there were not significant increase or decrease compared with the control group. Conclusions: These results suggest that GGD is effective to reduce depression-behavior in ovariectomized rats. However, GGD do not has significant efficacy to reduce anxiety-behavior in EPM test. Measurement of serum CORT level reveals significant decrease and it shows anti-depressant like effect. Results on immunity are not significant.
The Effect of Dried Roots of Rehmannia glutinosa Extract on Osteoblast in Rat Fetus Calvarial Cells
Im, Kyu-Jung ; Choi, Kyung-Hee ; Jung, Eun-Hye ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 33~43
DOI : 10.15204/jkobgy.2013.26.3.033
Objectives: Osteoporosis is characterized by bone loss and morbidity with osteoporotic fracture. In this study, the author aimed to evaluate the effect of dried roots of Rehmannia glutinosa extract (RGE) on osteoblast proliferation in murine calvarial cells. Methods: The osteoblast separated from murine calvariae was cultivated for 6 days and evaluated the cell function. After the addition of RGE on the culture medium, we determined the effect of RGE on the cell viability, cell proliferation, protein synthesis, alkaline phosphatase activity, collagen synthesis and calcified nodule formation of the cultivated osteoblast. Results: The results were summarized as follows. 1. RGE did not change the survival rate of rat calvarial osteoblast. 2. RGE increased the proliferation of rat calvarial osteoblast. 3. RGE increased ALP activity of rat calvarial osteoblast., 4. RGE slightly affected protein synthesis of rat calvarial osteoblast. 5. RGE increased collagen synthesis of rat calvarial osteoblast. 6. RGE slightly affected calcified nodule formation of rat calvarial osteoblast. Conclusions: From these results, it is concluded that RG might improve the osteoporosis resulted from augmentation of osteoblast proliferation.
Effects of Curcuma longa L. on MDA-MB-231 Human Breast Cancer Cells and DMBA-induced Breast Cancer in Rats
Yang, Dong-Seon ; Yang, Seung-Jeong ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 44~58
DOI : 10.15204/jkobgy.2013.26.3.044
Objectives: Breast cancer is the most common cancer among women and has rapidly increasing rate annually. At present, western cancer therapies by surgery, radiation, and anticancer drug have not been fully effective. So many interests are given to herbal medicine on cancer treatment recently. This study was designed to investigate the effects of Curcuma longa L. (CL) on MDA-MB-231 human breast cancer cells and DMBA-induced breast cancer in rats. Methods: In this experiment, MDA-MB-231 cells were cultured in cell culture plates. 0.0625, 0.125, 0.25, 0.5, 1.0 mg/ml of CL extract were tested for their anti-proliferative effects on MDA-MB-231 cells by MMT assay. And we induced breast cancer in rats. The changes in tumor's weight, and the effects on proliferations of splenocyte and thymocyte were investigated. Results: CL showed anti-proliferative effects on MDA-MB-231 cells in proportion to concentration of the CL. DMBA-induced breast cancer in rats, tumor's weight of the rat was not statistically significant, but showed a tendency to be reduced in the groups treated with CL. Proliferation rate of the rat's splenocyte and thymocyte increased in proportion to CL. In breast cancer tissue, expression of ER-
was weakened proportionately to the concentration of the CL. Conclusions: These data suggest that CL can prevent the proliferation of breast cancer, then CL is useful to treat patient with breast cancer.
A Study on the Duration and Character of Lochia in Women Hospitalized at Korean Medical Postpartum Care Center
Cho, Seung-Hee ; Kim, Song-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 59~72
DOI : 10.15204/jkobgy.2013.26.3.059
Objectives: The aim of this study was to assess the duration of lochia in women hospitalized at Korean medical postpartum care center and to identify factors that influence duration of lochia. Methods: On the obstetric variables of 315 cases, the duration of lochia was analyzed. In the postpartum care center, the obstetric variables were asked of 315 cases of women, and who examined a body composition. After discharge, women were surveyed for the duration of lochia by telephone. Results: The median duration of lochia was 30 days and the range was 18~53 days. Maternal age, parity and mode of delivery were associated with its duration. So, its duration was longer on women over the age of 35, multipara and women had a Cesarean section. Its duration was correlated with gestational age and BMI before pregnancy, but not neonatal gender, birth weight, maternal BMI change during pregnancy, maternal body weight gain, BMI before delivery. Conclusions: It was 30 days that the median duration of lochia of women who had been got Korean medical postpartum care management, and which was slightly different from previous studies. And it was influenced by maternal age, parity, mood of delivery, gestational age and BMI before pregnancy. In future more studies or surveys for the duration of lochia of women with no treatment, lochial pattern and so on should be done.
A Study on Factors Influencing Pregnancy in the Pilot Project for Korean Medical Treatment for Subfertility
Ahn, In-Suk ; Kim, Dong-Il ; Choi, Min-Sun ; Jang, Suk-Woo ; Jeong, Jae-Cheol ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 73~84
DOI : 10.15204/jkobgy.2013.26.3.073
Objectives: This study aims to identify associated factors in female infertility treatment using herbal medicine, acupuncture and moxibustion. Methods: Acupuncture and moxibustion treatments were performed with intake of herbal medicines (Jokyungjongoktanggagam-bang, Sutaehwangagam-bang) for six menstrual cycles in 32 subfertile women. The variables selected for initial analysis were age, duration and type of infertility, frequency of previous In Vitro Fertilization (IVF) and live births, weekly frequency of sexual intercourse, number of treatment cycles, endometrial thickness on MCD15 and hormonal parameter (anti-mullerian hormone, follicle-stimulating hormone, luteinizing hormone, estrone). Results: Six patients became pregnant (18.75%) and seven patients withdrew. Factors influenced pregnancy were age (
years), a shorter duration of infertility (<6 years), frequency of IVF (
), anti-mullerian hormone level (>1 ng/ml), and number of treatment cycles(
cycles). Conclusions: Korean medicine is a useful and optimized treatment option for women with younger age, fewer previous IVF cycles, shorter infertile duration and normal anti-mullerian hormone level at first 3 cycles of treatment.
The Cut Off Values for Diagnosing Hot flashes by Using Digital Infrared Thermographic Imaging
Jo, Jun-Young ; Hwang, Deok-Sang ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Kyung-Sub ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 85~92
DOI : 10.15204/jkobgy.2013.26.3.085
Objectives: The purpose of this study is to find diagnostic points and define the cut off values of hot flashes by using digital infrared thermographic imaging. Methods: Thermographic images of 75 patients with hot flashes (HF, n=35) and non-hot flashes (NHF, n=40) were retrospectively reviewed. We used the temperature difference between Ex-HN3 and CV17, LU4, CV12, CV4 for diagnosing hot flashes. The temperature differences of between two groups were analysed using independent samples t-tests. The cut off values were calculated by received operating characteristic curve analysis. Analyses were undertaken using SPSS version 17.0. and p-value of <0.05 was considered significant. Results: The temperature difference Ex-HN3 and LU4 were the most significantly different between groups (p<0.001). Using receiver operating characteristic curve analysis, the sensitivity, specificity, and area under the curve were 65.7%, 72.5%, 0.729, respectively. The optimum cut off value was defined as
. Conclusions: These results suggest that the digital infrared thermographic imaging is a reliable instrument for estimating hot flashes.
A Retrospective Cross-sectional Study on Leukorrhea in Relation with Lower Abdomen Temperature and Physical Symptoms
Ahn, Ji-Yoon ; Choi, Seok-Young ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Jang, Jun-Bock ; Lee, Kyung-Sub ; Lee, Chang-Hoon ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 93~102
DOI : 10.15204/jkobgy.2013.26.3.093
Objectives: This study aims to research character of the patients with leukorrhea including Digital Infrared Thermal Imaging (DITI) and symptoms associated with leukorrhea in view of Korean medicine theory. Methods: We studied 71 patients visiting
Korean Hospital from April, 2012 to March, 2013. The subjects were categorized in two groups, leukorrhea group (n=40) and control group (n=31). We investigated the difference of DITI and other physical symptoms between two groups. Results: The average temperature of CV4 in leukorrhea group (
) were significantly lower than that of control group (
)(p<0.01). And there is no statistical difference of temperature of CV17 located in chest area between two groups. But temperature difference between CV17 and CV4 (
) in leukorrhea group (
) is significantly higher than control group (
)(p<0.01). There is no correlation between leukorrhea and some sypmtoms, like menorrhea, irregular menstruation, fatigue, constipation and loss of appetite. But leukorrhea group is more likely to suffer from dyspepsia and insomnia than control group. Conclusions: Leukorrhea group is related to lower temperature in lower abdomen than control group. And patients with leukorrhea are more likely to appear dyspepsia and insomnia than no leukorrhea group.
A Clinical Study on 3 Cases of Complications after Total Thyroidectomy and Neck Dissection in the Papillary Thyroid Carcinoma
Park, Eun-Young ; Gwen, Hyoung-Geun ; Kong, Bok-Chul ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 103~113
DOI : 10.15204/jkobgy.2013.26.3.103
Objectives: Thyroid cancer is the most common cancer for female in Korea. This study aims to report the effects of Korean medicine on complications after total thyroidectomy and neck dissection in the papillary thyroid carcinoma. Methods: The 3 patients with papillary thyroid carcinoma were treated by Korean medicine such as acupuncture, moxibustion and pharmacopuncture therapy. We evaluated the results of treatments by change of symptoms. Results: After treatments such as acupuncture, moxibustion and pharmacopuncture therapy except herb medicine, the symptoms of complications after total thyroidectomy and neck dissection were improved. Conclusions: This study shows that Korean medicine has effects on complications after total thyroidectomy and neck dissection in the papillary thyroid carcinoma.
A Case Study on Short Term Hospitalization Program of Korean Medicine Treatment for Postmenopausal Hot Flush and Sweating
Park, Kang-In ; Kim, Jin-Woo ; Park, Kyoung-Sun ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 114~124
DOI : 10.15204/jkobgy.2013.26.3.114
Objectives: Postmenopausal hot flush and sweating is troublesome symptom to most of climacteric women. It is well known that Korean medicine is safe and effective on climacteric symptoms. So this study aims to report the clinical effect of Korean medicine on postmenopausal hot flush and sweating. Methods: The patient received herbal medication, acupuncture, moxibustion, cupping therapy, Gong-jin therapy, and Korean medicine music therapy during hospitalization (about 8 days). Results: Hot flush and sweating was effectively reduced after the treatment. Visual Analogue Scale (VAS) for hot flush and sweating decreased from 9 to 2. Hot flush score decreased from 20 to 8. Area of hot flush and sweating also markedly decreased. Conclusions: This case shows that Korean medicine is effective on climacteric symptoms.
A Case Report of Hyperprolactinemia Patient
Oh, Ja-Young ; Jang, Se-Ran ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 125~132
DOI : 10.15204/jkobgy.2013.26.3.125
Objectives: The purpose of this study is to report the effect of Traditional Korean Medicine (TKM) on hyperprolactinemia Methods: The patient in this case was a 26-year-old female. The patient was diagnosed as hyperprolactinemia with oligomenorrhea a month ago. We treated by Ickibohyoultang-gami and evaluated treatment effect by serum prolactin and basal body temperature. Results: After treatment, the Hyperprolactinemia value reduced and returned normal approach. And disorder of menstruation and basal body temperature became stable. Conclusions: TKM treatment is effective in patients with Hyperprolactinemia and disorder of menstruation.
4 Cases of Hyperemesis Gravidarum Patients Treated by Herbal Medicine and Auricular Acupuncture, and Safety of These Medical Interventions
Park, Seung-Hyeok ; Chae, Min-Soo ; Kim, Nam-Hoon ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Lee, Kyung-Sub ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 3, 2013, Pages 133~142
DOI : 10.15204/jkobgy.2013.26.3.133
Objectives: To identify effects and safety of Korean traditional herbal medicine and auricular acupuncture for hyperemesis gravidarum patients. Methods: Korean traditional herbal medicine and auricular acupuncture were applied to 4 hyperemesis gravidarum patients, and we investigated changes of symptoms, continuance of pregnancy, and whether they delivered or not. Results: Hyperemesis gravidarum symptom was improved in 3 patients, and 1 patient showed complete recovery. Among them, 2 patients had children by natural childbirth, 1 patient had a repeat cesarean due to previous cesarean section, and 1 patient has been maintaining pregnancy well for 25weeks. Conclusions: It is confirmed that symptoms of hyperemesis gravidarum patients were improved by Korean traditional herbal medicine and auricular acupuncture, and these medical interventions are safe.