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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 26, Issue 4 - Nov 2013
Volume 26, Issue 3 - Aug 2013
Volume 26, Issue 2 - May 2013
Volume 26, Issue 1 - Feb 2013
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Acute Oral Toxicity of Root of Polygala teunifolia Willd. Extract
Roh, Hang-Sik ; Jeong, Ja-Young ; Seok, Ji-Hyun ; Ha, Hun-Yong ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 1~13
DOI : 10.15204/jkobgy.2013.26.4.001
Objectives: In this study, it was carried out to evaluate the acute oral toxicity of Root of Polygala teunifolia Willd. in Sprague-Dawley (SD) rats. Methods: Male and female rats were administered orally with Root of Polygala teunifolia Willd. water extract of 1,000 mg/kg (low dosage group), 2,000 mg/kg (middle dosage group) and 4,000 mg/kg (high dosage group). We daily observed number of deaths, clinical signs and gross findings for 7 days. After 7 days, we measured body and organs weight. Also we analyzed hematological changes. Results: No dead SD rats and no clinical signs were found during the experiment period. Also other specific changes were not found between control and treated groups in hematology and serum biochemistry. But we found out histopathological changes in liver fat tissues of female. In addition, there were no significant changes of gross body and individual organs weight. Conclusions: These results suggest that water soluble extract of Root of Polygala teunifolia Willd. has not acute oral toxicity and oral
value was over 4,000 mg/kg in SD rats.
The Effect of Samul-tanggahyangbuja on Anti-Depressive Behavior and Immunity
Jang, Yoon-Jeong ; Kim, Song-Baek ; Choi, Chang-Min ; Seo, Yun-Jung ; Cho, Han-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 14~29
DOI : 10.15204/jkobgy.2013.26.4.014
Objectives: Samul-tang and Rhizome of Cyperus rotundus L. have been frequently used in gynecologic disease. The purpose of the present study is to explore the behavioral and neurobiological effects of Samul-tanggahyangbuja (SGH) on ovariectomized rats and to form a basis for clinical treatment. Methods: Ovariectomized rats were repeatedly stressed for over 2 weeks. After orally medicated with SGH (200 or 400 mg/kg/day), the anxiety response was tested using the Elevated Plus Maze (EPM) in rats. The serum levels of estradiol and IL-4, and immunohistochemical changes of IL-4 in the Locus coeruleus (LC) and Paraventricular Nucleus (PVN) were measured. Results: 1. In the EPM, SGH 400 mg significantly increased time spent on the open arms and decreased time spent on the closed arms, compared with the control group (p<0.05). 2. SGH tended to increase numbers of crossings in the open and closed arms in the EPM. However, it did not reach statistical significance. 3. SGH significantly increased the serum levels of estradiol compared with the control group (p<0.05). 4. SGH 400 mg significantly increased the serum levels of IL-4 compared with the control group (p<0.05). 5. IL-4 immunoreactivity was reduced in the control group compared with the normal group (p<0.05). However, SGH groups (200 and 400 mg) did not produce any significant effects on levels of IL-4 in the LC and PVN. Conclusions: These results suggest that SGH possesses the anti-depressant and immuno-modulatory effects on ovariectomized rats.
The Anti-depressive Effect of Samul-tanggahyangbuja on Chronic Mild Stress in Ovariectomized Rats
Jeong, Ji-Hye ; Choi, Chang-Min ; Seo, Yun-Jung ; Cho, Han-Baek ; Kim, Song-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 30~47
DOI : 10.15204/jkobgy.2013.26.4.030
Objectives: The purpose of the present study is to investigate anti-depressive effects of Samul-tanggahyangbuja (SGH) on ovariectomized and chronic mild stress (CMS) induced rats. Methods: Ovariectomized rats were exposed to CMS for 4 weeks. Changes of depression behavior were tested by using sucrose intake test (SIT), elevated plus maze (EPM), forced swimming test (FST) and Morris water maze test (MWMT) in rats until being orally medicated with SGH (100 or 400 mg/kg/day). In addition, the serum levels of corticosterone (CORT), IL-4, IL-
and changes of 5-HT in the brain were measured. Results: 1. SGH 400 mg/kg treated group (SGH 400) significantly increased amount of sucrose intake compared with the control group (p<0.05). 2. SGH 100 mg/kg treated group (SGH 100) and SGH 400 significantly increased the time spent in the open arms of the EPM compared with the control group (p<0.01). SGH 400 also significantly increased the number of crossing of the open and closed arms compared with the control group (p<0.05). 3. SGH significantly shortened the immobility time in FST compared with the control group (SGH 100 p<0.05, SGH 400 p<0.01). 4. SGH significantly increased performance of acquisition trials compared with the control group (p<0.05, on day 4, 5 of SGH 100 and 400). SGH 400 also significantly increased performance of retention trials compared with the control group (p<0.05). 5. The serum levels of corticosterone and IL-4 were not significantly different among the groups. There were no changes on the serum levels of corticosterone, IL-
and IL-4 after administration with SGH. 6. SGH 400 significantly increased the level of 5-HT in the hippocampus compared with the control group (p<0.05). SGH significantly increased the levels of 5-HT in the hypothalamus compared with the control group (SGH 100 p<0.05, SGH 400 p<0.01). Conclusions: These results suggest that SGH has the anti-depressive effect on ovariectomized rat and affect 5-HT system rather than hypothalamic-pituitary-adrenal (HPA) axis and immune system.
Effects of Herbal Medicine on Breastfeeding - Analysis of Marker Substances in Saenghwa-tang by HPLC and LC/MS/MS -
Park, Ka-Young ; Lee, Ah-Young ; Ban, Ji-Hye ; Park, Jung-Kyung ; Lee, Eun-Hee ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 48~65
DOI : 10.15204/jkobgy.2013.26.4.048
Objectives: We took breast milk samples and analyzed them using HPLC and LC/MS/MS, to evaluate the effects of taking Saenghwa-tang during breastfeeding on breast milk. Methods: The study participants were 20 lactating women who admitted in Korean medical postpartum care center. Breast milks were collected from paticipants who have been administrated Saenghwa-tang for more than 3 days. We used HPLC and LC/MS/MS for the determinations of amygdalin, liquiritins, 6-gingerol, decursin and decursinol angelate in Saenghwa-tang. Results: 1. Participants`
(standard deviation) of age is
, and 15 participants had normal delivery and 5 participants had cesarean delivery. 12 participants were primipara and 8 participants were multipara.
of lactating date is
. 2. Using HPLC, we learned LOQ level peak that matches the peak retention time of standard components of Saenghwa-tang was not detected from 20 breast milk samples. 3. Using LC/MS/MS, decursin of Angelicae Gigantis Radix was detected from HMSP 02, HMSP 04, HMSP 06, HMSP 11, and the each concentrations are 16, 2, 64, 11 ppb. Liquiritin of Glycyrrhizae Radix was not detected from HMSP 13~HMSP 18. Conclusions: Data obtained by this approach shows that this method is reliable and suitable for determining the safety of taking Saenghwa-tang during breastfeeding.
Anti-Inflammatory Effect of Ligustri Lucidi Fructus Water Extract in RAW 264.7 Cells Induced by LPS
Lee, Yong-Hyun ; Lim, Eun-Mee ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 66~81
DOI : 10.15204/jkobgy.2013.26.4.066
Purpose: This study was carried out to investigate the anti-inflammatory effects of Ligustri Lucidi Fructus water extract (LF) in the lipopolysaccharide (LPS)-induced mouse macrophages RAW 264.7 cell. Methods: Ligustri Lucidi Fructus was extracted with distilled water (2,000 ml) for 2 hours. In order to evaluate cytotoxicity of LF, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed. To investigate anti-inflammatory effects of LF, the concentration of nitric oxide (NO) was measured with NO assay, cytokine was measured by Bio-Plex cytokine assay, and intracellular calcium (Ca) was measured with Fluo-4 Ca assay in RAW 264.7 cell. And when p-value is below 0.05, it is judged to have the significant difference statistically (P<0.05). Results: 1. LF showed no cytotoxicity. 2. LF inhibited significantly the production of NO at the concentration of 25, 50 and
. 3. LF inhibited significantly the production of interleukin (IL)-4, macrophage inflammatory protein (MIP)-
, granulocyte colony stimulating factor (G-CSF) at the concentration of 25, 50, 100 and
. 4. LF inhibited significantly the production of granulocyte macrophage-colony stimulating factor (GM-CSF), vascular endothelial growth factor (VEGF) at the concentration of 50, 100 and
, the interferon (IFN)-
at 25, 50 and
respectively. 5. LF inhibited significantly the production of IL-
at the concentration of 50 and
, the IL-5 at 25 and
, the IL-12p70, MIP-
at 50 and
, the regulated on activation, normal T cell expressed and secrete d (RANTES) at 100 and
respectively. 6. LF inhibited significantly the production of IL-10, interferon gamma-induced protein (IP)-10 at the concentration of
. 7. LF inhibited significantly the production of intracellular Ca at the concentration of 25, 50, 100 and
. Conclusions: These results suggest that LF has anti-inflammatory effect and immuno-modulating activity.
A Study on the Relationship between the Obstetric Variables and Granulocyte/Lymphocyte Ratio in Some Postpartum Women
Cho, Seung-Hee ; Kim, Gun-Hee ; Shim, Gye-Seon ; Seo, Yun-Jung ; Cho, Han-Baek ; Choi, Chang-Min ; Kim, Song-Baek ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 82~93
DOI : 10.15204/jkobgy.2013.26.4.082
Purpose: The aim of this study was to investigate the relation between peripheral blood leukocyte differential - Granulocyte rate, Lymphocyte rate and its calculated Granulocyte/Lymphocyte ratio - and the obstetric variables. Methods: From 270 cases of women who were in the postpartum care center attached to Won-Kwang Korean Medical Hospital, 36 cases met exclusion criteria. On the obstetric variables of 234 cases, peripheral blood leukocyte differential - Granulocyte rate, Lymphocyte rate and its calculated Granulocyte/Lymphocyte ratio - was analyzed. In the postpartum care center, the obstetric variables were asked of 234 cases of women, and who measured leukocyte differential. Results: Mean granulocyte rate and lymphocyte rate of peripheral blood leukocyte differential showed statistically significant difference from those in healthy people and was high. There was statistically significant difference in granulocyte/lymphocyte ratio according to mood of delivery, parity and period passed from childbirth. But whether postpartum women with anemia or not, maternal age and gender of neonate were not associated with granulocyte/lymphocyte ratio, and which was not significantly correlated with gestational age and neonatal birth weight. Conclusions: These findings suggest that activation of the sympathetic nervous system in postpartum women is higher than in healthy people. And granulocyte/lymphocyte ratio was influenced by mood of delivery, parity and period passed from childbirth. In future, more studies or surveys, with less bias, for the relation between peripheral blood leukocyte differential and the obstetric variables are required.
Analysis of DITI, HRV about the Effect of Far Infrared Radiation Applied to Whole Body(`On-tong Therapy`)
Kim, Min-Young ; Ahn, Ji-Yoon ; Choi, Seok-Young ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Jang, Jun-Bock ; Lee, Kyung-Sub ; Lee, Chang-Hoon ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 94~106
DOI : 10.15204/jkobgy.2013.26.4.094
Objectives: The purpose of this study is to find the effect of Far Infrared Radiation (FIR) about improvement of chief complaints and health state. Methods: For this study we evaluated thermographic images, heart rate variability (HRV), visual analogue scale (VAS) score of 34 patients with various diseases. Tests were done two times, before and after treatments and we compared the test results. We used the temperature difference between CV12 and CV4, both sides of PC8, LR3 for recognizing improvement of blood circulation. We analyzed the change of complexity, stability of autonomic nervous system (ANS) by HRV test. The patients were asked to fill out questionnaire about the severity of symptoms by VAS score. Analyses were undertaken using SPSS ver.12.0.1 and p-value of < 0.05 was considered significant. Results: Statistical analysis shows that Far Infrared Radiation (FIR) had significant efficiency in increasing surface temperature and reducing VAS pain scores. In heart rate variability (HRV) test, LF/HF ratio showed tends to improve. Conclusions: The application of an FIR to whole body appears to alleviate various complaints of patients.
A Review Study of Researches on Acupuncture Therapy to Pregnant Women
Ryu, Soo-Hyeong ; Park, Kang-In ; Kim, Jin-Woo ; Park, Kyoung-Sun ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 107~122
DOI : 10.15204/jkobgy.2013.26.4.107
Objectives: This study was conducted to investigate the effectiveness and safety of acupuncture therapy for pregnant women. Researches on acupuncture therapy for pregnant women published since 2000 until 2013 were selected and analyzed. Methods: Bibliographic search was carried out using several online database systems using keywords like `pregnancy`, `pregnant`, `acupuncture`, `forbidden points` within a 13-year time span (2000-2013). Results: 18 journal articles published in Korea and 22 journal articles published abroad were selected. It is reported that acupuncture has significant effect on low back pain and pelvic pain, depression, insomnia during pregnancy. Stimulation of acupuncture during pregnancy seems to be safe with respect to obstetric adverse effects. Conclusions: We can conclude that further investigation is needed to accumulate enough information to establish evidence for acupuncture therapy for pregnant women.
Effect and Safety of Oxygen Chamber Therapy on Cold Hypersensitivity: A Randomized, Controlled Trial
Ha, Hun-Yong ; Yoon, Dal-Hwan ; Go, Ho-Yeon ; Han, Yong-Dae ; Kim, Nam-Sik ; Nam, Eun-Young ; Kim, Hyung-Jun ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 123~139
DOI : 10.15204/jkobgy.2013.26.4.123
Purpose: Cold hypersensitivity is regarded to be associated with blood circulation. This study is aims to evaluate the effects and safety of oxygen chamber therapy on cold hypersensitivity by comparing the temperature and Visual Analogue Scale. Methods: 42 outpatients who visited
University Oriental Hospital from July 11th, 2013 to August 28th, 2013 were analyzed. Patients were subjected to thermometer, and those with thermal difference greater than
between upper arm and palm and also with more than VAS 4 of cold hypersensitivity were diagnosed with cold hypersensitivity. 42 outpatients diagnosed with cold hypersensitivity are divided into two groups, one is the experimental group consisted of 21 patients and other was control group consisted of 21 patients. The experimental group had oxygen chamber therapy 10 times for 4 weeks. Thereafter the effects of oxygen chamber therapy on cold hypersensitivity was analyzed with t-text using SPSS for Windows version 21. Results: After the oxygen chamber therapy, experimental group had considerable improvement on cold hypersensitivity, in consequence of decreasing rate of thermal difference and VAS of cold hypersensitivity. Ear deafness and hand numbness were reported as an adverse effects in experimental group, but there was no serious adverse effects. Conclusions: This clinical trial showed oxygen chamber therapy could be effective and safe to reduce cold hypersensitivity.
Pilot Study on Variation of Menstruating Women`s Pulse Energy in Left and Right Chon, Kwan, Cheok
Lee, Ji-Yeon ; Yoo, Jeong-Eun ; Yun, Young-Jin ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 140~149
DOI : 10.15204/jkobgy.2013.26.4.140
Purpose: The purpose of this study is to investigate the change and correlation of pulse energy in Left and Right Chon, Kwan, Cheok during menstruation, especially around menstruation start date. Methods: The subjects of this experiment were 8 healthy women whose menstruation periods are regular. We measured 3D Blood Pressure Pulse Analyzer (3D-MAC) tests before and after menstruation start date. Results: The results were as follows 1. The pulse energy of the Right Chon was significantly decreased and Left Kwan was comparatively increased during the next day of menstruation start date than previous day. 2. There was a negative correlation between Left Kwan and Left Cheok, Right Chon and Right Kwan pulse energy during the previous and menstruation start date. The negative correlation disappeared between Right Chon and Right Kwan at the next day of menstruation start date. Conclusions: The results suggest that Chon, Kwan, Cheok pulse energy changes are related to menstruation and reflect physiological mechanism of menstruating women. Further study will be needed.
Relationships of High School Girls Menstrual Disorders with the Inbody Test Results by Sasang Constitutions
Cho, Hye-Sook ; Kim, Soo-Hyun ; Kim, Jong-Won ; Lee, In-Seon ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 150~168
DOI : 10.15204/jkobgy.2013.26.4.150
Purpose: The purpose of this study is to find out the patterns of teenage girls who is easy to suffer from dysmenorrhea with the Inbody test results by Sasang constitutions. Methods: The data from the 1681 participants were collected using a structured menstrual history questionnaire. Based on the survey responses, we had 97 adolescents with menstrual disorder as the test group and 97 adolescents without menstrual disorder as the control group. The clinical trials subjects were asked to respond to another questionnaire for identifying their constitutional types and undergo Inbody test. Results: The result of a comparison of the test and control groups showed that there` no relevance to the body fat mass and body fat percentage with menstrual irregularities. The lesser yang person with menstrual irregularities was no relevance to the body fat percentage. The greater yin person with menstrual irregularities was especially lacking in body fat mass and body fat percentage. The lesser yin person with menstrual irregularities was poor in body fat mass. Conclusions: As for study, female high school students with menstrual disorders have nothing to do with muscle mass. Body fats shortage could pose problems. According to the study, Taeumin female high school students usually needed to higher body fat than a general standard. It seems to be needed more body fat and weight than modern standards in period of poor sexuality for having a normal menorrhea especially Taeumin. It will take some continuing study that BMI standards should be changed or not on the Sasang constitutions.
Investigation of Current Treatment for Endometriosis in Chinese Medicine Journals
Cho, Hye-Sook ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 169~190
DOI : 10.15204/jkobgy.2013.26.4.169
Purpose: The purpose of this study is to examine acupuncture treatment suggested in the papers of endometrisis in Chinese Medicine Journals and to establish the further direction. Methods: The papers which were associated with endometrisis and acupuncture published between 2000 and 2012 in China Academic Journal were reviewed. Results: 25 studies met the condition. Acupuncture is reported as significant in improving clinical symptoms and reducing the size of endometrisis, which covers acupuncture, moxibustion, and burning acupuncture. Conclusions: Acupuncture treatment seems to be effective on endometrisis, from the paper research. It would be necessary to fulfill further study with a diversity of remedies and establish standard of evidence of them.
A Review on Korean Traditional Medicine Research against Cervical Dysplasia - Focused on Studies of Cervical Cancer and Cervical Dysplasia-
Yoo, Jeong-Eun ; Lee, Ji-Yeon ; Yoon, Young-Jin ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 191~203
DOI : 10.15204/jkobgy.2013.26.4.191
Purpose: This review is to figure out evidence that suggest effectiveness of Korean Medicine treatments against cervical dysplasia. Methods: Studies on cervical cancer and cervical dysplasia were searched through 6 databases: Korean Studies Information Service System(KISS), National Discovery for Science Leaders (NDSL), Korea Institute of Science and Technology Information (Korean TK), Oriental Medicine Advanced Searching Integrated System (OASIS), the Journal of Korean Medicine, and the Journal of Korean Obstetrics & Gynecology. After that, the articles were extracted with reference point of Korean Traditional Medicine. Results: 37 articles were included lastly according to selection criteria. 3 of them were case reports on cervical dysplasia, and 34 were in-vitro studies on Human Papilloma Virus (HPV) positive cancer cell. In case reports, acupuncture, moxibustion, medical herbs and pharmacoacupuncture were used for treatments of cervical dysplasia with about 3 months. Experimental studies on cervical cancer cell showed that several herbs function with clear heat, eliminate stasis (淸熱解毒, 化瘀消腫) have anti-cancer effects inducing apoptosis. Conclusions: The results of articles are not enough to use in practice. Therefore, we indicates more advanced research methodology as follows: development of Korean Medicine treatment protocol with oral and external, in-vivo experimental study, and evaluation immunity index.
A Clinical Study on 1 Case of Postpartum Patient with Pelvic Girdle Pain
Choi, Kyung-Hee ; Jung, Eun-Hye ; Kwon, Ji-Myung ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 204~212
DOI : 10.15204/jkobgy.2013.26.4.204
Objectives: The purpose of this study is to report the effects of traditional Korean treatment (acupuncture, herb medicine and Chuna manipulation treatment) on a postpartum patient with pelvic girdle pain. Methods: The postpartum patient with pelvic girdle pain was treated by traditional Korean treatment such as herbal medication (Boheotanggagam-bang), acupuncture. The patient was diagnosed pelvic insufficiency in pelvis AP x-ray. So we treated the patient a total of 10 times of acupuncture and Chuna manipulation treatment. Results: After the treatment, the patient`s pain was disappeared and the pelvic insufficiency in pelvis AP x-ray was improved. Conclusions: This case shows that traditional Korean treatment might be effective in improving postpartum patients` pain and pelvic insufficiency.
A Case Study with Gyejigabuja-tang on the Menopausal Female Patient who Complained of Excessive Sweating After Bilateral Salpingo-oophorectomy
Kim, Jin-Woo ; Park, Kang-In ; Park, Kyoung-Sun ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 213~222
DOI : 10.15204/jkobgy.2013.26.4.213
Purpose: The purpose of this study is to evaluate the effects of Gyejigabuja-tang on a menopausal female patient complained of excessive sweating after bilateral salpingo-oophorectomy (BSO). Methods: We studied one menopausal female patient complained of excessive sweating who visited OO University Hospital from 10th July 2013 to 23th July 2013. We only treated her with Gyejigabuja-tang. The climacteric symptoms of the patient had been estimated with Numeric Rating Scale (NRS) and Menopause Rating Scale (MRS). Results: After treatment, climacteric symptoms were improved and the score of MRS was reduced from 20 to 10 during 12days. NRS score of sweating was reduced from 10 to 2. NRS scores of fatigue, hot flush, thirst, anorexia, dyspepsia, back pain and cramp of calves also reduced after treatment. Conclusions: This study suggests that Gyejigabuja-tang significantly reduced the climacteric symptoms of patient.
A Case Report of Genital Ulcer
Seo, Eun-Bi ; Lee, Ji-Hyun ; Cho, Han-Baek ; Kim, Song-Baek ; Seo, Yun-Jung ; Choi, Chang-Min ;
The Journal of Oriental Obstetrics and Gynecology, volume 26, issue 4, 2013, Pages 223~230
DOI : 10.15204/jkobgy.2013.26.4.223
Objectives: This case study was designed to evalute the effect of Korean medical treatment on genital ulcer. Methods: This patient was treated with herbal medicine of Palmul-tang (八物湯), Yongdamsagan-tang (龍膽瀉肝湯), acupuncture and herbal applications. This efficacy of treatment was evaluated with inspection and patient`s report. Results: After treatments, the patient`s symptoms such as genital ulcer, erythema and swelling were improved. Conclusions: This case report shows that the Korean medical treatment is effective in the treatment of genital ulceration.