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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 27, Issue 4 - Nov 2014
Volume 27, Issue 3 - Aug 2014
Volume 27, Issue 2 - May 2014
Volume 27, Issue 1 - Feb 2014
Selecting the target year
Antimetastatic Effects of Jipae-san by Inflammation Control and Activation of Innate Immune System
Heo, Su-Jeong ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Lee, Kyung-Sub ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 1~14
DOI : 10.15204/jkobgy.2014.27.4.001
Objectives: This study was designed to investigate the anti-tumor metastasis by anti-inflammatory and innate immunomodulating effects of extracts of Jipae-san on cancer cells. Methods: Antimetastatic experiments were conducted in vivo mouse model by using 4T1 mouse mammary carcinoma cells. Cell viability of Jipae-san was tested with 4T1 mouse mammary carcinoma cells, colon 26-M3.1 carcinoma cells and macrophage. In addition expression of
and NO induced by LPS was measured after treating with Jipae-san. To observe innate immunomodulating effects of Jipae-san on macrophage, we measured
, IL-12, IL-6 and MCP-1, respectively. Cell cytotoxicity was tested with the macrophage stimulated with Jipae-san and we evaluated the activation of
and NO. And the effect of Jipae-san on metastasis was measured without NK-cell using GM1 serum. Results: Intravenous inoculation of Jipae-san significantly inhibited metastasis of 4T1 mouse mammary carcinoma cells. In an in vitro cytotoxicity analysis, cell growth are closer to 100% less than
concentration. The expression of
and NO induced by LPS after treating Jipae-san was down regulated in dose-dependent manner. Level of cytokines such as
, IL-12, IL-6 and MCP-1 of Jipae-san group were up regulated in compared to the control group. The macrophage stimulated with Jipae-san significantly inhibits the cancer cell at ratio of 10:1, 20:1. The activation of NO was significantly up regualted in a group of 5:1, 10:1, 20:1. The depletion of NK-cells by anti-asialo GM1 serum partly abolished the inhibitory effect of Jipae-san on tumor metastasis. Conclusions: Jipae-san appears to have considerable activity on the anti-metastasis by inflammation control and activation of innate immune system.
The Difference of Quality of Life on Blood Stasis Using SF-36
Lee, Yoon-Jae ; Sohn, Sung-Se ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 15~24
DOI : 10.15204/jkobgy.2014.27.4.015
Objectives: There were only small studies about the difference of the quality of life depending on blood stasis. We investigated that the blood stasis made the differences of quality of life. Methods: We recruited the participants stratified according to age and gender. The participants were assessed independently by two Korean medicine doctors more than 7 years of clinical experiences whether or not with blood stasis. And they responded at the questionnaire associated with blood stasis and SF-36. The analysis was done with IBM SPSS Statistics (ver. 21). Results: Total 101 participants were checked for with/without blood stasis. 40 participants were accord in the diagnosis with blood stasis by two doctors. Two researchers coincided in diagnosis with non-blood stasis in 42 participants. 19 participants showed the discrepancy between the assessment of blood stasis and they were classified as non-blood stasis. The mean age in group of blood stasis was
, it was not shown the significant difference comparing non-blood stasis group. The subscale of physical function (PF), role-physical (RP), bodily pain (BP), general health (GH), vitality (VT), mental health (MH) and role emotional (RE) in SF-36 were significantly low in the group of blood stasis. Blood test including biochemistry, fibrinogen, prothrombin time and D-dimer was not in abnormal range according to blood stasis without CRP. Conclusions: The patients that diagnosed of blood stasis showed the bad physical health status, and partially bad mental health. It is necessary to investigate whether Korean traditional treatment for blood stasis would be made improvement for quality of life. Moreover, the standardization of diagnosis on blood stasis would be needed.
Review of Experimental Studies on Estradiol Valerate-induced Polycystic Ovarian Syndrome in Herbal Medicine
An, Tteul-E-Bom ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 25~42
DOI : 10.15204/jkobgy.2014.27.4.025
Objectives: To observe the effects of Herb medication on Polycystic Ovary (PCO) in rats. Methods: Riss (Research Information Sharing Service) was searched for Oriental medicine about PCO on 2000~2014. So, Experimental studies using PCO model induced by Estradiol Valerate (EV) was selected to analyze how effects they were. Consequently, 10 studies published on 2000~2014 were selected to analyze about weight of model and both ovaries, the number aries, the number of follicle and corpus of follicle and corpus luteum, the level of serum Androstenedione (ADD) and total estrogen, the level of Nerve Growth Factor (NGF) and Corticotropin Releasing Factor (CRF), the crossover rate and the number of implantation. Results: Among them, there was significantly difference between treatment group and control group in weight of both ovaries, the number of follicle and corpora lutea, the crossover rate and the number of implantation. Conclusions: The effects of Herb medication was observed on making weight of ovaries with PCO to promote. The study about effect of Herb medication on NGF and CRF with PCOS had to be conducted. The further research have to focus on treatment of subfertility and infertility, that is field showing the advantage of Oriental medicine.
A Review on Clinical Studies of Herbal Treatment for Infertility Caused by Polycystic Ovary Syndrome -Focusing on Chinese Clinical Trials-
Won, An-Na ; Choi, Min-Sun ; Kim, Dong-Il ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 43~56
DOI : 10.15204/jkobgy.2014.27.4.043
Objectives: The purpose of this study is to review the trend of chinese clinical studies of herbal treatment for infertility caused by Polycystic Ovary Syndrome (PCOS). Methods: We searched the clinical studies published from 1979 to 2013 through CAJ (Chinese Academic Journal) with keywords of "PCOS and 不孕" or "多囊卵 巢綜合證 and 不孕". We analyzed the intervention type of clinical studies. In addition, We researched randomized controlled trials (RCTs) published from 2009 to 2013, assessed the quality of RCTs using the Jadad Scale and reanalyzed the intervention type of RCTs. Results: One hundred and seventeen clinical studies were finally selected. Clinical studies of herbal treatment for infertility caused by PCOS increased remarkably after the 2000s in China. Combined herbal medicine and western medicine was used the most frequently. RCTs published from 2009 to 2013 were fifty. Average of Jadad score of RCTs was 1.2. Combined herbal medicine and western medicine was also the most frequently used as intervention in RCTs. Conclusions: Clinical studies on effect of combined herbal medicine and western medicine for infertility caused by PCOS were mostly published in China. But Quality of studies was generally low. Further research on effect of herbal treatment for infertility caused by PCOS is needed.
Research of Relationship Between Cold Hypersensitivity and Sasang Constitution
Lee, Ji-Yeon ; Choi, Yu-Jeong ; Lee, In-Seon ; Cho, Hye-Sook ; Kim, Jong-Won ; Jeon, Soo-Hyung ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 57~68
DOI : 10.15204/jkobgy.2014.27.4.057
Objectives: The purpose of this research is to investigate the relationship between Sasang constitution and cold hypersensitivity. Methods: We investigated 391 outpatients who visited Dong-Eui Oriental Hospital OB & GY from June 12, 2013 to April 18, 2014. Among 134 patients who complained feeling of cold, we analyzed 107 patients whose Sasang constitution is confirmed. Results: 1. There were 21 persons 19.8% of under age 27, 28 persons 26.4% of age 28-34, 23 persons 21.7% of age 35-41, 18 persons 17% of age 42-48, 16 persons 15.1% of age over 49. 2. Among 107 patients, there were 52 persons 48.6% of Soeumin, 29 persons 27.1% of Taeeumin, 25 persons 23.4% of Soyangin, 1 person 0.9% of Taeyangin. And Taeyangin interior disease was 1 case 100%, Soyangin exterior disease was 22 cases 88% and interior disease was 3 cases 12%, Taeeumin exterior disease was 11 cases 37.9% and interior disease was 18 cases 62.1%, Soeumin exterior disease was 19 cases 36.5% and interior disease was 33 cases 3.5%. 3. In the distribution of cold-hypersensitive part, hands and feet with chills were 58 cases 4.7% by largest number, and the following was hands and feet in 24 cases 22.6%. 4. In the distribution of chief complaint, there were 25 cases 23.58% of menstrual pain, 19 cases 17.92% of postpartum symptoms, 17 cases 16.04% of oligomenorrhea and hypomenorrhea, 14 cases 13.21% of cold hypersensitivity. 5. In the distribution of chief complaint depending on age, menstrual pain of under age 27, postpartum symptoms of age 35-41 and cold hypersensitivity of over age 49 were at a high rate. Conclusions: Results suggest that patients with symptom of cold hypersensitivity have some tendencies in age, Sasang constitution, chief complaint, cold-hypertensive part.
Investigation of the Current Clinical Result of Korean Medical Treatment of Infertility -In Major University Korean Medicine Hospitals and Local Korean Medicine Clinics Participated in the Research-
Lee, Dong-Nyung ; Choi, Min-Sun ; Kim, Dong-Il ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 69~87
DOI : 10.15204/jkobgy.2014.27.4.069
Objectives: We analyzed retrospective clinical data of Korean medical institutes for infertility care and investigated current status and outcome of the Korean medical treatment of infertility as a part of foundational research for verifying validity of constructing national support system and developing appropriate policy on Korean medical treatment of infertility. Methods: We investigated data uploaded on the homepage of The Society of Korean Medicine for Subfertility (http://www.okinfertility.org) by Korean medical institutes for infertility care to get informations such as patients` age, body height, weight, methods of Korean medical treatment, cost and duration of treatment, success or failure of pregnancy and result of treatment. Results: The average age of patients was
and the average body height was
and the average body weight was
. The method of Korean medical treatment was Herbal medicine (97.5%), acupuncture (80.4%), moxibustion (57.7%), cupping (32.7%). The average cost of treatment was
won, and the average medical cost per visit was
won. The average duration of treatment was
weeks, and the average number of visits per patient was
times. The average duration of treatment was the longest in the group of infertile patients with the highest average medical cost per visit. The average pregnancy success rate was 30.9% overall, and that of the group of infertile patients was 25.8%. Conclusions: When we develop the standard project model with expectation for about 25% success rate of pregnancy and delivery in the group of patients who have idiopathic and ovulatory factors, it is desirable to perform acupuncture and moxibustion treatment 1-2 times a week with herbal medicine. The treatment period is set to at least 12 weeks. Average treatment fee maybe calculated by converting the averaged treatment cost of clinic`s one month worth of daily treatment fee and medical hospital`s ten day treatment fee into weekly treatment cost.
The Clinical Study of 21 Menopausal Disorder Patients Treated by Kamikubi-hwan
Cho, Seong-Hee ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 88~96
DOI : 10.15204/jkobgy.2014.27.4.088
Objectives: The purpose of this study is to evaluate the effects of Kamikubi-hwan on menopausal disorder patients. Methods: We surveyed 21 menopausal disorder patients was administered Kamikubi-hwan. The patients of menopausal disorder was estimated twice with Kupperman`s index (KI) and Stress response inventory (SRI). Results: After treatment, the mean of KI and SRI score were decreased. Symptoms of menopausal disorder were decreased. Conclusions: This study shows that Kamikubi-hwan is significantly effective on menopausal disorder patients.
A Case Report of Postabortal Syndrome Patient
Kim, Se-Hwa ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Lee, Kyung-Sub ; Lee, Chang-Hoon ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 97~108
DOI : 10.15204/jkobgy.2014.27.4.097
Objectives: This study is to report the clinical effect of oriental medicine on a patient suffering from postabortal syndrome with somatic pain disorder, Qi deficiency and depression. Methods: The patient had a miscarriage by cervical incompetence in 24 weeks` gestation even though she had operated cervical cerclage in 20 weeks` gestation. The patient received herbal medication, acupuncture, moxibustion during 20 days of outpatient treatment. The clinical effects were evaluated through VAS (Visual Analogue Scale) and EPDS (Edinburgh Postnatal Depression Scale Test). Results: The clinical symptoms of somatic pain and Qi deficiency were reduced during the treatment. The EPDS score also decreased from 19 points (high risk level) to 8 points (low risk level). Conclusions: This case study showed that herbal medicine, acupuncture and moxibustion treatment appeared to effectively reduce postabortal syndrome. Since patients previously experienced cervical incompetence tend to have habitual abortion for next pregnancy, further long term observation and preventive treatment are needed in this case for next safe pregnancy and childbirth.
A Clinical Study on Case 4, Hospitalized after Total Hysterectomy
Kim, Mi-Rim ; Lim, Eun-Mee ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 109~120
DOI : 10.15204/jkobgy.2014.27.4.109
Objectives: The purpose of this study is to report the effect of Korean medicine treatments on Postoperative symptoms. Methods: The patient was treated with herbal medicine, acupuncture and electronic moxibustion. The efficacy of treatment was evaluated with visual analogue scale (VAS), the degree of symptom relief and presence or absence of symptoms. Results: After hospital care with korean medicine treatments, symptoms such as fatigue, lower abdominal pain, thirst, hot flush, cold hypersensitivity of hands and feet and tinnitus were disappeared. Conclusions: To promote physical strength and reduction of fatigue, intensive hospital care with korean medicine treatment seems to be effective. After discharge, continued outpatient treatment for complications of surgery and menopausal disorder seems to contribute to quality of life and satisfaction for patient who undergoing hysterectomy.
A clinical Study on 2 Cases of Hemorrhagic Corpus Luteal Cyst
Park, Kyung-Mi ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 121~132
DOI : 10.15204/jkobgy.2014.27.4.121
Objectives: The purpose of this study is to report the effects of herbal medicine on corpus luteum and luteal hemorrhage. Ovulation is a physical event and hemorrhage from corpus luteum is known to occur in reproductive age group women. Life threatening hemorrhage requires surgical intervention and blood transfusion. Methods: The patients of this study are 34-year-old and 16-year-old females. They were diagnosed as the hemorrhagic corpus luteal cyst. Two patients was advised to be operated beacause of rupture possibility. They were treated by traditional Korean Medicine, herbal medicine (Bokryungdosu-tang), acupuncture and moxibustion. Results: After the treatment, the patients recovered their condition. One patient was diagnosed with disappearance of existing corpus luteum, the other was relieved of heavy abdominal pain, vaginal discharge and lumbago. Conclusions: Thess cases show that traditional Korean treatment might be effective on corpus luteum and luteal hemorrhage.
A Case Report of the Geriatric Stress Urinary Incontinence Patient Improved by Korean Medical Treatment
Park, Seung-Hyeok ; Chae, Min-Soo ; Jang, Jun-Bock ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Lee, Kyung-Sub ; Hwang, Deok-Sang ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 133~140
DOI : 10.15204/jkobgy.2014.27.4.133
Objectives: This study aims to identify effects of Korean medical treatment for stress urinary incontinence patient. Methods: The patient was treated by moxibustion at Shuidao (ST28), Sa-Am acupuncture lung tonification, Bojungikkitang-gamibang and Boshimdan for 2 weeks. These treatments are Korean medical treatment, and non-invasive. Results: After 2 weeks of Korean medical treatment, the symptoms of stress urinary incontinence disappeared. Conclusions: This case report shows that non-invasive Korean medical treatments are effective against stress urinary incontinence.
A Case Report of Ovarian Hyperstimulation Syndrome with Edema of Left Leg by In Vitro Fertilization
Kim, Jung-Ah ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 27, issue 4, 2014, Pages 141~149
DOI : 10.15204/jkobgy.2014.27.4.141
Objectives: The purpose of this study is to report the effects of herbal medicine and acupuncture on ovarian hyperstimulation syndrome (OHSS). Methods: A patient who had OHSS with edema and pain of left leg as chief complaints was treated by herbal medicne and acupuncture for 11days. We evaluated the results of treatment by change of symptoms, circumference of left leg, Visual Analogue Scale about left leg pain and walking time. Results: After treatment, symptoms of OHSS were almost improved. Circumference and pain of left leg were reduced and walking time was incresed after treatment. Conclusions: This study suggests that Korean medicine mainly herbal medicine and acupuncture is effective on OHSS.