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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Oriental Obstetrics and Gynecology
Journal Basic Information
Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
Editor in Chief :
Volume & Issues
Volume 28, Issue 4 - Nov 2015
Volume 28, Issue 3 - Aug 2015
Volume 28, Issue 2 - May 2015
Volume 28, Issue 1 - Feb 2015
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Effects of Taraxaci Herba on the Sex Hormon Changes and Lipid Metabolism in the Ovariectomized Rats
Kim, Ji-Eun ; Yang, Seung-Jeong ; Cho, Seong-Hee ; Park, Kyung-Mi ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 1~12
DOI : 10.15204/jkobgy.2015.28.1.001
Objectives: Taraxaci Herba (TH) have been used in oriental medicine for many centuries as a heat-clearing, detoxifying and stimulating milk secretion drug. Therefore, the purpose of this study was to investigate the effects of TH on the sex hormone changes and lipid metabolism in the experimental model. Methods: The experimental model of menopause was induced by bilateral ovariectomy in rats. We used TH extract with freeze-dried and
female Sprague-dawley rats for this Study. The level of serum total cholesterol, serum triglyceride, serum HDL-cholesterol, serum total estrogen, serum progesterone, serum follicle stimulating hormone (FSH), and body weight were measured. Results: The results of this study were obtained as follows; 1. Sample A and Sample B significantly decreased body weight and level of serum total cholesterol, and significantly increased level of serum total estrogen as compared with control group. 2. Sample A decreased level of serum triglyceride, and was increased level of HDL-cholesterol, serum progesterone, serum FSH as compared with control group. 3. Sample B significantly increased level of HDL-cholesterol, serum FSH as compared with control group. 4. Sample B decreased level of serum triglyceride, and was increased level of serum progesterone as compared with control group. Conclusions: These results suggest that TH could be applied effectively on the treatment of menopausal syndrome.
In Vitro Anti-inflammatory Effects of Hyunbulikyung-tang Aqueous Extracts on LPS activated Raw 264.7 Cells, and Synergic Effects with Piroxicam
Kim, Jung-Ah ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 13~28
DOI : 10.15204/jkobgy.2015.28.1.013
Objectives: To observe the in vitro anti-inflammatory effects of Hyunbulikyung-tang aqueous extracts (HBLKT) and the possible synergic combination effects with a nonsteroidal anti-inflammatory drug, piroxicam. Methods: Anti-inflammatory effects of HBLKT (yield=16.17%) were observed on LPS activated raw 264.7 cells based on
to cell viability, NO,
and IL-6 productions as compared with piroxicam, in the present study. In addition, the combination effects of HBLKT with piroxicam were observed after treatment of HBLKT 1/4
+ piroxicam 1/4
concentrations, respectively. Results: Significant (p<0.01 or p<0.05) increases of cell viabilities and decreases of NO,
and IL-6 cytokine releases were detected in HBLKT 1/4
+ piroxicam 1/4
concentration co-treatment as compared with each of single 1/4
concentration of piroxicam and HBLKT treatments, respectively. Although significant (p<0.01 or p<0.05) increases of cell viabilities and decreases of NO,
and IL-6 cytokine releases were also demonstrated in piroxicam 1/64
+ HBLKT 1/4
co-treatment as compared with LPS control, no significant changes were detected as compared with each of single 1/4
concentration of piroxicam and HBLKT treatments, in this experiment. Conclusions: Hyunbulikyung-tang showed cell protective and anti-inflammatory effects against LPS activated raw 264.7 cells. It, therefore, expected that HBLKT will be showed favorable effects to relieve dysmenorrhea related to over expressed inflammatory cytokines, and it also expected that the clinical dosages of piroxicam can be reduced as 1/8 levels as combination with HBLKT.
In Vitro Antibacterial Effects of Yeonkyokeumpae-jeon against Escherichia coli
Han, Sang-Kyum ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 29~45
DOI : 10.15204/jkobgy.2015.28.1.029
Objectives: The object of this study was to observe the in vitro antibacterial effects of Yeonkyokeumpae-jeon (YKKPJ) have been used for treating various gynecological diseases including mastitis in Korea, and individual six kinds of herbal composition aqueous extracts - Forsythiae Fructus (FF), Millettiae Caulis (MC), Lonicerae Flos (LF), Fritillaria Thunbergii Bulb (FT), Taraxci Herba (TH) and Prunellae Spica (PS) against E. coli. Methods: Antibacterial activities against E. coli of YKKPJ, FF, MC, LF, FT, TH and PS aqueous extracts were detected using standard agar microdilution methods. In addition, the effects on the bacterial growth curve were also monitored at MIC and
levels. The effects on the intracellular killing and bacterial invasion of individual test materials were also observed using Raw 264.7 and MCF-7. The results were compared with ciprofloxacin, a second generation of quinolone antibiotics in the present study. Results: MIC of YKKPJ, FF, MC, LF, FT, TH, PS aqueous extracts against E. coli were detected as
, repectively. YKKPJ, FF, MC, LF, FT, TH, PS aqueous extracts showed antibacterial effects against to E. coli, except for FT and TH, which were showed negligible antibacterial effects, respectively. In addition, ciprofloxacin with YKKPJ, FF, MC, LF and PS aqueous extracts also showed marked dosage-dependent inhibition of bacterial growth, and favorable inhibitory effects on the both bacterial invasion and intracellular killing assays using MCF-7 and Raw 264.7 cells were detected in this experiment. Conclusions: The results obtained in this study suggest that traditional polyherbal formula YKKPJ aqueous extracts showed more favorable antibacterial activities as compared to individual six kinds of herbal composition aqueous extracts. The antibacterial effects of YKKPJ against E. coli considered as results of complicated synergic effects of their six kinds of herbal components rather than simple antibacterial effects of single herbal components. It means, YKKPJ aqueous extracts may show potent anti-infectious effects against E. coil for mastitis.
Effects of Trogopterorum Faeces on the Apoptostic Cell Death in Breast Cancer Cells
Song, Yu-Rim ; Kim, Ji-Eun ; Yang, Seung-Jeong ; Park, Kyung-Mi ; Jung, Su-Jung ; Cho, Seong-Hee ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 46~57
DOI : 10.15204/jkobgy.2015.28.1.046
Objectives: This study was designed to investigate the effects of Trogopterorum Faeces on the apoptostic cell death in breast cancer cells. Methods: In the experiment, the effects of Trogopterorum Faeces on proliferation rates and type of cell death were investigated using MCF-7 cells in vitro. The effects on expression levels of caspase 3 and caspase 9 were also investigated. Results: The effects on expression levels of caspase 3 and caspase 9 were also investigated. In the present results, treatment with Trogopterorum Faeces decreased proliferation rates in a dose dependent manner.
(50 % inhibitory dosage) was
. In addition, treatment with Trogopterorum Faeces increased percentage of apoptotic cells. Finally the expression level of caspase 3 and caspase 9 were elevated by treatment with Trogopterorum Faeces respectively. Conclusions: This study suggests that Trogopterorum Faeces can trigger caspase dependent apoptosis in MCF-7 cells.
Effects of Fermented Soybean on Body Weight, Body Fat and Serum Lipid in Obese Women
Nam, Eun-Young ; Kim, Dong-Il ; Choi, Min-Sun ; Kim, Hyung-Jun ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 58~72
DOI : 10.15204/jkobgy.2015.28.1.058
Objectives: The purpose of this study was to examine the effects of fermented soybean on body weight, body fat, serum lipid profiles in obese women, especially specific to menopausal woman. Methods: Sixty healthy obese volunteers who visited
University Oriental Hospital from May 20th, 2014 to September 25th, 2014 took part in clinical trial. They divided into 2 groups, 30 volunteers allocated to fermented soybean and other 30 to placebo group. Body weight, BMI, waist and hip ratio, serum lipid were measured 3 times, and fat percentage, leptin, adiponectin were evaluated 2 times. Results: All 60 volunteers completed 12-week trial. 5 men were excluded, and 2 women against the clinical decision rule were excluded. In the end, 53 women were studied as clinical subjects. After 12 weeks intervention, there was no effects in comparison of group by time interaction. Without considering time interaction, there was a significant difference in triglyceride level between soybean group and placebo group (p=0.044). Treatment group were dividing by age 40, a group in age 40 or over 40, and other group aged below 40. There was a significant difference in group by time interaction of total cholesterol level, and without considering time interaction, there was a significant change in waist-hip ratio between groups. Conclusions: There were no effects on weight and body fat decrease in 12-week trial using fermented soybean as a supplement. But there were significant differences in triglyceride change between the treatment and placebo groups, also cholesterol and waist and hip ratio in soybean group divided by age 40. It seems that fermented soybean is effected on improving serum lipid profiles.
A Study on Pulse Energy Measured by 3D Blood Pressure Pulse Analyzer in Women Who Complain of Climacteric and Menopausal Symptoms
Lee, Ji-Yeon ; Yoon, Young-Jin ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 73~84
DOI : 10.15204/jkobgy.2015.28.1.073
Purpose: The purpose of this study is to analyze the characteristics of the pulse energy in women who complain of climacteric and menopausal symptoms. Methods: We analyzed the values of pulse energy on 45 climacteric and menopausal women. The patients' symptoms were assessed by Kupperman's index and Menopause Rating Scale (MRS). Statistical analysis was performed using SPSS 18.0 for window program, one way ANOVA, pearson correlation coefficient. Results: The results were as follows. 1. The pulse energy of the Left Chon was significantly largest and Left Cheok was comparatively smallest. 2. There was no statistically significant correlation in the pulse energy of Left Chon minus Left Cheok, Kupperman's index, MRS total sum score. Conclusions: The results suggest that the pulse energy of the Left Chon tends to be increased and Left Cheok decreased in climacteric and menopausal women.
A Study on the Relationship between Body Composition and Menopause Rating Scale (MRS), The Menopause-specific Quality of Life Questionnaire (MENQOL) of Postmenopausal Women
Park, Kang-In ; Pak, Yeon-Kyoung ; Park, Kyoung-Sun ; Hwang, Deok-Sang ; Lee, Chang-Hoon ; Jang, Jun-Bok ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 85~91
DOI : 10.15204/jkobgy.2015.28.1.085
Objectives: Postmenopausal symptoms are subject to many factors. Recently, obesity has been suggested as a factor of hot flush. So this study aims to report the relationship between body composition and Menopause Rating Scale (MRS), The Menopause-specific Quality of Life Questionnaire (MENQOL) of postmenopausal women. Methods: We studied 42 climacteric women who had visited Kyung Hee University Hospital at Gangdong from April 2011 to July 2014. 42 women had filled out MRS, MENQOL, and they had taken body composition tests. Pearson correlation tests were conducted. (Correlation was statistically significant at the 0.05 level) Results: Correlation between psychological subscale of MENQOL and Waist-Hip Ratio (WHR) was statistically significant (pearson correlation coefficient=0.385; p-value=0.012). But other subscales of MRS and MENQOL were not statistically related with body composition. Conclusions: WHR could be an important factor of psychological health of menopausal women. So, abdominal fat reduction must be considered when curing menopausal symptoms. In connection with climacteric depression, well-designed studies would be necessary.
Study on Heart Rate Variability Characteristics of Cold Hypersensitivity of Hands and Feet Patients
Pak, Yeon-Kyoung ; Park, Kang-In ; Park, Kyoung-Sun ; Hwang, Deok-Sang ; Lee, Chang-Hoon ; Jang, Jun-Bock ; Lee, Jin-Moo ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 92~101
DOI : 10.15204/jkobgy.2015.28.1.092
Objectives: Heart Rate Variability (HRV) is a diagnostic tool for assessing the function of the autonomic nervous system. Although studies on the HRV characteristics of the cold hypersensitivity of hands and feet have been done, no study has compared HRV characteristics of cold hypersensitivity of hands and feet patients to that of normal Korean women. For this reason, this study compared the HRV characteristics of cold hypersensitivity of hands and feet patients and normal Korean women. Methods: We studied 130 cold hypersensitivity of hands and feet patients who visited Kyung Hee University Hospital at Gangdong from 01 March 2011 to 11 August 2013. We measured HRV of Each patient. Patients are divided into under 29 years old, 30~39 years old, 40~49 years old and over 50 years old with age. Patient's HRV results are compared to that of normal Korean women in each age group. Results: In each age group, cold hypersensitivity of hands and feet patients' LF/HF was statistically lower than that of normal Korean women. Conclusions: HRV characteristics and symptoms of cold hypersensitivity of hands and feet is similar to that of cold induced vasodilation (CIVD). So, cold hypersensitivity of hands and feet can be considered as abnormal condition that CIVD is continued. More studies on measuring of blood flow of cold hypersensitivity of hands and feet patients are necessary.
A Pilot Study for the Practical Usage of Traditional Korean Medicine Diagnostic Methods in Women Infertility
Yoo, Jeong-Eun ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 102~112
DOI : 10.15204/jkobgy.2015.28.1.102
Objectives: This study was performed to obtain reference data of traditional Korean medicine diagnostic methods for the practical usage in women infertility. Methods: The study involved 38 female patients of age 20-38 years that had diagnosed of infertility. All the subjects answered to pattern identification questionnaire and Questionnaire for the Sasang Constitution Classification (QSCC II). Pattern identification scores and constitution types have been analyzed with variables of infertility factors and age. Statistical analysis was performed by adopting descriptive and inferential tests. Results: In pattern identification questionnaire analysis, the patterns were observed in order of frequency: liver stasis; blood deficiency; kidney-yang deficiency; kidney-yin deficiency; damp-heat; blood stasis; and phlegm. The group, less than 35 years old, had the higher average score of liver stasis (p<0.05). Also, the group with tubal and peritoneal factors, had the higher average score of blood deficiency (p<0.05). In QSCC II analysis, So-yang type had the higher average score of liver stasis, kidney-yang deficiency, and kidney-yin deficiency. So-eum type had the higher average score of liver stasis, kidney-yang deficiency, kidney-yin deficiency, and blood deficiency. While, Tae-um type had the higher average score of liver stasis and phlegm. Conclusions: We would accumulate the clinical data for the practical usage of traditional Korean medicine diagnostic methods in women infertility.
Review on the Acne Related Articles Published in Korean Medical Journals - Focusing on Experimental Studies Published after 2005 -
Yoon, Hee-Jung ; Kim, Dong-Il ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 113~127
DOI : 10.15204/jkobgy.2015.28.1.113
Objectives: This study was performed to analyze the trend of acne-related experimental studies in Korean medicine. Methods: We searched 17 articles related with experimental study of acne, published Korean medical journals from 2005 to 2014. We classified all articles according to the journal and checked on the kind of herbs. All articles were categorized into two types: cell experimental study and animal experimental study. Results: 1. Total 17 papers were searched; 7 articles (41.2%) were published in the Journal of Korean Medical Ophthalmology, Otolaryngology, Dermatology, 4 articles (23.5%) were published in the Journal of Korean Institute of Pharmacopuncture, 3 articles (17.6%) were published in Korean Journal of Oriental Physiology and Pathology, 2 articles (11.8%) were published in Korean Journal of Herbology, and 1 article (5.9%) was published in the Journal of Korean Medicine. 2. Total 17 kind of herbs were used in the studies; 10 articles (58.8%) used single herb, 7 articles (41.2%) used complex herbs. 3. Total 17 articles were categorized 2 types; 16 cell experimental studies (94.1%), 1 animal experimental study (5.9%). 4. Experimental researches were mainly investigated using Raw 264.7 cell line and P. acnes. The levels of NO, iNOS,
, PGE, COX-2,
, IL-6, NF-kB were analyzed to confirm of herbs' antibacterial, anti-inflammatory, antioxidant activity. Conclusions: Searching for natural antibiotics, it is needed to do experimental studies continuously, and also needed to diversify the kind herbs and experimental bacteria.
Two Case Report of Spontaneous Pregnancy Treated with Gamiseogagjihwang-tang after Repeated Failure in In Vitro Fertilization or Intrauterine Insemination Treatment
Koh, Ji-Eun ; Lyou, Myung-Sook ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 128~137
DOI : 10.15204/jkobgy.2015.28.1.128
Objectives: Spontaneous pregnancy is a rare event after repeated failure of in vitro fertilization (IVF) or Intrauterine insemination (IUI) treatment. So this paper is to report the natural pregnancy of Gamiseogagjihwang-tang treatments on two infertile patients who were repeatedly failed in IVF or IUI. Methods: One patient was a 35-year-old patient diagnosed with the adenomyosis and contralateral tubal obstruction, treated with 90 cc Gamiseogagjihwang-tang two times per day for 6 weeks after second failure of IVF. The other patient was a 34-year-old patient undergone induced abortion by three times, treated with 90 cc Gamiseogagjihwang-tang two times per day for 4 weeks after second failure of IUI. Results: Through taking Gamiseogagjihwang-tang without assisted reproduction techniques, two cases got pregnant naturally. Conclusions: These cases suggest that Gamiseogagjihwang-tang is effective in treating infertile female after failure in IVF or IUI and inducing spontaneous pregnancy. Therefore, there needs to be more trial on infertile patients treated with Seogagjihwang-tang.
A Case Report of Pregnancy of Infertility Patient with Thin Endometrium
Kwon, Ji-Myung ; Kim, Nam-Huyng ; Jang, Eun-Ha ; Kim, Eun-Seop ; Yoo, Dong-Youl ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 138~146
DOI : 10.15204/jkobgy.2015.28.1.138
Objectives: To report the effect of Korean medicine on 39-year-old infertile patient with thin endometrium. Methods: The patient who had thin endometrium was treated with herbal medication, acupuncture, moxibustion and steam bath for 4 months. Results: After the Korean medical treatment, the patient could give a natural birth to a healthy baby. Conclusions: The case report suggests that Korean medicine, especially herbal medicine and acupuncture is effective on thin endometrium.
A Case Report on 2 Cases of Patients with Uterine Fibroids Observed an Effective Result on Ultrasonography after Korean Traditional Medical Treatment
Gwak, Yu-Jin ; Park, Sang-Hee ; Jung, Myung-Ju ; Park, Sung-Woo ; Park, Ung ; Jo, Hee-Guen ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 147~157
DOI : 10.15204/jkobgy.2015.28.1.147
Objectives: We report two cases that have an effective result with Korean traditional medical treatment to two patients who have uterine fibroids, using transabdominal ultrasonography for checking the size of uterine fibroids. Methods: A 44-year-old patient and a 43-year-old patient were treated with an herbal medicine, acupuncture and cupping therapy. We followed up the symptoms and the size of uterine fibroids. Results: The 44-year-old patient was asymptomatic, her size of the uterine fibroid was reduced for 6 months. Also, the 43-year-old patient experienced that the symptoms such as urinary frequency, ovulation pain, heavy bleeding were improved and the size of the uterine fibroid was reduced. Conclusions: This results suggest that Korean traditional medical treatment if effective for both asymptomatic and symptomatic uterine fibroids and ultrasonography is useful for checking the effect of Korean traditional medical treatment. Further case series and studies are warranted.
A Case Report of One Patient with Infertility Accompanied by Adenomyosis and Uterine Myoma
Lee, Jeong-Im ; Nam, Eun-Young ; Kim, Hyung-Jun ; Lee, Dong-Nyung ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 158~166
DOI : 10.15204/jkobgy.2015.28.1.158
Objectives: Adenomyosis is the disease caused by ingrowth of lining tissue into the uterine muscle. Final treatment of the disease is hysterectomy. But if a patient want to get pregnant, there is a tendency to avoid surgical treatment. This paper introduces the potential of oriental medical treatment for infertility caused by adenomyosis through a case study. Methods: A 34-year-old female patient, who wants to get pregnant, was diagnosed with adenomyosis. She wants to take oriental medical treatment in the
Oriental Hospital. We applied herb-medication, acupuncture and moxibustion. Results: Overall condition including the symptoms was relieved and succeeded in pregnancy after oriental medical treatment. Conclusions: Oriental medical treatment has an effect infertility caused by adenomyosis.
A Case Report of Threatened Abortion
Yun, Young-Jin ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 28, issue 1, 2015, Pages 167~174
DOI : 10.15204/jkobgy.2015.28.1.167
Objectives: This study is to evaluate the effect of KI06 acupuncture point in the first trimester vaginal bleeding of a threatened abortion patient. Methods: A patient of threatened abortion was treated consequently with KI06 acupuncture point, and the result was inspected and evaluated using sono. Results: After consequent 4 times KI06 acupuncture point treatments, amount and frequency of bleeding in a patient of threatened abortion decreased to 80%, 50%, 20%, 10%. after more treatment the first trimester vaginal bleeding was improved completely. Conclusions: Treatment of KI06 acupuncture point in a threatened abortion patient was effective and further study is needed.