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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Journal of Oriental Obstetrics and Gynecology
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Journal DOI :
The Society of Korean Medicine Obstetrics and Gynecology
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Volume & Issues
Volume 29, Issue 3 - Aug 2016
Volume 29, Issue 2 - May 2016
Volume 29, Issue 1 - Feb 2016
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The Effect of Hwangnyeonhaedok-tang Pharmacopuncture on ST25 (天樞) in Rats with Dextran Sulfate Sodium (DSS)-Induced Colitis
Lee, Seung-Heon ; Park, Kyung-Mi ; Cho, Seong-Hee ; Youn, Dae-Hwan ; Yang, Seung-Jeong ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 1~13
DOI : 10.15204/jkobgy.2016.29.1.001
Objectives The purpose of this study is to find out the effect of various concentrations of Hwangnyeonhaedok-tang (HTT) pharmacopuncture on ST25 (天樞) in rats with dextran sulfate sodium (DSS)-induced colitis.Methods Colitis was experimentally induced by feeding rats with water mixed with 5% (w/v) DSS for 20 days. The rats were divided into 5 groups: the normal group (Nor, n=5), the control group - colitis induced rats with no treatment (Con, n=5), the acupuncture group - colitis induced rats with acupuncture applied on ST25 (Acu, n=5), the pharmacopuncture group 1 - colitis induced rats with 0.729 mg/250 g/40 μl of pharmacopuncture applied on ST25 (PA-1, n=5), the pharmacopuncture group 2 - colitis induced rats with 3.645 mg/250 g/40 μl of pharmacopuncture applied on ST25 (PA-2, n=5). The changes in weight, excrement concentration and hemafecia were observed 5 times every 2 days. The colon lengths were measured from appendix to the end of colon after the experiment. Hematological and serological exams were conducted the day after the last treatment by cardiac puncturing anesthetized rats.Results ST25 is the abdominal front point (募穴) of large intestine meridian and is known to have effect in colitis. Various concentrations of HTT pharmacopuncture (HTTP) applied on ST25, in rats with DSS-induced colitis inhibited decrease in colon lengths and body weight in both PA-1 and PA-2 groups. Hematological and serological exam results also showed that HTTP has significant effect on colitis in both PA-1 and PA-2 groups.Conclusions Colon lengths were significantly increased in the acupuncture group, PA-1 group and PA-2 group, compared to the control group. The body weight was significantly increased (p<0.05) in PA-2 group after the first treatment, compared to the control group. TNF-α, IL-6, AST were significantly decreased in PA-1 and PA-2 groups, compared to the control group.
In Vitro Cytotoxicity, Skin Regeneration, Anti-wrinkle, Whitening and In Vivo Skin Moisturizing Effects of Oncheongeum
An, Tteul-E-Bom ; Kim, Dong-Chul ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 14~34
DOI : 10.15204/jkobgy.2016.29.1.014
Objectives: The objective of this study was to evaluate the effects of cytotoxicity, skin regeneration, anti-wrinkle, whitening and skin moisturizing of Oncheongeum (OCE).Methods: The cytotoxicity of OCE lyophilized aqueous extracts (yield=13.82%) was observed against human normal fibroblast cells and B16/F10 murine melanoma cells by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium Bromide (MTT) assay, and skin regeneration and anti-wrinkle effects were also evaluated through the assay of collagen type I synthesis compared to the transformation of the growth factor (TGF)-β1, hyaluronidase, collagenase and matrix metalloproteinase (MMP)-1 inhibitory assays compared to oleanolic acid (OA), and elastase inhibitory effects compared to phosphoramidon disodium salt (PP). In addition, OCE’s whitening effects were measured by a tyrosinase inhibitory assay and melanin formation test in B16/F10 murine melanoma cells compared to arbutin, and skin moisturizing effects were observed through a mouse skin water content test, respectively. Results: No OCE treatment-related cytotoxic effects appeared on human normal fibroblasts and B16/F10 murine melanoma cells. OCE concentration-dependently increased the collagen Type I synthesis on human normal fibroblast cells, and also effectively inhibited hyaluronidase, elastase, collagenase and MMP-1 activities. In addition, OCE inhibited melanin production of B16/F10 murine melanoma cells and activity of tyrosinase. And significant and dose-dependent increases of skin water content were detected in OCE-treated mouse skin compared to vehicle control skins. Conclusions: OCE showed favorable and sufficient effects in skin regeneration, anti-wrinkle, whitening and skin moisturizing in this experiment. But more detail mechanisms and studies on the skin protective efficiency of in vivo are needed with the screening of active biological compounds in individual OCE herbs.
Effects of Boheotang-gagam on Milk Production and Factors Related Lactation in Postpartum Mice
Lee, Ah-Yeong ; Lee, Eun-Hee ; Im, Ji-Yeong ; Kim, Hong-Jun ; Lee, Chang-Hyun ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 35~52
DOI : 10.15204/jkobgy.2016.29.1.035
Objectives :The purpose of this study was to investigate the effect on factors related the expression of aquaporins (AQP) and milk production after administration of Boheotang-gagam in lactating mice. Methods: The SKH-1 mice were randomly allocated to the control group which was administered with distilled water for two weeks after the parturition and the experimental groups such as, lactating+400G group (L400G) which was administered with Boheotang-gagam 400 mg/day, lactating+600G group (L600G) which was administered with 600 mg/day for two weeks after the parturition, and 400G+lactating+400G group (400G-L400G) which was administered with 400 mg/day for 3 weeks starting one week prior to parturition for experiment (n=6 per group). Results: 1. With regard to the immunohistochemical staining reaction for AQP1, AQP3, and AQP5, stronger immune response was also showed in mammary gland in all experimental groups as compared to the control group. AQP1 showed stronger immune response in the capillaries and venules which were located around the interlobular duct, while stronger immune response of AQP3 and AQP5 showed in the secretory alveolar epithelia and intralobular and interlobular ductal epithelial cells. 2. In the western blot, L400G group showed the most increased expression followed by L600G and then 400G-L400G group in AQP1. In AQP3, the order of expression density was observed as L600G, 400G-L400G and L400G group. Lastly, in AQP5, L400G group presented the most increased expression followed by L600G and 400G-L400G group. Conclusions: Boheotang-gagam would have the effect of increasing the lactation of mice after the birth by increasing the prolactin level and adjusting the expression of AQPs and prolactin receptor in the mammary glands.
The Effect of Sex Education by School Doctor of Korean Medicine on Some Elementary School Students in Seoul
Lee, Seung-Hwan ; Kim, Kyeong-Han ; Kim, Dong-Il ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 53~68
DOI : 10.15204/jkobgy.2016.29.1.053
Objectives: This study is to identify the effect of sex education by school doctor of Korean medicine on elementary school students from fourth to sixth-grade. Methods: Eighty three students who received four sex eduction lectures by school doctor of Korean medicine were assigned as experimental group while 132 students who did not receive any sex education were assigned as control group. This study observed the changes in students’ sexual knowledge and sexual attitude before, after and three months after the sex education program. Results: Experimental group showed positive changes on sexual knowledge (male p=0.000, female p=0.046) and sexual attitude (male⋅female p=0.000). Three months after the conclusion of sex education program, the follow-up evaluation showed decline in effect of education, which suggests a need for continuous sex education. As students showed high level of satisfaction, we expect school doctor of Korean medicine can improve knowledge on health and further increase familiarity in Korean medicine by this kind of sex education Conclusions: Sex education by school doctor of Korean medicine for elementary school students from fourth to sixth grade has effectively changed sexual knowledge and attitude. Further, it is necessary to research the effect of sex education on elementary students over long-term period.
Effect and Satisfaction Measurement of Korean Medicine Treatment on Adolescent Dysmenorrhea
Park, Soo-Jung ; Joo, Jong-Cheon ; Kim, Jeong-Ho ; Kim, Seong-Bae ; Lee, Sang-Duk ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 69~77
DOI : 10.15204/jkobgy.2016.29.1.069
Objectives: The aim of this study is to evaluate the effect and satisfaction measurement of the Korean medicine treatment on the adolescent dysmenorrhea. Methods: The subjects of this study were 24 volunteers, suffering from dysmenorrhea, who were middle and high school students in Jeonbuk province. They were treated by Korean medicine, those were acupuncture, cupping, moxibustion and herbal medicine, for two months from July to December 2015. The results were investigated by the visual analogue scale (VAS) of overall pain, most severe pain and amount of the analgesic taken for menstrual period. The effects of treatment were assessed three times, those were before treatment, after treatment for 1 month and after treatment for 2 months, for two months. Results: The VAS score on dysmenorrhea was decreased significantly. Also, the VAS score on the disturbance in school activity was decreased significantly. The amount of analgesic taken for menstrual period was decreased, but not significantly. Conclusions: This study suggests that the Korean medicine treatment on the adolescent dysmenorrhea is effective.
A Review on Randomized Controlled Clinical Study on Acupuncture Treatment of Breast Cancer Patients
Lee, Yoon-Jae ; Lee, Sung-Yeop ; Jung, You-Hwa ; Lee, Seung-Yeol ; Jang, Jun-Bock ; Hwang, Deok-Sang ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 78~91
DOI : 10.15204/jkobgy.2016.29.1.078
Objectives: Breast cancer patients in Korea need to care about symptoms with complementary medicine including acupuncture. We reviewed the randomized controlled studies using acupuncture in breast cancer patients to establish a basic knowledge of clinical practice guidelines. Methods: We searched the following databases through July 2015: the Cochrane Central Register of Controlled Trials, Ovid-Medline, Ovid-EMBASE, the Allied and Complementary Medicine Databases and OASIS. The articles of RCTs using acupuncture in breast cancer for all symptoms were selected and analyzed. The acupoints, treatment period, inclusion criteria of participants, follow-up period and effectiveness were extracted. Results: Three hundred fifty five records after duplicate were screened, and 14 RCTs were selected. RCTs of Hot flush, pain, fatigue were reviewed. The adverse symptoms using medical treatment in breast cancer patients were targets of acupuncture in RCTs. The acupuncture treatment was decreased the hot flush, pain and fatigue. However, the effect was not confirmed due to various study design. Conclusions: The analysis of the research would be conjugated to establish a basic knowledge of clinical practice guidelines. Well designed studies in Korea are needed to confirm the efficacy and safety of acupuncture in patients with breast cancer.
Systematic Review of Fumigation Therapy for Atrophic Vaginitis
Baek, Seon-Eun ; Jang, Sae-Byul ; Choi, Kyung-Hee ; Yoo, Jeong-Eun ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 92~101
DOI : 10.15204/jkobgy.2016.29.1.092
Objectives: The purpose of this systematic review was to overview and evaluate the effectiveness of fumigation treatment for women with atrophic vaginitis. Methods: We searched articles from Pubmed, Chinese Academic Journals (CAJ) and Oasis online databases. Searching keywords were ‘fumigation’, ‘atrophic vaginitis’, ‘vaginitis’, ‘阴道炎’, ‘膣炎’, ‘老年性 阴道炎’, ‘坐熏’, ‘熏洗’, ‘熏浴’, ‘좌훈요법’, ‘질염’, ‘위축성질염’. After searching the articles, we performed quality assessment using Cochrane risk of bias (RoB) tool. Results: Among the 142 articles were searched, 5 randomized controlled clinical trials (RCTs) were finally selected. All of 5 studies showed that fumigation treatment has significant effect on atrophic vaginitis in terms of the effectiveness rate, but 3 studies were not statistically significant. Conclusions: Our systematic review found encouraging but limited evidence of fumigation therapy for atrophic vaginitis. We recommend clinical trials which obtain stronger evidence without the demerits of trial design.
The Research on the Characteristics of BMI and Sasang Constitutional on Dysmenorrhea Patients
Cho, Hye-Sook ; Lee, In-Seon ; Kim, Kyu-Kon ; Kim, Jong-Won ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 102~115
DOI : 10.15204/jkobgy.2016.29.1.102
Objectives: The purpose of this study is to find out the characteristics of dysmenorrhea patients with the Inbody test results by Sasang constitutions. Methods: The data from the 541 participants were collected using a structured measurement of menstrual pain. Based on the survey responses, we had 329 women with dysmenorrhea as the test group and 212 women without dysmenorrhea as the control group. The clinical trials subjects were asked to respond to another questionnaire for identifying their constitutional types and undergo Inbody test. Results: The result of a comparison of the test and control groups showed that the DSOM test showed that the scores of blood deficiency, qi stagnation, blood stasis and phlegm were significantly higher in dysmenorrhea. The result of the taeumin's test groups showed that the DSOM test showed that the scores of heat were significantly higher. For the Sasang constitution, there is a difference on the cause of the outbreak. Taeumin from blood deficiency, blood stasis, dampness, heart, kidney, phlegm and lung is associated with dysmenorrhea. Soeumin from blood deficiency, qi stagnation, blood stasis, liver, heart, spleen and phlegm is associated with dysmenorrhea. The ratio of overweight of taeumin was low in blood deficiency and yin deficiency. The ratio of lowweight of soeumin was high in heat. Conclusions: The DSOM test showed that the scores of blood deficiency, qi stagnation, blood stasis and phlegm were significantly higher in dysmenorrhea.
Two Cases of Oriental Medicine on Premature Ovarian Failure by Checking Ultrasonography and Serum Hormone Assay
Koh, Ji-Eun ; Lyou, Myung-Sook ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 116~126
DOI : 10.15204/jkobgy.2016.29.1.116
Objectives: The purpose of these cases is to report the effects of oriental medicine on two patients with premature ovarian failure. Methods: Two patients who had amenorrhea and hot flashes caused by premature ovarian failure were treated by oriental medicine such as herb medication. We estimated the effects of treatments by follow-up measurements of serum hormone level, menstrual cycle and symptoms. Besides, follicle and endometrium were checked by ultrasonography for academic research.Results After treatments, their symptoms of premature ovarian failure were improved and the menstrual cycle resumed. And the level of serum Follicle Stimulating Hormone decreased and the level of serum E
increased.Conclusions Two cases shows that oriental medicine has effects on patients with premature ovarian failure by follow-up measurements of serum hormone level, menstrual cycle and symptoms.
A Clinical Study on a Case of Arrhythmia after Stillbirth
Kim, Joon-Ho ; Kang, Na-Hoon ; Park, Kang-In ; Pak, Youn-Kyung ; Hwang, Deok-Sang ; Lee, Jin-Moo ; Lee, Chang-Hoon ; Lee, Kyung-Sub ; Jang, Jun-Bock ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 127~134
DOI : 10.15204/jkobgy.2016.29.1.127
Objectives Arrhythmia can occur frequently when state of pregnancy or after carriage, but it is rare that the symptom continues. We have a case of arrhythmia, which occurred after stillbirth and has lasted for about 4 months, treated by Korean medicine treatment, so we report a case on arrhythmia occurred after stillbirth.Methods Patient, who suffered from arrhythmia after stillbirth, was enrolled in this study. She received Korean medicine therapies such as herbal medicine, acupuncture and negative cupping.Results Discomfort and frequency of arrhythmia was reduced by Korean medicine therapiesConclusions The present study suggests that Korean medicine therapies have a effect on arrhythmia caused by stillbirth.
A Case Report on Two Spontaneous Pregnancies and Two Elevated Anti-Müullerian Hormone (AMH) of Subfertile Patients with Low AMH Level after Korean Medical Treatments
Choi, Yong-Ju ; Jung, So-Young ;
The Journal of Oriental Obstetrics and Gynecology, volume 29, issue 1, 2016, Pages 135~143
DOI : 10.15204/jkobgy.2016.29.1.135
Objectives: AMH is considered a sensitive marker of ovarian reserve, and it tends to be included among basic fertility tests. This paper is to report two spontaneous pregnancies and two elevated AMH which were achieved by subfertile women with low AMH level after Korean medical treatments. Methods: The patients in these cases were 36~41 years old. Four subfertile patients with low AMH level (0.01 to 1.88 ng/mL) were treated with herbal medication, acupuncture, moxibustion between June 2013 and December 2015. The patients were diagnosed as Kidney deficiency (腎虛), Blood extravasation (瘀血) and/or Liver Qi stagnation (肝氣鬱結). Results: The two subfertile women with low AMH level achieved spontaneous pregnancy and two subfertile women with low AMH were elevated AMH after Korean medical treatments. Conclusions: The case report suggests that Korean medical treatment can be an effective option for subfertile women with low AMH level before Assisted Reproductive Technology.