Go to the main menu
Skip to content
Go to bottom
REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Korea Journal of Herbology
Journal Basic Information
Journal DOI :
The Korea Association of Herbology
Editor in Chief :
Volume & Issues
Volume 15, Issue 2 - 00 2000
Volume 15, Issue 1 - 00 2000
Selecting the target year
Mechanism Study of Acori Graminei Rhizoma on the Pial Arterial Diameter in Rats
Lee Geum-Soo ; Jeong Hyun-Woo ; Kang Sung-Yong ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 1~1
Acori Graminei Rhizoma(AGR) has been used in Korea for many cenruries as a therapeutic agent for cerebral disease. The effect of AGR on the vascular system is not known. The purpose of this study was to determine the effect of AGR on the pial arterial diameter of male Sprague-Dawely rats. The changes in pial arterial diameter were determinated by video microscopy methods and video analyzer. The results were as follows ; 1. Pial arterial diameter was increased by AGR in a dose-dependent manner. 2. Pretreatment with 1H[I,2,4]oxadizolo[4,3-a]quinoxalin-1-one(ODQ,
, i.v.) significantly inhibited AGR induced increased pial arterial diameter. 3. Pretreatment with
significantly inhibited AGR induced increased pial arterial diameter. These results suggest that AGR causes a diverse response of pial arterial diameter. The increased in pial anerial diameter is also mediated by nitric oxide synthase and cyclic GMP(guanylyl cyclase).
Effect of Arisaematis Rhizoma on the Proliferation of Transplanted-L1210 cells in Mice
Jeon Hoon ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 9~9
We have previously observed that the proliferation of L1210 cells was inhibited by the administration of Arisaematis Rhizoma water extract (AE). In this present study, the mechanism of the inhibitory action on the proliferation of Ll210 cells was examined. AE decreased the proliferation of Ll210 cells and enhanced DNA fragmentation of L1210 cells in vivo system. DNA fragmentation of Ll210 cells was enhanced by co-culture of peritoneal macrophages obtained from AE-administered mice in vitro. AE increased nitric oxide production from peritoneal macrophage of Ll210-transpianted mice. In addition, AE enhanced the population of
cells. These results suggest that the inhibitory action of AE on the proliferation of Ll210 cells is partly caused by an induction of apoptosis via a production of nitric oxide in macrophages activated by Th cells.
A study on internal morphological standard in Platycodi Radix
Kim Jong-Uk ; Kim Hong-Jun ; Jin Young-Sung ; Yuk Sang-Won ; Han Kyeong-Sik ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 17~17
In order to strengthen objectivity and availability of oriental herb medicine, the standard formula for herbs has been attempted to set up by experimenting and documentary testing original herbs which were recorded in authorized document. The object herb medicines are Platycodi Radix. The internal morphological standard in this study is expected to supply the search for several physiochemical reaction, biological reaction, determination of indicator material and identification of gene with basic sources in the future. The result of study is as follows; In the shape of real herbs, I compared current herbs in market with original herbs which were just collected or were on the course of drying. It was possible that the internal shape could be identified by using microscope after butanol series. In powder herbs, it was possible to purify the shape by microscope through maceration of natural and powder herbs. Despite such a useful character, it was difficult to deal with powder herbs because it was uncertain to make a standard for them on account of the crush of these tissue. Since powders shape of herbs in a few documents were regard not as the powder shapes of natural herbs but as the maceration state of them. It is suggested that we should inspect the original herbs which are not crushed yet with a microscope in order to identify crushed shape of powder herbs from now on. An Additional standard establishment including physiochemical reaction and gene research is required in order to supplement the fault of this search.
Rhubarb Decreases Neutrophil Chemokine Production in the Skin and in the Serum Following Scald Burn Injury
Kim Seong-Bae ; Kang Byung-Soo ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 25~25
The present study was conducted to determine whether local production of neutrophil chemoattractant cytokines preceded the influx of neutrophils following dermal scald burn injury. In order to inhibit the influx of neutrophils, we examined the effect of Undulati Rhubarb(R. undulatum L.) to spread on scald skin. Detmal KC, human IL-8 family, level was elevated significantly at 24 h postburn and the level was higher at 72 h postburn than at 24 h postburn. Rhubarb markedly decreased the KC level by skin spread postburn. At 24 h postburn, KC was significantly increased in serum, Rhubarb decreased KC centent. However Rhubarb did not affect to protein concentration in serum at early stage within a 24 h postburn. This suggests that Undufati Rhubarb should be possible to alter neutrophil accumulation at the wound site by inhibition of the local chemokine production.
Effects on Cure and Prevention of an Obesity(Ⅳ)
Kim Youn-Sub ; Byun Sung-Hui ; Kim Sang-Chan ; Kuk Man ; Cho Eng-Haeng ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 37~37
We had experiment with five herb in order to find cure and prevention effects on the obesity. We fed control group rats high fat diet(Harlan, USA) and administered normal saline during 8 weeks, and experimental group rats high fat diet(Harlan, USA) and administered five herbal extract during 8 weeks. The results were as follows; 1. The body weight of all experimental group decreased than control group. 2. The average size of the epididymal fat cells in all experimental group decreased than control group but only Zeae Stigma and Crataegi Fructus group showed statistically significant difference with control group. 3. The fat drops area of hepatic lobule in all experimental group decreased than control group but Plantaginis Semen, Zeae Srigma and Crataegi Fructus group showed statistically significant difference with control group. 4. The area
of the insulin granules in Langerhans islet of all experimental group showed no difference with control group.
Studies on the Effects of the Parts of Cinamomum cassia PRESL on the Antixidation(Ⅰ)
Park Ryung-Joon ; Park Yong-Gi ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 45~45
The antioxidation effects of Cinnamomi Cortex (CC), Cinnarnomi Ramulus (CR), Cinnamomi Petiole (CP) on the radical scavenging ability from 1,1' -Diphenyl-2-picrylhydrazyl (DPPH), activities of nitrate reductase (NR), superoxide dismutase (SOD), xanthine oxidase and lipid peroxidase (LPO) in rat liver cells were examined In in vitro studies, CR extract had greater DPPH-radical scavenging ability than CC and CP. The NR acitiviry in the cells was more increased by the treatments of CC and CR extracts than CP extract. The enzyme activity of Xanthine oxidase of CC was decreased. Also, levels of lipid peroxidation were proportionally decreased to concentrations of CR. The recovery by CR extract treatment was similar to the level of ascorbic acid treatment. Therefore, it seems that CR extract has similar effects on the antioxidation compared with ascorbic acid, well-known antioxidant. The data indicate that CR has a depressive effect on the production of free radicals and changes in the acitivities of enzymes involved in the antioxidation. Compared to others, CP had smaller effects on the anti oxidation. These results suggest that CR seems to have more potent effects on the antioxidation than other parts of Cinamomum cassia and different mechanisms might be involved in the anitoxidation processes of CC, CP, and CR.
Studies on the Effects of Coicis Semen and Sophorae Radix on the Antioxidation
Park Yong-Gi ; Kang Byung-Soo ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 57~57
The antioxidation effects of Coicis Semen and Sophorae Radix on the radical scavenging ability from l,l'-Diphenyl-2-picrylhydrazyl(DPPH), activities of nitrate reductase(NR) and the contents of glutathione(GSH) superoxide dismutase(SOD), catalase, lipid peroxidase(LPO) in rat liver cells were examined. In in vitro studies, Coicis Semen extract had greater DPPH-radical scavenging ability than Sophorae Radix. The NR acitivity in the cells was more increased by the treatments of Coicis Semen extracts than Sophorae Radix extract. In in vivo studies, the acetaminophen-induced inhibitions of SOD, GSH, LPO and catalase activities were significantly recovered by the treatments of Coicis Semen and Sophorae Radix extracts. The recovery by Coicis Semen extract treatment was similar to the level of ascorbic acid treatment. Therefore, it seems that Coicis Semen extract has similar effects on the antioxidation compared with ascorbic acid, well-known antioxidant. These results suggest that Coicis Semen seems to have more potent effects on the antioxidation than Sophorae Radix extract.
Effect of Betulae Platyphyllae Cortex on Free radical in Diabetic Rats induced by Streptozotocin
Lim Beong-Ou ; Seo Tae-Won ; Shin Heung-Mook ; Park Dong-Ki ; Kim Sun-Ueou ; Cho Kum-Ho ; Kim Ho-Cheol ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 69~69
Type Ⅰ diabetes is caused by destruction of the pancreatic beta cells responsible for insulin-secretion. It can be induced by the drugs alloxan or streptozotocin (STZ). Both an increase in reactive oxygen free radical species and a decrease in the antioxidant defense mechanism lead to the increase in oxidative stress in diabetes mellitus. Oxygen radicals scavengers are effective in preventing diabetes in animal models. Experiments were conducted by two system. The Sprague-Dawley rats were treated with STZ intravenous injection after oral administrated Betula's extract and quercetin for a week, and were administrated them for a week. In vitro, Betula's extracts and quercetin showed a tendency towards inhibition of free radical oxidation in all. In vivo, Betula's extracts group exhibited suppression morphologic change in pancreatic islet compare quercetin group on light microscopy. The Betula's extract significantly inhibited formation of MDA compared to the STZ-induced diabetic group in pancreas. They also significantly inhibited formation of Phosphatidylcholine hydroperoxide(PCOOH) compared to the STZ-induced diabetic group in pancreas and plasma, which considered defense against destruction in beta cells. The protection by Betula's extracts may be due to scavenging of deleterious and highly reactive free radical which is generated by STZ. In streptozotocin-induced diabetic rats, the effect of Betula's extract are greater than that of quercetin. Based on this result, we concluded that Betula's extract has the ability to effectively suppress in vitro and in vivo oxidation, thereby providing additional evidence for their potential beneficial type Ⅰ diabetes.
Neuroprotective Effects of Acori Graminei Rhizoma on the Brain Ischemia induced by Four-Vessel Occlusion in Rats
Kim Young-Ock ; Kim Young su ; Leem Kang-Hyun ; Suk Kyoung-Ho ; Kim Sun-Ueou ; Ju-Young ; Ahn Duk-Kyun ; Kim Ho-Cheol ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 79~79
Acori Graminei Rhizoma(AR, 石菖浦), the rhizome of Acorus gramineus Soland, whose propetty, flavour and channel tropism is pungent in flavour(辛), warm in property(溫), acting on the heart and stomach channels(歸心胃經), has the effects of inducing resuscitation, tranquilizing the mind(開窮安神), resolving dampness, and regulating the functions of the stomach(化濕和胃). This drug is one of the popular drugs in traditional Korean medicine, which has been used to treat loss of consciousness and confusion of the mind(神志昏亂) due to mental disturbance by pathogenic dampness in the course of febrile diseases, and palpitation(心悸), insomina(失眼), amnesia(健忘) and tinnirus(耳鳴) due to insufficiency of the herat-qi. So, this study was planned to check the neuroprotective effect of AR on the global ischemia induced by 4-vessel occlusion in Wistar rats. AR extract was lyophilized after extraction with
methanol. We induced 4-vessel occlusion for 10 minutes and reperfused again. The number of CA1 pyramidal neurons were counted after 7 days of repel fusion under the cresyl violet staining. The results obtained that in 4-VO ischemia, AR showed significantly neuroprotective effects(1,000 and 500 mg/kg of AR extracts, p<0.05) compared with control group. Each neuroprotective ratio was about
respectively. Consequently, Acori Graminei Rhizoma has neuroprotective effects on the global ischemia induced by 4-vessel occlusion in Wistar rats.
The Effects of Fraction Obtained from Rhei Rhizoma on the Blood Lipids in Hypercholesterol Rats
Lee Young-Jong ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 87~87
The decoction of Rhei Rhizoma was divided into several fractions by the methods of extraction using methanol, membrane-permeability and HPLC. And the effects of the fractions on the contents of blood lipid in hyper-cholesterol rats and those on a pancreatic lipase were examined. The results were ; 1. The fraction, which was soluble in methanol, of total and LDL-cholesterol in the blood of hyper-cholesterol rats significantly decreased the levels. 2. The decoction prepared from Rhei Rhizoma strongly inhibited the activity of the pancreatic lipase. And some fractions obtained from the decoction also had such an inhibitory effects. 3. The fraction, which decreased the lipid contents, also had an inhibitory effect on the pancreatic lipase. But the effect was very weak. These results suggested that the inhibitory effects of Rhei Rhizoma on the contents of blood lipid was induced not by the inhibitory component of the pancreatic lipase but by some other factors.
The Effects of Fraction Obtained from Polygoni multiflori Radix on the Blood Lipids in Hypercholesterol Rats
Lee Young-Jong ; Son Young-Jong ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 95~95
The decoction of Polygoni mulriflori Radix was divided into several fractions by the methods of extraction using methanol, membrane-permeability and HPLC. And the effects of the fractions on the contents of blood lipid in hyper-cholesterol rats and those on a pancreatic lipase were examined. The results were: 1. The fraction, which was insoluble in methanol and also had molecular weight of above 10 kdal, significantly decreased the level of total and LDL-cholesterol in the blood of hyper-cholesterol rats. 2. The fraction, which had an effects on the lipid contents, also contained some materials which increased the contents of cholesterol and LDL-cholesterol. 3. The fraction, which had an effects on the lipid contents, also saliently inhibited the activity of pancreatic lipase. But it was not clear whether there was an association between the effect of decreasing the contents of blood liquid and that of inhibiting the activity of lipase.
The Effects of the Extracts from Xanthii Fructus about the Anti-allergic Action on IC-2 Cells.
Choi Young-Bong ; Seo Young-Bae ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 101~101
In order 10 investigate the immunosuppressant effects of Xanthii Fructus and about the expression of CD23, IgE and IL-4, it was necessary for it to be activated by phorbol I2-myristate 13-acetate (PMA) and ionomycin. We then analyzed it from the flow cytometry on the increase and the divorce of the B cells activated by anti-CD40. The results were obtained as follows: 1. The extracts of Xanthii Frucrus significantly decreased the expression of anti-CD23. 2. The extracts of Xanthii Fructus in combination with PMA, ionomycin decreased the expression of anti-CD23 as compared with PMA, ionomycin. 3. The extracts of Xaruhii Fructus in combination with IL-4 reduced the expression of anti-CD23 as compared with IL-4. above results demonstrates that the extracts of Xanthii Fructus suppress the expression anti-CD23 by suppressing activities of B cells and control anti-IgE by suppressing activities of B cells activated by PMA, ionomycin, IL-4.
A Clinical Observation on a case of Pressur Sore(an External Therapy with ASTRAGALI RADIX Powder)
Heo Young-ran ; Mun Seong-ho ; Choi Jung-gil ;
The Korea Journal of Herbology, volume 15, issue 2, 2000, Pages 111~111
Pressure sore is the ulceration and necrosis of the skin and underlying tissue usually occurred on the bony prominence of the body after prolonged or repeated pressure. Recently, the incidence of the pressure sore has been increased due to the development of the industry, increased number of the traffic accident and the cerebrovascular accident. Authors reviewed 4 sites of a patient who had received external application with ASTRAGALI RADIX powder for the pressure sore. Pressure sore of the patient was improved in about 4 months. ASTRAGALI RADIX has two effects: promoting tissue regenerarion(生肌) and evacuating the pus by administering tonics(排膿托毒). So ASTRAGALI RADIX is proper for the external application of the pressure sore.