Go to the main menu
Skip to content
Go to bottom
REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Korea Journal of Herbology
Journal Basic Information
Journal DOI :
The Korea Association of Herbology
Editor in Chief :
Volume & Issues
Volume 16, Issue 2 - 00 2001
Volume 16, Issue 1 - 00 2001
Selecting the target year
Analysis of cinnamic acid and cinnamic aldehyde in the different layer of Cinnamomi Cortex
Lee, Tae-Hui ; Mun, Jeong-Ho ; Kim, In-Rak ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 1~1
In order to prove which layer of Cinnamomi cortex had been used in Oriental medicine, the contents of cinnamic acid and cinnamic aldehyde as indexd component on 3 different layers of Cinnamomi Cortex were analysed respectivelyThe results were:1. The cinnamic acid contents of Cassiae Cortex Interior was 0.135%, inner bark layer, 0.031%, peridium, 0.023%, and average, 0.068%.2. The cinnamic aldehyde contents of Cassiae Cortex Interior was 1.686%, inner bark layer 0.139%, peridium, 0.183%, and average, 0.696%.From the above results, it is suggested that the main part of Cinnamomi Cortex showed pharmacological activity is its Interior.
Vasodilation Effect of the Ginkgo Folium Water Extract on isolated Rat Thoracic Aorta
Jeong, Gwon-Su ; Kim, Hyeong-Hwan ; An, Deok-Gyun ; Choi, Ho-Yeong ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 7~7
We have examined the relaxational response of the Ginkgo Folium water extract on isolated thoracic aorta from sprague dawley rat (300~350g) in the presence and absence of endothelium and the vasodilator nitric oxide. Segments of thoracic aorta obtained from rats immediately after delivery were mounted in organ baths superfused on a polygraph.We found that the thoracic aorta segments responded to the Ginkgo Folium water extract with a dose-dependent vasorelaxation. At 2.0 ㎎/㎖ Ginkgo Folium water extract, the relaxational response with and without endothelium were 75.8% and 6.9% of the maximum KCI-response. The Phenylepinephrine and 5-hydroxytrptamine - induced contraction at 10^-4M were inhibited by 77.3% and 75.8% after addition(2.0 ㎎/㎖) of the Ginkgo Folium water extract. After pre-treatment of the thoracic aorta with N^G-monomethyl-L-arginine(10^-4M), the vessels contracted in response to the nitric oxide synthase inhibitor. The present results show that nitric oxide may act as a crucial signal in the vasodilative action.In conclusion, Ginkgo Folium water extract-induced relaxation in the isolated rat thoracic aorta was composed of endothelium-dependent and dose-dependent relaxation. Endothelium-dependent relaxation may be mediated by release of endothelium derived relaxing factor, nitric oxide
Vasodilation effect of the various of the water extract of Eleutherococus senticosus ( Rupr et Maxim ) Maxim on isolated thoracic aorta and abdominal aorta from rat
;Kim, Hyeong-Hwan;An, Deok-Gyun;Choi, Ho-Yeong;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 13~13
In this study we have examined the actions of water extract of Eleutherococus senticosus (Rupr. et Maxim.) Maxim. (ESH), Stem, Root bark (RB) and Root xylem (RX) in isolated thoracic and abdominal aorta assay. To compare the vasodilation effect, put. ESH, Stem, RB and RX into them which vessels were precontracted by 5-hydroxytryptamine (5-HT). We found out the thoracic aorta segments were responded to ESH with a dose-dependent vasodilation. The 5-HT induced contraction at 10-4M were relaxed after addition of the 2.0 ㎎/㎖ ESH as 32.1% (Stem), 34.9% (RX) and 87.2% (RB). The 5-HT induced vasocontraction at 10^-4M were vasodilated such as 87.2% in thoracic aorta and 89.0% in abdominal aorta with 2.0㎎/㎖ ESH. Addition of 2.0㎎/㎖ ESH in thoracic aorta which was precontracted by the 5-HT at 10-4M were come out differently 0% (water fraction), 53.8% (butanol fraction) and 96.6% (ethyl acetate fraction). The 5-HT induced contraction at 10-4M with and without endothelium were inhibited by 87.2% and 87.8% after addition of the ESH (2.0 ㎎/㎖). In conclusion, ESH-induced relaxation in the isolated rat thoracic aorta and abdominal aorta were come out be dose-dependent relaxation, and ESH's ethyl acetate fraction was showed the potent vasodilation effect
Comparative studies on the angiogenic activity of water extract of Angelica Gigantis Radix , Angelica Sinensis Radix and Angelica Radix
Oh, Ha-Sik ; An, Deok-Gyun ; Choi, Ho-Yeong ; Kim, Hyeong-Hwan ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 19~19
A rat sponge implant model was used to examine the angiogenic effect of water extract of Angelica Gigantis Radix (EAG). Angelica Sinensis Radix (EAS) and Angelica Radix (EAA). It was based on subcutaneous implantation of sterile polyester sponges in the Sprague Dawley (SD) rat and we have characterized a dye method that incorporates 5% carmine red in 10% gelatin. Vascularity index (V.I.) expressed as
dye/mg dry tissue. The result of study is as follows;1. Subcutaneous implantation of sterile polyester sponges in SD rats enhanced the angiogenesis over 14 days, as determined by measurements of relative angiogenic effects by a vascularity index.2. Daily oral administration (100 mg/kg for 14 days) of EAS and EAA produced weak effect on sponge-induced angiogenesis but EAG caused intense neovasculalization.3. PBS (50
1) and EAG (100 mg/kg) - induced angiogenesis represents a special form of angiogenesis.4. The vasoconstrictor peptidem, angiotensin Ⅱ(AⅡ), in daily doses of 100 nmol, caused an intense neovascularization and coadministration of the AⅡ (100 nmol) and EAG (100 mg/kg), AⅡ and EAS (100 mg/kg) and AⅡ and EAA (100 mg/kg) produced angiogenic effect. Especially, AⅡ (100 nmol) and EAG (100 mg/kg) caused very potent angiogenesis.We have shown that oral administration of EAG (100 mg/kg) induced angiogenesis. Thus the sponge model offers a new means for continuous and reproducible studies on the controlling mechanisms of angiogenesis
Vasodilation Effect of the Water Extract of three Angelica Species and Four - Substance Decoctions in Rat Thoracic Aorta
Kim, Hyeong-Hwan ; Lee, Ju-Ho ; Lee, Je-Hyeon ; An, Deok-Gyun ; Park, Seong-Gyu ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 29~29
We have examined the relaxational reponse to the water extract of Angelica gigas Nakai (AG), A. sinensis(Oliv.) Diels (AS), A. acutiloba Kitagawa (AA), and Four-Substance Decoctions (AG-FSD, AS-FSD, AA-FSD) in isolated thoracic aorta from sprague dawley(SD) rat in the presence and absence of endothelium. Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to AG, AS, AA and AG-FSD, AS-FSD, AA-FSD were investigated in vessels precontracted with 5-hydroxytryptamine(5-HT) were compared in vasodilation effect. We found that the thoracic aorta segments responded to AG, AS, AA and AG-FSD, AS-FSD, AA-FSD with a dose-dependent vasodilation. The 5-hydroxytryptamine induced contraction at 10-4M were inhibited by 26.3%, 2.7%, 2.1% and 24.6%, 1.1%, 3.2% after addition of the 0.1 g/㎖ water extract of AG, AS, AA and AG-FSD, AS-FSD, AA-FSD. The 5-hydroxytrptamine induced contraction at 10^-4M with and without endothelium were inhibited by 24.6% and 6.9% after addition of the 0.1 g/㎖ water extract of AG-FSD.In conclusion, AG, AS, AA and AG-FSD, AS-FSD, AA-FSD-induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation. AG-FSD has very potent vasodilation.
Effects of Platycodi Radix powder on Serum Lipid Component of Rats Fed High Fat Diet
Byeon, Bu-Hyeong ; Seo, Bu-Il ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 35~35
Objects : This study was carried out to investigate the effects of Platycodi Radix powder on improvement of lipid composition in high fat-fed rats.Methods : Male sprague-Dawley rats of 7 weeks old, weighing 318.43
3.09g, were divided into two groups; the control group(C group: high fat(30%, Lard)) and platycodi Radix group(P group: 20% Platycodi Radix powder), they were fed experimental diets for 8 weeks.Results : Food intake and body weight gains had differences between the groups. Serum cholesterol levels were significantly lower in P group than C group. The level of serum HDL- Cholesterol was higher in P group than C group. The level of Serum LDL-C was significantly lower in P group than in C group. The ratio of HDC-Cholesterol to total Cholesterol were higher in P group than in the C group, too. The Value of atherogenic index(AI) was determined to be low in P group.
Effects on Cure and Prevention of the Obesity ( Ⅷ )
Kim, Yeon-Seop ; Byeon, Seong-Hui ; Kim, Sang-Chan ; Jo, Eung-Haeng ; Guk, Man ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 41~41
Objects : We had experiment with Chekamhanghyuluiiin plus Zeae Stigma in order to find effects on cure and prevention of the obesity.Methods : We fed control group rats high fat diet(Harlan, U.S.A.) and administered normal saline during 8 weeks, and experimental group rats high fat diet(Harlan, USA) and administered Chekamhanghyuluiiin plus Zeae Stigma extract during 8 weeks.Results :1. The body weight of all experimental group decreased than control group.2. The average size of the epididymal fat cells in all experimental group decreased than control group but only 7CH5 group showed statistically significant difference with control group.3. The fat drops area of hepatic lobule in all experimental group decreased than control group but 4CH10, 7CH5 and 7CH10 group showed statistically significant difference with control group.4. The area % of the insulin granules in Langerhans islet of 7CH5 and 7CH10 group showed difference with control group.Conclusion : Chekamhanghyuluiiin plus Zeae Stigma could be effective for the obesity.
Effect of Cibotium barometz on the Growth of Longitudinal Bone in Adolescent Male Rats
Im, Gang-Hyeon ; Kim, Ho-Cheol ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 49~49
In this study, we searched some herbal medicines on promoting the heights of longitudinal bone and found that the root of Cibotium barometz promotes longitudinal bone growth. The longitudinal bone growth was measured in the proximal tibia by fluorescence microscope with tetracycline. Tetracycline plays a chelate with calcium ion which is accumulated in bone forming-zones. The accumulated tetracycline made fluorescent lines corresponding to two injections. The growth rate of bones are evaluated by measuring the length between two lines. The longitudinal bone growth rate of control group for two days was 489.0
but, C. barometz administration significantly promoted the longitudinal bone growth(100 mg/kg, 764.2
, p<0.01). And the heights of proliferative and hypertrophic zones were also increased in C. barometz administered group measured by Nissl staining. To evaluate its growth promoting mechanisms, the induction of local insulin-like growth factor-1(IGF-1) and bone morphogenetic protein-2(BMP-2) were measured by using immunohistochemical method. C. barometz increased local induction of BMP-2 in hypertrophic and ossification zones, whereas IGF-1 did not increase. These results showed that administration of the extracts of C. barometz promoted longitudinal bone growth and its mechanism could be explained in part by regulation of BMP-2 induction in growth plates.
Effect of Epigallocatechin - 3 - Gallate on Expression of Cytokines in Human Mast Cell Line HMC - 1
Jo, Jeong-Je ; Im, Gang-Hyeon ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 57~57
The human mast cell is an effector cells in allergic inflammation and secrete a number of cytokines. Many allergic inflammations could be reduced with green tea treatments. The aim of this study was to investigate the potential effects of epigallocatechin-3-gallate(EGCG), the main polyphenol component in green tea, on pro-inflammatory cytokine productions(IL-1
, IL-6, TNF-
) and immune-regulating cytokine productions that promote the growth and differentiation of lymphocytes(IL-2, IFN-
) in I uM calcium-inonphore-A23178-activated human mast cell line HMC-1.Cytokines are immune regulating proteins secreted by many types of cells in the body. The effects of cytokines are pleiotypic actions on the immune system and inflammation. In this study, the effect of EGCG on the expression of cytokines was examined by RT-PCR using the human mast cell line(HMC-1), which is known to secrete and expressed, and expression of IL-2 and IFN-
were also increased. In order to investigate the protective effect of EGCG, HMC-1 cells were incubated with pretreatment of EGCG for 24 h. RT-PCR analyses of cytokine genes of cells pretreated with EGCG showed that expressions of IL-1
, IL-6 and IL-2 genes in these cells were lower and IFN-
was similar pattern compared to the calcium ionophore-treated group. This study would provide fundamental data on the possibility of the clinical treatment of green tea in immune diseases such as allergic disorder, asthma and atopic dermatitis, etc.
Studies on the digestive function of Rehmanniae Radixes Produced by Different Processe
Mun, Seong-Ho ; Lee, Yeong-Jong ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 65~65
Rehmanniae Radix preparata comes to be known that causes dyspepsia. The purpose of this study is to recognize the influence on the digestive function when Rehmanniae Radix preparata produced through different processes.The rats are divided 4 groups[dosed saline, dosed Rehmanniae Radix(dried), dosed Rehmanniae Radix preparata steamed 9 times, or dosed Rehmanniae Radix preparata steamed 9 times and added with Crataegi Frutus at final processing step]. By checking intake, output, and change in body weight, their digestive rates were figured. The results were such as the followings :1. All the groups dosed Rehmanniae Radix(dried), Remanniae Radix preparata(steamed 9 times), and Rehmanniae Radix preparata (steamed 9 times and added with Cretaegi Fructus at final step) have no influence on the amount of diet and feces.2. Both groups dosed Rehmanniae Radix preparata (steamed 9 times) and Rehmanniae Radix preparata (stream 9 times and added with Crataegi Fructus at final step) have no influence on the changes in body weight, but the group dosed Rehmanniae Radix (dried) reduces weight gain compared with others.3. The group dosed Rehmanniae Radix(dried) shows decreased digestive rate of fats, proteins, and carbohydrates compared with others.4. The group dosed Rehmanniae Radix preparata(steam 9 times) has no influence on the digestive rate of fats, but shows decreased digestive rate of proteins and carbohydrates. Compared with the other group dosed Rehmanniae Radix(dried), the group shows increased digestive rate of fats, proteins, and carbohydrates.5. The group dosed Rehmanniae Radix preparata (steamed 9 times and added with Crataegi Fructus at final processing step) has no influence on the digestive rate of fats and proteins, but shows decreased digestive rate of carbohydrates. Compared with the other group dosed Rehmanniae Radix preparata(steamed 9 times), the group shows increased digestive rate of proteins and carbohydrates.These results suggests that Rehmanniae Radix preparata (steamed 9 times) is more digestive than Rehmanniae Radix(dried). Also Rehmanniae Radix preparata (steam 9 times and added with Crataegi Fructus at final step) is more digestive than Rehmanniae Radix preparata(steam 9 times) especially for proteins and carbohydrates.
Effects of Carthami Flos and Leonuri Herba on the Liver Damaged with Carbon Tetrachloride Treatment in Rats
Gi, Seong-Sik ; Gil, Gi-Jeong ; Lee, Yeong-Jong ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 78~78
After orally administration of a single dose of carbon tetrachloride to rat, the rat was fed the decoctions prepared from Carthami Flos or Leonuri Herba twice at internals of 12 hours. Then, the effects of C. Flos and L. Herba on liver damage was examined. The results were : 1. The decoctions prepared from C. Flos and L. Herba decreased the activities of blood ALT and AST in the damaged rats, and the decoctions prepared from L. Herba increased the glucose level. 2. The decoctions decreased blood LDH activity and blood bilirubin level in the rats. 3. The decoctions prepared from C. Flos and L. Herba and no effects on the blood ALP activity in the rats. 4. The changes of the activities and the levels were not in proportion to the prescribed amount of the decoctions. It needs further study on the optimal dosage.
Inhibition Effects of Albizziae Radicis Cortex Methanol Extract on Lipid Peroxidation and Liver Damage in Benzo ( a ) pyrene Treated Mice
Park, Yong-Gi ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 91~91
To find new inhibition effects from oriental drugs. This study undertaken to investigate the inhibition effects of Albizziae radicis cortex methanol extract on lipid peroxidation and liver damage in benzo(a)pyrene treated mice. The activities of serum aminotransferase, cytochrome P-450, superoxide dismutase, catalase, glutathione peroxidase and the hepatic content of lipid peroxide after B(a)P treatment were increased than those of control, but those levels were significantly decreased by the treatment of Albizziae radicis cortex methanol extract. These results suggest that Albizziae radicis cortex methanol extract have a protective effect on liver damage by benzo(a)pyrene through the mechanisms of decrasing lipid peroxide and activities of free radical generating enzymes.
Studies on the Anti - oxidative effects of the Parts of Pueraria thunbergiana Bentham
Im, Gyu ; Park, Yong-Gi ; Gang, Byeong-Su ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 101~101
The Parts of Pueraria thunbergiana Bentham, Puerariae Flos(PF), Puerariae Radix(PR), Puerariae Leaf(PL), Puerariae Sprout(PS) were investigated effects of for DPPH(electron donating ability) radical ability, nitrate reductase activity(NR), superoxide dismutase activity(SOD), catalase activity, lipid peroxidase(LP) and glutathione(GSH). In vitro, DPPH radical ability and nitrate reductase activity(NR) were increased according to the increasing of PF, PR, PL, PS concentrations. Among others PF, PR were significantly increased to the level of BHT. In vivo, compared with normal group, SOD(superoxide dismutase) activity and catalase activity were decreased in the acetaminophen treated group. On the other hand, PF, PR, PL, PS in the pretreated groups SOD activity and catalase activity were significantly increased. Among others PF, PR were almost increased to the level of Ascorbic acid. Compared with normal group, lipid peroxidation was increased. Among others PF, PR, PS were almost significantly decreased to the level of Ascorbic acid. In the acetaminophen treated group, GSH activity was decreased by compare with normal group. And in the PF, PR, PL, PS pretreated groups, GSH activity was increased to the control group. Among others PF, PR were almost significantly increased to the level of Asorbic acid. These results suggest that among others PF was almost increased to the level of Ascorbic acid.
Effects of Bojungikgitang , Soeumin Bojungikgitang and its component groups on Antioxidant Activities in alloxan - induced diabetic rats
Park, Seon-Dong ; Seo, Gyo-Su ; Park, Won-Hwan ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 113~113
This study was performed to research the antioxidant activities of Bojungikgitang(補中益氣湯), Soeumin Bojungikgitant(少陰人 補中益氣湯) and its component groups. The experimental group was divided into five groups: Bojungikgitang(B1), Soeumin Bojungikgitang(B2), Bogihyulyak(B0 group), Siho-sengma(B1+) and Gwakhyang-soyeup(B2+). The results were obtained as follows: The level of glucose in control group was considerably increased as much as three times compared with normal group. And in experimental groups, B1 and B2 groups decreased the level of glucose in serum with significancy. And B0, B1+ and B2+ groups also decreased the level of glucose significantly. in vitro; All experimental groups had significant antioxidant activity in linoleic acid system on concentration in comparison with control group, especially B2+ group was higher than any others. In DPPH radical scavenging experiment and inhibitory effect experiment on superoxide generation in xanthine-xanthine oxidase system showed that all experimental groups had some scavenging activity on concentration. In the inhibitory effect experiment on lipid peroxidation reaction in
- system showed that each experimental groups had inhibitory effects on lipid peroxidation reaction compared with control group. in vivo; the amounts of lipid peroxide in serum and liver B1 and B2 group were reduced with significancy, and in other groups also were reduced significantly. In hepatic catalase activity test, all experimental groups showed increasing catalase activity significantly but B1 and B2 group with no significancy. In the hepatic glutathione measurement experiment, B1, B2 and B0 groups increased in comparison with control group significantly. And in the activity test of Glutathione- S-transferase, B1, B2 and B0 groups decresed in comparison with control group significantly. As result B1 and B2 groups has exhibited the better antioxidant activities than other groups in vivo. And in component groups, the effects of B0 group were best. These result suggest that in diabetes and antioxidative activity, Bojungikgitant(補中益氣湯) and Soeumin Bojungikgitang(少陰人 補中益氣湯) have strong antioxidant activity with no difference, and it is useful to prevent diabetes which is relevant of peroxidative damage by free radical.
Effects of Gunggwichongsoyijungtang and its component groups on diabetes in alloxan - induced diabetic rats
Park, Seon-Dong ; Choi, Oe-Cheol ;
The Korea Journal of Herbology, volume 16, issue 2, 2001, Pages 127~127
The purpose of this study was to research the effect of Gunggwichongsoyjungtant(芎歸蔥蘇理中湯) and its component groups on diabetes in alloxan-induced diabetic rats. Sprague-Dawley male rats weighing 200±10 gm were randomly assigned to two normal, two control and eight experimental groups. The experimental groups were classified into Gunggwichongsoyijungtant(GT group), Bogihyulyak(G-1 group), Onleeyak(G-2 group) and Balsanyigiyak(G-3 group). Diabetes was experimentally induced by abdomental injection of 100 ㎎/㎏ of body weight of alloxan. Animals were sacrificed at the 6th and 11th day of diabetic states. The results were obtained as follows: In carbohydrate metabolism, the level of glucose in control group was three-fold higher after alloxan injection than that of normal group. In GT group the level of glucose was decreased by 48% compared with that of control group, and in component groups it was decreased by 72%, 81%, and 82% respectively. In fat metabolism, the level of triglyceride in serum were lower in GT group by 74% with high significant difference and had similar tendency in components groups compared with that of control group. The levels of total cholesterol in serum were lower in GT group by 81% with significancy and had similar tendency in components groups. And the levels of HDL on serum were increased in GT group by 144% with significant difference. And in component group it had similar tendency compared with that of control group. In protein metabolism, the level of total protein and albumin were higher in GT group by 121% and 134% respectively with high significant difference, and G-1, G-2 group in component group also increased with significant difference compared with control group. In kidney function, the level of creatinine and BUN were decreased in GT group by 77% and 62% respectively with high significant difference, and other groups were lower but with no significancy compared with control group. In liver function, the level of GOT, GPT, γ-GTP, ALP and bilirubin were lower in GT group with significant difference. And in component group, it had similar tendency compared with control group. These results suggest that Gunggwichongsoyijungtant(芎歸蔥蘇理中湯) has strong effect on diabetes, so it is useful to prevent diabetes, and G-1 group had more effect on diabetes than any other groups in component groups.