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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Korea Journal of Herbology
Journal Basic Information
Journal DOI :
The Korea Association of Herbology
Editor in Chief :
Volume & Issues
Volume 19, Issue 4 - 00 2004
Volume 19, Issue 3 - 00 2004
Volume 19, Issue 2 - 00 2004
Volume 19, Issue 1 - 00 2004
Selecting the target year
The Cytotoxicity of Syringic Acid on Normal Human Skin Fibroblast
Han, Du-Seok ; Jin, Byung-Jo ; Lee, Joo-Hyun ; Seo, Bu-Il ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 1~1
Objective: The purpose of this study was to evaluate cytotoxicity of syringic acid on normal human skin fibroblast cell line. Methods: The cytotoxic effect of syrinlgic acid on normal human skin fibroblast cell line was detemined by MTT assay or XTT assay. The microscopic study was performed to observe the morphological change of normal human skin fibroblast cell line. Cells were grown with various concentrations of syringic acid for 48 hour. Results: The cytotoxicity of normal human skin fibroblast cell line by syringic acid was not showed a positive effect by MTT assay or XTT assay compared with control.
were 1,172.9 uM and 1,110.9 uM, respectively. In light microscopic observation, normal human skin fibroblast cell line treated with syringic acid showed slightly decreased cell number, but the morphological changes of this cell line were not observed. Conclusion: From these results, the syringic acid showed lower cytotoxicity on normal human skin fibroblast cell line by the colorimetric assay or morphological observation.
Study on the Effect of Gallic Acid on Normal Human Gingival Fibroblast
Han, Du-Seok ; Jin, Byung-Jo ; Lee, Joo-Hyun ; Seo, Bu-Il ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 7~7
Objective: The objective of this study was to investigate cytotoxicity of gallic acid on nomal human gingival fibroblast. Methods: The cytotoxicity of gallic acid on normal human gingival fibroblast was measured by MTT assay or XTT assay after cells were treated with various concentrations of gallic acid for 48 hours. Results: Gallic acid did not show the cytotoxic effect on normal human gingival fibroblast by MTT assay or XTT assay compared with control
were 2,158.3 uM and 2,03.1 uM, respectively. The values of
were represented as a non- toxic effect by toxic criteria of Borenfreund et., aI.(l988). Conclusion: These results suggest that the gallic acid does not show any cytotoxic effect on normal human gingival fibroblast by the colorimetric assay.
Studies on the mechanism of the anti-inflammatory effect of the Mudanpli(Cortex Moutan Radicis)
Rho, Young-Deuk ; Sim, Young-Seop ; Song, Ho-Joon ; Shin, Min-kyo ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 13~13
Objectives: In an effort to elucidate the mechanism of the anti-inflammatory effect of the Mudanpli (Cortex Moutan Ra야cis : the root cortex of Paeonia suffruticosa Andrews; Ranunculaceae), I determined the effects of the methanolic extract of Mudanpli (MEM) on the secretions of interleukin(IL)-8, a major mediator of acute neutrophil-mediated inflammation, and macrophage chemoattractant protein (MCP)-1, a major mediator of chronic macrophage-mediatted inflammation, in human monocytic U937 cells stimulated with phorbol myristate acetate (PMA). Methods : We were experimented IL-8, MCP-l secretion,
activity, MTT assay, RT-PCR. Results: MEM significanly inhibited PMA-induced secretions of IL-8 and MCP-l in a dose-dependent manner. The inhibitions of these chemokines by MEM were due to suppressions of IL-8 and MCP-1 genes. In addition, pentagalloylglucose (PGG), one of major constituents isolated from MEM, inhibited PMA-induced secretions of IL-8 and MCP-1 by suppressing IL-8 and MCP-1 genes via
B inactivation. Conlusioos : From the above result, MEM was found to have a anti-inflammatory effect.
Studies on the allergy asthma effect of Folium Perillae
Kang, Yong-Sung ; Lee, Seong-Cheol ; Shin, Ho-Dong ; Shin, Min-kyo ; Kim, Jae-Hong ; Song, Ho-Joon ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 25~25
Objectives : To evaluate effect of allergy by Folium Perillae (FP), the biochemical changes associated with allergy were measured in BALF, serum, splenocyte and lung of mice. Methods: After induction of allergic inflammation asthma by treatment of ovalbumine, water extracts FP were taken orally for five successive days on mice, respectively. Results: In the total cell of BALF, the FP extract treated group was not significantly, reduced compared to control level, but the reduction of eosinophil showed significantly at concentration of 100 and l000 mg/kg,b.w. On the other hand, substantial decrease in IgE antibody formation was significantly observed by administration with FP extract (300, 1000mg/kg), whereas IgGl was not affected. IgG2a antibody formation appeared to be decreased in serum from FP treated mice. The content of IL-4, IL-5 exhibited physiological role in lung was significantly reduced compared to control group after treatment of FP extract(300, l000mg/kg). IL-4 in splenocyte, FP extract was all significantly reduced compared to control group and IL-5 was significantly reduced at concentration of FP extract (300, l000mg/kg). Conclusions: From the above result, it could be concluded that Folium Perillae showed beneficial effect on the al1ergic asthma.
Studies on the Anti-tumor effects of the extract from Herba Ajugae multiflorae
Ryu, Myeng-Hwan ; Lee, Seong-Cheol ; Shin, Ho-Dong ; Shin, Min-kyo ; Song, Ho-Joon ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 35~35
Objectives: This study is carried out to specify Anti-tumor effects of liver cancer from HA(Herba Ajugae multiflorae). Methods: NCTC1469 mouse normal liver cell line was cultured in various concentrations of Nitrofurantion(NFT) for 72 hours, By adopting the MTS assays for cell viability, the activities of
and LDH, DNA synthesis and PKC, and the protein synthesis. it is shown that NFT induces liver cancer. Results: The Anti-tumor effects of the extract from HA are as follows, 1 NFT
for 72 hours. 2 NFT increased cell numbers and PKC activity when NCTC cells were incubated with
NFT for 72 hours. 3 NFT decreased DNA and Protein synthesis, On the other hand, increased LDH. PKC and
activity when NCTC liver cells were grown in various concentrations of NFT for 72 hours, 4 HA, on the effect of NFT-induced carcinogenecity. increased cell viability of NCTC. Protein and DNA synthesis, but decreased activity of LDH and PKC, also
. Conclusions: From the above results, it could be concluded that NFT had cytotoxic and carcinogenic effect on cultured NCTC cell line derived from mouse normal liver, Therefore, HA had beneficial protection of NFT-induced carcinogenecity.
A Study on a Morphological Identification of Glycyrrhizae Radix
Lee, Young-Jong ; Jo, Jin-Hee ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 47~47
Objective: To examine the differences in morphological characteristics of Glycyrrhizae Radix according to the original plant, author collected, analyzed and compared products such as Glycyrrhiza uralensis Fischer, Glycyrrhite glabra Linne, and G1ycyrrhiza pallidiflora Makino. Method: The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by Olymphus-BHT. Results: 1. External morphological characteristics of Glycyrrhizae uralensis Radix, Glycyrrhizae glabrae Radix, and Glycyrrhizae pallidiflorae Radix are similar as following: 1) Their roots are like round poles with the length of 25-100cm and the diameter of 0.6-3.5cm. 2) Their surfaces are red-purple or gray-brown, and have salient vertical wrinkles and lenticel. 2. Intersect of Glycyrrhizae uralensis Radix is less fiberous and more starchy, and has cambium rings, while Glycyrrhizae glabrae Radix is hard and fiberous, and Glycyrrhizae pallidiflorae Radix is the hardest and the most fiberous. 3. Internal morphological characteristics of the three are similar as following: 1) Cork layers of them are composed of several rows of brown cells, and have narrow cortex. 2) Ray of sieve tube is wide and mostly crooked. 3) Fibers are mostly composing a bundle, and its lignification level is low. 4) Parenchymatous cells of fiberous bundle include square crystal of calcium oxalate. Conclusion: Glycyrrhizae uralensis Radix, Glycyrrhizae glabrae Radix, and Glycyrrhizae pallidiflorae Radix are all alike in their external morphological characteristics, but they are become more fiberous and less starchy from the first to the third. Glycyrrhizae pallidiflorae Radix is so much fiberous that another study of its composition is needed for its medical use.
A Study on a Morphological Identification of Kalopanacis Cortex
Lee, Young-Jong ; Lee, In ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 53~53
Objectives : To examine the differences in morphological characteristics, the plants used as Kalopanacis Cortex were analyzed and compared according to the factors such as the original plant(Kalopanax pictus Nakai and Araiia elata Seem), where it is from, and when it was collected. Methods: The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by olymphus-BHT. Results: 1. Internal and external morphological characteristics of Kalopanacis Cortex were al] alike regardless of the place and period of Its collection as following: 1) External surface of it is brown, has thorns protruded like a cone, and has lenticel. 2) Internal surface of it is ye]]ow-white, and plane. 3) Its cork layer is composed of over 10 accessory cells. 4) Its cortex is narrow, stone cells are distributed around it, and its sieve tube is somewhat wide. 5) Its cortical fiberous bundle is composed of 10 or more fibers. 6) Its phloem ray has 1-3 rows of cells. 7) Its parenchymatous cell includes square crystal of calcium oxalate or druse of calcium oxalate in it. 2. Chinese Kalopanacis Cortex has rhytidome, but Korean Kalopanacis Cortex doesn't have it. 3. Araliae elatae Cortex and Kalopanacis Cortex have some differences as following: 1) Intersect of Araliae elatae Cortex has relatively more resin passages whose diameter is
. 2) Intersect of Kalopanacis Cortex has relatively more cortical fiberous bundles. 3) Parenchymatous cells of Kalopanacis Cortex include square crystal of calcium oxalate and druse of calcium oxalate, but those of Araliae elatae Cortex include only the latter. Conclusions: The findings of the present study show that Korean Kalopanacis Cortex has no morphological difference based on the period of collection, and that Korean and Chinese Cortex have morphological similarity. However, Chinese Kalopanacis Cortex is distinguishable because of its unique rhytidome, and distinction between Kalopanacis Cortex and Araliae elatae Cortex is also possible because parenchymatous cells of the former include square crystal of calcium oxalate and druse of calcium oxalate while those of the latter include druse of calcium oxalate only.
A Study on a Morphological Identification of Astragalus Root
Lee, Young-Jong ; Chung, Kwang-Hee ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 61~61
Objectives : As a basic research for development of standard product of Astraglalus Root, the morphologic characteristics of medicinal plants used as Astraglalus Root in Korea was studied. Therefore, medicinal plants distributed as Astraglalus Root in Korean market were widely collected, and the plants were analyzed and compared by microscope examination according to the factors such as the basic plant(Astragalus membranaceus Bunge & Astragalus membranaceus var. mongolicus(Bge.) Hsiao), habitat, and years of growth. Methods: The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by olvmphus-BHT Results: 1. Surfaces of the roots of Astragalus membranaceus and Astragahus membranaceus var. mongolicus are light brown, have vertical and horizontal wrinkles, lenticels, and fiberous roots. 2. Exodermis of the Korean root of Astragalus membranaceus is usually separated, but the Chinese roots of Astragalus membranaceus and Astragalus membranaceus var. mongolicus have exodermis. 3. Root of Astragalus membranaceus]는 has a longer length and a thicker diameter by the years of growing. 4. Internal morphological characteristics of the root of Astragalus membranaceus and Astragalus membranaceus var. mongolicus are similar as following: 1) Intersect is fiberous and starchy. 2) Cork layer is composed of several accessory cells. 3) Outside of the ray of sieve tube is curved, and fibers form a bundle. 4) Starch grains are included in parenchymatous cells. Conclusion: Internal forms of the root of Astragalus membranaceus and Astragalus membranaceus var. mongolicus are similar, so that any distinction based on internal forms is impossible. However, external forms of the root of Astragalus membranaceus show some difference in that a longer period of growing porduces a longer and thiker form, which can be applied to distinguish between the two.
A Study on a Morphological Identification of Foeniclulm and Anethum Fruit
Lee, Young-Jong ; Kim, Chung-Yuel ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 69~69
Objectives : Because fruits of Anethum grabeolens L. as well as those of Foeniculm vulgare Miller are sole as Foeniculi Fructus in domestic markets, morphological characteristics of them are attempted to be distinguished. In addition, morphological comparisons were also made between Korean and Chinese Foeniculi Fructus. Method: The slice of the tested material made by paraffin section technique was colored with Safranine Malachite Green contrast methods, and then observed and photographed by olymphus-BHT. Results: Base plants of Foeniculi Fructus (Foeniculm vulgare Miller & Anethum grabeolens L.) were examined by microscopic observation, according to the place of their collection. Findings in their external and internal morphological characteristics are as following: 1. Intersect of Foeniculi Fructus schizocarp has several layers of parenchymatous cells in mesocarp, and diameter of vitta is
2. Korean Foeniculi Fructus has cremocarp like a round pole, and intersect of schizocarp is somewhat like a pentagon. 3. Anethi Fructus cremocarp is like an oval pole, and intersect of schizocarp is somewhat oval, unclear three ridges are found at its rear part, and side ridges are protruded like thorns. Mesocarp of interesect of schizocarp is thin, and composed of 2-3 layers of parenchymatous cells. Vitta's diameter is
. Conclusion: Foeniculi Fructus and Anethi Fructus are easily distinguishable because of their difference in external and internal morphological characteristics. Moreover, Korean and Chinese Foeniculi Fructus are also distinguished from each other, because Korean has intersect of schizocarp like a half-circle, while Chinese has that like a pentagon
Antibacterial Activity of Combination use of Jengjengamiygin tang and Clarithromycin against Helicobacter pylori
Kwak, Min-Ah ; Seo, Bu-Il ; Byun, Joon-Seok ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 75~75
Objectives : To evaluate the antibacterial and synergic effects of Jengjengamiygin-tang(JJGM) with clarithromycin by in Vitro and in Vivo methods. Methods : The minimal inhibitory concentration(MIC),
of single use of clarithromycin, JJGM and their concomitant treatment against Helicobacter pylori were observed. In addition, the changes of ulcerative lesions and viable cell numbers were also monitored after having experimented gastric infected mice models with Helicobacter pylori. Results: 1. The concomitant treatment of clarithromycin and JJGM showed relatively more favorable antibacterial effects than those of each. 2. The numbers of ulcerative lesions were more effectively inhibited by combination use of clarithromycin and JJGM. 3. The numbers of viable Helicobacter pylori were more effectively inhibited by combination use of clarithromycin and JJGM. Conclusions : The concomitant treatment of clarithromycin and JJGM showed relatively more favorable antibacterial effects than those of each.
Effects of the Guipi-Tang and Placenta Hominis Blended Guipi Tang on the Changes of Body Weight and Lipid Metabolism in Ovariectomized Rats
Cho, Su-In ; Jo, Sung-Hee ; Jin, Cheon-Sik ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 85~85
Objectives : The present study was carried out to determine the effects of Guipi-Tang( GT) and Placenta Hominis blended Guipi-Tang(GT+PH) on the changes of body weight and lipid metabolism in postmenopausal stage. Methods : The experimental model of menopause was induced by bilateral ovariectomy in rats. These were administrated orally with aqueous extract of GT and GT+PH in experimental groups, The variance of body weight, femoral bone weight, serum level of cholesterol, triglyceride were measured. Animals were observed for 8 weeks, and vehicle and extracts of prescriptions were administered ad libitum. Results : Body weight increased significantly in 6 weeks after ovariectomy, and the weight of GT+PH administered group decreased significantly GT and GT+PH decreased the serum level of cholesterol and triglyceride. Conclusion : According to above results, GT and GT+PH can be used effectively for maintaining body weight and healthy life during postmenopausal stage.
Effects of Oriental Herbs on Human Skin with Non-invasive Methods
Park, Seong-Kyu ; Nam, Gae-Won ; Lee, Hae-Kwang ; Ahn, Sung-Yeon ; Kim, Eun-Joo ; Lee, Sung-Il ; Kim, Youn-Joon ; Ko, Jae-Sook ; Moon, Seong-Joon ; Chang, Ih-Seoup ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 91~91
Objectives: Oriental herbs have vanous effects on improving human health, but there have been few researches at the point of human skin. We have examined the physiological effects on healthy human skin by using non-invasive measurement devices. Methods: We prepared a skin application products as cream form contained oriental herbs, and measured various physiological effects such as skin moisture contents, red blood cell flow rates, skin surface temperature, corneocyte exfoliation and skin intensity when volunteers used the application products for 4 weeks. Results: The skin moisture contents were not only increased in human face skin after using the products, but also red blood cell flow rates in face skin were increased. After using the cream, the face skin temperature was increased and corneocyte exfoliation was decreased. Furthermore the upper dermisintensity of skin in female face was subsequently increased 4 weeks later. Conclusions: The results of our study indicate that the application products containing oriental herbs was improved the physiological effect of human facial skin. Moreover non-invasive techniques were useful to view improving skin condition objectively.
Vasodilation Effects between the Water Extract of Rheum palmatum L. and R. undulatum I. In Rat Thoracie Aorta
Kim, Hyung-Hwan ; Park, Soo-Yeon ; Ahn, Duk-Kyun ; Park, Seong-Kyu ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 99~99
Objectives: We have examined the relaxational response to the water extract of Rheum palmatum L. (ERP), R undulatum L (ERU) and its components in isolated thoracic aorta from sprague dawley (SD) rat. Methods: Rat thoracic aorta was investigated in vessel segments suspended for isometric tension recording by polygraph. Responses to ERP and ERU were investigated in vessels precontracted with 5-hydroxytryptamine. We found that the thoracic aorta segments responded to the water extract of ERP and ERU with a dose-dependent vasorelaxation. Results: We found that 1. The thoracic aorta segments responded to ERP and ERU with a dose-dependent vasodilation. 2. The 5- HT induced contraction at
were inhibited by
after addition of the 0.1g/mL water extract of ERP and ERU. 3. The 5-HT induced contraction at
were inhibited by
emodin. 4. The amounts of emodin were
in Rheum palmatum L. and R. undulatum L, respectable. Conclusion: In conclusion, ERP and ERU induced relaxation in the isolated rat thoracic aorta were composed of dose-dependent relaxation and it's major component, emodin, has potent vasodilation.
Effects of Different Dosages of Wild Aconiti Tuber Decoction on Rat Liver Cytochrome P450 Expression
Kim, Yun-Kyung ; Lee, Je-Hyun ; Kim, Chung-Sook ; Park, Seong-Kyu ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 107~107
Objective: Wild Aconiti Tuber is known as a toxic herb and used for anti-arthritic, analgesic, and so on. This study was carried out to evaluate the effects of different Dosage of Wild Aconiti Tuber Decoction on rat liver Cytochrome P450 expression. Methods: A clinical dosage, 0.4g/kg/day oral administrations of Wild Aconiti Tuber Decoction was investigated. Rats were given 2 weeks of clinical dosage p.o. group, Aconitine
i.p. group and control. Also, high dosage of 1, 5, 10 g/kg/day for 3 days p.o. group was investigated. CytochromeP450 induction/inhibition were tested by competitive RT-PCR in each group. Results. The amounts of aconitine in the methanol extract of Wild Aconiti Tuber was
. But aconitine was not detected in the water decoction of Wild Aconiti Tuber. Among several CYP450 isozymes, Wild Aconiti Tuber 0.4g/kg/day for 2 weeks p.o. group showed induction of 3A2, aconitine
for 2 weeks i.p. group showed inhibition of 2E1. While 1, 5, 10 g/kg/day for 3days p.o. group showed induction of lA2, 2El, 3Al, 3A2, 4A1. Conclusions: According to the results, though aconitine was not detected in the Wild Aconiti Tuber decoction, 0.4g/kg/day for 2 weeks p.o. (clinical dosage) group showed CYP450 3A2 induction and high dose group showed general induction of CYP450 isozymes.
Study on the effect of medicinal herbs used as Bu pyung(S. polyrhiza and L. paucicostata) on immune and anti-cancer
Ahn, Young-Seung ; Seong, Nak-Sul ; Ham, In-Hye ; Choi, Ho-Young ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 117~117
Objectives: S. polyrhiza and L. paucicostata can be easily seen in the ponds or rice fields of Korea. But korean native Bu-pyung(浮萍) are rarely used for economical reasons, and usually imported. Methods: The examination of the effect related to the immune, Human CD4-T cell proliferation promotion, HL-60 cell differentiation rate, Ig-E and
content were measured. Results: It can be seen that S. polyrhiza and L. paucicostata is effective on tumors and the immune. Also L. paucicostata was more effective on the production of Ig-E and blood pressure control, while S. polyrhiza was more effective on immune and tumor. Conculsions : Bu-pyung is mostly used on symptoms of measles not erupted(麻疹不透), urticaria and itching(風透瘙痒), dropsy with decreased urine(水腫尿少) which implies potential effect on immune, tumor and high blood pressure.
Effects of Coicis Semen on the Hyperlipidemia in Rat
Lee, Young-Jong ; Sohn, Young-Jong ; Lee, Eun-Sup ; Park, Jung-Soo ; Kim, Sung-Kee ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 129~129
Objective: In order to examine the effects of Coicis Semen(Job's Tears) on the hyperlipidemia, the extracts of Job's Tears were given to hyperlipidemic rats induced by cholesterol-rich chow. Method: The hyperlipidemic rats were administered with the extracts prepared from husk layer, bran layer, polished rice, unpolished rice or unhulled grain of Job's Tears each others during two weeks. And then, the effects of the extracts on body weight gain, total cholesterol, triglyceride and HDL-cholesterol were examined. Results and Conclusion : The water-extracts prepared from polished rice had an inhibition effects on the body weight gains of the corpulent rats induced by a high cholesterol diet. In addition, the methanol-extrats prepared from the bran layer and unpolished rice of Job's Tears decreased the levels of blood total cholesterol, and the methanol-extrats and the water-extrats of all samples decreased the levels of blood triglyceride. The results suggested that Job's Tears had some materials useful for alleviating the hyperlipidemia.
A Comparative Study on the Immunization and Anti-cancer Effect of the Root and the Aerial Part of Peucedanum japonicum Thunb
Cho, Yong-Ho ; Seong, Nak-Sul ; Ham, In-Hye ; Choi, Ho-Young ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 137~137
Objectives: Root of Peucedanum japonicum has traditionally been used as medicine but aerial part of P. japonicum has not been used as medicine. In order to examine the possibility of the substitute for the root as medicinal use. This study were performed comparing the activity of the aerial part and root of P. japonicum. Methods: We measured the proliferation of Human CD4 T cells, which are related to immunity, the differentiation of HL-60 cells, and the contents of IL-6, IgE and
and compared their anti-cancer effect on Hep3B and A549 cells. Results: As for Human CD4 T cells ami HL-60 cells, 10g/l methanol extract from the aerial part promoted the proliferation of the cells. Conclusion: In conclusion. this study presented that the aerial part of P. japonicum has immunizing and anti-cancer effects as high as its root, which has commonly been used as medicine. There should be more in-depth research on the aerial part of P. japonicum in the future.
Effects of Angelicae Koreanae Radix on the Vasomotor Responses and Focal Cerebral Ischemic Damage by MCAO
Yun, Won-Sik ; Kim, Hyung-Hwan ; Ahn, Duk-Kyun ; Rhee, Jae-Seong ; Ham, In-Hye ; Choi, Ho-Young ;
The Korea Journal of Herbology, volume 19, issue 3, 2004, Pages 147~147
Objectives : Gangwhal(羌活) is the root of Angelica koreana Kitagawa and a popular crude drug used to expel wind from the body surface (祛風解表), to remove dampness( 風濕) and to relieve pain (止痛). The effect was evaluated to the vasomotor responses in rats and focal cerebral ischemic damage by middle cerebral artery occulsion in mice. Methods: Cerebral ischemia was induced by MCAO and analyzed cerebral blood flow, mean arterial blood pressure, cerebral ischemia area and blood gas by injection water extract of Namganghwal(Ds) and Bukganghwal(Dn). Results: 1. Vasodilation effect of dried BukGangwhal(Dn) and dried NamGangwhal(Ds) appeared Dn (0.001, 0.01, 0.1, 1, 10g/ml) by each
at vein intercept, and vasodilation effect of Ds was the concentration dependence by each
appeared. 2. Change of brain bloodstream by pre-administrated Ds and Dn in Cerebral ischemia and blood gas induction by MCAO, didn't appear. Conclusion: According to the above results, we found that Dn and Ds could not recognize difference of effect in a comparison experiment about vasomotor and cerebral ischemia.