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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Korea Journal of Herbology
Journal Basic Information
Journal DOI :
The Korea Association of Herbology
Editor in Chief :
Volume & Issues
Volume 27, Issue 6 - Nov 2012
Volume 27, Issue 5 - Sep 2012
Volume 27, Issue 4 - Jul 2012
Volume 27, Issue 3 - May 2012
Volume 27, Issue 2 - Mar 2012
Volume 27, Issue 1 - Jan 2012
Selecting the target year
Effects of Atractylodis Rhizoma Alba extract on collagen-induced arthritis in mice
Kim, Song-Hee ; Park, Yong-Ki ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 1~6
DOI : 10.6116/kjh.2012.27.3.1
Objectives : The present study was undertaken to evaluate whether Atractylodis Rhizoma Alba ethanol (ARA-E) extract, which is the pericarp of
Koidz. has an effect on collagen-induced arthritis (CIA) in mice. Methods : Male DBA/1J mice were induced by intradermal injection of bovine collagen-II in Freund's incomplete adjuvant (IFA). The CIA mice in the onset of arthritis were treated daily with oral administration of ARA-E extract at dose of 50 mg/kg/bw for 28 days. Arthritis index, histopathological changes and the levels of anti-type II collagen (CII) IgG and inflammatory cytokine, TNF-
in sera of mice were measured to evaluate the antiarthritic effect of ARA-E. Results : ARA-E extract significantly decreased the arthritic scores and inhibited pathological changes of knee joint tissues in CIA mice. ARA-E extract also significantly decreased the serum levels of anti-CII IgG and TNF-
in CIA mice. These results indicate that ARA-E extract may effectively prevent arthritic damages in CIA mice, at least partially, by inhibiting the production of autoantibodies and inflammatory cytokine. Conclusions : This studies suggest that ARA-E has a therapeutic potential in inflammatory joint diseases such as rheumatoid arthritis.
Effects of Pear Extracts Containing Herbal Medicine (Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix) on Body Weight, Lipid Metabolism, and Immune Responses of Rats Fed with High Fat Diets ( I )
Kim, Wang-In ; Youn, Dae-Hwan ; Kim, Hwang-Gon ; Na, Chang-Su ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 7~13
DOI : 10.6116/kjh.2012.27.3.7
Objective : This study was conducted to observe the anti-hyperlipidemic and anti-inflammatory effects, as well as the metabolic benefits, of pear extract and herbal drug mixture (Lycii Fructus, Coicis Semen, Alimatis Rhizoma, and Astragali Radix) on rats fed with a high fat diet. Methods : The animals used were male rats and the control group was fed a high fat diet only. The experimental groups were divided into four. Exp I group was fed a high fat diet with a mixture of pear extract and 3% Lycii Fructus; Exp II group was fed a high fat diet with a mixture of pear extract and 3% Coicis Semen; Exp III group was fed a high fat diet with a mixture of pear extract and 3% Alimatis Rhizoma; and Exp IV group was fed a high fat diet with a mixture of pear extract and 3% Astragali Radix for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in Exp I and Exp III groups than the control group. The concentrations of serum total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, and triglyceride (TG) were significantly higher in Exp II than in the control group, and lower in Exp III group than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp III group than in the control group. In inflammatory activities, the Exp II group was significantly lower than the control group. Conclusion : The results indicated that Exp III group (administered a mixture of pear extract and Alimatis Rhizoma) most efficiently reduced fat accumulation and body weight, while the Exp II group (administered the mixture of pear extract and Coicis Semen) had the highest elevated lipid metabolism and immune activity.
Comparative Study on Different Species of Medicinal Herbs Used as Jeonho (Qianhu) Using Morphological Appearance and Chromatographic Fingerprint
Kim, Jung-Hoon ; Lee, Guem-San ; Choi, Go-Ya ; Kim, Young-Sik ; Lee, Seung-Ho ; Kim, Hong-Jun ; Jeong, Seung-Il ; Ju, Young-Sung ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 15~21
DOI : 10.6116/kjh.2012.27.3.15
Objective : This study aimed to compare the difference between
which have been used as herbal medicine, Jeonho (Angelicae Decursivae Radix) in Korea and provided the evidence to exclude
not to use as Joenho. Methods : The similarities of original medicinal herb with samples from local market were evaluated including morphological appearance and chromatographic fingerprint. In addition, relation between original medicinal herb and local samples were analyzed using statistical clustering methods. Results :
represented different morphological appearances and chromatographic fingerprint. Several samples from China exhibited similar morphological and chromatographic appearance with
. Eleven samples from Korea showed identical similarity to
. Conclusions : Since
represented obvious differences compared to
, it is required not to use
as medicinal herb, Jeonho. Additionally, exact identification and quality control must be applied to
from China in order to maintain therapeutical efficacy.
Anti-microbial Effect on Streptococcus mutans and Anti-oxidant Effect of the Butanol Fractions of Sanguisorbae Radix
Park, Geun-Hye ; Lee, Jin-Tae ; An, Bong-Jeun ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 23~29
DOI : 10.6116/kjh.2012.27.3.23
Objective : Sanguisorbae Radix(SO). that belong to Rosaceae is widely distributed in Asia including Korea, Japan and China. It has been used as traditional medicine from old times as a treatment for anti-inflammatory drugs. This study was designed to investigate the effects of n-BuOH fractions of SO on anti-oxidant effect and anti-microbial effect on
). Methods : The anti-microbial effect of
-BuOH fractions of SO. was assessed by the paper disk diffusion method and anti-oxidant effect was assessed by the DPPH radical scavenging effect, Superoxide anion radical scavenging effect and SOD like ability. Results : DPPH radical scavenging of the
-BuOH fraction from SO in 50 ug/mL was shown to be Fr-2 (89.9%), Fr-3 (88.7%), Fr-4 (76.3%), Fr-1 (59.4%), Fr-5 (56.2%). Superoxside anion radical scavenging activity of the n-BuOH fraction from SO. in 50 ug/mL for Fr-3 was shown to be 78%. SOD-like activity of n-BuOH fraction from the SO in 1000 ug/mL for Fr-3 were shown to be 76.1% respectively. The
-BuOH fraction from the SO had high anti-microbial effect on
. Conclusion : As a result, the
-BuOH fraction from SO. has good anti-microbial and anti-oxidant effects in a concentration-dependent manner.
Inhibitory effect of Mori Folium ethanol extract on pro-inflammatory mediator in lipopolysaccharide - activated RAW 264.7 cells
Park, Sang-Mi ; Byun, Sung-Hui ; Kim, Young-Woo ; Cho, Il-Je ; Kim, Sang-Chan ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 31~38
DOI : 10.6116/kjh.2012.27.3.31
Objectives : Mori Folium is one of the traditional medicinal herb. It was commonly used for sericulture in the world and has been traditionally administered as natural therapeutic agent for the treatment of filariasis, diabetes and dropsy in East Asia. This study investigated an anti-inflammatory potential of Mori Folium ethanol extract (MFE). Methods : We examined the effects of MFE on the lipopolysaccharide (LPS)-induced production of nitric oxide (NO) and prostaglandin
) in a murine macrophage cell line, RAW 264.7. Results : MFE inhibited production of NO and
in a dose dependent manner and also decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2, interleukin (IL)-1, IL-6 and tumor necrosis factor-
. As a plausible molecular mechanism, increased degradation of I-
and phosphorylation of I-
and MAP kinases by LPS were partly blocked by MFE treatment. Conclusions : These results suggest that MFE has an anti-inflammatory therapeutic potential, which may result from inhibition of NF-
activation and MAPK phosphorylation, thereby decreasing the expression of pro-inflammatory genes.
The various mechanisms of Korean traditional medicines for anti-cancer
Park, Yeong-Chul ; Park, Yong-Ki ; Lee, Sun-Dong ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 39~55
DOI : 10.6116/kjh.2012.27.3.39
Objectives : Recently there have been encouraging results, from a western perspective, in the cancer research field regarding the anticancer effects of herbal medicine. This paper was aimed to review herbal medicine playing its anticancer role in terms of apoptosis, inflammation control, differentiation and telomerase. Methods : New studies for tang, medicinal herb itself or effective ingradients of medicinal herb showing anti-cancer effectiveness were reviewed and summarized in terms of pharmacological action. Results : Ethanol extracts of
greatly inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects.
may be responsible for its anticancer activity showing inhibition of
synthesis via suppression of COX-2 expression. Saikosaponins isolated from
induced the differentiation of C6 glioma cells, cancer cells, into astrocytes, normal cells. Acetone extract of
inhibited proliferation of human lung cancer cells via inducing apoptosis and suppressing telomerase activity. Conclusions : Herbal medicine inhibited cancer cell growth inducing cell apoptosis and cytotoxic effects. Inflammation persisting for a decade eventually elevates the risk of cancer sufficiently that it is discernible in case control epidemiological studies. Differentiation therapy is defined as a therapy to treat cancers by inducing differentiation of the stem cells. Telomerase expression is a hallmark of cancer. Nearly the complete spectrum of human tumors has been shown to be telomerase positive.
A herbological study on the plants of Polyporaceae in Korea
Park, Jang-Pil ; Lee, Soon-In ; Jeong, Jong-Gil ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 57~65
DOI : 10.6116/kjh.2012.27.3.57
Objective : For the purpose of developing Korean herbology of the plants to Polyporaceae in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods : The examined herbological books and research paper which published domestically and abroad. Results : 1. Polyporacease plants (raised in Korea) are devided into 31 classes with 59 species. Among them, 26 species in 19 classes were found serviceable, which indicates 44 % of all Polyporacease plants. 2. Among those 59 species,
includes 5 species.
, a medicinal plant, includes 3 species. 3. Dividing the serviceable plants of Polyporacease, the fruit body family had the largest number; 25. 4. Out of plants Polyporacease, neutral taste plants was 17 species and sweet taste was 14 species. 5. Only 8 species of Polyporaceae plants were found to enterd into the spleen and heart. 6. 11 species were found to prevent cancer, 7 species were found to dispel wind-dampness and Alleviate edem antittusive and antasth matic. 7. There were no toxic species in the Plyporaceae. Conclusion : There were totaled to 31 genera and 59 species in Polyporaceae in Korea and among them medicinal plants are 19genera, 26 species, some 44% in total.
Effect of Ssanghwa-tang Extract on Antioxidant and Anti-aging Enzyme Activities
Park, Ji-Young ; Hwang, Jae-Gyu ; Yun, Jong-Kuk ; Han, Kil-Hwan ; Do, Eun-Ju ; Kim, Sung-Ok ; Kim, Mi-Ryeo ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 67~74
DOI : 10.6116/kjh.2012.27.3.67
Objectives : The present study was designed to investigate effects of Ssanghwa-tang (Shu
ng) on oxidation/reduction reaction-related and aging-related enzymes
. Methods : We performed MTT assay, collagenase inhibition assay, elastase inhibition assay, tyrosinase inhibition assay, DPPH free radical scavenging assay, SOD-like activity and xanthine oxidase (XO) inhibition assay. Results : The 50% ethanol (EtOH) extract of Ssanghwa-tang (SHT) showed 55% inhibition of collagenase activity, and 42% inhibition of elastase activity at 1 mg/ml concentration. Also it's treatment showed 18% inhibition of tyrosinase activity, to relate whitening effect, at the same dose of 50% ethanol extract of SHT. Antioxidant activities were determined by DPPH radical scavenging, XO inhibiting activity and SOD-like activity. These scavenging, XO-inhibiting and SOD-like activities were measured in 80%, 75%, and 28% inhibitions, respectively, at a 1 mg/ml treated dose, compared to those of control. The inhibitory effects of 50% EtOH extract on aging and oxidation-related enzyme activities were higher than those of water extract and 95% EtOH extract. Conclusions : Taken together, our findings suggest that the SHT has potential and applicable benefits for development of cosmetics to have anti-aging (anti-wrinkle and whitening) and anti-oxidation functions.
Comparitive study on anti-asthmatic activities of Patrinia scabiosaefolia Fischer ex Link and Patrinia villosa Jussieu in a mouse model of asthma
Cha, Jong-Tae ; Lee, Jang-Cheon ; Lee, Young-Cheol ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 75~82
DOI : 10.6116/kjh.2012.27.3.75
Objective : In the present study, we investigated the pharmacological profile of the aqueous extract of
Fischer ex Link (EPS) and
Jussieu (EPV) for its anti-asthmatic activities. The purpose of this study is to ascertain if EPS result in better anti-asthmatic activities and functional outcome as compared with EPV. Methods : In this study, BALB/c mice were systemically sensitized to ovalbumin (OVA) followed intratracheally, intraperitoneally, and by aerosol allergen challenges. We investigated the effect of EPS, EPV on the recruitment of pulmonary inflammatory cells, various immune cell phenotypes, Th1/Th2 cytokine gene expression and production and histamine production in serum. Results : In BALB/c mice, we found that EPV-treated groups had more effectively suppressed inflammatory cell infiltration of lung and BALF, B220+IgE+, CD11b+Gr-1+ cell population in lung and these occurred by suppressing the gene expression of IL-4, IL-5 and IL-4 cytokine production in BALF and serum. Conclusions : These results suggest that EPV may play an important role in the control of anti-asthmatic activities by down-regulation of Th2 cytokine (especially IL-4, IL-5). In general, EPV has shown a better anti-asthmatic activities compared to EPS.
Effects of Dendrobii herba against Intracerebral Hemorrhage in Rats
Lee, Jung-Dong ; Kim, Youn-Sub ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 83~88
DOI : 10.6116/kjh.2012.27.3.83
Objects : This study was performed in order to observe the effects of water extract of Dendrobii herba on intracerebral hemorrhage(ICH), Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. After the water extracts of Dendrobii herba were administrated orally once a day for 3 days, hematoma volume, percentage of brain edema, expression of iNOS and MPO were observed using immunohistochemistry. Results : Rats fed with water extracts of Dendrobii herba showed reduction of hematoma volume and percentage of brain edema compared with controls. In addition, Infiltration of myeloperoxidase (MPO) expressing neutrophil and expression of inducible nitric oxide synthatase(iNOS) were significantly reduced in rats fed with water extracts of Dendrobii herba. Conclusion : These results demonstrated that water extracts of Dendrobii herba reduced brain damage of intracerebral hemorrhage(ICH) and subsequent ICH-induced cerebral edema, and inhibited neutrophil infiltration.
Effects of Salvia Miltriorrhiza Radix on Neuronal Apoptosis following Intracerebral Hemorrhage of Rats
Lee, Hung-Gi ; Kim, Youn-Sub ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 89~94
DOI : 10.6116/kjh.2012.27.3.89
Objects : The purpose of this study was to observe the effect of Salviae Miltriorrhiza Radix(SMR) water-extract on intracerebral hemorrhage(ICH) and neuronal apoptosis in the injured areas. Method : ICH was induced by the stereotaxic intrastriatal injection of bacterial collagenase type IV in Sprague-Dawley rats. The rats were givened oral SMR treatment once a day for three days after the ICH treatment. TUNEL positive cells in the affected regions were performed by TUNEL assay, Bax and Bcl-2 positive cells by immunohistochemistry and the Bax expression by western blotting method. Results : The results are as follow; 1. SMR significantly reduced the number of TUNEL positive cells in the peri-hematoma reigions of ICH-induced rats. 2. SMR significantly reduced the number of Bax positive cells in the peri-hematoma regions of ICH-induced rats. 3. SMR did not affect the number of Bcl-2 positive cells in the peri-hematoma regions of ICH-induced rats. 4. SMR significantly reduced the Bax expressions compared with ICH group in hemorrhagic hemisphere of ICH-induced rats. Conclusion : These results suggest that SMR is effective in reducing neuronal apoptosis.
A Study on the Acute Toxicity of Leejung-tang(Lizhong-tang) and Fermented Leejung-tang(Lizhong-tang) Extract in ICR Mice
Jung, Young-Pil ; Hwang, Yun-Hwan ; Lee, Ji-Hye ; Yim, Nam-Hui ; Cho, Won-Kyung ; Ma, Jin-Yeul ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 95~100
DOI : 10.6116/kjh.2012.27.3.95
Objectives : This study was carried out to investigate the acute toxicity and safety of
) and fermented
) extract. Methods : To evaluate their acute toxicity and safety, 0(control group), 1250, 2500 and 5000 mg/kg of
) and fermented
) extracts were orally administered to 35 male and 35 female ICR mice. After a single administration, we observed survival rates, general toxicity, changes of body weight, and autopsy. Results : Compared with the control group, we could not find any toxic alteration in any of treated groups (1250, 2500 and 5000 mg/kg). Conclusions :
) and fermented
) were over 5000 mg/kg and it is very safe to ICR mice.
Dose range finding study of KOB03, a new polyherbal medicine for the treatment of allergic rhinitis, by oral administration for four weeks in Sprague-Dawley rats
Jung, Jin-Ki ; Park, Yong-Ki ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 101~106
DOI : 10.6116/kjh.2012.27.3.106
Objectives : To evaluate the toxicity of KOB03, polyherbal medicine for the treatment of allergic rhinitis, we performed the dose-range finding test of KOB03 by oral supplementation for 4 weeks in Sprague-Dawley rats. Methods : The water extract of KOB03 consisting of five different herbs was supplied from GLP company. KOB03 was supplemented by gavage at 0, 500, 2,500 and 5,000 mg/kg/day for 4-week consecutive days. We recorded the clinical signs of toxicity, body weight, organ weights, hematology, gross and histological changes in target organs of rats, and clinical chemistry analysis. Results : KOB03 at all doses was shown no mortality or abnormal clinical signs in rats during at the observation period. Furthermore, there was no difference in body weight and food-take consumption, organ weight, gross pathological findings, and urine analysis among the groups of rats treated with different doses of KOB03. The hematological analysis and clinical blood chemistry data were revealed no toxic effects from KOB03-supplemented rats. Conclusions : The results suggest that KOB03 is a wide margin of safety on dose-range toxicity in rats. The no observable adverse effect level (NOAEL) of the test, KOB03 in rats is no less than 5,000 mg/kg/day.
Effects of Tong Xin Lou (TXL) on levels of serum lipid in high fat diet-induced dyslipidemia in mice
Ha, Tae-Hoon ; Kim, Hyun-Young ; Kim, Hyung-Woo ; Cho, Su-In ; Kim, Young-Gyun ;
The Korea Journal of Herbology, volume 27, issue 3, 2012, Pages 107~112
DOI : 10.6116/kjh.2012.27.3.107
Objectives : This study was designed to investigate the effects of Tong Xin Lou (TXL) on lipid accumulation in liver tissue in Hypercholesterolemic mice. TXL is new drug, which is one of Cardiotonic Pills. TXL is used for activating the blood flow in the restoration stage of cerebral infarction, and for alleviation of angina pectoris including the symptoms as chest oppressed and stabbing pain. Methods : Hyperlipidemia was induced by providing high fat diet for 6 weeks. Normal group was provided with normal rodent diet. TXL was administered orally in the concentration of 10 mg/day for 2 weeks (TXL group). D/W was administered orally in CTL group for 2 weeks. We observed histopathological changes in liver and heart tissues, and also investigated the effect on body weights, and levels of total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride in serum. Results : In this study, TXL did not affects weight gain in hypercholesterolemic mice. TXL group showed downward tendency of lipid accumulation compared with CTL group. In addition, oral administration of TXL lowered levels of total cholesterol (P < 0.05) and triglyceride (P < 0.05), which were elevated by induction of hypercholesterolemia. Conclusion : These results suggest that TXL can prevent lipid accumulation in liver tissue through regulation of dyslipidemia.