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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Korea Journal of Herbology
Journal Basic Information
Journal DOI :
The Korea Association of Herbology
Editor in Chief :
Volume & Issues
Volume 27, Issue 6 - Nov 2012
Volume 27, Issue 5 - Sep 2012
Volume 27, Issue 4 - Jul 2012
Volume 27, Issue 3 - May 2012
Volume 27, Issue 2 - Mar 2012
Volume 27, Issue 1 - Jan 2012
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Effect of pear extracts containing herbal medicine(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on body weight, lipid metabolism and immune responses in rats fed high fat diets (II)
Kim, Wang-In ; Youn, Dae-Hwan ; Kim, Hwang-Gon ; Na, Chang-Su ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 1~7
DOI : 10.6116/kjh.2012.27.5.1
Objectives : This study was conducted to 9% compared with the previous experimental obesity-induced metabolic function in rats that it was a mixture of pear extract and herbal drugs(Lycii Fructus, Coicis Semen, Alimatis Rhizoma and Astragali Radix) on high fat diet-induce obesity rats. Methods : The animals were used in male rats. Control group fed high-fat diet only. Experimental groups were divided four, ExpI group was fed high-fat diet with a mixture pear extract and Lycii Fructus 9%, Exp II group was fed high-fat diet with a mixture pear extract and Coicis Semen 9%, Exp III group was fed high-fat diet with a mixture pear extract and Alimatis Rhizoma 9%, and Exp IV group was fed high-fat diet with a mixture pear extract and Astragali Radix 9% for 4 weeks. Results : The body weight gain increased in all groups, but attenuated gradually in the experimental groups compared to the control group. The food intakes were significantly lower in all Exp groups than the control group. The concentrations of serum total cholesterol (TC), LDL-cholesterol, and free fatty acid were significantly lower in Exp II than in the control group. Also the concentration of serum free fatty acid was significantly lower in the Exp IV group than in the control group. In inflammatory activities, the Exp II, IV group was significantly lower than the control group. Conclusion : The results indicated that Exp I group (administered a mixture of pear extract and Lycii Fructus) reduced fat accumulation, body weight and the highest elevated lipid metabolism, while the Exp II group (administered the mixture of pear extract and Coicis Semen) and Exp IV group (administered the mixture of pear extract and Astragali Radix) had the highest elevated immune activity.
Protective effect of Poncirus trifoliata and Citrus aurantium extract on acute pancreatitis in mice model
Park, Kyoung-Chel ; Bae, Gi-Sang ; Choi, Sun-Bok ; Jo, Il-Joo ; Gwak, Tae-Sin ; Lee, Guem-San ; Park, Sung-Joo ; Song, Ho-Joon ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 9~14
DOI : 10.6116/kjh.2012.27.5.9
Objective : We investigated the effect of Poncirus trifoliata and Citrus aurantium extract in mice with cerulein-induced acute pancreatitis (AP) model. Methods : AP was induced via intraperitoneal injection of cerulein (50
) given every hour for 6h. Poncirus trifoliata (PT: 200 or 400 mg/kg) and Citrus aurantium (CA: 200 or 400 mg/kg) extract were injected 1 h before in mice with cerulein-induced AP. Mice were sacrificed at 6 h after last injection of cerulein. Blood samples were taken to determine serum amylase and lipase levels. The pancreas and lungs were rapidly removed for morphological examination, myeloperoxidase assay. Results : PT pre-treatment significantly protected the pancreas and lung damages and reduced the MPO activity and serum amylase in cerulein-induced AP. However, CA pre-treatment did not significantly protected the pancreas and lung inflammation in cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP. Conclusion : These results suggest that PT but not CA could protect the cerulein-induced AP.
The Antioxidant Activity of Nelumbinis Stamen in GC-2 spd(ts) Cells
Park, Eun-Hwa ; Chang, Mun-Seog ; Kil, Ki-Jeong ; Park, Seong-Kyu ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 15~20
DOI : 10.6116/kjh.2012.27.5.15
Objectives : The purpose of this study was to estimate the antioxidant activity of water extract of Nelumbinis stamen (WNS) in GC-2 spd (ts) cells. Methods : we investigated the effect of WNS in mouse GC-2 spd (ts) cells by MTT assay. The protective effects of WNS against hydrogen peroxide-induced oxidative stress in GC-2 spd (ts) cells were examined by measuring cell viability. Lipid peroxidation levels and catalase were measured. Results : WNS showed cell viability as 101.9, 108.9, 111.8, 125.8, 134.5% in 2.5, 5, 10, 25, 50
concentrations, respectively. The protective effect of WNS concentration was 2.5
against hydrogen peroxide-induced oxidative stress in GC-2 spd (ts) cells. LPO were decreased significantly at 2.5, 5, 25
of WNS concentrations. Catalase activity was significantly increased at 2.5, 5 and 10
of WNS concentrations, respectively. Conclusions : In conclusion, WNS has antioxidant activities in GC-2 spd(ts) cells against oxidative stress.
Effects of OMC-2010 extracts on cytokine productions in mouse spleen cells
Bae, Gi-Sang ; Park, Kyoung-Chel ; Choi, Sun-Bok ; Jo, Il-Joo ; Seo, Sang-Wan ; Kim, Jong-Jin ; Shin, Yong-Kook ; Kim, Min-Sun ; Park, Kyu-Hwan ; Kim, Hyun-Sik ; Song, Ho-Joon ; Park, Sung-Joo ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 21~25
DOI : 10.6116/kjh.2012.27.5.21
Objective : This study was performed to estimate the effects of OMC-2010 extract on cytokine production in mouse spleen cells. Methods : Mouse spleen cells were pre-treated with ethanol and water extract of OMC-2010 for 1 h, then stimulated with lipopolysaccharide (LPS, 1
) for 48 h. Then the cells were harvested for real-time reverse transcription polymerase chain reaction to detect cytokines. Results : OMC-2010 ethanol extract significantly inhibited the LPS-induced interleukin (IL)-1beta, tumor necrosis factor (TNF)-alpha and IL-5 mRNA expressions, but not shown such changes in IL-6, IL-4, IL-13. OMC-2010 water extract significantly inhibited the LPS-induced TNF-alpha, and IL-5 mRNA expressions, but not shown such changes in IL-1beta, IL-6, IL-4, IL-13. Conclusions : Theses results could suggest that both ethanol and water OMC-2010 extract could inhibit the TNF-alpha and IL-5 mRNA expression.
A Comparative Study of Memory Improving Effects of Taraxaci herba on Scopolamine-induced Amnesia in Mouse
Sohn, Moon-Ki ; Shin, Yong-Wook ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 27~35
DOI : 10.6116/kjh.2012.27.5.27
Objectives : The purpose of this study was to characterize the effect of the fraction of Taraxacum officinale and T.coreanum on the learning and memory impairments induced by scopolamine. Methods : The cognition-enhancing effect of Taraxacum officinale and T.coreanum was investigated using a passive avoidance test, the Morris water maze test and Y-maze test in mice. Drug-induced amnesia was induced by treating animals with scopolamine (1 mg/kg, i.p.). Results : The results showed that the Aug harvested T.offiicinale extract-treated group (200 mg/kg, p.o.) and the tacrine-treated group (10 mg/kg, p.o.) significantly ameliorated scopolamine-induced amnesia based on the Passive avoidance Y-maze test and Watermaze test. And these results are same manner in DPPH radical scavenger effect and Acetylcholineseterase inhibition effect. Conclusions : These results suggest that Taraxacum officinale extract maybe a useful cognitive impairment treatment, and its beneficial effects are depending on the collecting time and origin plants. As a result, Taraxacum officinale harvested in August improve memory most.
Changes in the Anti allergic Effect of Citrus unshii Pericarpium According to Storage Period
Shin, Yong-Wook ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 37~44
DOI : 10.6116/kjh.2012.27.5.37
Objectives : The present study was undertaken to determine whether the ethanol extact of Citri Pericarpium (CP, Pericarp of Citrus unshiu Markovich, Rutaceae) is effective against atopic dermatitis according to it's storage period. Methods : To evaluate antiallergic effect of CP and OCP (Old Citri Pericarpium) evaluated in vivo their inhibitory effects against passive cutaenous anaphylaxis (PCA) reaction induced by IgE-antigen complex and scratching behaviors by compound 48/80. The Anti-atopic effects were measured by contact dermatitis, prurient animal model and PCA reaction. Contact dermatitis in mice as a model of the Type IV reaction caused by Oxazolone. Results : The results showed that anti-pruritus effects, analgesic effects of CP was depends on its hesperetin contents. And It also showed that keep longer in storage appeared to be higher in hesperetin contents. Both CP and OCP(Old CP) have a dose-dependent analgesic action in acetic acid induced writhing syndrome. OCP Potently inhibited PCA reaction in mice, although OCP weakly inhibited in long term contact dermatitis model in mice. Conclusions : These results suggest that the Proportional to the storage period, Citri Pericarpium possesses analgesic effects and anti-allergic effects.
Analysis of China's Efforts to Protect Medicinal Resources and the Intellectual Property Rights of Traditional Chinese Medicine - in light of the adoption of the Nagoya Protocol -
Lee, Min-Ho ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 45~53
DOI : 10.6116/kjh.2012.27.5.45
Objectives : In recent years, the Chinese Government has been providing full support aimed at promoting the excellence of Chinese culture, including Traditional Chinese Medicine (TCM), to the world after recognizing Chinese culture and medicine as elements that can generate national wealth. Methods : In investigating China's awareness of the issues surrounding the intellectual property rights of TCM, as well as its implementation of protective measures, this study analyzed the law and platform policies of the Chinese Government, as well as the designation status of China's intangible cultural heritages and the recent research trend in the TCM field. Results : First, China is taking various protective measures based on laws and institutional devices, including the Patent Act. Second, China is protecting the intellectual property rights of traditional Chinese medicines by registering them as Chinese intangible cultural heritages or UNESCO world heritages. Third, China is seeking to promote TCM throughout the wider world through various research and academic conferences, and by strengthening ties between nations. Conclusions : With the adoption of the international regimes of the WIPO and CBD, and particularly the Nagoya Protocol in 2010, China is seeking to implement measures aimed at maximizing the national interest based on the intellectual property rights of TCM. China began to implement a system of protection of medicinal resources and the related traditional knowledge after recognizing the potential crisis that could occur if Chinese medicine-related patents were taken over by foreign countries. As such, the system now takes various forms.
Antioxidant and Anti-inflammatory Effects of Fractions from Pruni persicae Flos
Lee, Jin-Young ; An, Bong-Jeun ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 55~63
DOI : 10.6116/kjh.2012.27.5.55
Objectives : The solvent extracts of Pruni persicae Flos were investigated for the activities of anti-oxidant and anti-inflammatory effects to apply as a functional ingredient for cosmetic products. Methods : In this study, the fractions of P. persicae Flos were extracted with 70.0% acetone and purified using Sephadex LH-20 column chromatography. As a result, eight fractions were isolated. We performed MTT assay, total polyphenol contents, DPPH free radical scavenging assay, SOD-like activity, xanthine oxidase inhibition assay, astringent activity assay, hyaluronidase inhibition assay and the production of nitric oxide. Results : For anti-oxidant effects, the electron donating ability of fraction (Fr.) 2-5, Fr.-8 isolated from P. persicae Flos was above 90.0% at 100 ppm respectively. The superoxide dismutase (SOD) - like activity of Fr.-5 isolated from P. persicae Flos was 92.1% at 1,000 ppm. The xanthine oxidase inhibitory effect of Fr.-6 isolated from P. persicae Flos was about 83.3% at 1,000 ppm. Hyaluronidase inhibition activity related to the anti-inflammation effect was 94.0% for Fr.-4 isolated from P. persicae Flos at 500 ppm. In the anti-inflammation effect, the Fr.-4 isolated from P. persicae Flos inhibited the generation of nitric oxide. Conclusions : All these findings suggested that the fractions of P. persicae Flos has a great potential as a cosmeceutical ingredient with a anti-oxidant and anti-inflammatory effects.
Cosmeceutical Activities of Doinseunguitang and Its Composition
Lee, Jin-Young ; Lee, Soo-Yeon ; Jun, Hye-Ji ; Yoon, Ji-Young ; Hwang, Hyun-Uk ; Park, Joo-Hoon ; An, Bong-Jeun ; Son, Jun-Ho ; Hwang, Ju-Young ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 65~75
DOI : 10.6116/kjh.2012.27.5.65
Objectives : Cosmeceutical activities such as anti-oxidative and anti-aging effects of the Doinseunguitang and its composition, a traditional prescription, were evaluated. Methods : We performed MTT assay, melanin synthesis inhibition assay, DPPH free radical scavenging assay, SOD-like activity, xanthine oxidase inhibition assay, astringent activity assay, tyrosinase inhibition assay, elastase and collagenase inhibition assay. Results : The results were obtained as follows : DPPH free radical scavenging of water extract Doinseunguitang (DISG) and ethanol extract DISG was 60% and 50% at 1,000 ppm. Xanthine oxidase inhibition effect of ethanol extract showed more than 80% at 500 ppm. Tyrosinase inhibition and inhibition melanin synthesis activities were measured in 40% and 50% at 1,000 ppm and 100 ppm. Elastase and collagenase inhibition rate of ethanol extracts DISG 40% and 80% at 1,000 ppm. It was concluded that compositive ingredients (Persicae Seman, Glycyrrhizae Radix, Cinnamomi Ramulus, Rhei Rhizoma) influenced the most results. Conclusions : The results indicated that, ethanol extract which is superior in its anti-oxidative and anti-aging effects is useful to be applied in herbal cosmetic industry.
A herbalogical study on the plants of Violaceae in Korea
Lee, Soon-In ; Jeong, Jong-Gil ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 77~83
DOI : 10.6116/kjh.2012.27.5.77
Objective : For the purpose of developing Korean herbalogy of the plants to Violaceae in Korea, the literatures of the successive generations have been thoroughly investigated to prepare this article. Methods : The examined herbalogical books and research paper which published at home and abroad. Results : 1. Violaceae plants (raised in Korea) are devided into 1 classes with 57 species. Among them, 14 species in 1 classes were found serviceable, which indicates 32 % of all Violaceae plants. 2. The herb is main medicinal part if medicinal plants in the Violaceae, which is used in 14 species. 3. According to the nature and flavor of medicinal plants in the Violaceae, they were classified into cold 8 species, and cool 7; bitter taste 8; acrid taste and little bitter taste 6 in the order. 4. According to the meridian propism of medicinal plants in the Violaceae, they were classified into liver meridian 6 species, heart meridian 3 species in the order. 5. According to the properties and principal curative action, they were classified into drugs for clearing heat, removing toxins 12 species; drugs for alleviate edema 7, and drugs for arresting bleeding 6 in the order. 6. There were no toxic species in the Violaceae family. Conclusion : There were totaled to 1 genera and 57 species in Violaceae in Korea and among them medicinal plants are 1genera, 14 species, some 32% in total.
Effects of Saposhnikoviae Radix on allergic responses in OVA-induced Allergic rhinitis mice
Jung, Jin-Ki ; Park, Yong-Ki ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 85~91
DOI : 10.6116/kjh.2012.27.5.85
Objectives : In this study, we investigated the effect of Saposhnikoviae Radix on allergic responses in ovalbumin(OVA)-induced Allergic rhinitis(AR) mice. Methods : BALB/c mice were orally administrated with Saposhnikoviae Radix water extract (SRW, 50 mg/kg) or anti-histamine drug, Ketotifen (10 mg/kg) as a reference drug, followed by sensitization and challenge of OVA. Mice were measured clinical symptoms and the serum levels of histamine, IgE, IL-4, and IFN-
, and observed histopathological changes of nasal mucosa H&E staining. Results : SRW significantly decreased rubs and the serum levels of histamine, IgE, and IL-4, and then increased the serum levels of IFN-
in OVA-induced AR mice, and inhibited histopathological changes of nasal mucosa with inflammation and the eosinophils infilteration. Conclusions : These data suggest that SRW has anti-allergic effect through the inhibitory property of Saposhnikoviae Radix against allergic responses in allergic rhinitis.
Effects of Peony-Licorice Mixture Supplementation on Blood Glucose and Lactate Levels
Ha, Sung ; Lee, Ho-Keun ; Seo, Dong-Il ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 93~97
DOI : 10.6116/kjh.2012.27.5.93
Background : The purpose of this study was to examine that the effects of Peony-Licorice (PL) mixture supplementation on post-exercise blood glucose and lactate in professional women basketball players. Methods: Eleven professional women basketball players were participated in this study. The subjects participated in two trials, PL supplementation and water supplementation. They did 20-meter shuttle run test, and measured blood glucose and lactate level before, immediately, after 3 minutes, after 5 minutes and after 10 minutes the test. Results: There was not interaction effect on blood glucose(p<0.433) and lactate(p<0.770) levels. Blood glucose and lactate levels were increased in PL group and water group after the test. Conclusion: PL supplementation could not affect changing blood glucose and lactate level. Therefore, we suggest that PL supplementation may not be positive ergogenic aid for improving exercise performance in professional women basketball players.
Effects of CJB Water Extract on Obesity-Related Factors in Hypothalamus of Rats Fed High-Fat Diet
Hwang, Jeong-Soo ; Suk, Jang-Mi ; Choi, Hye-Min ; Shin, In-Soon ; Hwang, Su-Jung ; Park, Ji-Young ; Kim, Sung-Ok ; Seo, Bu-Il ; Kim, Mi-Ryeo ;
The Korea Journal of Herbology, volume 27, issue 5, 2012, Pages 99~107
DOI : 10.6116/kjh.2012.27.5.99
Objectives : This study was conducted to investigate the anti-obesity effects of mixed water extract of Plantaginis Semen & Poria (CJB) on obese rats induced with high fat diet. Method: Male Sprague-Dawley rats were divided into three groups; Normal group, high-fat (HF) group, HF+CJB(100 mg/kg, P.O.) for 8 weeks. The body weight, food intake and weights of adipose tissues were measured, respectively. Lipid profiles in serum were analyzed by automatic analyzer of blood. Obese marker proteins and the changes of NPY and LR immunoreactivities in hypothalamus were analyzed by Western blot and immunohistochemistry. Results : CJB significantly reduced body weight, food intake, adipose tissue weights compared to HF group. Serum triglyceride and total cholesterol were significantly higher in HF group than in Normal group however, CJB significantly lowered those of HF group. HDL-cholesterol level in CJB groups was elevated compared to HF group. The pAMPK in hypothalamus were decreased in that of HF group and that of CJB group decreased. Inversely, ACC was increased in HF group and that of CJB groups decrease. Expression of
in hypothalamus was increased by CJB treatment. However,
levels in CJB group were decreased compared to HF group. The expressions of NPY and LR in PVN and ARC of hypothalamus were decreased in CJB group, respectively. Conclusion : Administration of CJB can play anti-obesity through regulations of NPY and LR activities and obesity marker proteins in obese rat's hypothalamus.