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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Pharmacopuncture
Journal Basic Information
Journal DOI :
KOREAN PHARMACOPUNCTURE INSTITUTE
Editor in Chief :
Volume & Issues
Volume 14, Issue 4 - Dec 2011
Volume 14, Issue 3 - Sep 2011
Volume 14, Issue 2 - Jun 2011
Volume 14, Issue 1 - Mar 2011
Selecting the target year
Purification and Characterization of a Fibrinolytic Enzyme from Snake Venom of Macrovipera lebetina turanica
Kwon, Ki-Rok ; Park, Do-Il ; Lee, Seung-Bae ; Choi, Suk-Ho ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 5~14
DOI : 10.3831/KPI.2011.14.2.005
Objectives: Fibrinolytic enzyme preparations were isolated from the snake venom of Macrovipera lebetica turanica in this study. Methods: The purity of the preparations was determined using SDS-PAGE and the enzymic characteristics of the purified fibrinolytic enzyme were determined. Results: 1. All of the two preparations with fibrinolytic activity obtained from the snake venom of M. l. turanicat contained the major polypeptide with the molecular weight of 27,500. One of the preparation showed purified fibrinolytic enzyme. 2. The purified fibrinolytic enzyme hydrolyzed
-chain of fibrinogen faster than
-chain but not
-chain. 3. The fibrinolytic activity was inhibited completely by EDTA, EGTA, 1,10-phenanthroline, and dithiothreitol. 4. The fibrinolytic activity was inhibited completely by calcium chloride, iron(III) chloride, mercuric chloride, and cobalt (II) chloride. 5. The fibrinolysis zone formed after addition of zinc sulfate was smaller but clearer than the control. Conclusions: These results suggested that the fibrinolytic enzyme purifed from the snake venom of M. l turanica was a metalloprotease containing dithiol group.
Inhibitory Effect of Rehmannia Glutinosa Pharmacopuncture Solution on β-hexosaminidase Release and Cytokine Production via FcεRI signaling in RBL-2H3 Cells
Kang, Kyung-Hwa ; Kim, Cheol-Hong ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 15~24
DOI : 10.3831/KPI.2011.14.2.015
Background: Type I allergy is involved in allergic asthma, allergic rhinitis, and atopic dermatitis which are accompanied by an acute and chronic allergic inflammatory responses. Rehmannia glutinosa is a traditional medicine in the East Asian region. This study examined whether a Rehmannia Glutinosa pharmacopuncture solution (RGPS) had anti-allergic or anti-inflammatory effects in antigen-stimulated-RBL-2H3 cells. Methods: We determined the effect of RGPS on cell viability using the 3-[4,5-dimethylthiazolyl]-2,5-diphenyltetrazolium bromide (MTT) assay. We also examined the effect of RGPS on the release of
-hexosaminidase and the secretion of IL-4 and TNF-
using ELISA. In addition, we evaluated the effect of RGPS on the mRNA expression of various cytokines; IL-2, IL-3, IL-4, IL-5, IL-13 and TNF-
using RT-PCR. Furthermore, we assessed the activation of mitogen-activated protein kinases (MAPKs) and nuclear factor (NF)-
B using Western blotting after RGPS treatment. Results: We found that RGPS (
dilution) did not cause any cytotoxicity. We observed significant inhibition of
-hexosaminidase release and suppression of the protein secretion of IL-4 and TNF-
and mRNA expression of multiple cytokines in antigen-stimulated-RBL-2H3 cells after RGPS treatment. Additionally, RGPS suppressed not only the phosphorylation of MAPKs, but also the transcriptional activation of NF-
B in antigen-stimulated-RBL-2H3 cells. Conclusions: These results suggest that RGPS inhibits degranulation and expression of cytokines including IL-4 and TNF-
via down-regulation of MAPKs and NF-
B activation in antigen-stimulated-RBL-2H3 cells. In conclusion, RGPS may have beneficial effects in the exerting anti-allergic or anti-inflammatory activities.
The Effects of Dry Cupping Therapy on the Shoulder Pain and Fatigue of Nurses
Sohn, Dorina ; Yoon, Hyun-Min ; Jung, Hyang-Mi ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 25~35
DOI : 10.3831/KPI.2011.14.2.025
Objective : This research was done to identify the effects of dry cupping therapy on the shoulder pain and fatigue of nurses. Methods : The research design was time series design. The participants were 27 nurses with shoulder pain at P University Hospital in Busan metropolitan city from July 6, 2009 to August 3, 2009. The dry cupping therapy was done 4 times, twice a week for 2 weeks. Before intervention, the severity and frequency of pain and fatigue were measured three times at one week intervals, and then those were measured after one week and two weeks of experimental treatment. The results were analyzed using descriptive statistics, paired t-test and repeated measure ANOVA with the SPSS program. Results : There were statistically significant difference in severity and frequency of shoulder pain, and fatigue after dry cupping therapy. Dry cupping therapy was effective for the management of shoulder pain and fatigue among nurses in this study. Conclusion : Therefore dry cupping therapy can be considered an effective nursing intervention that relieves shoulder pain and fatigue of nurses.
A Clinical Pilot Study Comparing Sweet Bee Venom parallel treatment with only Acupuncture Treatment in patient diagnosed with lumbar spine sprain
Shin, Yong-Jeen ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 37~43
DOI : 10.3831/KPI.2011.14.2.037
Objectives : This study was carried out to compare the Sweet Bee Venom (referred to as Sweet BV hereafter) acupuncture parallel treatment to treatment with acupuncture only for the patient diagnosed with lumbar spine sprain and find a better treatment. Methods : The subjects were patients diagnosed with lumbar spine sprain and hospitalized at Suncheon oriental medical hospital, which was randomly divided into sweet BV parallel treatment group and acupuncture-only group, and other treatment conditions were maintained the same. Then, VAS (Visual Analogue Scale) was used to compare the difference in the treatment period between the two groups from VAS 10 to VAS 0, from VAS 10 to VAS 5, and from VAS 5 to VAS 0. Result & Conclusion : Sweet BV parallel treatment group and acupuncture-only treatment group were compared regarding the respective treatment period, and as the result, the treatment period from VAS 10 to VAS 5 was significantly reduced in sweet BV parallel treatment group compared to the acupuncture-only treatment group, but the treatment period from VAS 5 to VAS 0 did not show a significant difference. Therefore, it can be said that sweet BV parallel treatment is effective in shortening the treatment period and controlling early pain compared to acupuncture-only treatment.
Dose dependent effects of Jungsongouhyul Pharmacopuncture on Low Back Pain
Jeong, Man-Jin ; Kwon, O-Gon ; Woo, Chang-Hoon ; An, Hee-Duk ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 45~52
DOI : 10.3831/KPI.2011.14.2.045
Objectives : The object of this study is to analyse about Low Back Pain's intensity according to dosage of Jungsongouhyul pharmacopuncture. Method : Three groups were made with 15 patients in Po-Hang Oriental Hospital, which is affiliates to Daegu Haany University. They were observed August 1st, 2010 to September 30th. 2010. Each group was treated by based on acupuncture, herb and other therapy and differential dosage of Jungsongouhyul pharmacopuncture 0,4, 0.8, and 1.2cc. We had measured pain threshold and Visual Analog Scale during first week of their admission. The statistical analysis was performed by using the oneway ANOVA and Tukey's test. Result : Change of VAS was not statistically significant. Change of pain threshold was statistically significant. Multiple comparisons of pain threshold between the group1,2 was not statistically significant. Multiple comparisons of pain threshold between the group1,3 and group2,3 was statistically significant. Conclusions : Jungsongouhyul Pharmacopuncture 1.2cc was more effective than 0.4 and 0.8cc.
Effect of Acupotomy Therapy on Lateral Epicondylitis Diagnosed by Ultrasonography
Lim, Na-Ra ; Lim, Jin-Young ; Kim, Dong-Woung ; Lee, Jong-Deok ; Kim, Sung-Chul ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 53~59
DOI : 10.3831/KPI.2011.14.2.053
Purpose: This observation was to report the clinical effects of acupotomy in treating lateral epicondylitis. Methods: Three patients diagnosed with lateral epicondylitis were treated with acupotomy. Two were male and one was female. The improvement of symptom were evaluated by visual analog scale (VAS) and self-consciousness symptoms of Cozen test. Results: After one treatments, patient's chief complaint and the pain near the lateral epicondyle while cozen test were notably improved. Conclusions : This study demonstrates that oriental medical treatment with acuputomy therapy has significant effect in improving symptoms of lateral epicondylitis. As though we had not wide experienced in this treatment, more research is needed.
Pharmacopuncture and Autohemo-Seperated Regeneration Pharmacopuncture for Acute Traumatic Subdeltoid Bursitis with Patial Tear of Subscapularis Tendon After Bongchuna Treatment - A Case Report -
Oh, Won-Kyo ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 61~74
DOI : 10.3831/KPI.2011.14.2.061
This is a case report about effect of syeom pharmacopuncture, bee venom and autohemo-seperated regeneration pharmacopuncture(ASRP) for acute traumatic subdeltoid bursitis with partial tear of subscapularis tendon, which was diagnosed by symptoms and MRI(Magnetic resonance imaging) and caused by bongchuna treatment. We evaluated the patient using Visual Analogue Scale(VAS) every two or four days and range of movement(ROM), physical examination of shoulder about one per ten days and observed improvement with reexamination by ultrasonography and MRI as well. Pharmacopuncture rapidly reduced pain and improved range of motion and function of shoulder in patients with acute sub-deltoid bursitis even though it was severe symptom. Our result suggest that autohemo-seperated regeneration pharmacopuncture might be effective in regenerating the tear of soft tissue such as subscapularis tendon.
Proposal of Self Targeting Therapy of Mountain Ginseng Pharmacopuncture
Cho, Byung-Jun ; Kwon, Ki-Rok ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 75~80
DOI : 10.3831/KPI.2011.14.2.075
Objectives & Methods: This research may accounts for Self Targeting Therapy (STT) which is a peculiar operation of Mountain Ginseng Pharmacopuncture. The objectives include analysis of its mechanism and reporting of clinical cases. Results: 1. STT of Mountain Ginseng Pharmacopuncture refers to the function of curing and making a diagnosis of the disease by oneself. 2. The mechanism of STT is to pursue the latent illness and make the remedial action by oneself. In this process, the symptom of latent disease is outwardly expressed. 3. The most popular symptom expressed is manifestation of pecular sensation along the specific meridians. Then followed headache, dizziness, powerless and etc. Diverse symptoms can be expressed by a patient. 4. If the revealed symptoms are carefully observed, the cause of the disease or the patient state can be diagnosed easily. Conclusion: The mechanism of STT of Mountain Ginseng Pharmacopuncture can be a great asset in clinical trials. Other studies on STT of Mountain Ginseng Pharmacopuncture should be followed in the future.
The suggestion of common cause of disease, characteristics of human body, and medical treatment
Cho, Byung-Jun ; Kwon, Ki-Rok ;
Journal of Pharmacopuncture, volume 14, issue 2, 2011, Pages 81~91
DOI : 10.3831/KPI.2011.14.2.081
Objectives & Methods: This suggestion was attempted to be elevated the recognition of common characteristics in disease. So, we performed to analyze the correlation of common cause of disease, characteristics of human body, and medical treatment. And the results are as follows. Results: 1. The cause of disease is consist of genetic factor, aging, habit, food of not good in health, weather, environment, deficit of the physical activity, stress and so on. 2. Generally, human has common and individual weakness. Individual weakness is appeared similar to the occurrence of volcano and lapse. 3. The correlation of disease and medical treatments is possible to explain using the quotation of the law of motion made by Isaac Newton, the great physicist. 4. When the process of the medical treatment was not progressed, the prognosis is determined by the correlation of the homeostasis(H') in human body and the homeostasis(H) of disease. 5. The prognosis of disease is determined by the relationship between the energy of disease(F) and medical treatment(F'). 6. The exact diagnosis is possible to predict the treatment sequence, and the facts that homeostasis in human body and disease, relationship between the energy of disease(F) and medical treatment(F'), action and reaction are important to determine the prognosis. 7. The careful observation of improving response and worsening action of disease becomes available for exact prognosis. Conclusion: The above described contents may be useful in clinical studies, and the concrete clinical reports about this will be made afterward.