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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal DOI :
The Korean Society of Toxicology
Editor in Chief :
Volume & Issues
Volume 2, Issue 2 - Dec 1986
Volume 2, Issue 1 - Jun 1986
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THE POISONOUS MUSHROOMS IN JAPAN
Yamaura, Yoshio ; Yokoyama, Kazumasa ;
Toxicological Research, volume 2, issue 2, 1986, Pages 51~62
Of mushrooms found in Japan, approximately 35 species are classified as poisonous mushrooms. The mushroom poisonings caused by these mushrooms are classified as three types accodring to the symptoms and their toxic constitutents. The first type is the cholera-like symptom which is induced mainly by the toxic constitutents such as cyclopeptide and gyromitrin. The second type is the neurological mainfestations induced by muscarine (cholinergic), muscimol (delirium), psilocybin (hallucinogenic) and coprine (antabuse-like).
REPRODUCTION STUDIES WITH PRANOPROFEN: A NONSTEROIDAL ANTINFLAMMATORY AGENT IN RATS-PERINATAL AND POSTNATAL TEST.
Moon, Hwa-Hwey ; Kim, Pu-Young ; Cho, Dae-Hyun ; Heo, Ok-Soon ; Park, Sook-Hee ; Yoon, Tae-Bo ; Kim, Soon han ;
Toxicological Research, volume 2, issue 2, 1986, Pages 63~77
prenatal and postanatal study on pranoprofen, as an antiinflammatory agent, was conducted by oral administration in Sprague-Dawley pregnancy rats from day 17 of gestation to day 21 of after delivery. Pranoprofen was intubated doses of 1.0, 2.5 and 5.0 mg/kg/day and dose of 5.0mg/kg/day of Indomethacin was used as positive control. After delivery, several study indexes such as length of gestation, No. of implantations, No. of live pups, No. of perinatal deaths, sex ratio and No. of malformation were checked and then all the newborns were feeded and investigated physical and behavioral changes.
TOXICOLOGICAL STUDY ON TRADITIONAL KOREAN HERBAL DRUGS (V)
H.N. K. G ; Moonshik Zong ; Chang, Il-Moo ;
Toxicological Research, volume 2, issue 2, 1986, Pages 79~87
Water extracts of 21 traditional Korean herbal drugs were prepared, and a dose range of 100 mg/kg to 400 mg/kg was administered orally into mice once a day for five days. Changes of serum enzyme activities of glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), blood urea nitrogen (BUN), alkaline phosphatase, body weight changes and histo pathological examination of various organs were investigated. Water extract of Ephedra Herba caused severe body weight loss at a dose of 100 mg/kg and death from a dose level of 200 mg/kg by oral administration. Angelica koreanae Radix and Anthrisci Radix showed a slight body weight loss and damages to liver and kidney.
HEPATOTOXICITY OF T-2 TOXIN IN RATS
Kang, Tae-Gyu ; Lee, Yong-Soon ;
Toxicological Research, volume 2, issue 2, 1986, Pages 89~102
T-2 toxin was given to rats(Spargue Dawley) with a 4mg/kg and 2mg/kg dose p.o. Data was based on the T-2 toxin 4mg/kg treated group except for counting of acidophil bodies. GPT activities increased significantly from 0.5 to 10 hours. GOT activities were also increased at 1 and 5 hours significantly and the relative weights of liver were increased at 0.5 and 5 hours significantly. There were slight necrotic foci in microscopic observation. There was dose-dependent trend for the frequency of the acidophil body between the 4mg/kg treated group and the 2mg/kg treated group.
Comparison of EEC and US system for safety evaluation procedures and regulations involving drugs and industrial chemicals
Zbinden, G. ;
Toxicological Research, volume 2, issue 2, 1986, Pages 103~111