Go to the main menu
Skip to content
Go to bottom
REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal Basic Information
Journal DOI :
The Korean Society of Toxicology
Editor in Chief :
Volume & Issues
Volume 5, Issue 2 - Dec 1989
Volume 5, Issue 1 - Jun 1989
Selecting the target year
TOXICITY STUDY ON CHINESE HERBAL DRUGS USING THE MICRONUCLEUS ASSAY IN MURINE BONE MARROW ERYTHROCYTES
Ian C. Guest ; Yoo, Sang-Ou ; Paik, Nam-Woo ; Lee, Young-Wook ; Oh, Ki-Bong ; Yang, Heyong-Cheol ; Suh, Nan-Joo ; Chang, Il-Moo ;
Toxicological Research, volume 5, issue 2, 1989, Pages 71~77
A mouse whole animal bioassay was employed to screen for potential mutagenicity of ethanol/water extracts of 16 Chinese herbal drugs that are commonly prescribed in Korea. Specific cytogenetic toxicity was measrured by recording evidence of clastogenesis toxicity was measured by recording evidence of clastogenesis via the mouse bone marrow micronucleus test. Male ICR mice administered ethanol extract of Pinelliae tuber (Pinellia eternata Breitenbach, ARACEAE, 양복) and ddY female mice administered extract of Angelica Koreanae radix(Angelica Koreana Maximowicz, UMBELLIFERAE, ) (both by oral administration, at a dose of 600 mg/kg), in a short-term dosing schedule, demonstrated significant increase in micronucleated polychromatophilic erythrocytes, indicating the increase of clastogenicity.
RENAL EXCRETION OF
IN CADMIUM-INTOXICATED RATS
Kim, Yung-Kyu ; Park, Yang-Saeng ;
Toxicological Research, volume 5, issue 2, 1989, Pages 79~87
Changes in urinary
excretions, renal cortical microsomal
-K-ATPase activity, cortical tissue electrolyte content and plasma aldosterone level were studied in rats treated with CdCl2 (2 mg Cd/kg/day, s.c. injection) for 7-14 days. After 7 days of cadmium exposure, urinary excretion of
was markedly reduced. This change was accompanied by an increase in
-ATPase activity, a fall in tissue
content, a rise in tissue
content and an elevation of plasma aldosterone level.
STUDIES ON EPIDERMAL-DERMAL SEPARATION AND ENZYME ACTIVITIES IN NEONATAL RAT EPIDERMIS
Kim, Hyeyoung ;
Toxicological Research, volume 5, issue 2, 1989, Pages 89~96
Rapid and complete epidermal-dermal separation procedure were determined in neonatal rat skin by light microscopic observation and by compairing enzyme activities in the separated epidermis. Microscopic appearance demonstrated the at four different separation procedures used in the study resulted in good separation of epidermis from dermis` heating method (i.e., immersion in 55C water for 30 sec, followed by immersion in 0-4C water) and microwave irradiation for 10 sec were saving time.
GENERATION OF p-DINITROBENZENE ATMOSPHERE AND METHEMOGLOBIN FORMATION IN RATS
Kim, Young-Chul ;
Toxicological Research, volume 5, issue 2, 1989, Pages 97~104
A new exposure system was developed to generate p-dinitrobenzene (p-DNB) containing atmosphere. A glass column was filled with small glass beads coated with the chemical. The p-DNB containing medium was heated to a temperature beyond the boiling point of p-DNB. A stream of air flow was forced to pass through the column and let it mixed with fresh air before introducing into an inhalation chamber. The concentration of p-DNB in the chamber air was measured by direct assaying the air directly and by sampling the chemical using a microfilter installed in the chamber.
ACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN RATS AND MICE
Moon, Chang-Kiu ; Park, Kwang-Sik ; Mock, Myung-Soo ; Jung, Myung-Kiu ; Kim, Ji-Young ;
Toxicological Research, volume 5, issue 2, 1989, Pages 105~109
Single dose of Hantabax, HFRS-vaccine, was given to both sexes of Sprague-Dawley rats and ICR mice, subcutaneously and intraperitoneally. Any toxic symptom was not noted in the treated animals. Macroscopic examination on the organs of tested animals showed no abnormal findings. In general toxicological aspects Hantabax was practically nontoxic in rats and mice upto a single dose of 1000 times of human clinical dose equivalent via subcutaneous and intraperitoneal administration.
SUBACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN MICE
Moon, Chang-Kiu ; Park, Kwang-Sik ; Mock, Myung-Soo ; Jung, Myung-Kiu ; Kim, Ji-Young ; Jeong, Ja-Young ; Kang, Kyung-Sun ;
Toxicological Research, volume 5, issue 2, 1989, Pages 111~121
Subacute toxicity of Hantabax, epidemic hemorrhagic fever vaccine, was investigated in ICR mice with subcutaneous injection. Any significant toxic symptom was not observed in the treated mice during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in all organs examined.
SUBACUTE TOXICITY OF HANTABAX (HFRS-VACCINE) IN RATS
Moon, Chang-Kiu ; Park, Kwang-Sik ; Mock, Myung-Soo ; Jung, Myung-Kiu ; Kim, Ji-Young ; Lee, Yong-Soon ; Jeong, Ja-Young ; Hur, Gyeung-Haeng ; Kang, Kyung-Sun ; Hwang, Gui-Seo ; Kim, Seong-Gon ; Won, Hyun-Soon ;
Toxicological Research, volume 5, issue 2, 1989, Pages 123~133
Subacute toxicity of Hantabax, epidemic hemorrhagic fever vaccine, was investigated in Sprague-Dawley rats with subcutaneous injection. Any significant toxic clinical symptom was not observed in the treated rats during the experimental period. Macroscopic examination on the organs of tested animals showed no abnormal findings. On autopsy, no significant changes were found in organs examined.
EFFECTS OF GANODERMA LUCIDUM EXTRACT ON THE DEVELOPMENT OF RAT LIVER PRENEOPLASTIC LESIONS
Kim, Jong-Soo ; Lee, Yong-Soon ;
Toxicological Research, volume 5, issue 2, 1989, Pages 135~149
The effect of Ganoderma lucidum (Polyporaceae) extract on initiation and promotion of liver preneoplastic lesions in chemical carcinogenesis were examined in male rats. Male Fisher 344 rats, 8 weeks old, were injected i.p. with diethylnitro-samine(DENA` 200 mg/kg) as an initiator and were fed on diet containing 0.02%-acetaminofluorene (2-AAF) as a promoter for 2 weeks (group 1, 2` 2-4 week) and were fed on basal diet (group 3 and 4). The rats in test groups(group 1 and 3) were fed on diet containing 0.1% of Ganoderma lucidum extract for 6 weeks (2-8 week).
INHIBITORY EFFECTS OF RED GINSENG EXTRACT ON DEVELOPMENT OF PEPSINOGEN 1 DECREASED PYLORIC GLANDS IN RAT STOMACH
Lim, Chang-Hyeong ;
Toxicological Research, volume 5, issue 2, 1989, Pages 151~166
This study was carried out to investigate the effect of red ginseng extract on development of pepsinogen 1 decrased pyloric glands in experimental stomach carcinogenesis in Sprague-Dawley male rats. Sequential quantitative analyses (by ABC immunohistochemical staining) were made of pepsinogen 1 decreased pyloric glands (PDPG) after treating rats first with a single dose (160 mg/kg) N-methyl-N'-nitrosoguanidine (MNNG) and then with N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) (100ug/ml of drinking water) as a second gastric carcinogen (or promoter).
TERATOGENICITY STUDY OF SODIUM GLYCYRRHIZINATE IN THE DEVELOPING CHICK EMBRYO
Park, Jae-Jun ; Lee, Yong-Soon ; Ahn, Hee-Yul ;
Toxicological Research, volume 5, issue 2, 1989, Pages 167~171
Potential teratogenicity of sodium glycyrrizinate in developing chick embryo was investigated. Body length was shortened significantly by dosage related when compared to untreated and vehicle control, but there was no significant difference on body weight, hind-limb length, claw length in all of the groups.