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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Korean Society of Toxicology
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Volume & Issues
Volume 7, Issue 2 - Dec 1991
Volume 7, Issue 1 - Jun 1991
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RECENT ADVANCES IN HEPATOTOXICITY STUDIES
Satoh, Tetsuo ;
Toxicological Research, volume 7, issue 2, 1991, Pages 113~128
Hepatotoxicity has many facets. Those to be discussed in this review include the mechanism for the hepatotoxic effects, nature of the injury, and animal models of hepatotoxicity suitable for the detection of chemical injury. Some therapeutic drugs used for treatment of hepatitis are also presented. In addition, as an important and serious problem in future, alternative toxicity testing is discussed.
PREVENTIVE EFFECTS OF RED GINSENG SAPONIN ON HYPERKERATOSIS: ULTRASTRUCTURAL OBSERVATION AND LIPID ANALYSIS
Kim, Hyeyoung ;
Toxicological Research, volume 7, issue 2, 1991, Pages 129~139
Preventive effect of red ginseng saponin on experimentally-induced hyperkeratosis was investigated by ultrastructural observation, skin weight and epidermal lipid analysis. Hexadecane increased skin weight per unit area and epidermal lipids, free fatty acids, cholesterol and triglyceride in guinea pig skin. Topical application of ginseng saponin reduced these hyperkeratotic responses regradless of the concentration and the purity of ginseng saponin. Ultrastructurally, lipids and empty space-containing multiple horny cells were piled and nuclear remnants, desmosome, desmosomal bodies, tight junction were shown in the stratum corneum of hexadecane-treated skin,
PROTECTIVE EFFECT OF SELENIUM ON GLUTATHIONE METABOLISM BY MERCURY TOXICITY IN THE CHO CELLS
Byun, Boo-Hyung ; Cho, Su-Jung ; Chung, An-Sik ;
Toxicological Research, volume 7, issue 2, 1991, Pages 141~149
The treatment with 5ng/ml of mercuric chloride caused time-dependent decreases, and in the activities of GSH S-transferase and GSH-peroxidase, and in the concentration of GSH in CHO cells. Three hours after treatment of
, the activity of GSH S-transferase was decreased to almost half value of control group and the activity of GSH-peroxidase was reduced significantly at 6 hr after treatment. The concentration of GSH was decreased 2 hr after treatment of
and was decreased to nearly half value of control group 3 hr after treatment.
ASSAY OF POTENTIAL ANTIMUTAGENICITY OF ETHNIC MEDICINAL PLANT EXTRACTS OF PAPUA NEW GUINEA BY USING SOS CHROMOTEST (E. coLi PQ 37)
K. Sundarrao ; Jeho Yum ; Chang, Il-Moo ;
Toxicological Research, volume 7, issue 2, 1991, Pages 151~155
Thirty six crude drug samples have been prepared from different parts of twenty five plants belonging to different families, and antimutangenic activities were studied by using SOS chromotest (E. coli PQ 37). The following crude extracts of PNG medicinal plants which had a appreciable antimutagenic activity against mitomycin C were: Artocarpus communis (stem bark), Cycas circinalis (leaves), Merremia peltata (leaves), Intsia palembanica (leaves), Annona muricata (stem bark), and Artocarpus altilis (root bark).
CYTOTOXICITY OF PATULIN AND ITS EFFECT ON THE LAMBDA DNA CLEAVAGE BY RESTRICTION ENDONUCLEASE
Lee, Kil-Soo ;
Toxicological Research, volume 7, issue 2, 1991, Pages 157~163
The effect of patulin, a mycotoxin, on the growth of Escherichia coli cell was investigated. E. coli cell elongation usually shown in SOS-response for DNA repair was induced by 20 mg of patulin per ml. After staining the E. coli chromosome with fluorescence dye(DAPI, 4', 6-diamino-2-phenyl-indole), chromosomal DNA partitioning was not affected by patulin. The observation indicateds that patulin acts as a DNA damaging agent which is effective for E. coli cell elongation introduced by the inhibition of septum formation.
육체운동이 사염화탄소의 간독성에 미치는 영향
Toxicological Research, volume 7, issue 2, 1991, Pages 165~171
Effects of forced physical exercise on the CCl4 hepatotoxicity were examined in adult female rats. Rats were treated with CCl4 (2 mmol/kg, ip) and introduced into a cylindrical cage rotating at 9 rpm for 20 min/hr for 6 hr. Eighteen hr following the termination of exercise serum sorbitol dehydrogenase (SDH), glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT) activities and glucose-6-phosphatase activity were determined as parameters for hepatotoxicity. Physical exercise inhibited the
induced increases in SDH, GOT, GPT activity, and glucose-6-phosphatase activity were determined as parameters for hepatotoxicity.
A STUDY ON MEMBRANE TRANSPORT OF BRAZILIN USING PRIMARY CULTURED RAT HEPATOCYTES
Moon, Chang-Kiu ; Park, Kwang-Sik ; Kim, Seonh-Gon ; Moon, Chang-Hyun ;
Toxicological Research, volume 7, issue 2, 1991, Pages 173~181
Membrane transport of brazilin was investigated i primary cultured rat hepatocytes. Brazilin was transported into hepatocytes very slowly and reached plateau at about 60 minutes. Saturation of transport process was not observed and the transport was not affected by ouabain, metabolic inhibitors, and its structural analog. The amount of brazilin transported into hepatocytes was decreased when the environmental temperature was decreased. These results suggest that brazilin might be transported into hepatocytes by simple diffusional process.
In vitro 계에서의 Streptozotocin 분해 및 세포내 흡수
Toxicological Research, volume 7, issue 2, 1991, Pages 183~189
Since streptozotocin has been known to be chemically stable only under acidic condition(pH 4), the spontaneous degradation and cellular uptake of streprozotocin in neutral incubation medium was determined by chemical assay. Streptozotocin levels in both phosphate buffered saline (pH 7.4) and Krebs-Henseleit buffer (pH 7.4) decreased with a half life of about 2 hours. The presence of erythrocytes or pepatocytes under the same buffers did not affect the streptozotocin degradation rate at all. However, streptozotocin levels in plasma isolated from rats decreased rapidly compared to those in neutral buffers.
PULMONARY XENOBIOTIC CONJUGATION IN THE ISOLATED PURFUSED RABBIT LUNG AND IN VITRO: EFFECT OF ETHANOL
Yang, C.Mierha ; Carlson, Gary P. ;
Toxicological Research, volume 7, issue 2, 1991, Pages 191~208
Pulmonary conjugation pathways may be important for the metabolism of xenobiotics introduced via airways of systemically. The objective of this study was to determine the pulmonary conjugating capacity in both the isolated perfused rabbit lung (IPRL) and in vitro, and the ability of ethanol to alter the above. The IPRL was capable of conjugating glutathione (GSH) with either 1-chloro-2,4-dinitrobenzene (CDNB) of 1,2-epoxy-(p-nitrophenoxy) propane(ENP). The pulmonary GSH conjugation with ENP was inhibited by cibacron blue, indicating the presence of glutathione-S-transferase (GST) u and/or classes, but it was not altered by buthionine sulfoximine, a selective inhibitor of Gamma-glutamylcysteine synthetase.
MOLECULAR CONTROLS OF EPIDERMAL GROWTH AND DIFFERENTIATION: TRANSFORMING GROWTH FACTORE
Son, Youngsook ; Fuchs, Elaine ;
Toxicological Research, volume 7, issue 2, 1991, Pages 209~229
In the epidermis of skin, a fine balance exists between proliferating progenitor cells and terminally differentiating cells. We examined the effects of TGF-betas and retinoic acid (RA) on controlling this balance in normal human epidermal keratinocytes cultured under conditions where most morphological and biochemical features of epidermis in vivo are retained. Our results revealed marked and pleiotropic effects of both TGF-beta and RA on kerationcytes. In contrast to retinoids, TGF-betas acted on mitotically active basal cells to retard cell proliferation.
BIOACTIVATION OF DIBROMOETHANE BY CONJUGATION WITH GLUTAHIONE
Kim, Dong-Hyun ;
Toxicological Research, volume 7, issue 2, 1991, Pages 231~238
The pesticide and carcinogen ethylene dibromide(EDB) is metabolized both by cytosolic GSH S-transferase and by microsomal mixed function oxygenase. Cytochrome P-450 IIE1 appears to be major enzyme to metabolize EDB.EDB is activated to a mutagen by enzymatic conjugation with glutathione (GSH). Such activation is an exception to the general mode of detoxification via GSH S-transferase action. The primary DNA adduct (>95) is S-[2-(N7-guanyl)ethyl] GSH and a minor adduct is S-[2-(N7-guanyl)ethyl]cysteine, which is excreted in the urine and may serve as a biomarker of damage.
ANTAGONISTIC EFFECTS OF INTERFERONS (INFs) AND SODIUM ORTHOVANADATE ON RESPONSES PRODUCED BY TCDD IN SEVERAL CULTURE SYSTEMS
Kim, Hwan-Mook ;
Toxicological Research, volume 7, issue 2, 1991, Pages 239~255
Several types of IFNs were tested for their ability to suppress TCDD-inducible P-450 dependent mixed function oxidase (MFO) system in mouse primary hepatocytes. Mouse IFN-gamma (IFN-G) markedly suppressed EROD activity when added at the same time as TCDD (10 nM). The antagonism of EROD activity by IFN-G exhibited both a dose-(10-100 U/ml) and time-depedence. In contrast, mouse IFN-A/B was only moderately suppressive and only at high concentrations (500 U/ml). Rat IFN-G was even more selective than mouse, wherase human IFN-G had no activity.
FACTORS TO BE CONSIDERED WHEN EVALUATION PRENATAL TOXICITY OF CHEMICALS
Toxicological Research, volume 7, issue 2, 1991, Pages 257~265