Go to the main menu
Skip to content
Go to bottom
REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 10, Issue 4 - Dec 2010
Volume 10, Issue 3 - Sep 2010
Volume 10, Issue 2 - Jun 2010
Volume 10, Issue 1 - Mar 2010
Selecting the target year
Effects of Vitex rotundifolia on radical scavenging and nitric oxide production
Choi, Jae-Ki ; Cha, Dong-Seok ; Lee, Yong-Jae ; Ko, Sung-Hoon ; Park, Ho-Jun ; Lee, Se-Yeoun ; Choi, Jae-Hyuk ; Jeon, Hoon ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 51~58
DOI : 10.3742/OPEM.2010.10.2.051
Vitex rotundifolia (V. rotundifolia) has been used for treating headache, dizziness, toothache and removal of fever as a traditional medicine in Korea. In the present study, we examined the antioxidant and anti-inflammatory activities of 85% methanol extract of V. rotundifolia. In various radical scavenging assays, V. rotundifolia exhibited strong scavenging effect on 1, 1-diphenyl-2-picrylhydrazyl free radical, superoxide radical, nitric oxide. To elucidate the anti-inflammatory properties of V. rotundifolia, we investigated the inhibition effects of nitric oxide production in IFN-gamma and LPS-stimulated mouse peritoneal macrophages. V. rotundifolia suppressed nitric oxide production, iNOS and COX-2 expression dose-dependently through suppression of NF-
activation without notable cytotoxicity. These findings mean that V. rotundifolia may be beneficial in oxidative stress-mediated inflammatory disorders.
Antihyperglycemic and lipid lowering effect of Tectona grandis in alloxan induced diabetic rats
Ghaisas, M.M. ; Navghare, V.V. ; Takawale, A.R. ; Zope, V.S. ; Tanwar, M.B. ; Phanse, M.A. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 59~65
DOI : 10.3742/OPEM.2010.10.2.059
In India, Tectona grandis is traditionally used in the treatment of diabetes mellitus and lipid disorder. In the present study, the antihyperglycemic and lipid lowering effect of ethanolic extract of bark of Tectona grandis (TG) was evaluated using alloxan induced diabetes in rats. Alloxan was given at the dose of 140 mg/kg, i.p. After induction of diabetes, TG was administered for 42 days p. o. and simultaneously different biochemical parameters like plasma glucose, liver glycogen content, serum triglyceride, cholesterol, LDL-cholesterol and HDL-cholesterol were estimated. Diabetic control showed significant increase (P < 0.01) in plasma glucose, serum triglyceride, cholesterol, LDL-cholesterol and significant decrease (P < 0.01) in serum HDL-cholesterol and liver glycogen content. Treatment with TG showed significant reduction (P < 0.01) in plasma glucose when compared with diabetic control. The elevated levels of serum triglyceride and cholesterol levels were significantly reduced (P < 0.01) by TG. TG treatment for 42 days showed significant decrease in serum LDL-cholesterol (P < 0.01) and significant increase in serum HDL-cholesterol level (P < 0.01). Moreover, diabetic control there was significant decrease in liver glycogen content which was significantly increased (P < 0.05) by treatment with TG. Hence, from the result obtained in the present study it can be concluded that Tectona grandis has the potential to treat diabetes condition and associated lipid disorder.
Toxicity studies on Trigonella foenum-graecum L. seeds used in spices and as a traditional remedy for diabetes
Al-Ashban, R.M. ; Abou-Shaaban, R.R. ; Shah, A.H. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 66~78
DOI : 10.3742/OPEM.2010.10.2.066
Acute (24 h) and chronic (90 days) oral toxicity studies on the ethanol extract of Trigonella foenumgraecum Leguminosae (L.) seeds were carried out. Acute dosages were 0.5, 1.0 and 3 g/kg while chronic dosage was 100 mg/kg per day of the extract. All morphological, biochemical, haematological and spermatogenic changes, in addition to mortality, body weight changes and any change in vital organs were recorded. Histopathological investigations were done on vital organs. Growth arrest in the treated animals was observed. The treated mice gained no significant weight during chronic treatment while there was a significant gain in body weight of the control group mice. Biochemical studies revealed a significant decrease in blood sugar levels of fenugreek treatment groups while haematological parameters remained comparable to the control. In the treatment, male group there was a significant decrease in weight of testes as compared to the control. There was a marginal weight gain in kidney weight of mice after chronic treatment as compared to the control. Fenugreek chronic treatment caused a highly significant spermatotoxic effects in male mice.
Hepatoprotective and antioxidant activity of the methanolic extract of Mucuna pruriens Bak. roots
Mujeeb, M. ; Bagri, P. ; Aeri, V. ; Khan, S.A. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 79~85
DOI : 10.3742/OPEM.2010.10.2.079
The methanolic extract of natural roots of Mucuna pruriens was screened for hepatoprotective and antioxidant effects in carbon tetrachloride (
) induced hepatotoxicity in Albino rats. The degree of protection was measured by estimating biochemical parameters like serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, total protein and level of serum bilirubin (both total and direct). The extract also reduced
induced lipid peroxidation both in-vitro and in-vivo. Hepatoprotective activity of methanolic extract at dose 300 mg/kg body weight, i.p., was comparable with standard drug Silymarin (25 mg/kg, i.p.). Furthermore, histopathological experiments were also carried out to support the study.
Central nervous system depressant effect of two spices ajowan (Carum copticum Karst.) and bay leaves (Cinnamomum tamala T.Nees.)
Rahman, T. ; Rahman, K.A. ; Rajia, S. ; Alamgir, M. ; Khan, Mahmud T.H. ; Choudhuri, M. Shahabuddin K. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 86~89
DOI : 10.3742/OPEM.2010.10.2.086
Two common Indian spices Carum copticum Karst (ajowan) and Cinnamomum tamala T.Nees. (bay leaves) has been investigated first time to report the activity on the central nervous system. Preliminary study of the hot water extract showed depressant activity on the hole board test as evidenced from the ambulation and head dipping scores. The extracts further quicken the onset and increased the duration of pentobarbital induced sleeping time.
Antidiabetic activity of Argyreia speciosa (sweet) (Burm.f.)Boj. in normoglycemic and Streptozotocin-induced diabetic rats
Habbu, P.V. ; Mahadevan, K.M. ; Kulkarni, V.H. ; Marietta, P. ; Pratap, V. ; Thippeswamy, B.S. ; Veerapur, V.P. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 90~102
DOI : 10.3742/OPEM.2010.10.2.090
Effect of ethanol (ASE) and water (ASW) extracts of Argyreia speciosa on blood glucose and lipid profile was investigated in normoglycemic and Streptozotocin (STZ)-induced diabetic animals. In oral glucose and sucrose tolerance test, treatment with ASE and ASW (100 and 200 mg/kg) and Glidenclamide (10 mg/kg) significantly improved the glucose and sucrose tolerance in normal animals. In addition, respective treatment for fifteen-day resulted in significant percentage reduction in serum glucose (SG) ie., 30.39% (lower dose of ASE) and 33.21% (higher dose of ASW). In standardized STZ (50 mg/kg, iv)-induced diabetic rats, a single dose of ASE and ASW treatment exhibited reduction in SG levels at different time intervals compared to basal levels. Administration of both the doses of ASE and ASW for fifteen-day days exhibited greater percentage reduction in glycemia (24.6%, 24.7%, 23.9% and 21.9% respectively) and also ameliorated restored to near normal value of all tested lipid parameters. Further, treatment also exhibited significantly improved glucose tolerance over the period of 120 min compared to diabetic control group. Eventhough treatment failed to increase serum insulin levels significantly but peripheral utilization of insulin was increased as evident by insulin tolerance test. Taken together, present study supports the traditional usage of title plant in the treatment of diabetes mellitus.
Seed extracts of a Bangladeshi medicinal plant Abrus precatorius L. show antifertility activity in female rats
Hannan, M.A. ; Hossain, M.A. ; Islam, M.T. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 103~110
DOI : 10.3742/OPEM.2010.10.2.103
The seed powder of Abrus precatorius L. has traditionally been used as oral contraceptive agent by the women in some rural areas in Bangladesh. The present study aimed to examine the antifertility activity of A. precatorius seed extracts in experimental female rats. Finely ground seeds were extracted with aqueous acetone followed by successive partitioning with n-hexane, ethyl acetate (EtOAc), methanol (MeOH) and water. Water suspended crude seed powder, organic fractions of acetone extract and a standard contraceptive drug (
) were separately administered orally to the female rats for 30 days. n-Hexane, EtOAc and MeOH solubles at the doses of 2, 4 and 6 mg/rat/day, respectively and crude seed powder at 100 mg/rat/day exhibited 100% antifertility activity with lowest levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH) and
-estradiol. Histological study of ovary and uterus of these rats exhibited reduced number of developing follicles and increased number of atretic follicles in the ovary, and fewer uterine glands with shrunken morphology, reduced endometrial height, poor vascularity and compact stroma in uterus. However, the activities of serum glutamate oxaloacetate transaminase and serum glutamate pyruvate transaminase and the body weight of the rats remained almost unaffected in all the seed extract treated rats compared to control. These results suggest that A. precatorius seed extracts reduced the levels of serum FSH, LH and
-estradiol probably by affecting hypothalamic-pituitary-gonadal axis. The reduced levels of these hormones might have affected the oestrous cycle, follicular development, and subsequently the establishment of pregnancy in treated rats.
Hepatoprotective activity of Nyctanthes arbor-tristis (l.)
Wagh, A.E. ; Yeotkar, U.S. ; Nimbhorker, M.G. ; Deshmukh, T.A. ; Patil, V.R. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 111~115
DOI : 10.3742/OPEM.2010.10.2.111
The flowers of Nyctanthes arbor-tristis Linn. of Oleaceae widely used in Ayurvedic system of medicine for the treatment of diuresis, liver disorder, spleen enlargement sciatica, bitter, stomachic, carminative and tonic to hair. The aim of the present study was to evaluate the alcoholic and aqueous extracts of the flowers of Nyctanthes arbor-tristis for hepatoprotective effect against carbontetrachloride induced liver damage in rats. Administration of alcoholic and aqueous extracts of the leaves of Nyctanthes arbor-tristis protect the liver from toxic effects of carbontetrachloride by reducing the elevated levels of Serum glutamate pyruvate transaminase, Serum glutamate oxaloacetate transaminase, Alkaline phosphatase and serum bilirubin. Results revealed that both the alcoholic and aqueous extracts showed significant hepatoprotective activity by reducing the elevated levels of biochemical parameters at a dose of 200 mg/kg body weight. The results were supported by histopathological studies of liver samples which showed regeneration of hepatocytes by the extracts.
The improving effects of Saengmaeksan on ulcerative colitis
Kim, Min-Cheol ; Kim, Su-Jin ; Choi, In-Young ; Ki, Ji-Ye ; Kim, Dae-Seung ; Jeon, Yong-Deok ; Bae, Go-Eun ; Choi, Sun-Kyung ; Jeong, Hyun-Ja ; Park, Yun-Jum ; Kim, Hyung-Min ; Um, Jae-Young ; Hong, Seung-Heon ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 116~122
DOI : 10.3742/OPEM.2010.10.2.116
Saengmaeksan (SMS) is a well known Korean traditional herbal prescription, which consists of 3 different herbs, Radix Ophiopogonis, Radix Ginseng, and Fructus Schisandrae. SMS has been commonly used in various disease including respiratory system and cardiovascular System in Korea. The objective of this study is to find out the improving effects of SMS against Dextran Sulfate Sodium (DSS)-induced ulcerative colitis. SMS reduced clinical signs of DSS-induced colitis, including body weight loss, shorten colon length, and increased disease activity index. The results showed that SMS significantly inhibited the activation of nuclear factor-
p65 in the colon tissues of DSS-treated mice. In addition, we observed that result showed that the levels of IL-6 in plasma were increased in DSS treated group compared to those of the normal group, but these increased levels were reduced by administration with SMS. Taken together, these findings suggest that SMS has improving effects on DSS-induced ulcerative colitis, which may explain its beneficial effect in the regulation of chronic intestinal inflammation.
Assessment of lactogenic potential of some traditional herbs
Raval, M.A. ; Patel, H.P. ; Mishra, S.H. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 123~133
DOI : 10.3742/OPEM.2010.10.2.123
The entire plant of Leptadenia reticulata (Asclepidaceae) is extensively used as lactogen, traditionally, in veterinary practice. The plants of Dregea volubilis and Pentatropis microphylla (Asclepidaceae) are now used as its substitute and sometimes replace the original drug as traditional lactogen. The lactogenic potential of these drugs was studied in rats using, pup weight, weight of mother, parenchyma percentage, secretary rating, estimation of total protein content and glycogen content of mammary glands tissues as assessment parameters. HPTLC profiles of bioactive extracts were also generated to serve the authentification needs. The results of present studies show that P.microphylla forms a better substitute over D. volubilis.
Dolichos biflorus Linn attenuate progression of renal damage in alloxan-induced diabetic rats
Chidrewar, G.U. ; Mane, V.S. ; Ghaisas, M.M. ; Deshpande, A.D. ;
Oriental Pharmacy and Experimental Medicine, volume 10, issue 2, 2010, Pages 134~140
DOI : 10.3742/OPEM.2010.10.2.134
Dolichos biflorus Linn. (Fabaceae), commonly known as Horse gram is a medicinal plant, used in folk medicine for treating kidney stones and diabetes mellitus. The purpose of the present study was to investigate the effects of daily oral feeding of various doses of methanolic extract of Dolichos biflorus seeds (DB) for 42 days on blood glucose concentrations and kidney functions in Alloxan-diabetic rats. Plasma glucose levels, body weight, serum creatinine, and urinary albumin levels were monitored on
day. Renal hypertrophy was assessed as the ratio between the kidney weight and body weight of the rats. Plasma glucose concentrations in Alloxan-diabetic rats were significantly reduced by the administration of DB (350 mg/kg) and DB (700 mg/kg) on day 15 and onwards (P < 0.01). After 15 days of Alloxan administration urinary albumin levels (UAE) were over 5 fold higher in diabetic controls as compared to normal controls. Treatment with DB significantly prevented the rise in UAE levels from day 15 to 43 in comparison to diabetic controls (P < 0.01). Renal hypertrophy was significantly higher in diabetic controls as compared to non-diabetic controls. Treatments with DB (350 mg/kg) and DB (700 mg/kg) significantly prevented renal hypertrophy (P < 0.01) as compared to diabetic controls. DB (175 mg/kg) failed to modify renal hypertrophy. Thus the present study indicates that methanolic extract of Dolichos biflorus may be useful in management of hyperglycemia and kidney functions in Alloxan-diabetic rats.