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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 3, Issue 4 - Dec 2003
Volume 3, Issue 3 - Sep 2003
Volume 3, Issue 2 - May 2003
Volume 3, Issue 1 - Feb 2003
Selecting the target year
Inhibitory effects of Korean plant resources on human immunodeficiency virus type 1 protease activity
Park, Jong-Cheol ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 1~7
DOI : 10.3742/OPEM.2003.3.1.001
Some Korean plants were found to inhibit HIV-1 protease activity. The extracts of Acanthopanax koreanum (stem bark), Berchemia berchemiaefolia (stem), Berchemia berchemiaefolia (bark), Distylium racemosum (leaves), Distylium racemosum (stem), Lindera erythrocarpa (leaves), Physalis alkekengi var. francheti (root), Platycarya strobilacea (stem), Rodiola rosea (root), Rosa davurica (stem), Syringa dilatata (leaves), Viburnum awabuki (stem) and Viburnum awabuki (leaves) showed significant inhibitory effect against HIV-1 protease. Camelliatannin H from Camellia japonica and uvaol from Cratagus pinatrifida were potent active inhibitors of HIV-1 protease with
, respectively. The cure and prevention of AIDS have been a global challenge since it was discovered in the ealy 1980s. However, the development of anti-HIV agent that can effectively treat or prevent this disease are still demanded.
Neuropharmacological study of some Ayurvedic medicinal plants
Hannan, JMA ; Shahriar, Masum ; Islam, M Naimul ; Sattar, Mafruhi ; Haque, Sabera ; Choudhuri, MSK ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 8~17
DOI : 10.3742/OPEM.2003.3.1.008
Water extract (kwath) of six different widely used Ayurvedic medicinal plants were tested in mice for possible neuropharmacological efficacy. In the present experiments it was observed that a number of plant tested causes a significant level of Central Nervous System (CNS) depression, in that it significantly decreased the spontaneous Motor activity, and also lowered the exploratory behavior of the treated animals. Terminalia chebula (HAA), Terminalia bellerica (BHA), Emblica officinalis (AA), Piper longum 1. (PP). exhibited depressant action of on the CNS. Apart from them a mild to moderate degree of depression was evident as a consequence of administration of Zingiber officinale Rosc (SUT), Piper nigrum L. (MRC). However, none of the plant tested did not exhibit significant effects on pentobarbital induced narcosis, and this indicated that the sedating effects of the drug was not associated with the risk of fatal consequences on overdose.
Highly purified chitosan reduce blood alcohol concentration, aspartate aminotransferase, and alanine aminotransferase levels in human
Chung, Hwan-Suck ; Koo, Hyun-Na ; Moon, Young-Hoe ; Kim, Hyung-Min ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 18~20
DOI : 10.3742/OPEM.2003.3.1.018
The purpose of this study was to examine the effect of supplementary highly purified chitosan (HPC) on blood alcohol concentration in healthy human. The human study was performed with two sections. Each section of the study was conducted by two-phase cross-over design with a week wash-out period. All volunteers took HPC in one phase, and took a placebo in the next phase. Blood alcohol concentrations were different between in those taking HPC and in those taking the placebo in the human. And the concentration of serum aspartate aminotransferase (AST, GOT) and alanine aminotransferase (ALT, GPT), the indicator of liver cell damage, was lowered in those taking HPC, compared to those taking the placebo. In conclusion, taking HPC prior to drinking alcohol can somewhat reduce alcohol concentration in human blood and liver cell damage.
Pharmacological study of 'treenoponchomul'-an Ayurvedic diuretic preparation
Haque, Sabera ; Hannan, JMA ; Shahriar, Masum ; Islam, M Naimul ; Sattar, Mafruhi ; Choudhuri, MSK ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 21~28
DOI : 10.3742/OPEM.2003.3.1.021
The pharmacological effects of an Ayurvedic diuretic drug 'Treenoponchomul' (TPM) was investigated in animal model. The pharmacological actions of the test drug along with that of the components thereof, on the Central Nervous System (CNS) were studied. The drug under study TPM showed little effect on the CNS, the same can not be said about the components. The most prominent CNS depressant effect was observed with Saccharum officinarum Linn. (EE) in that it lowered the spontaneous motor activity as well the exploratory -behavior of the animals. An exploration retarding effect of moderate degree, was evident with Imperata cylindrica Beauv. (UU), and Phragmites maxima Blatter & McCann (NN). Although the test drug did not alter the normal locomotor and/ or exploratory behavior of the treated animals, it did significantly (p<0.01) lower the locomotion of the amphetamine induced hyperactive animals. TPM along with its components (especially Desmostachya bipinnata Stapf. Root, KU), significantly reduced the gastro-intestinal motility of the treated animals (p<0.01). The test drug and its components lowered the body weight of the treated animals, on being administered chronically (30 days), with EE being the only exception.
Reductive effect of body weight in rats fed a high-fat diet by Sense-line
An, Hyo-Jin ; Chung, Hwan-Suck ; Jeong, Hyun-Ja ; Lee, Soon-Ah ; Kim, Hyung-Min ; Baek, Seung-Hwa ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 29~33
DOI : 10.3742/OPEM.2003.3.1.029
Sense-line (SL), a dietary functional food, is our invention for weight loss. To evaluate such an effect of SL, we analyzed the plasma levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and weight changes after rats were fed on high fat diet with SL for 20 days. Plasma total cholesterol level and LDL-cholesterol level was decreased by 52% and 91.89% in 5% SL treated group and by 13% and 51.45% in 10% SL treated group, respectively. But HDL-cholesterol was not changed. In addition, the weight was significantly lower in SL group than in high-fat diet group (P<0.05). Our findings indicate that SL may contain compounds with actions, which can treat blood circulatory trouble as well as overweight.
Immune-enhancement effect of JaSaengHwan
Shin, Hye-Young ; Koo, Hyun-Na ; Hong, Seung-Heon ; An, Hyo-Jin ; Kim, Hyung-Min ; Shin, Tae-Yong ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 34~39
DOI : 10.3742/OPEM.2003.3.1.034
We investigated the immune enhancement effects of JaSaengHwan (JSH). The forced swimming test (FST) has been used as a screening model for new immune enhancement agents. We found that JSH (0.1 mg/ml) significantly reduced the immobility time in the FST compared to the control. Also, we investigated the effect of JSH on the proliferation of T cell and production of cytokines in human T-cell line, MOLT-4 cells and mouse peritoneal macrophages. JSH (1 mg/ml) significantly increased the cell proliferation by
(p<0.05) and also significantly increased the interleukin (IL)-2, IL-4 and interferon
production compared with media control (about 2-fold for IL-2, 3-fold for IL-4 and 1.5-fold for
, p<0.05) at 24 h. In addition, JSH increased the production of IL-12 on the mouse peritoneal macrophages (by 3.6-fold for IL-12, p<0.05). In conclusion, these data indicate that JSH may have an immune-enhancement effect.
Effect of Bamboo salt-pro on carries-inducing properties of Streptococcus mutans
Shin, Hye-Young ; You, Hyeon-Hee ; Shin, Tae-Yong ; Kim, Hyung-Min ; You, Yong-Ouk ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 40~45
DOI : 10.3742/OPEM.2003.3.1.040
We studied the effect of Bamboo salt-pro on the growth and acid production of S. mutans. The growth of S.mutans was reduced by the presence of the Bamboo salt-pro (1 mg/ml) and NaCl (1 mg/ml) significantly, and the positive control group (1 % of NaF) also exhibited antibacterial activity significantly. Bamboo salt-pro (1 mg/ml) reduced the rate of acid production by S. mutans. Bamboo salt alone did not demonstrate such a reduction in acid production at the concentration of 1 mg/ml. The inhibitory action of Bamboo salt-pro on acid production was found at a concentration of 1 mg/ml, but bamboo salt alone was not at a concentration of 1 mg/ml. In addition, we investigated the anti-inflammatory effect of Bamboo salt-pro on human mast cell line HMC-1. Bamboo salt-pro (0.1 and 0.01 mg/ml) inhibited significantly the secretion of inflammatory cytokine, tumor necrosis factor-a with
respectively. Our results suggest that Bamboo salt-pro importantly contributes to the prevention or treatment of periodontitis and other oral diseases and inflammatory diseases.
Action of enzyme food, Green Life Enzyme on systemic and local anaphylaxis
Moon, Phil-Dong ; Na, Ho-Jeong ; Kim, Hyung-Min ;
Oriental Pharmacy and Experimental Medicine, volume 3, issue 1, 2003, Pages 46~50
DOI : 10.3742/OPEM.2003.3.1.046
We studied the inhibitory effect of Green Life Enzyme (GLE) on compound 48/80-induced anaphylactic response in a murine model. GLE inhibited compound 48/80-induced systemic anaphylactic shock at the dose of 10 g/kg by 87.5%. When GLE was given as pre-treatment at concentrations ranging from 0.01 to 1.0 g/kg, it inhibited passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE. In addition, GLE (0.1 mg/ml) inhibited anti-DNP IgE-induced tumor necrosis
production from mast cells by 69% compared to saline value. These results indicate that GLE may possess anti-anaphylactic and anti-inflammatory activity.