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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 5, Issue 4 - Dec 2005
Volume 5, Issue 3 - Sep 2005
Volume 5, Issue 2 - Jun 2005
Volume 5, Issue 1 - Mar 2005
Selecting the target year
Can herbal drug(s) meet the challenges of genomewide screen results on rheumatoid arthritis
Paul, Bholanath ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 251~261
DOI : 10.3742/OPEM.2005.5.4.251
Rheumatoid arthritis (RA) is an autoimmune/inflammatory disorder with a complex genetic component. RA is characterized by chronic inflammation of the synovial membrane in the joint, which leads to the progressive destruction of articular cartilage, ligament and bone. Several cytokines such as tumor necrosis
and interleukin-6 (IL-6) have been implicated in the pathological mechanisms of synovial tissue proliferation, joint destruction and programmed cell death in rheumatoid joint. Genome wide screening of subjects suffering from autoimmune diseases especially arthritis revealed linkage to inflammatory molecules like
and IL-6, inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), nuclear factor-kappaB
and human leucocyte antigen/major histocompatibility complex (HLA/MHC) locus. The status of the pharmacological mechanism of herbal drugs in the light of genome wide screening results has been discussed to reinforce the therapeutic potential and the pharmacological basis of the herbal drugs.
Authentication and quality control of Cordyceps sinensis, a traditional Chinese medicine known as winter-worm summer-grass
Cheung, Jerry KH ; Li, Shao P ; Tsim, Karl WK ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 262~271
DOI : 10.3742/OPEM.2005.5.4.262
Cordyceps, one of the most valued traditional Chinese medicines, consists of the dried fungus Cordyceps sinensis growing on the larva of caterpillar. It is also known as 'winter-worm and summer-grass' because of its appearance during different seasons. The parasitic complex of the fungus and the caterpillar is found in soil of a prairie at an elevation of 3,500 to 5,000 meters in northwestern part of China. According to Chinese medicinal theory, Cordyceps is used to replenish the kidney and soothe the lung, and indeed many clinical applications have been reported. The natural Cordyceps is rare and expensive on the local market, and therefore, several mycelial strains have been isolated from natural Cordyceps and manufactured in large quantities by fermentation technology, and they are commonly sold as health food products in Orient. The adulterants of Cordyceps are commonly found on the market, and therefore the authentication of these products has to be defined. Having the urgent need from current market, different chemical markers such as nucleoside, ergosterol, mannitol and polysaccharide are being used for quality control of Cordyceps. Unfortunately, these markers are far from optimization, and therefore extensive works are needed to define the pharmacological efficiency of these markers.
Therapeutic potentials and untoward effects of Piper betle and its quid
Rai, Sujay ; Mal, Mainak ; Wahile, Atul ; Mukherjee, Pulok K. ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 272~282
DOI : 10.3742/OPEM.2005.5.4.272
Piper betle Linn. (PB), which belongs to the family Piperaceae, is used traditionally in many Asian countries for treatment of a variety of aliments. It has also been used in Ayurveda and Unani systems of medicine. PB leaves are also used as a masticatory in the form of quid. The basic preparation of PB leaves for chewing purposes (PB quid) is known as Paan in India. It is recommended in ancient scripture of Ayurveda and is closely associated with Indian culture. PB is reported to have several therapeutic potentials as well as to produce some untoward effects. The review deals with phytoconstituents present, therapeutic potentials and untoward effects of PB.
DMNQ S-52, a new shikonin derivative, inhibits lymph node metastasis via inhibition of MMPs production
Lee, Soo-Jin ; Kim, Sung-Hoon ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 283~293
DOI : 10.3742/OPEM.2005.5.4.283
Our previous study showed that a novel synthetic shikonin derivative, 6-(1-hydroxyimino-4-methylpentyl)5,8-dimethyoxy 1,4-naphthoquinone S-52 (DMNQ S-52) induced apoptosis. In the present study, we investigated its anti-metastatic activities as compared with shikonin because DMNQ S-52 was synthesized for overcoming weak points of shikonin such as high toxicity, low solubility and deleterious effects. DMNQ S-52 showed the weaker cytotoxicity
against Lewis lung carcinoma (LLC) cells than that of shikonin
. DMNQ S-52, at non-toxic concentrations
, significantly inhibited the invasion and migration of LLC cells. DMNQ S-52 also significantly inhibited the production of MMP-9, MTl-MMP and uPAR. Moreover, daily i.p. administration of DMNQ S-52 at dose of 5 mg/kg in mice resulted in a potent inhibition of the primary tumor size of LLC in the lung as well as the metastasis of lymph nodes. These findings suggest that the DMNQ S-52 has therapeutic potential to inhibit metastasis via inhibition of MMP family and uPA/plasminogen system.
Anti-rheumatoidal effects of Uncaria Tomentosa and Maytenus by a prolonged application
Choi, In-Sook ; Yamashita, Takenori ; Nakamura, Takashi ; Maenaka, Toshihiro ; Hasegawa, Takeo ; Itokawa, Yuka ; Ishida, Torao ; Rhee, Juong-Gile ; Gu, Yeun-Hwa ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 294~300
DOI : 10.3742/OPEM.2005.5.4.294
Uncaria Tomentosa and Maytenus are known to have anti-inflammatory and anti-rheumatoidal effects after either a single application or application over a short-term period. We applied these natural products to Wister rats every day for two weeks and investigated the effects of this long-term application on inflammation. This was done by measuring footpad edema, which was induced by a locally injected carrageenan. There was a dramatic reduction in edema in both U. Tomentosa- and Maytenus-treated rats; furthermore, the reduction lasted as long as three days for rats treated with U. Tomentosa. When the Balb/C mice underwent similar treatment for one month, the level of IgM in the blood of U. Tomentosa-treated mice decreased while the level of IgG in Maytenus-treated mice increased. This suggests that the long lasting effects of U. Tomentosa may be related to a low level of IgM and the subclass switch from IgM to IgG. Since the anti-inflammatory effects of U. Tomentosa lasts for three days, it may prove useful in treating rheumatoid arthritis when applied for an extended period of time, especially since this product is known to have minimal side effects.
Anxiolytic activity of standardized extract of Korean ginseng - a study on exploratory behavior
Mohan, M ; Kasture, SB ; Balaraman, R ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 301~307
DOI : 10.3742/OPEM.2005.5.4.301
The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbal medicine. We investigated the standardized extract of Korean ginseng on animal models of anxiety based on exploratory behavior. Korean ginseng extract (KGE) (3, 10 and 30 mg/kg) was administered intra-peritoneally. The anxiolytic activity was studied using elevated plus maze (EPM) paradigm, light/dark apparatus (LDA), open field apparatus (OFA) and the hole board apparatus (HBA). Diazepam (1mg/kg) was used as a standard anxiolytic drug. In EPM, KGE (10 mg/kg) significantly (P < 0.05) increased the time spent in open arms and the number of entries in open arms. In LDA, KGE (10 mg/kg) increased the number of transitions. In OFA, KGE (3 and 10 mg/kg) significantly increased (P < 0.05) the number of squares traversed. In HBA the number of head pokes were significantly increased with KGE (3 and 10 mg/kg). KGE at all selected doses did not affect the motor coordination. Thus, the study suggests that saponin containing standardized Korean ginseng extract possess anxiolytic activity.
Effect of oil and aqueous extract of Neem (Azadirachta indica) seeds on growth of Aspergillus species and biosynthesis of aflatoxin
Rashid, Faraz ; Naaz, Farah ; Abdin, MZ ; Zafar, Shadab ; Javed, Saleem ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 308~315
DOI : 10.3742/OPEM.2005.5.4.308
Aflatoxin contamination is a major problem in several food crops. Aflatoxin, a mycotoxin, produced by Aspergillus flavus has gained immense concern in the scientific world because of its tremendous harmful effects. The study was focused to see the effect of oil and aqueous extract of neem (Azadirachta indica) seeds on the growth of Aspergillus and production of aflatoxin by the mold. Various amounts of neem oil
and aqueous extract of neem (5 - 50 mg/ml) were used both in the broth as well as the solid medium. Fungistatic (MIC) and minimal fungicidal concentrations (MFC) were found to be
respectively for neem seed oil. At the concentration of
neem oil and 5 mg/ml of aqueous extract, a significant decrease in the aflatoxin content was found in broth medium. Aflatoxin production was totally inhibited at
and 50 mg/ml for neem oil and aqueous extract of neem respectively, in both treatments. There was significant inhibition of mycelium dry weight by the neem seed oil. Mycelial growth was totally inhibited at
of neem seed oil concentration in broth, whereas it was not affected at all by aqueous extract. It can therefore be inferred that the oil and extract from the neem seed leads to inhibition of aflatoxin production while neem seed oil also significantly inhibits the mycelial growth. Neem seed oil thus can be used as potent, natural and easily available anti-aflatoxigenic agent.
In vitro antioxidant activity of various extracts of Aristolochia bracteolata leaves
Badami, Shrishailappa ; Jose, Christy K ; K, Choksi Rakshit Kumar ; Dongre, Santosh Kumar H ; PC, Jagadish ; B, Suresh ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 316~321
DOI : 10.3742/OPEM.2005.5.4.316
Aristolochia bracteolata is being used in traditional medicine for a variety of ailments. Three successive and two crude extracts of its leaves were subjected for in vitro antioxidant activity using seven different methods. The successive ethyl acetate and crude methanol extracts have shown potent antioxidant activity in ABTS method with
, respectively. The crude methanol and successive chloroform extracts have shown moderate antioxidant activity in scavenging of hydroxyl radical by p-NDA method. All the extracts have shown moderate to low antioxidant activity by other methods.
Antitumor and antioxidant activities of Bryonia laciniosa against Ehrlich's Ascites Carcinoma bearing Swiss albino mice
Sivakumar, T ; Kumar, R Sambath ; Perumal, P ; Vamsi, MLM ; Sivakumar, P ; Kanagasabai, R ; Baskaran, MV ; Karki, Subhas S ; Mazumder, UK ; Gupta, M ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 322~330
DOI : 10.3742/OPEM.2005.5.4.322
The plant Bryonia laciniosa (Family: Cucurbitaceae) has been indicated for the treatment of various diseases one among which is cancer. The purpose of this study was investigating experimentally the possible anti-tumor effect and antioxidant role of Bryonia laciniosa leaves in animal model. The methanol extract of Bryonia laciniosa (MEBL) administered at the doses of 62.5, 125 and 250 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of MEBL on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters (lipid peroxidation, antioxidant enzymes) were estimated. Treatment with MEBL decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of MEBL also decreases the levels of lipid peroxidation and increased the levels of glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT). The present work indicates that the methanol extract of Bryonia laciniosa exhibited significant antitumor and antioxidant activity in vivo.
Neuropharmacological screening of the methanolic extract of Hibiscus vitifolius flowers
Seethalakshmi, S ; Chamundeeswari, D ; Rani, S Jamuna ; Parvathavardhini, S ; Vasantha, J ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 331~335
DOI : 10.3742/OPEM.2005.5.4.331
The methanolic extract of Hibiscus vitifolius flowers (HVE), was evaluated for neurophamacological activities by carrying out rota rod, locomotor activity and traction performance in mice and swim endurance activity in rats in different dosages (10, 30 and 100mg/kg body weight). HVE showed a significant effect on central nervous system by increasing the time taken for rota rod, traction performance and locomotor activity while swimming time was found to be decreased when compared to normal control animals. These results suggest that HVE possess significant anxiolytic and anti depressant activity which may be attributed to the presence of flavonoid in HVE.
A relationship between Stroke and Sasang Constitution in Korean
Ko, Ho-Yeon ; Jun, Chan-Yong ; Park, Jong-Hyeong ; Yoon, Yoo-Sik ; Lee, Sun-Dong ; Han, Chang-Ho ; Jung, Woo-Sang ; Moon, Sang-Kwan ; Cho, Ki-Ho ; Ko, Seong-Gyu ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 336~346
DOI : 10.3742/OPEM.2005.5.4.336
Experts of Sasang Constitution Medicine of Traditional Korean Medicine have classified stroke patients with four types of Sasang constitutions in their clinical practice and some types of Sasang constitutions have been regarded as risk factors of stroke, but this is uncertain because there were no evidences by large scale of prospective studies. The purpose of this was to study the association between strokes and Sasang constitutions. Case-control study has been conducted to the patients admitted to the research hospitals. The patients were confirmed stroke by brain MRI or CT scans and recruited from May 2003 to August 2005. The subjects who met the requirement of inclusion and exclusion criteria were 108 patients as the cases and 107 as healthy controls. Data collection has been performed by the trained specialists majoring neurologists through interviews, physical examinations, and laboratory testes. No statistical significance was obtained between the strokes and Sasang constitutions, yet Taeumin, and Soyangin types showed a trend of increase in the incidence of strokes as compared with Soeumin. To acquire more concrete data on this theme, we need further and large scale of prospective researches.
Evaluation of some indigenous plant extracts for antiimplantation activity in albino rats
Pateel, Mallikarjun ; Sharanabasappa, Sharanabasappa ; Malashetty, Viajykumar B ; Patil, Saraswati B ; A, Veeranagoud ;
Oriental Pharmacy and Experimental Medicine, volume 5, issue 4, 2005, Pages 347~351
DOI : 10.3742/OPEM.2005.5.4.347
In the present investigation twelve indigenous medicinal plants have been screened for their antiimplantation activity in albino rats. The plant material was subjected for soxhlation successively and separately from non-polar solvents to polar solvents i.e., petroleum ether benzene and ethanol. Out of these three extracts the petroleum ether extract of seeds of Citrus medica, aerial part of Oxalis corniculata and Tinospora cardifolia have showed maximum antiimplantation activity. Ethanol extract of leaves of Cardiospermum helicacabum, roots of Echinops echinatus, leaves of Melia azedarach, seeds of Momordica charantia and bark of Terminalia bellirica have shown maximum antiimplantation activity amongst the three extracts of each plant material screened. Though all the three extracts of seeds of Annona squamosa and leaves of Zizyphus jujube screened for antiimplantation activity, no extract has showed any loss in implantation. The details of the results obtained are discussed.