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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 6, Issue 4 - Dec 2006
Volume 6, Issue 3 - Sep 2006
Volume 6, Issue 2 - Jun 2006
Volume 6, Issue 1 - Mar 2006
Selecting the target year
Kasture, Veena S ; Kasture, Sanjay B ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 253~263
DOI : 10.3742/OPEM.2006.6.4.253
The plant is used in India as well as several countries since several centuries for treating different types of ailments. The plant is an important constituent of the Ayurvedic Materia Medica and finds mention in several ancient texts including Caraka Sanhita (
century A.D.) and the Bhavprakasa (
century A.D.). The scientific studies on this plant have reported several activities of this plant. Though the plant has cardiotonic, vasoconstrictor, sedative, neuro-muscular blocking, and anticancer activities, it is more popular as memory enhancer. Traditionally, a poultice made of the boiled plant is placed on the chest in acute bronchitis and coughs of children. The plant contains saponins: bacosides A and B, hersaponin, sapogenins: bacogenin
stigmasterol, and flavonoids: luteolin and luteolin-7 glucoside, nicotine, brahmine, and herpestine. This review focuses on the scientific data published since 1931.
Occupational asthma and related respiratory diseases
Mahajan, Shailaja G ; Mehta, Anita A ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 264~273
DOI : 10.3742/OPEM.2006.6.4.264
Epidemiological evidences and clinical as well as experimental observations have suggested a link between asthma and occupations. This relationship also involves other aspects like nonimmunologic exposures in the environment that can increase the chance of developing work related asthma and respiratory diseases. The purpose of this pamphlet is to supply information of work related diseases, which will give patients suffering with asthma, an intelligent understanding of their disease, and thus stimulate their interest so that they will cooperate more readily with their allergist. Recognizing the symptoms, causes, risk factors, diagnosis and treatment is an important part of managing occupational asthma and related diseases, so that it helps in decline of this rapidly increasing prevalence throughout the world.
Effect of Allium sativum on cytochrome P450 and possible drug interactions
Janil, Ashutosh ; Mehta, Anita A ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 274~285
DOI : 10.3742/OPEM.2006.6.4.274
Allium sativum (Family Amaryllidaceae or Liliaceae) is used worldwide for various clinical uses like hypertension, cholesterol lowering effect, antiplatelets and fibrinolytic activity etc. Due to these common house hold uses of Allium sativum, as a herbal supplements, and failure of patients to inform their physician of the over-the-counter supplements they consume leads to drugnutrient interactions with components in herbal supplements. Today these types of interactions between a herbal supplement and clinically prescribed drugs are an increasing concern. In vitro studies indicated that garlic constituents modulated various CYP (cytochrome P450) enzymes. CYP 3A4 is abundantly present in human liver and small intestine and contributes to the metabolism of more than 50% of commonly used drugs including nifedipine, cyclosporine, erythromycin, midazolam, alprazolam, and triazolam. Extracts from fresh and aged garlic inhibited CYP 3A4 in human liver microsomes. The in vivo effects of garlic constituents are found to be species depended and the dosing regimen of garlic constituents appeared to influence the modulation of various CYP isoforms. Studies have indicated that the inhibition of various CYPs by organosulfur compounds from garlic was related to their structure also. Studies using in vitro, in vivo, animal and human models have indicated that various garlic constituents can be the substrates, inhibitors and or inducers of various CYP enzymes. The modulation of CYP enzyme activity and expression are dependent on the type and chemical structure of garlic constituents, dose regime, animal species and tissue, and source of garlic thus this review throws light on the possible herb drug interaction with the use of garlic.
Effects of Panax notoginseng, ginsenoside Rb1, and notoginsenoside R1 on proliferation of human breast carcinoma MCF-7 cells
Xie, Jing-Tian ; Aung, Han H ; Wang, Chong Zhi ; Mehendale, Sangeeta R ; McEntee, Eryn ; Wicks, Sheila ; Li, Jing ; Yuan, Chun-Su ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 286~292
DOI : 10.3742/OPEM.2006.6.4.286
In this study, we evaluated the antiproliferative effects of Panax notoginseng, ginsenoside Rb1, and notoginsenoside R1 in the human breast carcinoma MCF-7 cell line. Our results indicated that both Panax notoginseng radix extract (NRE) and Panax notoginseng rhizoma extract (NRhE) possess significant antiproliferative activities in MCF-7 cells. Compared to control group (100%), at the concentrations of 0.05, 0.5, and 1.0 mg/ml NRE, cell growth was concentration-dependently reduced to 81.0
6.1 (P < 0.01), 34.2
4.8 (P < 0.001), and 19.3
1.9 (P < 0.001), respectively. Similar results with NRhE at concentrations of 0.5 and 1.0 mg/ml were obtained in these MCF-7 cells. To identify the responsible chemical constituent, we tested the antiproliferation effects of two representative saponins, ginsenoside Rb1 and notoginsenoside R1, on the MCF-7 cells. The data showed that ginsenoside Rb1 was endowed with antiproliferative properties, while notoginsenoside R1 did not have an inhibitory effect in the concentrations tested. Our studies provided evidence that Panax notoginseng extracts and ginsenoside Rb1 may be beneficial, as adjuvants, in the treatment of human breast carcinoma.
Regions in China identification and quality control of radix Codonopsis by chemical fingerprint: Evaluation of lobetyolin from different cultivated
Chou, Gui X ; Gao, Qiu T ; Li, Jun ; Duan, Ran ; Cheung, Anna WH ; Chu, Glanice KY ; Jiang, Zhi Y ; Dong, Tina TX ; Tsim, Karl WK ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 293~299
DOI : 10.3742/OPEM.2006.6.4.293
By using high-performance liquid chromatography-photodiode array detection, a simple and accurate chromatographic fingerprint method was developed for the identification of Radix Codonopsis (roots of Codonopsis) from different sources. Eighteen herbs of Codonopsis at different habitats in China, including roots from Codonopsis pilosula, Codonopsis pilosula var. modesta and Codonopsis tangshen were analyzed by the fingerprint. The amount of lobetyolin was calibrated, which was found to be more consistent in roots of Codonopsis pilosula as compared to that of Codonopsis pilosula var. modesta and Codonopsis tangshen. Having the fingerprint results, hierarchical clustering analyses were performed to classify the eighteen herbs into three groups: Codonopsis pilosula, Codonopsis pilosula var. modesta and Codonopsis tangshen. This clustering analysis agrees very well with the pharmacognostic identification result, and which could be used as a tool in the quality control of Radix Codonopsis.
Pethidine induced changes in ovarian follicular kinetics and biochemical parameters in albino rats
Patil, Somanath Reddy ; Patil, Saraswati B ; Malashetty, Vijaykumar B ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 300~305
DOI : 10.3742/OPEM.2006.6.4.300
Pethidine at the dose level of 0.5 mg and 0.75 mg/100 g body weight administered for 20 days to the cycling albino rats caused decrease in the ovarian weight and its protein content. The ovarian folliculogenesis in treated rats is hampered; as a result the follicles which are at the different stages of growth underwent regression. Therefore, the number of healthy follicles is reduced and atretic follicles increased. The elevated levels of ovarian cholesterol and decreased level of glycogen in the pethidine treated rats indicates the inhibition brought in steroidogenesis, which is dependent on pituitary gonadotrophins.
Antibacterial potential of Clerodendrum inerme, crude extracts against some human pathogenic bacteria
Khan, Abdul Viqar ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 306~311
DOI : 10.3742/OPEM.2006.6.4.306
This communication emphasized upon the sensitivity of the crude extracts of clerodendrum inerme against some of the human pathogenic bacteria. Five plant extracts (Petrol, Benzene, Methanol, Ethly acetate and Aqueous) under six different concentrations(500
, 1 mg/ml, 2 mg/ml, 5 mg/ml, 10 mg/ml and 15 mg/ml) were tested by disk diffusion method. Methanol, Ethyl acetate and Aqueous extracts of the plant showed significant inhibition against fifteen of the eighteen bacteria tested. No earlier report on antibacterial activity of this taxon could be found in literature.
Association among apolipoprotein E gene polymorphism, diabetes mellitus, and ischemic cerebrovascular disease in Koreans
Kim, Do-Hwan ; Cho, Kwang-Ho ; Moon, Byung-Soon ; Son, Mu-Song ; Jeong, Se-Jin ; Lee, Hye-Jung ; Hong, Seung-Heon ; Kim, Hyung-Min ; Um, Jae-Young ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 312~318
DOI : 10.3742/OPEM.2006.6.4.312
The association between apolipoprotein E (apoE) gene polymorphism and ischemic cerebrovascular disease (ICVD) has been controversial. These controversies may be due to inaccurate classification of patients and ethnic differences. The aim of the present study was to assess the relationship between apoE gene polymorphism and the development of ICVD in a population from Korea. We investigated 136 patients with ICVD and 357 controls without ICVD. No differences in the apoE genotypes frequencies (
= 3.660, df = 5, P = 0.454) and even in the alleles frequencies (
= 1.946, df = 2, P = 0.378) were observed in the ICVD patients compared with that in controls. The data have been compared with data found in other population groups. However, the risk of ICVD associated with apoE
genotype was increased nearly 3-fold in subjects possessing the history of diabetes mellitus (OR 3.3, 95% CI 1.2-9.4, P = 0.026). We concluded that the apoE polymorphism is not associated with ICVD at least in the Korean population, but the apoE frequencies found in this study differ significantly from those obtained in Japanese.
Antioxidant and analgesic activity of Clerodendrum visconsum leaf
Rahman, Shafiur ; Sarder, Mokaddez ; Shilpi, Jamil Ahmad ; Hasan, Choudhury Mahmud ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 319~323
DOI : 10.3742/OPEM.2006.6.4.319
The crude ethanolic extract of the leaves of Clerodendrum viscosum (Family: Verbenaceae) was evaluated for its antioxidant and analgesic activities to investigate the scientific basis of the traditional uses. The antioxidant property of the extract was assessed by 1, 1-diphenyl -2- picryl hydrazyl (DPPH) free radical scavenging assay. The extract showed prominent antioxidant activity (
) which was comparable to standard drug ascorbic acid (
).The extract produced significant (P<0.001) writhing inhibition in acetic acid induced writhing in mice at the dose of 125 mg, 250 mg and 500 mg/kg body weight respectively, which were comparable to the standard drug diclofenac sodium. The results tend to suggest that the crude leaves extract at the above doses have antioxidant and analgesic activities and indicate that it might possess biologically active constituents having free radical scavenging and analgesic activities respectably.
Anti-allodynic effect of bee venom on neuropathic pain in the rat
Lee, Bae-Hwan ; Chae, Youn-Byoung ; Hwang, Hye-Jeong ; Choi, Young-Kook ; Hahm, Dae-Hyun ; Han, Seung-Moo ; Kang, Sung-Keel ; Lee, Hye-Jung ; Pyun, Kwang-Ho ; Shim, In-Sop ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 324~329
DOI : 10.3742/OPEM.2006.6.4.324
Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine if bee venom injection into acupoint ihibits neuropathic pain, which is difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanical and cold allodynia were tested in order to evaluate the antiallodynic effects of bee venom injection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodynia dose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanical and cold allodynia. These results suggest that bee venom-acupuncture as well as morphine is very effective to inhibit mechanical allodynia.
A study on clinical efficacy of Abutilon indicum in treatment of bronchial asthma
Paranjhape, Archana N ; Mehta, Anita A ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 330~335
DOI : 10.3742/OPEM.2006.6.4.330
The present investigation was carried out to determine the efficacy and safety of Abutilon indicum (A. indicum) (Eng: Country Mallow, Fam: Malvaceae) in patients of bronchial asthma. Dried aerial parts of A. indicum were finely powdered and given in the dose of 1 gm tid to 30 patients of either sex in the range of 15 - 80 years with mild to moderate bronchial asthma with or without any concurrent medication. The respiratory functions (FVC,
and MVV) were assessed using a spirometer prior to and after 4 weeks of treatment. Efficacy of the drug in improving clinical symptoms and severity of asthmatic attacks was evaluated by interviewing the patient and by physical and hematological examination at the end of the treatment. 4 weeks treatment with the drug showed statistically significant improvement in various parameters of pulmonary functions in asthmatic subjects. Also significant improvement was observed in clinical symptoms and severity of asthmatic attacks. None of the patient showed any adverse effect with A. indicum. The results of the present study suggest the usefulness of A. indicum in patients with mild to moderate bronchial asthma.
Effect of Berberis tinctoria leaf (Berberidaceae) extract on antidiabetic, antihyperlipidemic and antioxidant status in streptozotocin induced diabetes in rats
Murugesh, K ; Yeligar, Veerendra C ; Dash, Deepak Kumar ; Maiti, BC ; Maity, Tapan K ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 336~343
DOI : 10.3742/OPEM.2006.6.4.336
The present study was carried out to investigate the antidiabetic and antioxidant effect of methanolic extract of Berberis tinctoria leaves (MEBT), in streptozotocin induced diabetic rats. Oral administration of MEBT extract (150 mg/kg and 300 mg/kg) for a period of 14 days. Blood glucose levels, body weight food and liquid intake were measured on every
day over a period of 14 days. In diabetic rats, MEBT at the dose of 150 mg/kg and 300 mg/kg body weight resulted in significant reduction in blood glucose levels. The study was further investigated to determine antioxidant and antihyperlipidemic potential of MEBT in streptozotocin (STZ) induced diabetic rats. These results suggest that the MEBT possess antidiabetic activity and is able to ameliorate biochemical damages in STZ induced diabetic rats and the results were found to be in a dose dependent manner.
Antinociceptive and sedative effects of the bark of Cerbera odollam Gaertn.
Ahmed, Firoj ; Hossain, M Hemayet ; Rahman, Ahmed Ayedur ; Shahid, Israt Zahan ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 344~348
DOI : 10.3742/OPEM.2006.6.4.344
The crude methanolic extract of the bark of Cerbera odollam Gaertn. was evaluated for its possible antinociceptive and neuropharmacological activities in animal models. At the dose of 250 and 500 mg/kg body weight, the extract showed a significant antinociceptive effect in acetic acid induced writhing in mice comparable to that produced by aspirin, used as standard drug (P<0.001). The extract significantly reduced the time of onset of sleep (P<0.01) and potentiated the pentobarbital induced sleeping time in mice at the dose of 400 mg/kg of body weight significantly (P<0.001). It also decreased the open field score in open field test significantly at the dose of 400 mg/kg of body weight (P < 0.05). The obtained results tend to suggest the probable antinociceptive and neuropharmacological activities of the crude extract.
Analgesic activity of three Channa spp. fish extracts
Solihah, MH ; Israf, DA ; Zuraini, A ; Arifah, AK ; Zakaria, MS ; Zakaria, ZA ; Sulaiman, MR ; Jais, AM Mat ; Somchit, N ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 349~354
DOI : 10.3742/OPEM.2006.6.4.349
In the present study, three Malaysian Channa spp. fish Channa striatus, Channa micropeltes and Channa lucius were assessed for their analgesic activity. Distilled water and mixture of chloroform: methanol were used for extraction. The analgesic or antinociceptive activity was investigated by abdominal writhing and hot plate test. The water extract of Channa striatus and the chloroform: methanol extract Channa lucius produced potent antinociceptive effect when assessed with the abdominal writhing test. The activity was compared to morphine where the activity of the extracts was less potent than the opioid. In the hote plate test, water extract of Channa striatus revealed significant activity and chloroform:methanol extract of Channa micropeltes had moderate activity. However, these activities were statistically lower than morphine. Collectively, this study also showed that Channa striatus extract was more potent analgesic agent when compared to the other closely related snakehead Channa micropeltes and Channa lucius.
Antioxidant, antinociceptive activity and general toxicity study of Dendrophthoe falcata and isolation of quercitrin as the major component
Hasan, Md Shihab ; Ahmed, Md Iqbal ; Mondal, Sukla ; Masud, Mohammad Methedi ; Sadhu, Samir Kumar ; Ishibashi, Masami ; Uddin, Shaikh Jamal ;
Oriental Pharmacy and Experimental Medicine, volume 6, issue 4, 2006, Pages 355~360
DOI : 10.3742/OPEM.2006.6.4.355
Plants have been used in traditional medicinal system for centuries. Bangladeshi medicinal plants have received considerable attention from the researchers for evaluation of their bioactivity. As a part of our ongoing research of screening the Bangladeshi medicinal plants, the ethanolic extract of Dendrophthoe falcata have been chosen for the present study. The ethanolic extract of the leaves of the plant have been assessed for their antioxidant, antinociceptive, and general toxicity. The extract showed potent antioxidant activity (
) using DPPH radical scavenging assay, which is comparable to the standard ascorbic acid (
). The extract significantly and dose dependently inhibited the acetic acid induced writhing in mice (71.2%, P < 0.001 and 28.0%, P < 0.05 for 500 and 250 mg/kg body weight, respectively). A general toxicity was assessed by a simple and low cost assay using brine shrimp lethality as an indicator. The extract showed low level of toxicity (
). Using different chromatographic techniques, quercitrin (quercetin 3-O-
-rhamnoside) was separated as the major component from the extract. The structure was elucidated by detailed 1D and 2D NMR and mass spectral analysis.