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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 7, Issue 4 - Dec 2007
Volume 7, Issue 3 - Sep 2007
Volume 7, Issue 2 - Jun 2007
Volume 7, Issue 1 - Mar 2007
Selecting the target year
Oriental medicine mangifera indica
Rai, Sujay ; Basak, Souvik ; Mukherjee, Kakali ; Saha, BP ; Mukherjee, Pulok K ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 1~10
DOI : 10.3742/OPEM.2007.7.1.001
Mangifera indica Linn. (MI) (Family: Anacardiaceae) is commonly known worldwide as mango and ‘Aam’ in India. MI shares an important place in treatment of several diseases in various ancient system of medicine like Ayurveda and other Indian System of Medicine and some other Traditional Medicines world wide. Almost all the parts of MI have been used in oriental medicine, so in this review attempt has being made to review the history, traditional uses, phytoconstituents and therapeutic potentials of mango.
Pharmacological classification of herbal anti-asthmatics
Goyal, Bhoomika R ; Agrawal, Babita B ; Goyal, Ramesh K ; Mehta, Anita A ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 11~25
DOI : 10.3742/OPEM.2007.7.1.011
Bronchial asthma is a major public health problem worldwide and the morbidity and mortality of asthma have increased in last few decades. There is high prevalence of usage of alternative traditional system of medicines for the treatment of asthma. Large numbers of medicinal plant preparations have been reported to possess anti-asthmatic effects. Plant cells are now considered to be the chemical factories synthesizing a large variety of chemical compounds. Further, Ayurvedic system of medicine has an elaborate description of asthma from the earliest times describing it as 'Shwasa' meaning disease pertaining to breathing. This review classifies the antiasthmatics herbs based on the possible mechanism of action reported. Thus, these plants can be used to obtain a polyherbal formulation which contains various herbs acting at particular sites of the pathophysiological cascade of asthma for prophylaxis as well as for the treatment of asthma.
Genetic relationships and molecular authentication of plant origins and the commercial medicinal herbs in peony using RAPD markers
Bang, Kyong-Hwan ; Jung, Jin-Ho ; Kim, Ok-Tae ; Chung, Jong-Wook ; Ham, In-Hye ; Seong, Nak-Sul ; Luo, Rong ; Zhang, Gui-Jun ; Choi, Ho-Young ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 26~33
DOI : 10.3742/OPEM.2007.7.1.026
Genetic polymorphism and molecular authentication were investigated with the commercial medicinal herb, Peony (Paeonia spp.), using random amplified polymorphic DNA (RAPD) markers. To identify the polymorphism of the RAPD patterns among plant origins, 20 different random primers were applied to the genomic DNA extracted from Paeonia spp. plants such as Paeonia (P.) lactiflora, P. officinale and P. japonica. Ten primers out of 20 primers could be used to discriminate the plant species in the same genus and 72 out of 81 scored DNA fragments (88.9%) generated with these primers were polymorphic. Especially, four primers, such as OPA1, OPA3, OP9, and OPA13, were useful to discriminate the plant origins among the species of Peony. In the results of cluster analysis using RAPD data obtained from the 10 primers, Peony (Paeonia spp.) plants used in this study were grouped into the two distinctive clusters, genetically. Herb medicine, especially P. lactiflora, were easily identified, when species-specific primers were applied to the investigation for discriminating herb medicine currently traded in domestic herb market, Kyungdongmart. Consequently, RAPD analysis was useful method to discriminate plant origins and the commercial medicinal herbs, Paeonia spp..
Analgesic and antipyretic actions of Muntingia calabura leaves chloroform extract in animal models
Zakaria, ZA ; Kumar, G Hanan ; Zaid, Siti NH Mohd ; Ghani, Marwiza A ; Hassan, MH ; Hazalin, Nurul AMN ; Khamis, Mahirah M ; Devi, G Rathna ; Sulaiman, MR ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 34~40
DOI : 10.3742/OPEM.2007.7.1.034
The present study was carried out to elucidate the potential of Muntingia (M.) calabura leaves chloroform extract (MCCE) as antinociceptive, anti-inflammatory and antipyretic agents using various animal models. The dried powdered leaves of M. calabura (20 g) were soaked in chloroform for 72 h and the supernatant obtained was then evaporated to dryness. The crude dried extract (0.912 g), dissolved in dimethyl sulfoxide (1:20; w/v) and considered as a stock solution (100% concentration/strength), was then diluted to the concentrations of 10 and 50% and used together in all experimental models. The MCCE was found to show significant (P < 0.05) antinociceptive and antipyretic activities, but less remarkable anti-inflammatory activity. Only the antinociceptive activity of MCCE measured using the abdominal constriction test and in the first phase of the formalin test occurred in a concentration-dependent manner. The anti-inflammatory activity of 50 and 100% concentrations MCCE was observed only at the range of time interval of 60 - 120 and 60 min, respectively. Based on the results, we conclude that the M. calabura leaves chloroform extract possessed remarkable antinociceptive and antipyretic, but less effective anti-inflammatory, activities and thus justifies the Peruvian folklore claims of its medicinal values.
Anxiolytic effect of chronic ginseng treatment using elevated T-maze in mice
Mohan, M ; Kasture, SB ; Balaraman, R ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 41~45
DOI : 10.3742/OPEM.2007.7.1.041
The roots of the plant Korean ginseng have been extensively used in the traditional Chinese herbal medicine. The effects of chronic administration of Korean ginseng extract (KGE) were investigated on two different anxiety models: the elevated T-maze (for inhibitory avoidance and escape measurements) and the open field test (OFT). Diazepam (1 mg/kg), KGE (10, 30 and 100 mg/kg) were administered orally for 15 days. On the 14th day, mice were previously exposed for 30 min to one of the open arms of the T-maze, 24 h before the test. On 15th day, mice had two exposures to the enclosed and open arm of the elevated T-maze followed by exposure to the open field apparatus. The number of line crossings in the apparatus was used to assess locomotor changes. Cumulative Concentration Response Curve of 5-HT was plotted using rat fundus which were pre-treated in a similar way. Treatment with Diazepam (1 mg/kg) and KGE (10, 30 and 100 mg/kg) significantly (P < 0.05) impaired inhibitory avoidance performance but did not impair escape latency. In OFT, diazepam facilitated locomotion as compared to vehicle and other treatment groups. KGE at any of the selected doses did not impair locomotion. Concentration response curve of 5-HT was shifted towards the right with suppression of maxima in rats treated with KGE. The results suggest that KGE exerts anxiolytic like behaviour in a specific subset of defensive behaviour, particularly those related to generalized anxiety disorder.
Anticonvulsant potential of callus cultures of Convolvulus microphyllus Sieb.
Ahmad, Sayeed ; Zafar, Rasheed-Uz ; Shahid, Mohd ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 46~50
DOI : 10.3742/OPEM.2007.7.1.046
Callus cultures of Convolvulus microphyllus Sieb. was induced on Murashige and Skoog's medium supplemented with 2,4-dichloro phenoxy acetic acid, 6-benzyl adenine, indole acetic acid and kinetin (1 ppm each). Methanolic extracts of whole plant, leaf, stem and leaf and stem calli were tested for anticonvulsant activity against standard drug phenytoin using maximal electroshock model on mice. It was observed that the animals treated with methanolic extracts of stem callus, leaf callus and whole plant (200 mg/kg, oral) showed significant protection against tonic convulsions induced by transcorneal electroshock. Anticonvulsant activity of methanolic extract of stem callus was comparable to that of standard drug phenytoin.
In vitro and in vivo studies on theophylline mucoadhesive drug delivery system
Bandyopadhyay, AK ; Perumal, P ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 51~64
DOI : 10.3742/OPEM.2007.7.1.051
Mucus is an aqueous gel complex with a constitution of about 95% water, high molecular weight glycoprotein (mucin), lipid, salts etc. Mucus appears to represent a significant barrier to the absorption of some compounds. Natural mucoadhesive agent was isolated and purified from the aqueous extract of the seeds of prosopis pallida (PP). Formulated tablet with the isolated material by wet granulation method. Some natural edible substances are in consideration for candidates as mucoadhesive agents to claim more effective controlled drug delivery as an alternative to the currently used synthetic mucoadhesive polymers. Subjected the materials obtained from natural source i.e. PP and standard synthetic substance, sodium carboxymethyl cellulose for evaluation of mucoadhesive property by various in vitro and in vivo methods. Through standard dissolution test and a model developed with rabbit, evaluated in vitro controlled release and bioadhesive property of theophylline formulation. Mucoadhesive agent obtained from PP showed good mucoadhesive potential in the demonstrated in vitro and in viνo models. The results suggest that the mucoadhesive agent showed controlled release properties by their application, substantially. In order to assess the gastrointestinal transit time in vivo, a radio opaque X-ray study performed in healthy rabbit testing the same controlled release formulation with and without bioadhesive polymer. Plasma levels of theophylline determined by the HPLC method and those allowed correlations to the in vitro mucoadhesive study results. Better correlation found between the results in different models. PP may acts as a better natural mucoadhesive agent in the extended drug delivery system.
Antioxidant activity of water and alcohol extracts of Thuja orientalis leaves
Nizam, Iram ; Mushfiq, M ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 65~73
DOI : 10.3742/OPEM.2007.7.1.065
Water and alcohol extracts were prepared from dried and powdered leaves of Thuja orientalis (T. orientalis). The reducing power, total phenolic content, the 1,1-diphenyl-2-picrylhydrazyl scavenging activity, inhibitory effect on Fe (II)-EDTA-
(Fenton reaction system) induced DNA damage and inhibitory effect on human red blood cell (RBC) hemolysis were evaluated in the present study. At a concentration of 200 mg, water and alcohol extracts of T. orientalis inhibited the hydrolysis of DNA by 72.859% and 65.312%, respectively. Water and alcohol extracts of T. orientalis also inhibited 2,2'-Azobis(2-amidinopropane) dihydrochloride induced RBC hemolysis to the extent of 69.30% and 54.55%, respectively. The reducing power and antioxidative activity of water extract was found to be more than that of alcohol extract. This is attributable to the presence of higher amount of phenolic compounds in water extract. The present results indicate that the T. orientalis extracts are rich sources of natural antioxidants and can protect DNA and human red blood cells against free radical induced oxidative damage.
Hepatoprotective activity of methanol extracts of Glinus oppositifolius and Trianthema decandra against paracetamol induced liver damage
Gupta, M ; Mazumder, UK ; Haldar, PK ; Manikandan, L ; Senthilkumar, GP ; Kandar, CC ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 74~78
DOI : 10.3742/OPEM.2007.7.1.074
The plants, Trianthema decandra and Glinus oppositifolius are commonly used by tribal people in India for the treatment of liver diseases. Hepatoprotective activity of methanol extracts of Glinus oppositifolius and Trianthema decandra at the dose of 250 and 500 mg/kg body weight administered orally was evaluated against paracetamol induced liver damage in rats. Biochemical parameters such as serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, serum alkaline phosphatase, bilirubin, total serum protein, lipid peroxide and glutathione content of the liver were estimated to determine liver function and metabolism. From the biochemical observations, it was concluded that methanol extracts of Glinus oppositifolius and Trianthema decandra significantly restored the altered biochemical parameters towards normal condition in paracetamol induced liver damage.
Kinetics and diffusion studies in urease-alginate biocatalyst beads
Nakarani, Mukesh ; Kayastha, Arvind M ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 79~84
DOI : 10.3742/OPEM.2007.7.1.079
Urease was immobilized with calcium alginate by entrapment method in the form of spherical beads and stored in Tris/acetate buffer (pH 7.3) at
. Urease immobilized at different concentration of alginate beads (3%, 4% and 5%) showed higher apparent
values than the soluble urease. Furthermore,
has been shown to be corelated with effective diffusion coefficient (De) at different concentration of alginate gel. The present study showed that diffusion and reaction contribute to control the overall rate.
Antioxidant potentials of Hypericum hookerianum (Family: Hypericaceae) on CCl
induced hepatotoxicity in rats
Wahile, Atul ; Mukherjee, Kakali ; Kumar, Venkatesan ; Saha, Bishnu Pada ; Mukherjee, Pulok K ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 85~93
DOI : 10.3742/OPEM.2007.7.1.085
Free radicals are known to play important role in pathophysiology of hepatic disorders and antioxidants are employed along with other chemotherapeutic agents in treatment of such diseases. In search of natural antioxidant, successive extracts of Hypericum (H.) hookerianum (Family: Hypericaceae) were evaluated by in vitro and in vivo methods. Extracts of aerial parts of H. hookerianum were subjected for 1,1-diphenyl 2-picryl hydrazyl radical scavenging activity (DPPH assay), nitric oxide radicals scavenging assay and thiobarbituric acid reactive substances (TBARS) assay. Methanolic extract was found to be more active than other extracts in DPPH and in vitro TBARS assay with
respectively. While petroleum ether extract showed more potentials in scavenging the nitric oxide radicals with
. The administration of
to the control animals caused decrease in the level of catalase and superoxide dismutase, together with significant increase in the level of TBARS in liver and kidney. Reversal of these changes towards normal group was observed by administration of H. hookerianum methanolic extract at 50 and 100 mg/kg body weight, while other extracts were found to be less active.
Attenuation of streptozotocin mediated oxidative stress, hyperglycemia and toxicity in rats by treatment with B-20 drpos - a homoeopathic preparation
Pillai, KK ; Najmi, Abul K ; Anwer, Tarique ; Sultana, Yasmin ; Sharma, Manju ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 94~99
DOI : 10.3742/OPEM.2007.7.1.094
The present study is aimed at finding the effect of B-20 drops, a homoeopathic formulation, in streptozotocin (STZ) induced diabetic rats. B-20 drops comprises of the constituents derived from plants and other natural sources, and are generally prescribed by the homoeopathic physician, in cases of hyperglycemia and diabetes. The elevated levels of fasting blood glucose and pancreatic lipid peroxides observed in rats treated with STZ were significantly reduced by the treatment of B-20 drops. The reduced liver glycogen contents were also brought back to near normal level by B-20 drops treatment in STZ diabetic rats. STZ induced histopathological changes in pancreas and liver was also partially reversed by B-20 drops. The findings indicate that B-20 drops help in improving the glycogen stores in the liver and prevents STZ induced damage through free radicals by decreasing the pancreatic lipid peroxides levels.
Short Communication Antinociceptive activity of Avicennia officinalis
Shahid, IZ ; Karmakar, D ; Sadhu, SK ; Ahmed, F ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 1, 2007, Pages 100~102
DOI : 10.3742/OPEM.2007.7.1.100
The crude ethanol extract of leaves of Avicennia officinalis Linn. (Family: Avicenniaceae) was screened for its antinociceptive activity. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg body weight (P < 0.001) comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. The result tends to suggest the antinociceptive activity of the extract.