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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
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Volume & Issues
Volume 7, Issue 4 - Dec 2007
Volume 7, Issue 3 - Sep 2007
Volume 7, Issue 2 - Jun 2007
Volume 7, Issue 1 - Mar 2007
Selecting the target year
An introduction to the recently excavated Chunggang Medical Records and research on their medical value
Kim, Nam-Il ; Yun, Seng-Yick ; Hong, Sae-Young ; Ahn, Sang-Woo ; Cha, Wung-Seok ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 103~113
DOI : 10.3742/OPEM.2007.7.2.103
This study is a report on recently discovered medical records based on traditional medicine in the 1900s. First, the contents of the records and their significance are described in detail. Next, a simple example of the research follows, in order to explain the medical and historical significance the records contain and to answer the question of how this historical document can contribute to future medical and historical studies. The documents dealt with in this study, the Chunggang Medical Records, are medical records compiled by a Korean doctor of oriental medicine by the name of Younghun Kim who practiced in the center of Seoul for a period of over 60 years. The records, which eventually amounted to over 1,500 books, were made known to the academic world when the descendents recently donated them to Kyunghee University. The reason these medical records attract so much attention from academic circles, even though they are the work of one individual, is that they contain abundant information on general public medical health at the time, in addition to the fact that Kim Younghun was a well known figure among Oriental Medicine doctors in Korea. The medical records start in 1915 and continue until Kim Younhun's death in 1974, though they have some damaged or missing parts. Kim's medical records are a gold mine not only for scholars studying the medical history of the early 1900s, but also for doctors trying to emulate the techniques embedded in a great predecessor's medical practice.
Antifertility activity of hydro alcoholic extract of Moringa concanensis Nimmo: An ethnomedicines used by tribals of Nilgiris region in Tamilnadu
Ravichandiran, V ; Suresh, B ; Sathishkumar, MN ; Elango, K ; Srinivasan, R ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 114~120
DOI : 10.3742/OPEM.2007.7.2.114
In the present study, the hydro alcoholic extract of Moringa concanensis and their different fractions were evaluated for it's anti implantation, abortifacient, estrogenic and antiestrogenic activity. Hydro alcoholic extract of Moringa concanensis has showed potent antiimplantation and abortifacient activity at 200 mg/kg and 400 mg/kg respectively and marked estrogenic activity when administered individually and anti estrogenic activity was observed when administered along with ethinyl estradiol (1
) as well as their different fractions of Moringa concanensis showed significant antiimplantation and abortifacient activity at 100 mg/kg. Moreover, all tested fractions showed significant anti estrogenic activity when administered simultaneously with ethinyl estradiol.
Enhanced anti-inflammatory activity of curcumin, a naturally occurring pigment in turmeric via cyclodextrin complexation
Kohli, K ; Ali, J ; Najmi, AK ; Anwer, MT ; Ansari, MJ ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 121~127
DOI : 10.3742/OPEM.2007.7.2.121
Curcumin, a dietary pigment responsible for the yellow color of curry, has been used for the treatment of inflammatory diseases and exhibits a variety of pharmacological effects such as anti- inflammatory, anti-tumor, anti-oxidant, and anti-viral activity. In order to examine the potency of the curcumin in inflammation we used carrageenan induced rat hind paw odema model. As curcumin is practically water insoluble, it is hypothesized that pharmacological activity of curcumin could be improved by enhancing its water solubility. Water soluble complexes of curcumin with cyclodextrins were prepared and screened for greater solubility. Pure curcumin 100 mg/kg body weight along with curcumin complexes equivalent to 100 mg/kg body weight of pure curcumin were tested for the anti-inflammatory activity in Wister rats male rats using carrageenan induced hind paw edema model and compared with that of the reference compound diclofenac sodium at a dose level of 10 mg/kg body weight. Results were statistically analyzed using ANOVA. All the treatment groups showed statistically significant anti-inflammatory activity compared with that of vehicle control and positive control.
Effect of a polyherbal formulation (Diarun plus) on the glycemic status modified by physiological means in non-diabetic mice and rats
G, Senthilvel ; M, Jegadeesan ; P, Thirugnanasambantham ; E, Mayisvren ; M, Balasubramanian ; N, Narayanan ; S, Viswanathan ; Austin, Anoop ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 128~132
DOI : 10.3742/OPEM.2007.7.2.128
Diarun plus, a polyherbal formulation containing herbal ingredients of folkloric Antidiabetic effect, was investigated for its effect on glycemic status in rats and mice. In contrast to conventional chemical induced diabetic animal models, changes in glycemic states were induced by physiological maneuvers. Results revealed that in euglycemic animals Diarun plus elicited little change (-10 to +10%), which was insignificant. In food deprivation/swim exercise induced hypoglycemia, Diarun plus reduced the degree of hypoglycemia in both rats and mice (from 38% to 27% in rats and 45% to 32% in mice). Similarly, the marked hyperglycemia induced by dextrose (70% in rats and 95% in mice) was reduced markedly to 8% and 25% respectively. The findings of the present study suggests that the ingredients of Diarun plus have the unique property of maintaining near euglycemic state irrespective of the altered glycemic state, and that have no significant effect in euglycemic condition.
Anti-tumor effect of Euphorbia hirta on Ehrlich's ascites carcinoma in mice
Kumarappan, CT ; Sunderi, S Karpagam Kumara ; Jaswanth, A ; Lakshmi, S Mohana ; Mandal, Subhash C ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 133~140
DOI : 10.3742/OPEM.2007.7.2.133
Anti-tumor activity of Euphorbia hirta (50 mg/kg and 100 mg/kg) has been evaluated against Ehrlich's ascites carcinoma (EAC) in Swiss albino mice. Intraperitoneal (i.p) administration of Euphorbia hirta was effective in reducing solid tumor mass development induced by EAC cells. It exhibited significant anti-tumor activity in mice, when used at the dose of 100 mg/kg/day i.p., for 14days. The administration of Euphorbia hirta (100 mg/kg/day i.p.) resulted in an increase (P<0.001) of the life span (59.9%) of ascites tumor bearing mice as compared to the control group. After 14 days, on developed tumor masses, Euphorbia hirta administration brought about significant reduction in tumor volume and it reverse the changes in the hematological parameters, responding to tumor inoculation. The results are indicative of the anti-tumor activity of Euphorbia hirta against EAC induced tumor in a dose dependent manner.
Anti-inflammatory, anti-ulcer and hypoglycaemic activities of ethanolic and crude alkaloid extracts of Madhuca indica (Koenig) Gmelin seed cake
M, Seshagiri ; RD, Gaikwad ; KS, Jyothi ; S, Ramchandra ; S, Paramjyothi ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 141~149
DOI : 10.3742/OPEM.2007.7.2.141
Madhuca indica has been used ethnomedically in Indian folks. In the present study we have investigated anti-inflammatory, anti-ulcer and hypoglycaemic effect of ethanolic extract (EE) and crude alkaloid extract of Madhuca indica seed cake on albino rats. The study showed that the EE had a significant, dose dependent anti-edematogenic, anti-ulcerogenic and hypoglycaemic activity, whereas the crude alkaloid extract exhibited a significant only. Both the extracts possess dose dependent inhibitory activity on carrageenan-induced edema, inhibiting prostaglandins or mediators involved in prostaglandin synthesis, the second phase of inflammation. The EE was significantly effective in protecting pylorus-ligation-induced gastric ulcers at a higher dose level. The active principle of EE seems to be a selective inhibitor of the COX II (prostaglandin synthesis) without important effect on COX I since, EE exhibited both anti-edematogenic and anti-ulcerogenic effect. The EE was effective in reducing the plasma glucose level in normal albino rats in a dose dependent manner, producing hypoglycaemic effect by stimulating the release of insulin from the
and/or increasing the uptake of glucose from the plasma.
A study on wound healing activity of Bacopa monnieri Linn. aerial parts
Ghosh, Tirtha ; Maity, Tapan Kumar ; Dash, Deepak Kumar ; Boss, Anindya ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 150~156
DOI : 10.3742/OPEM.2007.7.2.150
Bacopa monnieri is being used in the traditional system of medicine for a variety of ailments. In the present study, the ethanolic extract of Bacopa monnieri aerial parts has been studied for its wound healing activity using various models in rats. Significant increase in wound contraction and skin breaking strength were observed in the excision and incision wound models respectively. There was also significant increase in hydroxyproline content, DNA content, superoxide dismutase activity, catalase activity, glutathione level and decrease in the level of thiobarbituric acid reactive substances in the
day post wounding tissue of experimental rats in the ethanol extract treated groups with respect to the control group. The effect of the extract was found to be comparable with the standard drug nitrofurazone. From the results it may be concluded that the plant Bacopa monnieri is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine. Saponins may be responsible for the observed wound healing activity.
Pharmacological profiles of Holarhena antidysenterica (L.) Wall bark
Rahman, Shafiur ; Ali, Eunus ; Haque, Rubyat ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 157~161
DOI : 10.3742/OPEM.2007.7.2.157
We undertook the present study to evaluate different pharmacological as antioxidant, antibacterial and cytotoxic activities of the crude ethanolic extract of the stem bark of Holarhena antidysenterica (Family: Apocynaceae). The antioxidant property of the extract was assessed by 1,1-diphenyl-2-picryl hydrazyl free radical scavenging assay. The extract showed antioxidant activity (
), which was comparable to standard drug ascorbic acid (
). The extract showed a broad spectrum of antibacterial activity against all tested gram positive and gram negative bacteria most prominent against Enterococci, Staphylococcus pyogenase and Shigella sonnie. And the zones of inhibitions were ranging from 10 - 21 mm for all the tested bacteria. Its cytotoxic property was evaluated by brine shrimp lethality bioassay. The extract showed significant lethality and the
values were 80
respectively. The results tend to suggest that the extract might possess chemical constituent(s) that are responsible for antioxidant, antibacterial and cytotoxic activities.
Antioxidant capacity of crude extract and fractions from Woodfordia fruticosa flower
Bhatt, Lok Ranjan ; Baek, Seung-Hwa ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 162~170
DOI : 10.3742/OPEM.2007.7.2.162
Woodfordia fruticosa Kurz. (Lythraceae), commonly known as Dhayero, is used in the treatment of various ailments in Nepal. In this study, the antioxidant capacity of crude extract and different polarity fractions of Woodfordia fruticosa flowers were assayed for their scavenging abilities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) and nitric oxide radicals, competitive
-carotene bleaching, reducing power, metal chelating ability and total phenolic content. Crude extract and polar fractions showed stronger antioxidant capacity and contained very high level of total phenolics. They exhibited strong DPPH radical scavenging, nitric oxide scavenging and reducing power, medium
-carotene bleaching and poor metal chelating capacity. Positive correlation obtained between total phenolic content and antioxidant capacity assays, indicated the contribution of phenolics toards antioxidant capacity.
Copper binding capacity and physicochemical properties of pectins with different degrees of esterification. Approach to standardization of pectin preparations
Kovalev, Valeri V ; Khotimchenko, Maxim Y ; Khotimchenko, Yuri S ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 171~181
DOI : 10.3742/OPEM.2007.7.2.171
Metal binding activity of the pectin samples with different physicochemical properties was studied. It was found that in vitro copper binding capacity of pectins is depending on the following factors: degree of esterification, content of non-methylated anhydrogalacturonic acid, and pH of solution. There was found that the maximum copper uptake capacity increases correspondingly to reduction of the degree of esterification of pectin, rise of the non-methylated anhydrogalacturnic acid content and the solution pH. It is proposed to use for standardization of pectin samples such parameters as the degree of esterification, content of anhydrogalacturonic acid, and intrinsic viscosity.
Antiamnesic potentials of Foeniculum vulgare Linn. in mice
Joshi, Hanumanthachar ; Parle, Milind ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 182~190
DOI : 10.3742/OPEM.2007.7.2.182
Alzheimer's disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementia is one of the aged related mental problems and a characteristic symptom of Alzheimer's disease. Nootropic agents like piracetam and cholinesterase inhibitors like
are used in situations where there is organic disorder in learning abilities, but the resulting side-effects associated with these agents have limited their utility. Foeniculum (F.) vulgare Linn. is widely used in Indian traditional systems of medicines and also as a house remedy for nervous debility. The present work was undertaken to assess the potential of F. vulgare as a nootropic and anti-cholinesterase agent in mice. Exteroceptive behavioral models such as Elevated plus maze and Passive avoidance paradigm were employed to assess short term and long term memory in mice. To delineate the possible mechanism through which F. vulgare elicits the anti-amnesic effects, its influence on central cholinergic activity was studied by estimating the whole brain acetylcholinesterase activity. Pretreatment of methanolic extract of fruits of F. vulgare Linn. for 8 successive days, ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging induced memory deficits in mice. F. vulgare extract significantly decreased transfer latencies of young mice and aged mice, increased step down latency and exhibited significant anti-acetyl cholinesterase effects, when compared to piracetam, scopolamine and control groups of mice. F. vulgare might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly.
Antinociceptive, antidiarrhoeal and cytotoxic activity of Aegiceras corniculatum
Ahmed, F ; Mamun, AH AI ; Shahid, IZ ; Rahman, AA ; Sadhu, SK ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 191~196
DOI : 10.3742/OPEM.2007.7.2.191
The ethanol extract of leaves of the mangrove Aegiceras corniculatum Blanco (Myrsinaceae) was screened for its antinociceptive, antidiarrhoeal and cytotoxic activities. The extract produced significant writhing inhibition in acetic acid-induced writhing in mice at the oral dose of 250 and 500 mg/kg body weight (P < 0.001), which was comparable to the standard drug diclofenac sodium at the dose of 25 mg/kg of body weight. When tested for its antidiarrhoeal effects on castor oil induced diarrhoea in mice, it increased mean latent period and decreased the frequency of defecation significantly at the oral dose of 500 mg/kg body weight (P<0.05; P<0.01) comparable to the standard drug loperamide at the dose of 50 mg/kg of body weight. Moreover, when tested for toxicity using brine shrimp, the extract showed potent activity against the brine shrimp Artemia salina (
10 mg/ml). The overall results tend to suggest the antinociceptive, antidiarrhoeal and cytotoxic activities of the extract.
Tissue culture of the plant Pluchea indica (L.) Less. and evaluation of diuretic potential of its leaves
Pramanik, Kartick Chandra ; Biswas, Ria ; Mitra, Anupama ; Bandyopadhyay, Durba ; Mishra, Moumita ; Chatterjee, Tapan Kumar ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 197~204
DOI : 10.3742/OPEM.2007.7.2.197
The present study focused on the establishment of micropropagation protocol for the high value Pluchea (P.) indica (L.) Less., genotype, an important medicinal plant and evaluation of the diuretic activity of the leaf extract of the tissue cultured plant. Leaf explants, nodal segments and shoot tips were cultured in MS medium supplemented with auxin and cytokinin and their combinations. With the objective of inducing callus giving rise to new adult plants, naphthalene acetic acid was found to be most effective for (80%) for callus induction. The methanolic extract of leaves of the micropropagated P. indica was investigated for its diuretic activity in Wistar albino rats. Urinary excretion parameters were studied for evaluation of diuretic activity using Frusemide (20 mg/kg, p.o.) as standard. The extract showed significant diuretic activity at the doses of 100, 200 and 300 mg/kg. p.o. An oral acute toxicity study for the extract was carried out and the
value was found to be 2,825 mg/kg body weight.
Pharmacodynamic evaluation of hypoglycemic effect of Damtab in healthy adult male volunteers
Sahu, Pratap Kumar ; Pillai, KK ; Saha, Nilanjan ; Sharma, Manju ; Najmi, AK ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 2, 2007, Pages 205~210
DOI : 10.3742/OPEM.2007.7.2.205
The objectives of the study were (1) To evaluate the safety and tolerability of Damtab. (2) To characterize hypoglycemic effect of Damtab, if any. (3) To evaluate insulin sensitivity effect of Damtab, if any. Hypoglycemic effect of Damtab (700 mg and 1,400 mg) were examined. Gliclazide (80 mg) was used as an active control. Placebo was used as control. Breakfast was given, half an hour before dosing whereas lunch, snacks and dinner were given at 6, 10 and 14 h post dose. An oral glucose tolerance test was conducted to calculate the insulin sensitivity index from the values of glucose and insulin during oral glucose tolerance test. Both giclazide 80 mg and Damtab 1,400 mg significantly lowered plasma glucose level up to 6 h. Insulin sensitivity index of Damtab (1,400 mg) was found to be similar to that of placebo. A significant increase in insulin level at 1 h post dose of Damtab (1,400 mg) was observed. Damtab 700 mg shows placebo like effect whereas Damtab 1,400 mg possesses hypoglycemic effect.