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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 8, Issue 4 - Dec 2008
Volume 8, Issue 3 - Sep 2008
Volume 8, Issue 2 - Jun 2008
Volume 8, Issue 1 - Mar 2008
Volume 7, Issue 5 - Feb 2008
Selecting the target year
A study on the classification system of herbology
Jang, Woo-Chang ; Jeong, Chang-Hyun ; Baik, Yoo-Sang ; Mohk, In-Seok ; Kim, Me-Riong ; Kim, Yun-Ji ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 447~458
DOI : 10.3742/OPEM.2008.7.5.447
This paper reviews the historic origin and traits of the classification system used in current Korean herbology textbooks. By reassessing its value, it proposes the most relevant path for future revisions and supplementations. Through an evaluation of the history of the modern style of classification in terms of its efficacy and statistic analysis of the distribution of individual herbs in each category, this paper shows how the classification systems of Korean herbology textbooks were influenced by contemporary Chinese herbology, particularly that of the Cheong [淸] Dynasty. An examination of the academic background, strengths and weaknesses of each classification system demonstrates the need for future research on classification systems to concentrate on resolving the following issues: how well the setting and composition of each classification system reflects reality, and how closely it is connected to related sciences such as etiology and pathogenesis, prescriptionology, and diagnosis.
Effect of Neem (Azadirachta indica) oil on the progressive growth of a spontaneous T cell lymphoma
Mallick, Sanjaya Kumar ; Gupta, Vivekanand ; Singh, Mahendra Pal ; Vishvakarma, Naveen Kumar ; Singh, Nisha ; Singh, Sukh Mahendra ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 459~465
DOI : 10.3742/OPEM.2008.7.5.459
The present study was undertaken to investigate the effect of in vivo administration of neem oil intra-peritoneally (i.p.) to mice bearing a progressively growing transplantable T cell lymphoma of spontaneous origin, designated as Daltons lymphoma (DL), on the tumor growth. Mice were administered various doses of neem oil mixed in groundnut oil, which was used as a diluting vehicle or for administration to control DL-bearing mice. Administration of neem oil resulted in an acceleration of tumor growth along with a reduction in the survival time of the tumor-bearing host. Neem oil administered DL-bearing mice showed an augmented apoptosis in splenocytes, bone marrow cells and thymocytes along with an inhibition in the anti-tumor functions of tumor-associated macrophages. Thus this study gives an altogether a novel information that neem oil instead of the popular belief of being anti-tumor and immunoaugmentary may in some tumor-bearing conditions, behave in an opposite way leading to an accelarated tumor progression along with a collapse of the host's anti-tumor machinery. These observations will thus have long lasting clinical significance, suggesting caution in use of neem oil for treatment of cancer.
Triticum aestivum (Wheatgrass) formulation: An alternate treatment for the patients with Thalassemia
Desai, TR ; Solanki, JK ; Buch, Pankaj ; Goyal, RK ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 466~476
DOI : 10.3742/OPEM.2008.7.5.466
We have developed the tablet formulation of Triticum aestivum (wheatgrass) and investigated clinically, its effects in patients suffering from b-thalassemia (major) at K. T. Children Hospital, Civil Hospital, Rajkot. The tablets (wheatgrass powder 250 mg.) were given 3 times in a day for 9 months. Blood samples were collected at the start, after 6 months and 9 months and analyzed for various biochemical and hematological parameters. Treatment with wheatgrass formulation for 9 months produced significant decrease in hemoglobin, total RBC, eosinophil and reticulocyte counts. The mean corpuscular volume (MCV) and mean corpuscular hemoglobin concentration (MCHC) were significantly increased was significantly increased. The serum ferritin was also significantly decreased. There was no influence on serum magnesium, serum iron and Thiobarbituric acid reacting substances (TBARS). Our data indicate that treatment with wheatgrass on patients with
-thalassemia (major) may have beneficial effects in the form of a decrease in ineffective erythropoiesis, stimulation of hemoglobin synthesis in RBC, decrease in iron load and decrease in eosinophil count.
Hypouricemic and xanthine oxidase inhibitory activities of the fractions of Coccinia grandis L. Voigt
Umamaheswari, M ; Chatterjee, TK ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 477~484
DOI : 10.3742/OPEM.2008.7.5.477
The present study was aimed at investigating the hypouricemic and xanthine oxidase inhibitory activities of the various fractions of the hydromethanolic extract of the leaves of Coccinia grandis L. Voigt (Cucurbitaceae). The leaves of this species was used in traditional medicinal system for the treatment of gout, rheumatism, jaundice, bronchitis, fever, skin eruptions, wounds, etc. The degree of xanthine oxidase inhibition was determined in vitro by measuring the increase in absorbance at 295 nm associated with uric acid formation. Among the fractions tested, the chloroform fraction exhibited highest potency (
). This was followed by the pet-ether (
), ethyl acetate (
) and residual (
) fractions. The
value of allopurinol was
. In addition, the hypouricemic and hepatic xanthine oxidase (XO)/xanthine dehydrogenase (XDH) inhibitory activities of the fractions were examined in vivo using oxonate (280 mg/kg, i.p.) induced hyperuricemic mice. At a dose of 200 mg/kg orally for 7 days, the pet-ether, chloroform and ethyl acetate fractions produced a significant (P < 0.01) reduction in serum urate level and also inhibited hepatic XO/XDH activities when compared to hyperuricemic mice. These inhibitory effects were weaker than that observed for the standard drug, allopurinol (10 mg/kg, p.o.). Lineweaver-Burk analysis of the enzyme kinetics indicated that the mode of inhibition was of a mixed type. These results suggest that the use of Coccinia grandis leaves for the treatment of gout could be attributed to its XO inhibitory activity.
Antinociceptive and anti-inflammatory activities of Pandanus fascicularis Lamk. leaves in animal models
Panda, Prabhudutta ; Panda, DP ; Panda, PK ; Nayak, SS ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 485~493
DOI : 10.3742/OPEM.2008.7.5.485
The present study was carried out to elucidate the potential of, chloroform extract of Pandanus (P.) fascicularis Lamk (Family-Pandanaceae) leaves on antinociceptive, behavioral study and anti-inflammatory effects using various animal models The dried, powdered leaves of, P. fascicularis were extracted successively with petroleum ether (
) and chloroform in soxhlet apparatus. The chloroform extract (yield 21.6% w/w with respected to dry powdered plant material) was selected for all experimental procedure. Two models were employed to investigate the effects on nociception, the tail immersion and hot plate method in Swiss albino mice and anti inflammatory effect were investigated by employing the carrageenan induced rat paw edema test in. adult Wister albino rats. Behavioral study was investigated by elevated plus maze method in Swiss albino mice. Results were revealed that the PFCE was found significant antinociceptive effect (P < 0.001) at the dose levels of 100, 200 and 400 mg/kg, orally in mice and produced remarkable antiinflammatory effect (P < 0.001) at the same dose levels used in the rats. Behavioral study of the PFCE has no significant anxiolysis effect when used orally. It concludes that, PFCE possessed remarkable antinociceptive effect and anti-inflammatory effect but no anxiolytic effect on animal models.
The anti-hypertensive effect of ginseng in patients with mild hypertension
Kim, Young-Suk ; Jung, Woo-Sang ; Park, Seong-Uk ; Moon, Sang-Kwan ; Park, Jung-Mi ; Ko, Chang-Nam ; Cho, Ki-Ho ; Bae, Hyung-Sup ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 494~500
DOI : 10.3742/OPEM.2008.7.5.494
Ginseng has been traditionally used to recover vital energy from Qi deficiency in oriental countries. Recent reports suggested that ginseng could regulate blood pressure (BP), but much controversy still remain. Therefore, we intended to assess the anti-hypertensive effect of some ginseng species on Koreans and Chinese. This is a randomized, double blinded controlled clinical trial. The study subjects were recruited from the mild hypertensive patients who belonged prehypertension(120/80 to 139/89 mmHg) and stage I hypertension (140/90 to 159/99 mmHg) in Korea and China. After assigning the subjects into a Korean, a Chinese, and an American ginseng group by randomization, we prescribed ginseng with the dose of 4.5 g per a day for 4 w. To assess the anti-hypertensive effect, we compared the mean of systolic and diastolic BP between before and after ginseng medication by 24 h Ambulatory Blood Pressure Monitor (24 h ABPM). We also monitored adverse effect and laboratory findings to secure the subjects' safety. There were 64 subjects treated with Korean ginseng, 58 treated with Chinese ginseng, and 64 treated with American ginseng. All of the ginseng species reduced subjects' BP. Especially, Korean and Chinese ginseng showed more excellent effects. The secondary analysis on the subjects' nationality revealed that all of the ginseng species showed more significant anti-hypertensive effect in Chinese than in Koreans. We suggest ginseng could be useful for mild hypertension regardless of its species. And it would be safe within the dosage of 4.5 g per a day.
Analgesic effect of Clematidis Radix (CR) herb-acupuncture in a rat model of pain and inflammation
Hwang, Hye-Jeong ; Kim, Seung-Tae ; Lee, Hye-Jung ; Kim, Young-Suk ; Shim, In-Sop ; Park, Hi-Joon ; Choi, Won-Ju ; Kim, Jang-Hyun ; Hahm, Dae-Hyun ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 501~508
DOI : 10.3742/OPEM.2008.7.5.501
Anti-nociceptive and anti-inflammatory effects of Clematidis Radix (CR)-distillates were investigated in three different pain animal models. Highly purified distillate of CR was injected to Zusanli (ST36) acupoint, called CR herb-acupuncture in the Korean traditional medicine. In tail flick latency test, the CR herb-acupuncture treatment did not show a significant effect of relieving acute phasic pain. To investigate the anti-inflammatory effect of CR herb-acupuncture, inflammatory pain was induced by subcutaneous injection of formalin to the plantar tissue or intra-articular injection of carrageenan to the tibio-tarsal joint in the rats. And the medicinal effect of CR herb-acupuncture was evaluated by analyzing pain behavior such as licking or biting behavior, or by measuring weight distribution ratio between two foot and ankle circumference. In the rat formalin test, the analgesic effect of CR herb-acupuncture was more pronounced in the late phase (for 20 min after the early phase) than in the early phase (for the first 10 min post formalin injection). It also significantly alleviated the carrageenan-induced monoarthritis, in terms of weight distribution ratio and ankle edema. These results revealed that CR herb-acupuncture was effective to treat the inflammatory pain and could be used as an analgesic treatment with an antiinflammatory effect.
Effects of Gyejijakyakjimo-tang extract on inhibition of PGE
synthesis and NO production in murine raw 264.7 macrophage cells
Park, Kyoung-Su ; Hwang, Mi-Ja ; Nam, Ki-Bong ; Ryu, Ji-Mi ; Chung, Seok-Hee ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 509~517
DOI : 10.3742/OPEM.2008.7.5.509
Gyejijakyakjimo-tang is a multi-herbal formula that is composed of nine medicinal herbs. Gyejijakyakjimo-tang has been reported to have antipyretic and analgesic effects. Gyejijakyakjimo-tang has traditionally been used for goat and rheumatoid arthritis. However, analgesic and antiinflammatory effects of Gyejijakyakjimo-tang has not been clarified yet. In this study, we investigated the analgesic and anti-inflammatory effect of the aqueous extract of Gyejijakyakjimo-tang. We evaluated the aqueous extract of Gyejijakyakjimo-tang on Lipopolysaccharide (LPS)-induced inflammation in murine raw 264.7 macrophage cells. For this study, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, reverse transcription-polymerase chain reaction (RT-PCR), prostaglandin
) immunoassay, and nitric oxide (NO) detection were performed. Gyejijakyakjimo-tang suppressed
synthesis and NO production by inhibiting the LPS-induced expressions of COX-2 and iNOS mRNA in murine raw 264.7 macrophage cells. These results show that Gyejijakyakjimo-tang has the analgesic and anti-inflammatory effect by mostly suppressing COX-2 and iNOS expressions, and resulting in the inhibition of
synthesis and NO production.
Inhibitory effects of Gamichungsangbohatang on chemokines related asthma in A549 human epithelial cells
Jeong, Seung-Yeon ; Lee, Sung-Hun ; Roh, Young-Lae ; Kim, Jae-Hwan ; Jung, Hee-Jae ; Jung, Sung-Ki ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 518~526
DOI : 10.3742/OPEM.2008.7.5.518
Recently a major goal in asthma therapy is to reduce or prevent the inflammatory response of airway. Eosinophilic accumulation in the tissue is a prominent feature of allergic diseases including asthma. Production of chemokines by bronchial epithelial cells may contribute to the allergic inflammation by recruiting eosinophils. In this study we evaluated the inhibitory effect of Gamichungsangbohatang (GMCSBHT), used traditionally in treating asthma, on secretion of chemokines for eosinophils in human A549 epithelial cells. Chemokines such as eotaxin, RANTES, IL-8 were inhibited in a dose-dependent manner, but IL-16 showed no inhibition by GMCSBHT. These findings indicate that GMCSBHT might be a therapeutic value in treating asthma by suppression of chemokines secretion associated with local accumulation of eosinophils.
Analgesic and anti-inflammatory effect of the aqueous extract of root of Angelica Dahurica
Choi, In-Ho ; Lim, Hyung-Ho ; Song, Yun-Kyung ; Lee, Jin-Woo ; Kim, Young-Sick ; Ko, Il-Gyu ; Kim, Ki-Jeong ; Shin, Mal-Soon ; Kim, Khae-Hawn ; Kim, Chang-Ju ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 527~533
DOI : 10.3742/OPEM.2008.7.5.527
Angelica dahurica (Umbelliferae) grows in China, Japan, Russia, and Korea. The root of Angelica dahurica has been used as a traditional folk medicine to treat headache and toothache. In this study, the effects of the aqueous extract of Angelica dahurica on acetic acid-induced abdominal pain, carrageenan-induced edema, and thermal hyperalgesia were investigated using mice and rats. The present results showed that the aqueous extract of Angelica dahurica inhibited acetic acidinduced abdominal pain in mice and reduced carrageen-induced edema in rats. The present study showed that the aqueous extract of Angelica dahurica possesses anti-inflammatory and analgesic effects.
Protective effect of Shenqi-wan and its fractions on N-methyl-D-aspartate-induced excitotoxicity in rat hippocampus
Lee, Joung-Hun ; Kim, Youn-Sub ; Kim, Young-Sick ; Kim, Sung-Eun ; Sung, Yun-Hee ; Kim, Bo-Kyun ; Lee, Jin-Woo ; Ham, Dae-Hyun ; Lee, Hye-Jung ; Kim, Chang-Ju ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 534~539
DOI : 10.3742/OPEM.2008.7.5.534
Shenqi-wan, Oriental herbal medicine formulation, has traditionally been used for the treatment of delayed mental and physical development in children, complications of diabetes, and glomerulonephritis. In the present study, we investigated the protective effect of the aqueous extract of Shenqi-wan and its fractions against N-methyl-D-aspartate (NMDA)-induced exitotoxicity in rat hippocampal CA1 neurons. Fractions were elucidated at 0 - 10 min, 11 - 20 min, and 21 - 30 min by using gravity column chromatography method. In the present results, treatment with NMDA on cultured hippocampal slices induced neuronal death in the hippocampal CA1 region. Pretreatment with the Shenqi-wan did not exerted protective effect, however its fractions suppressed NMDA-induced neuronal damage. The fraction elucidated at 11 - 20 min showed the most potent protective effect. These results revealed that effective substances of the Shenqi-wan against NMDA-induced excitotoxicity may exist mainly in the fraction elucidated at 11 - 20 min.
Aqueous extract of Paeonia radix suppresses lipopolysaccharide-induced expressions of cyclooygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells
Hong, Sung-Kwan ; Kim, Youn-Sub ; Yang, Hye-Young ; Chang, Hyun-Kyung ; Kim, Yu-Mi ; Shin, Mal-Soon ; Baek, Seung-Soo ; Kim, Chang-Ju ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 540~548
DOI : 10.3742/OPEM.2008.7.5.540
Paeonia radix is the root of Paeonia aliflora Pallas, which is a perennial plant classified in the family Paeoniaceae. Paeonia radix possesses several pharmacological effects such as analgesic, anti-inflammatory and anti-allergic, anti-oxidative, and anti-coagulant activities. In this study, we investigated the effect of the aqueous extract of Paeonia radix on the lipopolysaccharide-induced inflammation in mouse BV2 microglial cells. The aqueous extract of Paeonia radix at respective concentration was treated one hour before lipopolysaccharide treatment. In the present results, the aqueous extract of Paeonia radix suppressed prostaglandin
synthesis and nitric oxide production by inhibiting the lipopolysaccharide-stimulated mRNA expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells. These results demonstrate that Paeonia radix exerts anti-inflammatory and analgesic effects probably by suppressing mRNA expressions of cyclooxygenase-2 and inducible nitric oxide synthesis. The present study demonstrates that Paeonia radix may offer a valuable mean of therapy for brain inflammatory diseases.
Modulation of the aqueous extract of Bupleuri radix on glycine-induced current in the acutely dissociated rat periaqueductal gray neurons
Sung, Yun-Hee ; Shin, Mal-Soon ; Kim, Tae-Soo ; Lee, Sang-Won ; Kim, Youn-Jung ; Shin, Hye-Sook ; Kim, Hong ; Kim, Chang-Ju ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 549~555
DOI : 10.3742/OPEM.2008.7.5.549
Bupleuri radix (Umbelliferae), the dried root of Bupleurum Chinense DC, has been clinically used to mitigate pain sensation. The descending pain control system consists of three major components, and modulation of pain in the periaqueductal gray is the most extensively studied descending pain control system. However, the relation of Bupleuri radix on the descending pain control system has not been clarified. In the present study, modulation of the aqueous extract of Bupleuri radix on glycine-induced ion current in the acutely dissociated periaqueductal gray neurons was investigated by using nystatin-perforated patch-clamp technique under voltage-clamp condition. In the present results, the glycine-induced ion current was significantly suppressed by 0.1 mg/ml Bupleuri radix, while treatment with
naltrexone, opioid receptor antagonist, alleviated Bupleuri radix-induced inhibition on glycine-induced ion current. The present study showed that the aqueous extract of Bupleuri radix may activate descending pain control system through inhibition on glycine-induced ion current in the periaqueductal gray neurons and this effect is mediated by opioid receptors.
Effects of amygdalin on the functional recovery and c-Fos expression in the ventrolateral periaqueductal gray region after sciatic crushed nerve injury in rats
Kim, Toung-Wook ; Lim, Hyung-Ho ; Song, Yun-Kyung ; Kim, Sung-Eun ; Lee, Jin-Woo ; Lee, Myoung-Hwa ; Seo, Jin-Hee ; Shin, Mal-Soon ; Lim, Baek-Vin ; Kim, Chang-Ju ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 556~563
DOI : 10.3742/OPEM.2008.7.5.556
Peripheral nerve injuries are a commonly encountered clinical problem and often result in a chronic pain and severe functional deficits. The expression of c-Fos is sometimes used as a marker of increased neuronal activity. We have prepared the aqueous extract of amygdalin from Armeniacae semen for pain control. In the present study, we investigated the effects of amygdalin on the recovery rate of the locomotor function and on the expression of c-Fos in the ventrolateral periaqueductal gray (vlPAG) region following sciatic crushed nerve injury in rats. Walking track analysis for the evaluation of functional recovery and immunohistochemistry for the c-Fos expression were used in this study. In the present results, characteristic gait change with dropping of the sciatic function index (SFI) was observed and c-Fos expression in the vlPAG was suppressed following sciatic crushed nerve injury in rats. Amygdalin enhanced SFI value and restored c-Fos expression in the vlPAG to the control value. The present our study indicated that amygdalin activates neurons in the vlPAG, and it facilitates functional recovery following peripheral nerve injury.
Protective effects of Polygala tenuifolia on ischemia-induced 4 vessel occlusion in rats
Kim, Young-Ock ; Kim, Su-Kang ; Cho, Ah-Rang ; Chung, Joo-Ho ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 564~568
DOI : 10.3742/OPEM.2008.7.5.564
The root of Polygala tenuifolia Willd (PT) is known to have neuroprotective effects and as an antidementic herb in Chinese and Japanese traditional medicine. We examined potential neuroprotective effects of PT using the 4-vessel occlusion model in rats. In this study, the efficacy of PT for the prevention of neuronal damage and for the reduction of memory impairment was investigated. The results indicate that PT confers significant neuroprotection especially for ischemic hippocampal neurons.
Anti-inflammatory and anti-nociceptive effects of extract of Astragalus membranaceous
Kim, Young-Ock ; Kim, Su-Kang ; Cho, Ah-Rang ; Chung, Joo-Ho ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 569~572
DOI : 10.3742/OPEM.2008.7.5.569
The root of Astragalus membranaceous (AM) has been used to treat edema and arthritis in the traditional Korean medicine. To elucidate the anti-inflammatory and anti-nociceptive effects of ethanol extract of AM, the carrageenan-induced paw edema using a plethysmometer and thermal hypersensitivity using the plantar test were measured. Ibuprofen was used as a control drug. Pretreatment with AM (400 mg/kg p.o.) significantly reduced paw edema, compared to the carrageenan-treated rats. In the plantar test, the thermal withdrawal latency in AM-treated group was significantly increased than the carrageenan-treated group. The results indicate that AM could have be the anti-inflammatory and anti-nociceptive properties.
Carcinostatic effect of allergen removed Rhus Verniciflua stokes based Traditional Korean Medicine on a patient with lung adenocarcinoma; single case report
Jeong, Jong-Soo ; Park, Jae-Woo ; Yoon, Seong-Woo ; Choi, Won-Cheol ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 573~578
DOI : 10.3742/OPEM.2008.7.5.573
Lung cancer is one of the leading causes of cancer mortality and overall treatment outcomes for lung cancer are still to be considered disappointing despite of development of new medical therapeutics on cancer. Cytostatic agents are considered as novel medication in the treatment of cancer though its benefit is most appropriately assessed through survival end points rather than the objective-response end points. We present a case of a lung adenocarcinoma patient who showed tumor lesion in patient's two different lung sites. From the day of diagnosis, the tumor lesion stayed with the almost same size with more than 1 year of Allergen-Removed Rhus Verniciflua Stokes (A-RVS) based Traditional Korean Medicine treatment without any western conventional treatment. No significant side effect was noted and the patient maintained good performance status throughout the treatment period. We assume A-RVS may have cytostatic effect on NSCLC patient and our observation justifies further investigation.
The effectiveness of moxibustion on dysphagia after stroke; A Case Series
Cho, Ki-Ho ; Kim, Tae-Hoon ; Jung, Woo-Sang ; Park, Seong-Uk ; Moon, Sang-Kwan ; Park, Jung-Mi ; Ko, Chang-Nam ; Kim, Young-Suk ; Bae, Hyung-Sup ;
Oriental Pharmacy and Experimental Medicine, volume 7, issue 5, 2008, Pages 579~582
DOI : 10.3742/OPEM.2008.7.5.579
This study was aimed to evaluate the effectiveness of moxibustion on dysphagia after stroke. We conducted his study in the Department of Cardiovascular and Neurologic Diseases (Stroke Center), Hospital of Oriental Medicine, Kyung Hee Medical Center, from May 1, 2005 to August 1, 2006. After recruiting dysphagia patients after stroke, we applied the Direct Moxibustion (
) to the Chon-Jung acupoint 5 times, and assessed its effect on swallowing reflex by Swallowing Provocation Test (SPT) before and 30 min after treatment. Effectiveness of the swallowing reflex was assessed by the Latency Time of Swallowing Reflex (LTSR) which was checked from test starting to the onset of swallowing reflex. Thirty four subjects with dysphagia were treated with moxibustion. The mean of the latency time in swallowing reflex was shortened from
seconds after moxibustion, which had statistical significance (P < 0.001). We suggest that moxibustion at Chon-Jung could be useful for dysphagia after stroke. Further study with a randomized controlled trial compared to placebo is needed to confirm this suggestion.