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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Oriental Pharmacy and Experimental Medicine
Journal Basic Information
Journal DOI :
Kyung Hee Oriental Medicine Research Center, Kyung Hee University
Editor in Chief :
Volume & Issues
Volume 9, Issue 4 - Dec 2009
Volume 9, Issue 3 - Sep 2009
Volume 9, Issue 2 - Jun 2009
Volume 9, Issue 1 - Mar 2009
Selecting the target year
Molecular targets of pepper as bioavailability enhancer
Gohil, Priyanshee ; Mehta, Anita ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 269~276
DOI : 10.3742/OPEM.2009.9.4.269
Black pepper (family Piperaceae), is called king of spices because it is one of the oldest spice and alone accounts for about 35% of the world's total spice trade. The pepper is used in Ayurvedic medicine for the treatment of various ailments particularly neurological, broncho-pulmonary and gastrointestinal disorders. Pepper has also been reported to have various pharmacological actions but recently, it is highlighted as a bioavailability enhancer. This results in higher plasma concentration of drugs, nutrients, ions and other xenobiotics, rendering them more bioavailable for physiological as well as pharmacological actions in the body. Numerous scientific studies reported that piperine; a main bioactive compound of pepper, is responsible for its bioavailability enhancing property. It's a well known fact that pepper enhances bioavailability by inhibition of microsomal enzyme system but other mechanisms are also responsible to acts as a bioavailability enhancer. The brief overview of the mechanism of action of pepper as well as its applications as bioavailability enhancer is given in the present article.
In vitro anti-oxidant activity of the leaves of Dillenia indica
Saha, Moni Rani ; Alam, Ashraful ; Hasan, Raquibul ; Akter, Raushanara ; Hossain, Mokarram ; Mazumder, Ehsanul Hoque ; Rana, Sohel ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 277~284
DOI : 10.3742/OPEM.2009.9.4.277
The methanol extract of Dillenia indica was tested for antioxidant activity as determined by free radical scavenging of DPPH radical scavenging assay, reducing power, total antioxidant capacity measured by phosphomolybdenum method, total phenolic content and total flavonoids content determination assays. The extract showed significant activities in all antioxidant assays compared to the standard antioxidant in a dose dependent manner. In DPPH radical scavenging assay the
value of the extract was found to be 100.53
while ascorbic acid has the
. Dillenia indica extract showed strong reducing power and total antioxidant capacity. Moreover, methanol extracts also possess high amount of phenolics and flavovonoids and expressed as gallic acid and rutin equivalent respectively. The remarkable activities exhibited in reactive oxygen species scavenging may attributed to the high amount of hydrophilic phenolics present in Dillenia indica.
The protective effect of anti-oxidant in cadmium-induced hair cell death
Kim, Su-Jin ; Myung, No-Yil ; Jeong, Hyun-Ja ; Um, Jae-Young ; Kim, Hyung-Min ; Hong, Seung-Heon ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 285~291
DOI : 10.3742/OPEM.2009.9.4.285
) is a heavy metal and a potent carcinogen implicated in tumor development through occupational and environmental exposure. However, the auditory effect of
is not poorly understood. The purpose of the present study was to investigate whether prevent the ototoxic effects of
by antioxidnat in auditory cell line, HEI-OC1. Rosmarinic acid is a naturally occurring phenolic compound and also known to possess marked antioxidant properties. We showed that antioxidnat inhibited the the cytochrome c release induced by
. In addition, we showed that the regulatory effect of antioxidnat on apoptosis is through the caspase-9 activation, and extracellular signal-regulated kinase activation in auditory cells. These results suggested antioxidnat its therapeutic usefulness, against
induced activation of caspase-9 and ERK.
Hesperidin improves warm ischemia/reperfusion-induced oxidative renal injury in rats
Gandhi, Chintan ; Zalawadia, Rishit ; Balaraman, R. ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 292~302
DOI : 10.3742/OPEM.2009.9.4.292
Ischemia/reperfusion injury, which is commonly seen in the field of renal surgery or transplantation, is a major cause of acute renal failure. Previous studies showed that antioxidant treatments attenuated renal ischemia/reperfusion injury. The objective of this study was to examine the role of hesperidin in modulating reactive oxygen species induced inflammation and apoptosis after renal ischemia/reperfusion injury. Rats were subjected to right nephrectomy, 15 days later 45 min of renal ischemia and 24 h reperfusion with or without treatment with hesperidin. Renal function, inflammation and apoptosis were compared at 24 h after reperfusion injury. Hesperidin improved the renal dysfunction and reduced inflammation and apoptosis after ischemia/reperfusion injury. In conclusion, hesperidin shows potent anti-apoptotic and antiinflammatory properties due to antioxidant property. These findings may have major implications in the treatment of human ischemic acute renal failure.
Antisteroidogenic activity of Raphanus sativus seed extract in female albino mice
Haldar, P.K. ; Mazumder, U.K. ; Bhattacharya, Sanjib ; Manikandan, L. ; Bhattacharya, Siladitya ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 303~306
DOI : 10.3742/OPEM.2009.9.4.303
The defatted methanol extract of Raphanus sativus Linn. (Cruciferae) seed (MERS) was evaluated for its antisteroidogenic potential in mature female Swiss albino mice. The methanol extract at the doses of 100 and 200 mg/kg body weight significantly elevated the levels of cholesterol and ascorbic acid contents which serve as a precursor for the synthesis of steroid hormones in ovaries. The extract also significantly inhibited glucose-6-phosphate dehydrogenase and
-hydroxy steroid dehydrogenase, the two key enzymes involved in ovarian steroidogenesis. Hence the extract (MERS) exhibited significant antisteroidogenic activity.
Protective effect of Asystasia gangetica reduced oxidative damage in the small intestine of streptozotocin-induced diabetic rats
Kumar, K. Asok ; Umamaheswari, M. ; Sivashanmugam, A.T. ; Subhadradevi, V. ; Somanathan, S.S. ; Ravi, T.K. ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 307~314
DOI : 10.3742/OPEM.2009.9.4.307
Oxidative stress plays an important role in the pathogenesis of various diabetic complications and small intestine is vulnerable to damage resulting in morphological and functional changes. In this study, the effects of Asystasia gangetica leaf extract (AGLE) on oxidative stress status in small intestine of diabetic rats were examined. The leaves of Asystasia gangetica was extracted with 70% ethanol. Oral administration of AGLE once daily (100 mg/kg and 200 mg/kg b.w.) for 28 days to diabetic rats significantly (P < 0.05) increased antioxidant levels of catalase, superoxide dismutase, glutathione peroxidase, glutathione, GSSH, carbohydrate metabolizing enzyme, glucose-6-phosphate dehydrogenase. The increased levels of protein carbonyl content, lipid peroxidation and xanthine oxidase/xanthine dehydrogenase in diabetic rats were reverted back to near normal levels on treatment with AGLE. Both doses of AGLE offered significant activity (P < 0.01) against oxidative damage and were comparable with standard, glibenclamide. The results revealed the occurrence of oxidative stress in small intestine during diabetes and suggest the potential of AGLE as an antioxidant in protecting the tissue defense system against oxidative damage in streptozotocin-induced diabetes.
A pentacyclic triterpenoid possessing analgesic and anti-inflammatory activities from the fruits of Dregea volubilis
Biswas, M. ; Biswas, K. ; Ghosh, A.K. ; Haldar, P.K. ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 315~319
DOI : 10.3742/OPEM.2009.9.4.315
In present study evaluate the analgesic and anti-inflammatory activity of the compound obtained from the petroleum ether (40 - 60
) extract of the fruits from Dregea volubilis in Swiss albino mice and in Wister albino rats respectively. Dried and crushed fruits of Dregea volubilis were extracted by petroleum ether (40 - 60
), the proper solvent system was developed by TLC and subjected to column chromatography for obtaining the pure compound/s. IR, MASS, NMR (PMR, C13 NMR and DEPT) spectroscopic analysis were done to elucidate the structure of the compound/s. The petroleum ether (40 - 60
) extract of the fruits of Dregea volubilis led to isolation of a pentacyclic triterpenoid designated as taraxerone and characterized as D- friedoolean- 14- en, 3 one. Taraxerone had been screened for analgesic activity in Swiss albino mice and anti-inflammatory activity in Wister albino rats at the dose of 5 mg/kg body weight orally and exhibit significant analgesic and anti-inflammatory properties.
Anti-inflammatory, antinociceptive and diuretic activities of Trema orientalis Linn
Uddin, Sarder Nasir ; Yesmin, Mst Nazma ; Pramanik, M.K. ; Akond, Ma ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 320~325
DOI : 10.3742/OPEM.2009.9.4.320
The pharmacological interest coupled with traditional uses (antidiarrhoeal, antiseptic, analgesic etc) prompted us to test for anti-inflammatory, antinociceptive and diuretic activitities of Trema (T.) orientalis Linn. The crude methanolic leaves extract of T. orientalis was investigated for its possible anti-inflammatory activities using carrageenin induced rat paw edema model and cotton pellet implantation method in mice. Then the extract analyzed for its antinociceptive activities by acetic acid induced writhing model in mice. The extract possessed significant anti-inflammatory activity in both models at the doses of 200 and 400 mg/kg body weight of mice. Moreover, the extract showed significantly reduced the number of acetic acid-induced abdominal constriction in mice of 200 and 400 mg/kg body weight. The extract also showed positive diuretic activity in albino mice.
Antinociceptive and gastro-protective effect of the ethanolic extract of the flowering top of Anthocephalus Cadamba Roxb
Subhan, Nusrat ; Hasan, Raquibul ; Hossain, Mokarram ; Akter, Raushanara ; Majumder, Muntasir Mamun ; Rahman, Mostafizur ; Ahmed, Kamaluddin ; Ghani, Abdul ; Alam, Ashraful ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 326~334
DOI : 10.3742/OPEM.2009.9.4.326
The effect of alcoholic extract of Anthocephalus (A.) Cadamba Roxb. was evaluated in experimental models of pain and ulcer. Hot tail flick test, hot plate test and acetic acid induced writhing test were employed for evaluating the peripheral as well as central analgesic mechanism exerted by the extracts. Gastroprotective activity was examined by HCl and ethanol induced gastric damage test. Test group received crude extract 500 mg/kg showed maximum time needed for the response against thermal stimuli (6.26
0.439 s) which is comparable to diclofenac sodium (6.56
0.381 s) in hot tail flick method. These experimental results also followed the experimental results of hot plate test where crude extract 500 mg/kg showed maximum time needed for the response against thermal stimuli (4.74
0.234 s) which is comparable to diclofenac sodium (5.58
0.585 s). The crude extract at 500 and 250 mg/kg showed significant reduction in acetic acid induced writhing in mice with a maximum effect of 68.026% reduction at 500 mg/kg dose which is comparable to standard diclofenac sodium (79.93%). In gastroprotective study the extract of A. Cadamba (250 and 500 mg/kg) significantly inhibited ulceration induced by both HCl and ethanol dose dependently. Results of the study suggest that the extract possesses both analgesic and gastroprotective activity on mice.
Antiarthritic action of polar fraction from Sida rhombifolia aerial parts
Gupta, S.R. ; Nirmal, S.A. ; Patil, R.Y. ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 335~338
DOI : 10.3742/OPEM.2009.9.4.335
Aerial parts of Sida rhombifolia Linn. (Malvaceae) were extracted successively using various solvents and screened for various parameters of antiarthritic activity such as adjuvant-induced arthritis, motor performance, and histopathological study. The ethanol and the aqueous extracts showed potent activity; further these extracts were fractionated by using column chromatography. The fraction ET1 isolated from ethanol extract showed the most potent antiarthritic activity.
Dose dependent effect of benzene extract of Ocimum sanctum leaves on cauda epididymal spermatozoa of albino rats
Ahmed, Mukhtar ; Ahamed, R. Nazeer ; Aladakatti, R.H. ; Ghodesawar, M.G. ;
Oriental Pharmacy and Experimental Medicine, volume 9, issue 4, 2009, Pages 339~349
DOI : 10.3742/OPEM.2009.9.4.339
An attempt has been made to assess whether the dose dependent effect of benzene extract of Ocimum sanctum leaves on the morphological changes in the cauda epididymal spermatozoa and sperm parameters in male albino rats. Scanning Electron Microscope observations illustrate the disturbance in plasma membrane as well as acrosomal membrane. Most of the sperms appear morphologically abnormal in the mid region of the tail; there is formation of balloon like cytoplasmic droplet. Sperm parametric study exhibits decrease in the total sperm count, sperm motility, forward velocity and increase in the percentage of abnormal sperms in dose dependent manner on treatment benzene extract of Ocimum sanctum leaves. The results suggest that the effects may have resulted from a general disturbance in the proteins and alteration in cauda epididymal milieu probably due to androgen deficiency consequent upon antiandrogenic property of Ocimum sanctum leaves.