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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Oral Medicine and Pain
Journal Basic Information
Journal DOI :
The Korean Academy of Orofacial Pain and Oral Medicine
Editor in Chief :
Volume & Issues
Volume 35, Issue 4 - Dec 2010
Volume 35, Issue 3 - Sep 2010
Volume 35, Issue 2 - Jun 2010
Volume 35, Issue 1 - Mar 2010
Selecting the target year
Apoptotic Effect of Co-Treatment with Valproic Acid and HS-1200 on Human Osteosarcoma Cells
Kim, Duck-Han ; Lee, Kee-Hyun ; Kim, In-Ryoung ; Kwak, Hyun-Ho ; Park, Bong-Soo ; Jeong, Sung-Hee ; Ko, Myung-Yun ; Ahn, Yong-Woo ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 165~175
Valproic acid (VPA) is a well-known anticonvulsive agent and has been used in the treatment of epilepsy for almost 30 years. VPA emerged in 1997 as an antineoplastic agent as well, when findings indicated the substance inhibited proliferation and induced differentiation of primitive neuroectocdermal tumor cells in vivo (Cinatl et al., 1997). Antitmor activity of VPA is associated with its targeting histone deacetylases. Bile acids and their synthetic derivatives induced apoptosis in various kinds of cancer cells and anticancer effects. It has been reported that the synthetic chenodeoxycholic acid (CDCA) derivatives showed apoptosis-inducing activity on various cancer cells in vitro. This study was undertaken to investigate the synergistic apoptotic effect of co-treatment with the histone deacetylases inhibitor, VPA and a CDCA derivative, HS-1200 on human osteosarcoma (HOS) cells. Cell viability was evaluated by trypan-blue exclusion. Induction and augmentation of apoptosis were confirmed by Hoechst staining, flow cytometry (DNA hypoploidy and MMP change), Westen blot analysis and immunofluorescent staining. In this study, HOS cells co-treated with VPA and HS-1200 showed several lines of apoptotic manifestation such as nuclear condensations, the reduction of MMP, the decrease of DNA content, the release of cytochrome c into cytosol, the translocation of AIF onto nuclei, and activation of caspase-7, caspase-3 and PARP whereas each single treated HOS cells did not. Although the single treatment of 1 mM VPA or
HS-1200 for 48 h did not induce apoptosis, the co-treatment of them induced prominently apoptosis. Therefore our data provide the possibility that combination therapy of VPA and HS-1200 could be considered as a novel therapeutic strategy for human osteosarcoma.
laser in Minor Surgery of Oral Soft Tissue : Case Reports
Park, Ju-Hyun ; Jeon, Young-Mi ; Kwon, Jeong-Seung ; Ahn, Hyung-Joon ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 177~182
Conventional surgical therapy for oral soft tissue includes the use of scalpel, diathermy, cryotherapy and electrosurgery. But, these therapies have some surgical problems. Nowadays, laser surgery can be considered as the another option for conventional surgical therapy. Compared to conventional surgical therapies, advantages of laser therapy include maintenance of sterile conditions, promotion of wound healing, reduction of bleeding, less instruments, post operative pain reduction, less scar, saving cost by using fewer materials, staff and time. Carbon dioxide (
) laser uses gaseous medium, and has long wavelength about 10,600nm. The first advantage of
laser for surgical treatment of oral soft tissue is hemostasis and visibility improvement by making relatively dry field. These case reports are about cases of minor surgery of oral soft tissue using
laser, and emphasize advantages of laser compared to conventional surgical therapies.
Changes of Taste Threshold after Smoking in Young Korean Men
Hong, Seong-Ju ; Ryu, Ji-Won ; Ahn, Jong-Mo ; Yoon, Chang-Lyuk ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 183~192
The aim of this study is to determine a relationship between the smoking and the gustation. For that purpose, the survey is about the subjective taste change after smoking compared the electrical taste thresholds by EGM on healthy young Korean men before and after smoking. The results of the electrogustometry showed significant differences between smokers and non-smokers, also between before smoking and directly after smoking in smokers showed significant differences which indicated the immediate, but temporary effects of smoking on the taste thresholds. There were no difference of gustatory function by the amount of smoking and the degree of addiction. Based on the results of this study, further studies will be focused on the difference of gustatory function between before and after smoking using the chemical taste test, and the relationship between change of olfactory and gustation by smoking.
The Effect of Mandibular Protrusion on Dynamic Changes in Oropharyngeal Caliber
Jung, Jae-Kwang ; Hur, Yun-Kyung ; Choi, Jae-Kap ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 193~202
The purpose of this study was to determine the sites of narrowing/obstruction and to measure the regional severity of narrowing through the evaluation of dynamic changes in upper-airway of healthy subjects. The selected 9 subjects were proved not to have any sleep-related disorder such as snoring or obstructive sleep apnea through clinical examination, radiological examination, sleep study with a portable recording system. Afterward, the Electron Beam Tomography was performed during the waking and sleeping state of subjects, with their mandible in resting and protruded position. Intravenous injection of Dormicum
was used for the induction of sleep. The maximum and minimum cross-sectional areas at each airway level during tidal ventilation were measured and the Collapsibility Index for each level of cross-section was also computed. In a comparison with results under variable conditions, the result was showed that the significant difference between each airway level divided with upper, middle, lower region of upper airway is not observed in the average minimum cross-sectional areas and Collapsibility Index. The significant difference only between in wake and sleep state was observed in the average minimum cross-sectional area at the lower region. Also, in wake state, the significant difference between resting and protrusive position of mandible for the average minimum was also observed in cross-sectional area at middle region. In sleep state, no significant difference between resting and protrusive position of mandible was observed in cross-sectional area and the Collapsibility Index.
Effect on the Pain Characteristics of Tension-Type Headache by Buccomucosal Linea Alba
Kim, Hyoung-Sok ; Auh, Q-Schick ; Hong, Jung-Pyo ; Chun, Yang-Hyun ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 203~212
This study was designed to evaluate the pain characteristics of tension-type headache by buccomucosal linea alba. Patients with tension-type headache visited the Department of Oral Medicine, K University Dental Hospital were recruited to this study. Experimental group (n=79) was composed of tension-type headache with buccomucosal linea alba and control group (n=79) was composed of tension-type headache without buccomucosal linea alba. Evaluation list was pain quality, pain intensity, pain laterality, pain increase by routine physical activity and then it was analyzed statistically. The results were as follows : 1. Pain quality of tension-type headache patient was not significantly different by buccomucosal linea alba. 2. Pain intensity of tension-type headache patient was significantly different by buccomucosal linea alba. (p=.043). 3. Pain laterality of tension-type headache patient was not significantly different by buccomucosal linea alba. 4. Pain increase by routine physical activity of tension-type headache patient was not significantly different by buccomucosal linea alba. Therefore, it was considered that the tension-type headache patient was influenced by buccomucosal linea alba in the pain quality.
Survey of Pain to Palpation of the Occipitofrontalis Muscle in Patients with Temporomandibular Disorders
Im, Yeong-Gwan ; Kim, Byung-Gook ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 213~219
Aim: The aims of this study were to survey the frequency of pain to palpation of the occipitofrontalis muscle in a TMD patient group, and to identify patients showing pain to palpation of the occipitofrontalis muscle that is also consistent with patients' headache symptom. Methods: A total of 218 TMD patients (
years) participated in this study. Patients' symptoms, including headache, were surveyed by questionnaire. Temporomandibular joints, jaw muscles, and pericranial muscles including the occipitofrontalis muscle were examined with digital palpation. Pain to palpation (i.e. tenderness) was scored from 0 to 3 according to the patients' response, and frequencies were calculated of pain to palpation scores for each site of the pericranial muscles. Results: Twelve patients among 218 TMD patients (5.5%) showed pain to palpation (scores of 1, 2) on the occipitalis or frontalis sites, and seven patients (3.2%) had moderate pain (a score of 2) to palpation. Among 218 TMD patients, there was only one patient whose primary symptomatic site of headache corresponded with the result of pain to palpation of the occipitofrontalis muscle. Conclusion: It can be concluded that examination with palpation of the occipitofrontalis muscle could be considered in the evaluation of TMD patients' headache symptom when other factors have been ruled out.
Treatment of Chronic Myofascial Pain with Botulinum Toxin : Case Report
Hong, Seong-Ju ; Yoon, Chang-Lyuk ; Ahn, Jong-Mo ; Ryu, Ji-Won ;
Journal of Oral Medicine and Pain, volume 35, issue 3, 2010, Pages 221~227
MyoFascial Pain Syndrome(MFPS) is defined as a regional pain syndrome characterized by muscle pain caused by myofascial trigger points (MTrPs). Myofascial pain is a common cause of persistent regional pain such as neck pain, shoulder pain, headaches, and orofacial pain. Clinicians who deal with orofacial pain must also understand the role of myofascial pain. This case report presents the treatment of botulinum toxin A for chronic myofascial pain.