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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Ginseng Research
Journal Basic Information
Journal DOI :
The Korean Society of Ginseng
Editor in Chief :
Volume & Issues
Volume 1, Issue 1 - Dec 1976
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Pharmacology of Ginseng
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 1~12
Breeding of Panax ginseng and Plant Tissue Culture
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 13~18
Production of Panax ginseng in Korea has been increased tremendously in the last two decades, the acreage and number of growers hating been spread across the country. Improvement of variety, on the other hand, has been seldom carried out during this period, rendering the ginseng growing risky and hazardous. Breeding work with such perennial crop as ginseng if rather time-consuming, and there are few genesources to start with. Authorities concerned with ginseng Production pay hwy little attention to breeding researches for nimbus of reasons. As this crop is cultivated over the entire area of Korea. Breeding work cannot be allowed to delay forth. In the precut article, improvement of ginseng was discussed from the view point of two different categories of brooding concept: (1) conventional breeding and (2) breeding based on the somatic tell genetics.
Biochemical Studios on the Chemical Components of Korean Ginseng:(I) Effects of Components of Ginseng on the Activity of Aminoacyl-tRNA Synthetase
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 19~24
Ginseng extracts were frnctionelod into several fractions with carious organic solvents, and the effects of these fractions on the activity of aminoacyl-tRHA synthetase was examined. Fractions which showed positive effect on the activity of the aminoacyl-tRNA synthetase were obtained both from white ginseng and red ginseng. The total methanol extract of whit ginseng and the ether extract from the total methanol extract of red ginseng gave Positive results. Therefore it may be Presumed that the Positive components have rather nonpolar nature.
Biochemical Studies on the Chemical Components of Borean Ginseng (ll) Effects of Ginseng Components on the Activity of RNA Polymerase
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 25~28
Ginseng extracts were fractionated into several fractions with various organic solvents, and the effects of these fractions on the activity of RNA polymerase were examined. Fractions which showed positive effect on the activity of RNA polymerase were obtained both from white ginseng and red ginseng. For white ginseng the components which hare shown a positive effect on RNA polymerase roue found in total methanol extracts, the residual aqueous solution from ethyl acetate extraction and the methanol insoluble fraction of the above solution, whereas for red ginseng the positive components roue found in total methanol extracts and in ethyl ether extracts. These finding suggest that the ginseng components which have Positive effect on RNA polymerase be composed of Polar and nonpolar moieties, which may be cleaved into the ports during the processing the of red ginseng.
Biochemical Studies on the Chemical Components of Korean Ginseng(III) Effects of Ginseng Components on the Activity of Succinate Dehydrogenase
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 29~32
Succinate dehydrogenase was activated by ethyl acetate extract from the methanol extract of white ginseng previously treated with petroleum ether and ethyl ether to remove all highly nonpolar components, and the residual aqueous solution from the ethyl acetate extraction. Also, all of the extracted fractions of red ginseng except the ether extract gave positive results. On the contrary to some suggestions by other workers that alkaloids of ginseng may enhance the succinate degydrogenase activity, our results show that the alkaloids may have exhibited some inhibitory eject on this enzyme.
A Study on the Psychopharmacological Actions of Panax ginseng in Animals
Hong, Sa-Ack ; Kim, Myeong-Seok ; Jang, Hyeon-Gap ;
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 33~50
As a continuation of series of works on the pharmacological actions of Panax ginseng. three kinds of behavioral experiments were carried out using rats and mice. The occurrence of component Posterns of general behavioral activity in rat was examined by visual scanning using the ting sample method in the ad lib. And he hunger deprivated situation. In normal ad lib. situation, the eating behavior of rat treated with 100mg/kg of ginseng saponin was significantly more frequent than that of saline control at the night and throughout the 24 hr period. But grooming was less frequent than the control at the same period. In the hunger situation followed by 90~120 hrs of feed deprivation, the locomotive activity and rearing awe significantly more often and sleeping was less frequent in the two dosage g roups of ginseng saponin (10 and 100 mg/kg) than in the saline group though out the observation period. Training of avoidance conditioning in rats was done in a two-way shuttle box. The number of conditioned response (CR) in which the animal avoided sucessfully an electric shock by running in to the other compartment of the hex was regarded as an index of learning performance. Ginseng saponin in doses of 2.5 mg/kg Produced a significantly increased CR in total avoidance tria1s compared with the control. Although other dosage groups of ginseng saponin (5.0, 50mg and 100 mg/kg) showed no significant statistical difference from the normal control, it tended to increase in CR in the ginseng groups than in the control. An aggressive behavior in mice was observed in n shock-generating fighting box. The occurrence of reflexive fighting between two animals induced by an electric shock applied to the feet war checked as an index of aggression. The occurrence of reciprocal fighting episode immediately after the onset. Of the shock was significantly decreased in the dosage group of 400 mg/kg ginseng saponin, but it did net differ in the 100 mg/kg group of ginseng saponin from the control group. The dose, 400 mg/kg of ginseng saponin, inhibited fighting behavior in more than 80% of the Pairs. but 100 mg/kg of ginseng did inhibit it in less than 20% of the pairs.
An Ecochemical Study on Soil Sickness
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 51~58
The phenomenon of sail sickness in the continuous cropping of ginseng is n serious problem for the cultivation practices and is an unelucidated subject scientifically. Present study is concerned mainly with ecochemical search on the cause of soil sickness in the continuous cropping of ginseng and the obtained results are summarized as follows: The humic substances isolated from both cultivated and uneulvidated soils with ginseng were compared with respect to its IR spectra but any difference which may be causative of sail sickness between them was not detected. In contrast, same saponin-like substances extracted from the ginseng cultivate soil in root tone were detected but not from the uncultivated soil. Presumably. the saponin like substances in the soils are originate) from the ginseng radices and are accumulaetd in root zone year by year, while the interrelation between the root exudate of ginseng and soil sickness is still obscure. According to a survey on the distributive Pattern of microflora in rhizosphere of ginseng radices the number of fungi is relatively diminished with the cul tivation years, while the number of actinomycetes is increased. It is supposed that the soil sickness in the continuous cropping of ginseng has any correlation between the activities of microflora in rhizosphere and the reef exudates.
Studies on the Antidotal Effect of Panax ginseng The Therapeutic Effect of Ginseng on the Acute Alcoholism
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 59~78
In order to investigate the influences of Panax ginseng (white ginseng and red ginseng) on the anesthetic effect and toxic effect of alcohol, experimental studies .had been carried out with albino rabbits, mongolian dogs and mice. The anesthetic effect of alcohol was observed by measuring the induction time, .anesthetic time, recovery time and duration from the beginning of induction to , the recovery of anesthesia (total time), respectively. and toxic effect (
) of alcohol was measured. In addition to these experiments, al cohol concentration in .blood, blood sugar level, serum transaminase (GOT and GPT) activities and serum alkaline phosphatase activity were measured. Also in order to study the clinical effect of alcohol in healthy students, code .substitution, response time and muscle coordination were tested. The results were obtained as follows. 1. In the rabbits and mongolian Jags, the induction time of anesthesia by the administration of alcohol was delayed by the pretreatment of ginseng but recovery time and total time of anestksia were markedly shortend. 2. The bleed alcohol concentration was decreased by the pretreatment of ginseng , but not affected in mongolian dogs. 3. The blood sugar level, serum transaminase (GOT and GPT) activities and alkaline phoshatase activity in rabbits and dogs induced by the administration of alcohol were affected by the Pretreatment of ginseng. Because those were included within normal ranges, the differnces have no remarkable significance. 4. Liver alcohol dehydrogenase activity of rabbit was increased by the treatment of ginseng, especially it was markedly increased by the treatment of red ginseng 5. The average lethal dose of alcohol to mice was increased by the pretreatment. of ginseng, especially it was markedly increased by the pretreatment of red .ginseng. 6. In the clinical experiments, the blood alcohol concentration induced by alcohol administration was not affected by the pretreatment of ginseng whereas the bleed sugar level was increased. Blood alcohol concentration and bleed sugar level were measured after three hours alcohol administration. 7. The response time of healthy students administered with alcohol was markedly shortened by the pretreatment of ginseng but the experiments on the code substitution and muscle coordination were not affected.
Studies on the Ginseng Saponins(I) On the Determination of the Ginseng Saponins in Ginseng Tea and Extract
Journal of Ginseng Research, volume 1, issue 1, 1976, Pages 79~88
A determinatien of the saponins in ginseng tea and extract was carried out by using the quantitative TLC autodetector equipped with a hydrogen flame ionization detector. In order to apply to the Quality central of the ginseng tea and extract. the optimum condition and recovery percentage for the quantitative determination of saponins in these products duo studied. The results obtained were as follows: The method was adequate to estimate whether the ginseng extract used for the Products and She raw ginseng extract were the same quality or net. Most of the individual peak area was increased with the concentration of the total saponin. But some of the peak areas were net increased quantitatively in the ease of the sample containing high concentration ginseng extract. To deternine the saponins in ginseng tea correctly high volume low concentration was better than the low volume high concentration. Optimum concentration of ginseng extract in sample to determine the individual saponins was in the range of 0.5∼1.5g. The recovery percentage of the total saponin was 99.5% on the average.