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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Ginseng Research
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Journal DOI :
The Korean Society of Ginseng
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Volume & Issues
Volume 19, Issue 3 - Dec 1995
Volume 19, Issue 2 - Aug 1995
Volume 19, Issue 1 - Apr 1995
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Effect of Korean Red Ginseng and Western Ginseng on Body Temperature, Pulse Rate, Clinical Symptoms and the Hematological Changes in Human
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 1~16
Effects of Korean red ginseng (KG) and western ginseng (WG) on body temperature, pulse rate, clinical symptoms and hematological changes in human were studied after administration p.o. with Korean red ginseng and western ginseng for 10-days. KG was more effective in keeping homeostsis in than western ginseng in the changes of body temperature and pulse rate. KG was more effective in low body temperature and SOEVMIN (소음인), while inducing tachycardia especially in SOYANGIN (소양인) and TAEEUMIN (태음인). WG tended to drop temperature abruptly and also descended pulse rate with greater range than KG. KG and WG could cause side effects such as headache and gastrointestinal syndromes and induce hypertension or hypotension abruptly in specific constitutions. However, KG and WG did not cause abnormal changes in urinalysis and hematology.
Effectiveness for Erectile Dysfunction after the Administration of Korean Red Ginseng
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 17~21
A study was designed to investigate the effectiveness of Korean Red Ginseng (ERG) as an oral agent for erectile dysfunction (EF), which was compared to that of placebo and trazodone. Patients who were believed to have EF of mild or non-organic etiologies, randomized into 3 groups to receive 600 mg KRG 3 times daily (group A), placebo (group B) and 25mg trazodone once a day after evening (group C). All agents were given orally. Ninety patients, composed of 30 in each group, were included and analyzed only when clinical follow-up could be achieved at the end of the study for at least 3 months. There were no significant differences(p>0.05) between each group in mean age (43.7 years), duration of EF (5.8 years), the state of marriage (married : 80 patients) and duration of marriage (18.2 years). In group A, the parameters such as rigidity and tumescence on erection, early detumescence, libido and patient's satisfaction were significantly more effective than that of other group (p<0.05). But there were no significant differences in the parameters such as the frequency of coitus, premature ejaculation and morning erection between 3 groups (p>0.05). The efficacy achieved with KGR (60%) was significantly higher (p<0.05) than that of placebo (30%) and trazodone (30%). There were no significant changes on level of serum testosterone and type of AVS-penogram in group A. No side effect was demonstrated in all patients.
The Central Effects of Red Ginseng Total Saponin Component
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 22~26
The present study was undertaken to elucidate the characteristics of red ginseng total saponin in behavioral changes on ambulation, forced swim test and convulsion in mice. The ambulation and the duration of immobility on forced swim test were not affected by red ginseng total saponin. On the other hand, the duration of immobility inducted by DMI, PGL but not CIP was significantly decreased, and the onset of convulsion induced by pentylenetetrazole was significantly shortened by preadministration of red ginseng total saponin. These results suggest that red ginseng total saponin component may play an important role in modulating synergism with drugs acting on depression and convulsion, and that the characteristics of synergetic effect induced by red ginseng total saponin potentate the central norepinephrine neuron activity.
Anticancer Effect of Hydrophobic Protein Fraction from Red Ginseng by Clonogenic Assay
Kim, Chang-Han ; Lee, Myung-Sub ; Lee, Kyung-Ho ;
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 27~30
We established the model of clonogenic assay with cancer cell lines such as SW-156(kidney), SNU-5(stomach), Hep G2(liver), and WiDr(colon), and we investigated anticancer effect of hydrophobic protein fraction(N-fraction) from Korea red ginseng by using this model. The results of clonogenic assay showed that N-fraction had anticancer activity against SNU-5 above 100
/ml concentration, and did not exhibit anticancer activity against cell lines such as SW-156, WiDr, and Hep G2 up to 1,000
/ml concentration. This result suggests that N-fraction has specially anti-stomach cancerous effect.
Antioxidant Action of Ginseng : An hypothesis
Lee, D.W. ; Sohn, H.O. ; Lim, H.B. ; Lee, Y.G. ; Aprikian, A.G. ; Aprikian, G.V. ;
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 31~38
Antioxidant effect of Korean ginseng (Panax ginseng C.A. Meyer) was investigated in rats. Long-term administration of ginseng water extract protected the activity of liver cytosotic SOD, catalase and glutathione peroxidase from being significantly decreased with advancing age (p<0.05). It was more effective toward glutathione peroxidase than other antioxidant enzymes. However, the level of sulfhydryl compounds and its related enzymes such as glutathione reductase and glutathione-5-transferase was not significantly changed by the administration of ginseng. Liver microsomal formation of reactive oxygen species such as superoxide and hydrogen peroxide did not show a significant difference between two groups although it was slightly decreased with age, but lipid peroxidizability of microsomal membrane induced by a prooxidant was slightly lower in ginseng-treated rats. Interestingly, antioxidant capacity of plasma from ginseng treated rats on autooxidation of ok-brain homogenates was much higher than that of normal ones. However, resistance of RBC membrane against oxidative stress showed a similar tendency. The content of serum TBA reactive substances lowered consistently in the rats treated with r ginseng at all corresponding age and a significant difference between two groups was found at 24 months of age (p<0.05). Ginseng extract protected lipid peroxidation in brain and liver. This protection was more effective in the stressed rats imposed by immobilization than normal ones. In conclusion, ginseng water extract protected the age related deterioration of major antioxidant enzymes, and this effect was more striking with increasing duration of treatment. This comprehensive antioxidant action of ginseng seems to be bra certain action of ginseng other than a direct antioxidant action, which might be a long term normalizing effect through the harmony of various components.
Influence of Total Saponin from Korean Red Ginseng on Structural Changes in Phospholipid Membranes and Ghost Erythrocytes
Kim, Yuri-A. ; Vlasimir, R.Akoev ; Tarahovsky, Yuri-S. ; Ruslan, Elemesov ; Park, Kyeong-Mee ; Song, Yong-Bum ; Rhee, Man-Hee ; Park, Hwa-Jin ;
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 39~44
Total saponin from Korean red ginseng changed thermodynamic parameters of membranes from dipalmitoylphosphatidylcholine (DPPC) and ghost erythrocytes of human. In liposomes from DPPC, temperature of the main transition (Lb'-La) in liquid-crystalline phase increases by 0.2
in average, but enthalpy does not change. Total saponin at a concentration of smaller than
% "stabilizes" the timid bilayers. At larger than 0.07 of saponin/DPPC ratio, saponin leads to an exclusion of the bound lipid molecules from the main phase transition into lamella liquid crystalline La-phase. Total saponin influences specifically all erythrocyte membrane transitions in a concentration-dependent manner, i.e. on the structures of all the main membrane skeleton proteins. A high structural specificity of saponin with membrane proteins, could be a base of specificity of physiological response of not only erythrocytes, but also other cells.her cells.
Complete Assignment of
-NMR Signals for (20S) and (20R)-Protopanaxadiol by 2D-NMR Techniques
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 45~50
(20S)- and (20R)-protopanaxadiol were prepared from crude ginseng saponin by chemical treatment. The
-NMR signals of these compounds were fully assigned by various NMR techniques such as DEPT, 1H-1H COSY, HMQC, HMBC and NOESY.
Cloning of Ribulose-1,5-bisphosphate Carboxylase/oxygenase Large Subunit(rbcL) Gene from Korean Ginseng (Panax ginseng C.A. Meyer)
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 51~55
The DNA fragment containing ginseng ribulose-1,5-bisphosphate carboxytase/oxygenase large subunit(rbcL) gene was cloned from the ginseng chloroplast EcoRl library by colony lift hybridization with tobacco rbcL gene probe. From the screened clone, the DNA fragment containing ginseng rbcL gene was digested with several restriction enzyme and analyzed by Southern blot hybridization for the construction of restriction map. The ginseng rbcL gene fragment was subcloned in pBluescript II SK + vector and sequence analysis was performed. The nucleotide sequence of ginseng rbcL gene was compared with those of petunia, tobacco, alfalfa, rice and barley, which showed a homology of 93.1%, 95.2%, 90.5%, 85.5% and 84.3%, respectively.
Molecular Cloning of ATPase
-Subunit Gene from Mitochondria of Korean Ginseng (Panu ginseng C.A. Meyer)
Park, Ui-Sun ; Choi, Kwan-Sam ; Kim, Kab-Sig ; Kim, Nam-Won ; Choi, Kwang-Tae ;
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 56~61
Molecular cloning and restriction mapping on ATPase
-subunit gene (atpA) were carried out to obtain genomic information concerned with the gene structure and organization in Korean ginseng mitochondria. Two different clones containing the homologous sequence of atpA gene were selected from SalI and PstI libraries of mitochondrial DNA (mtDNA) of Korean ginseng. The sizes of mtDNA fragments inserted in SalI and PstI clones were 3.4 kb and 13 kb, respectively. Southern blot analysis with [
] labelled Oenothera atPA gene probe showed that atpA gene sequence was located in 2.0 kb XkaI fragment in PstI clone and in 1.7 kb XbaI fragment in SalI clone. A partial sequening ascertained that the SalI clone included about 1.2 kb fragment from SalI restriction site to C-terminal sequence of this gene but about 0.3 kb N-terminal sequence of open reading frame was abscent. The PstI fragment was enough large to cover the full sequence of atpA gene. The same restriction pattern of the overlapped region suggests that both clones include the same fragment of atiA locus. Data of Southern blot analysis and partial nucleotide sequencing suggested that mtDNA of Korean ginseng has a single copy of atpA gene. Key words ATPase a-subunit, mitochondrial DNA, Panax ginseng.
Effect of Controlled Atmosphere and Modified Atmosphere Storage on the Apparent Quality and Saponin Component of Fresh and Red Ginseng
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 62~72
During the controlled atmosphere storage (CA), fresh ginseng showed good appearance in quality, and other deterioration of freshness was not observed until 12 weeks. On the other hand, MA storage had kept freshness only in treatment of 1 until 8 weeks. There was no significant difference between treated and non-treated sample with preservatives, and not treated sample was not infected with various different fungi. Moisture contents and hardness of ginseng in all treatments were not changed much until 12 weeks, and surface shrinkage did not occur either. But shear stress increased somewhat in all treatments after 12 weeks. The granule of microstructure in tissue diminished slightly. The apparent Quality of red ginseng was good until 4 weeks of treatment. But as time passed, white skin and wrinkled skin were generated and darkened in its color. B-1 in CA and E-1 in MA were found to be the most favorable one. The content of crude saponin did not change significantly during storage of CA or MA by preservation conditions and period. Though a small increase in saponin content from 4.92% to 5.43% was recognized in B-1, which was treated with preservative and 6.0% In B-2, control, this could rather explain increment of soluble component by butanol. Thus, there was no change in total contents of ginsenoside pattern and composition of each content. The Rbl content in B-1 and B-2 were 0.98%, and 0.97%, respectively, whereas that of control was 0.96%. E-1 of MA, treated with preservative was 5.32% after 12 weeks, but was 5.73% in control, indicating that ginsenosides pattern was quite similar to that of CA storage.
Effects of Vesicular-Arbuscular Mycorrhizae on The Growth of American Ginseng
Thomas, S.C.Li ;
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 73~76
Newly sprouted American ginseng (Panax quinquefolium L.) seedlings were transplanted to forest pots with mycorrhizae-infested soil and grown in screenhouse for 2 years. Growth patterns, mortality rate and fresh root weight were investigated. Plants in VAM soil had lower mortality rales than control. In soils infested with two species of mycorrhizal fungi (Glomu deseyicola, frappe, Bloss and Merge and G. intraradices, Schenck and Smith), 28-35% of plants produced 3-prongs in the second season and significantly increased fresh root weight by 41 to 43%.
Chemical Components of Rusty Root of Ginseng
Journal of Ginseng Research, volume 19, issue 1, 1995, Pages 77~83
This study was conducted to investigate the chemical components of rusty root for seeking the cause of rust. Na, Fe contents were higher in various tissues of six-year-old rusty root than healthy root. Contents of total sugar in epidermis of rusty root was low but crude lignin and suborn contents were high. Crude lipid content increased with the rate of rusty symptoms in each part of root respectively. Pentadecanoic, stearic, oleic, lignoseric acid contents increased in cortex of tap root with the rate of rusty symptoms but decreased in pith. Total ginsenoside and crude saponin contents increased , in pith and cortex of tap root with the rate of rusty symptoms but decreased in lateral and fine root.