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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Herbal Formula Science
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Journal DOI :
The Korean Journal of Oriental Medical Prescription
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Volume & Issues
Volume 15, Issue 2 - Dec 2007
Volume 15, Issue 1 - Jun 2007
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A review on composition, action, compatibility of ingredients, clinicical application of Gwibitang
Park, Yang-Gu ; Kim, Yun-Kyung ; Yun, Young-Gab ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 1~8
The source of Gwibitang(歸脾湯) is the book of Jesaebang(濟生方), The formulae is excluded Angelicae gigantis radix(當歸) and Polygalae radis(遠志) in the Jesaebang(濟生方), Jn the Guch iryuyo(口齒類要), Jeongcheryuyo(正體類要) and Gyojubuinyangbang(校註婦人良方), has been bec ame White Pria cocos Wolf(白茯笭) instead of Hoelen cum Pini Radix(白茯神), and is followed constitution of Uihagypmun(醫學入門) in the Donguibogam(東醫寶鑑). Basic formulae of Gwibitang(歸脾湯) consist of Sanjointang(酸棗仁湯), Sagunjatang(四君子湯). Hwanggitang, Danggwibohyeoltang(當歸補血湯), a kind of Jeongjihwan(定志丸類), a kind of Chongmyeongtang(聰明湯類). To deficiency of the heart and spleen, apply Sanjointang(酸棗 仁場), a kind of Jeongjihwan(定志丸), Sagunjatang(四君子湯) and Hwanggitang. To insufficiency of the spleen-gi(脾氣), apply Sagunjatang(四君子湯), Hwanggitang and a kind of Jeonssiigongsan(定志小丸). To deficiency of blood, apply Danggwibohyeoltang(當歸補血湯). Gwibitang(歸脾湯) is used for a mnesia and severe palpitation as a result of deficiency of the heart and spleen and deficiency of both gi(氣) and blood(血).
A Study of "Nineteen Medicaments of Mutual Antagonism"
Park, Pil-Sang ; Kang, Ok-Hwa ; Lee, Go-Hoon ; Park, Shin-Young ; Kang, Suk-Hoon ; Lee, Seung-Ho ; Choi, Jang-Gi ; Chae, Hee-Sung ; Kwon, Dong-Yeul ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 9~19
Nineteen Medicaments of Mutual Antagonism currently belong to pharmaceutical incompatibility and some of them cannot be used in a same prescription: if they are used in a prescription, the treatment effect is rather reduced or toxic response may be produced. Therefore. inthisstudy, it was intended to look about how Nineteen Medicaments of Mutual Antagonism were defined through survey of literatures and to review the meaning and clinical potential. According to "Sinnongbonchogyeong," "Medicaments contain the substance that suppress toxins and the toxins may be removed with use of mutual restraint or mutual detoxication substances" and they have been used in terms of this concept. Since Tang and Song era, mutual restraint and mutual inhibition were confused and were difficult to be distinguished. In terms of pharmaceutical incompatibility, the original meaning of mutual restraint was deteriorated in "Sinnongbonchogyeong". That is. mutual restraint has been used as the concept of mutual inhibition or incompatibility. When various literatures were reviewed. it could be found that Nineteen Medicaments of Mutual Antagonism were firstly included in the phrases of songs and then in "seven emotion." It could be supposed that Nineteen Medicaments of Mutual Antagonism was created based on the clinical experiences of the author and the influence of doctors. Such supposition means indicates that the interactions among medicaments could effectively be applied and mutual restraint did not belong to pharmaceutical incompatibility. However. many doctors used mutual restraint and mutual inhibition in clinical practice with no distinguishment since Song era and. especially, it is supposed that. when medicaments were used with mixing. the pharmaceutical incompatibility of "Nineteen Medicaments of Mutual Antagonism" or "Eighteen Incompatible Medicaments" were emphasized and influenced on the efficacy of pharmaceutical preparations or acted as an obstacle in treating diseases. That is. an error was transferred: mutual restraint and mutual inhibition were not distinguished and were discretionally added or deleted through common people or professionals with no specific verification. The pharmaceutical preparations that belong to Nineteen Medicaments of Mutual Antagonism belong to pharmaceutical incompatibility but. when reviewed various literatures and clinical reports. they are not thought to be the ones that can never be used. Therefore. systematic literature review and experimental research should be performed.
The latest study trend about DM and So-gal -search oriental medical science article from 2003 to 2007-
Lee, Yeon-Kyeong ; Choi, Geu-Ho ; Shin, Hyun-Cheol ; Kang, Seok-Bong ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 21~33
At this moment, because there're lots of necessity to have an attention on diabetus mellitus (DM), in this article searched over all the Korean oriental medical academic journals about DM from 2003 to 2007, Method: Through data base system that Daegu Haany University affiliated information center & Korean Studies Information Center manage, selected 60 articles worthy to look up that are searched by the keyword 'DM' & '消渴'. Result and Conclusion: 5 articles of observing 'DM' & '消渴' itself academically, 29 articles of experimental study, 8 articles of clinical research study and 18 articles of case report. For experimental study, mostly it were concerning type II DM modeled rat medicated herb and its effect, so there were only a few type I experimental study. For observing articles, generally the causes, pathology, treatments, acupuncture methods and medication et al., variable studies were done. In clinical research, diverse categories were subject, which is to prove the efficacy of medication, acupuncture, physical therapy and diet supplements. And in case reports, focused not only on improvement in blood sugar level but also its complications.
Analysis of Studies on Palmul-tang for Establishment of Evidence Based Medicine
Ma, Choong-Je ; Lee, Nam-Hun ; Ma, Jin-Yeul ; Ha, Hye-Kyung ; Yu, Young-Beob ; Shin, Hyun-Kyoo ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 35~45
Objective : The purpose of this report was to provide the information activity and safety of Palmul-tang by analyzing domestic/international papers and theses about Palmul-tang, Methods: Domestic/international papers and theses related to Palmul-tang were reviewed and analyzed, These papers were then classified by year, experimental method and subject, Results: The following results were obtained in this study. 1. The study of Palmul-tang started from 1985 and was continuously increased. The study was mainly forcused on experimental model rather than clinical study. 2. As these studies were classified by subject, papers related to immune intensification were most abundant by 20 papers, Besides there were several papers related to cardiovascular activity, reproductive activity, anti-apoptotic activity and cerebral hemodynamics. 3. Among the papers related to immune intensification. the studies on recovery of fatigue were mostabundant by 10 papers and the studies of on immune cell and cytokine express were six. In addition to. several studies were associated with anti-cancer activity and anti-allergic activity. Recovery of fatigue was determined by measurement of fatigue markers in a living body such as lactate. CPK, pyruvate and triglyceride and assessment of exercise capability of animals such as swimming test. slopped plate test. Rota-rod test, and activity cage test after Palmul-tang treatment. 4. According to experimental data. it is supported that Palmul-tang has been used as Qi and Blood intensifier with immune intensification and recovery of fatigue. 5. The paper related to safety of Palmul-tang was only one paper which is studied on acute toxicity of Palmul-tang with experiment with ICR mouse. There was no study on evaluating safety by observing liver and kidney functions after Palmul-tang treatment Conclusion: Palmul-tang is being used in various ways associating with immune intensification. cardiovascular activity and reproductive activity. However. studies on efficacy and mechanism of Palmul-tang should be conducted at the molecular biology level and studies on safety of Palmul-tang need to be completed at the clinical level.
A study on Applications of prescriptions including Radix Angelicae Dahuricae as a main component in Donguibogam
Lee, Sung-Jun ; Jang, Sean-Il ; Yun, Young-Gab ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 47~64
This report describes 94 prescriptions related to the use of Radix Angelicae Dahuricae main bl ended from Donguibogam. The following conclusions were reached through investigations on the prescriptions that use Radix Angelicae Dahuricae as a key component. 11.7% of wind. 10.6% of carbuncle and deep-rooted carbuncle. recorded the largest number of clinical frequency of the prescriptions in therapeutic use when Radix Angelicae Dahuricae was ta ken as a monarch drug in prescriptions, Prescriptions that utilize Radix Angelicae Dahuricae as t he main component are used in the treatment of apoplexy and carbuncle and deep-rooted carbuncle. headache. wound and they are also used for treating 26 different types of diseases. The prescriptions are compounded with Radix Angelicae Dahuricae as a monarch drug can ap ply to apoplexy, exogenous febrile disease, invasion by wind. wind-cold pathogen, wind-heat path ogen. epidemic disease, pestilence. bruise, bites, deficiency of liver and kidney, deficiency, phlegm-fire, phlegm-heat. The dosage of Radix Angelicae Dahuricae is 0.37g to 7.5g, however 3.75g has be en taken the most for clinical application. The function of Radix Angelicae Dahuricae is to expelling Wind and relieving pain, to expelling wound and forming muscle. to astrict and neutralizing poison. to expelling wind and to getting through body hole. to emit and relieving pain from the combination of drugs and prescriptions.
Study trends on acupuncture and moxibustion Treatment of Cancer
Wi, Jun ; Jeong, Yeong-Pyo ; Chu, Min-Gyu ; Yoon, Yeo-Choong ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 65~77
Objective: To review and summarize the existing evidence on acupuncture&moxibustion treatment for cancer and cancer related symptoms. Methods : We searched Pubmed and jurnal of Korean acupuncture &moxibustion. Results: We selected 17 articles. effectivness of cancer acupuncture &moxibustion treatment. 14 articles reported acupuncture &moxibustion to be effective in subjective symptoms and quality of life. Other three articles reported that acupuncture&moxibustion treatment was moderately effective but insignificant compared to sham acupuncture&moxibustion treatment. Conclusion: For the study on acupuncture&moxibustion treatments in cancer it is necessary that we conduct research on the various natures of acupuncture&moxibustion. More clinical data would be needed to prove the effects of acupuncture&moxibustion treatment in cancer.
Study on Application of the Colla Corii Asini Blended Prescription from The Dongeuybogam
Kim, Chae-Hyun ; Jeung, Jong-Kil ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 79~87
This study was investigated to make sure the range of the Colla Corii Asini treatment. the nature of disease and the pathology of it in D ongeuyboga. The following conclusion were reached through invetigations on the prescriptions that use the Colla Corii Asini as a ingredient. 1. The Colla Corii Asini was used a internal disease more than a surgical disease in the dongeuybogam. 2. The Colla Corii Asini was used lung and large intestine disease in abundance and especially anhidrosis. cough and dysentery. 3. The Colla Corii Asini was applied much more disease about blood in the dongeuybogam, but some was used almost bleeding disease. one was used blood deficiency. 4. The processed Colla Corii Asini was used more than the Colla Corii Asini in the dongeuybogam, because of convenience of preparation and ease of intestinla drug absorption. 5. The Colla Corii Asini was used more useful dysentery than tranquilizeing mind in cooperation with Rhizoma Coptidis in the dongeuybogam. 6. Instead of the Colla Corii Asini, we can apply the Colla Comus Cervi or they are mutual reinforcement.
Effect of Kyungisan in on the Regional Cerebral Blood Flow and Mean Arterial Blood Pressure in Rats
Jung, Jong-An ; Hong, Seok ; Jun, Sang-Yun ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 89~98
Kyungisan (KGS) has been used in oriental medicine for many centuries as a therapeutic agent for treatment of stroke caused by deficiency of qi(氣虛). This study was performed to evaluate effects of KGS extract on the regional cerebral blood flow(rCBF) and mean arterial blood pressure(MABP) in rats. The result of this study were as follow ; 1. KGS significantly increased rCBF irrelevant to MABP in normal rats, 2. To prescribe KGS after pretreatment with indomethacin(IDN) decreased rCBF as compared with control group to administered only KGS in normal rats. But the change of MABP is not significantly as compared with control group. 3. To prescribe KGS after pretreatment with methylen blue( MTB) decreased MABP and rCBF as compared with control group to administered only KGS in normal rats. Especially, it significantly decreased rCBF. These results suggest that KGS increase rCBF by enlargement diameter of pial artery in brain. The active mechanism of KGS is related with prostaglandin activated by cyclooxygenase. So, I suggest that KGS has an anti-ischemic effect through the improvement of cerebral blood flow and can be used for stroke.
Anti-Inflammatory Effect of Jungcheonhwadamgangki-tang ga Antler in Xylene-Application Mouse Ear Acute Inflammation Model
Cho, Dong-Hee ; Son, Ji-Young ; Lee, Yeon-Kyeong ; Choi, Kyu-Ho ; Park, Mee-Yeon ; Choi, Hae-Yun ; Kim, Jong-Dae ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 99~111
In the present study, the anti-inflammatory effect of "Jungcheonhwadamgangki-tang ga Antler" water extract was tested in Xylene-Application mouse ear acute inflammation model. The test articles were once dosed before Xylene-Application, and the changes on body weight and ear weights and histopathological observation of induced ear were conducted with ear histomorphometry. The obtained results were as follows. The increases of absolute and relative ear weight detected in vehicle control compared to that of sham, were significantly and dose-dependently inhibited by Jungcheonhwadamgangki-tang ga Antler in the present study. A classic acute inflammatory histological changes such as subcutaneous edema, thickness and infiltration of inflammatory cells, was detected in vehicle control. However, these histological changes were significantly and dose-dependently inhibited by Jungcheonhwadamgangki-tang ga Antler. In addition, the increases of ear thickness half and thickness full detected in the vehicle control were also dose-dependently decreased in the all Jungcheonhwadamgangki-tang ga Antler-dosing groups. Base on these results, it is concluded that Jungcheonhwadamgangki-tang ga Antler extracts has clear anti-inflammatory effect on the acute inflammation such as bronchial asthma.
Acute Toxicity Study on Samul-tang(Siwu-tang) in Mice
Ma, Jin-Yeul ; Yu, Young-Beob ; Ha, Hye-Kyung ; Huang, Dae-Sun ; Ma, Choong-Je ; Shin, Hyun-Kyoo ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 113~117
Objectives: Samul-tang(Siwu-tang) has been traditionally prescribed a medicine as a restorative. Methods: In this study, we investigated the acute toxicity about water-extracted Samul-tang(Siwu-tang). Twenty-five mice completed 14 days of oral Samul-tang(Siwu-tang) at the respective doses of 0(control group), 2560, 3200, 4000 and 5000mg/kg. Results: We observed survival rates, general toxicity, change of body weight, and autopsy. Conclusions: Compared with the control group, we could not find any toxic alteration in all treated groups (2560, 3200, 4000 and 5000mg/kg).
of Samul-tang(Siwu-tang) was over 5000mg/kg and it is very safe to ICR mice.
Observation of Microorganism in Herbal Decoction mafactured by Korean Medical Clinic
Yu, Young-Beob ; Ma, Jin-Yeul ; Ha, Hye-Kyung ; Huang, Dae-Sun ; Kim, Bok-Kyu ; Shin, Kwang-Soo ; Shin, Hyun-Kyoo ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 119~126
Objectives: This study presents observation of microorganism such as total aerobic bacteria, total fungus, E. coli, Pseudonomas aerugjnosa, Staphylococcus aureus, and Salmonella typhimurium in herbal decoction manufactured by Korean medical clinic. Methods: We examined to observe microorganism using the requirements for the experimental methods recommended by FDA. For the identification, we observed microscopic methods and carried out polymerase chain reaction (PCR) and DNA purification. The purified DNA samples were analyzed by DNA sequencer. As compared with NCBI database. the results were identified by sequences similarity. Results and conclusion: 26 (55%) of 46 decoctions observed positive for microbial test. 12 (46 %) of 26 positive decoctions exceed requirement of microbial limit test. These microbial colony identified genus of Bacillus using microscopic and DNA sequencing methods.
Effect of Yong-dam-sa-gan-tang on apoptosis in human hepatoma HepG2
Yun, Hyun-Jeong ; Kim, Han-Seong ; Heo, Sook-Kyoung ; Hwang, Seong-Goo ; Park, Won-Hwan ; Park, Sun-Dong ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 127~137
The purpose of this study was to investigate the effect of Yong-dam-sa-gan-tang (YST) on apoptosis in HepG2 cells, First of all. to study the cytotoxic effect of methanol extract of YST on HepG2 cells, the cells were treated with various concentrations of YST and then cell viability was determined by XTT reduction method and trypan blue exclusion assay. YST reduced proliferation of HepG2 cells in a dose-dependent manner. To confirm the induction of apoptosis, HepG2 cells were treated with various concentrations of YST. The cleavage of poly AD P-ribose polymerase (P ARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of caspase-3, procaspase-8 and procaspase-8 were examined by western blot analysis. YST decreased procaspase-3, procaspase-8 and procaspase-9 levels in a dose-dependent manner and induced the clevage of PARP. YST triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome c from mitochondria to cytosol. Furthermore, YST also downregulated the anti-apoptotic Bcl-2 and upregulated the pro-apoptotic-Bax. Therefore, this result suggest that YST induced HepG2 cell death through the mitochondrial pathway. Sustained activation of the Ras/Raf/MEK/ERK cascade in cells results in a cell cycle arrest and has been implicated in the differentiation of certain cell types, in many cases acting to promote differentiation. YST decreased the activation of Ras/Raf/MEK/ERK cascade in a dose-dependent manner. These results suggest that YST is potentially useful as a chemo-therapeutic agent in HepG2.
Antioxidant Effect of Cynomorii Herba on HepG2 Cells and Diphenyl-picryl-hydrazyl (DPPH) Radical Scavenging Activity
Chang, Mun-Seog ; Yang, Woong-Mo ; Kim, Do-Rim ; Park, Eun-Hwa ; Park, Soo-Yeon ; Park, Seong-Kyu ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 139~145
The purpose of this study was to investigate the anti-oxidant effect of Cynomorium songaricum. The extract of Cynomorii Herba was studied for diphenyl-picryl-hydrazyl (DPPH) radical scavenging activity, HepG2 cell viability and
-induced cytotoxicity by a modified MTT assay. DPPH radical scavenging activity was measured after 30 minutes. The extract was tested by 1. 5, 10, 50, 100 and 500
concentrations. HepG2 cell viability by a modified MTT assay was measured in the concentrations of 10, 50, 100, 250, 500 ug/ml for 24 h. The results showed that the extract scavenged DPPH radical up to 52.2% with 50 ug/ml concentration. The extract did not reduced the cell viability and
cytotoxicity (69.4%) was blocked by the extract in the concentrations of 50, 100, 250 and 500
. In conclusion, the extract of Cynomorii Herba has potent antioxidant activity.
Anti-stress effects of Sihoueokgantang in the passive avoidance test and the forced swimming test
Jo, Yong-Kook ; Lee, Tae-Hee ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 147~160
Objectives: This study is carried out to investigate the anti-stress effects of the sihoueokgantang in rats. Methods: we performed the passive avoidance test and the forced swimming test. The degrees of TH were also measured with immunohistochemical method in the regions of VTA and LC. Results: 1. As the results of the passive avoidance test. the sihoueokgantang showed tendency to improvement in compared with control group. 2. As the results of the forced swimming test, immobility of rats was significantly decreased in sihoueokgantang in compared with control group. 3. As the results of TH expression in the region of the LC, TH-immunoreactive cells were significantly decreased in the sihoueokgantang 100 mg/kg. As the results of TH expression in the region of the VTA. TH-immunoreactive cells were significantly decreased in the sihoueokgantang 400 mg/kg. Conclusion: As the results above, it can be considered that sihoueokgantang has the effects of preventing depression and memory decrease caused by stress.
Chunggangunbi-tang-gamibang's Effect on Alcoholic Liver Cirrhosis with Ascites
Jeong, Eun-Woo ; Cho, Yoon-Sung ; Kim, Hyun-Sik ; Kim, So-Yeon ; Lee, Sang-Kwan ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 161~169
We applied Chunggangunbi-tang-gamibang to a 64 year-old male patient who had alcoholic liver cirrhosis with ascites. Chunggangunbi-tang-gamibang has been used to treat alcoholic liver disease and because of its beneficial effects. The patient with the disease expected several symptoms induced by Alcoholic liver cirrhosis, and we diagnosised differentiation of symptoms, using Chunggangunbi-tang-gamibang while removing dampness through diuresis and invigorating the spleen. After medication we could find remarkable effects on clinical symptoms, blood test results and abdomen ultrasonographic images. From this case, it is thought that using Chunggangunbi-tang-gamibang is very effective to improve the symptom of alcoholic liver cirrhosis with ascites.
A Case report of acute stroke patients treated with Chungyoung-tang
Cho, Yoon-Seong ; Jung, Eun-Woo ; Kim, So-Yeon ; Kim, Hyun-Sik ; Lee, Sang-Kwan ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 171~178
This study is clinical report for a acute stroke patient who was improved by treatment of a herbal medication. Stroke patients often shows spirit disorder in early stage. However, the cases which applied Onbyung theory are rare. This paper aims to show that Onbyung theory can be effective to acute stroke. We diagnosed the patient as invasion of the yong system by heat(熱入營分), which showed confusion, insomnia, delirium, anxiety, reddened tongue and dry mouth with cracked lip. After administration of Chungyung-tang(淸營湯) in Wen bing Tiao (溫病條辨), the patient showed those symptoms were highly improved. Thus, we concluded that Onbyung Theory can the patient be adapted to improve the symptom of acute stroke.
One Case of Irritable Bowel Syndrome Patient Treated With Jengjengamiyijin-tang (Zhengchuanjiaweierchen-tang)
Kim, Hoi-Young ; Nam, Hyo-Ik ; Son, Hyun-Soo ; Park, Sang-Moo ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 179~186
The irritable bowel syndrome(IBS) is the most common gastrointestinal disorder in clinical practice and is characterized by abdominal pain associated with a chronic disturbance of defecation. The subject is a-69-year-old man who has abdominal pain, chronic diarrhea. anorexia. general weakness and has been diagnosed as irritable bowel syndrome. We diagnosed this patient as the Gastrointestinal Phlegm(食痰) and prescribed Jengjengamiyijin-tang (Zhengchuanjiaweierchen-tang). In the result, we had improvement of his symptoms.
A Case Report of Ulcerative Colitis Medicated by Danggwihwahyeolsan-gamibang and Gami-Jeonssibaekchulsan
Hur, Jin-Il ; Cho, Dong-Hee ; Son, Ji-Young ; Kwak, Min-A ; Kim, Dae-Jun ; Byun, Joon-Seok ; Park, Kyung ;
Herbal Formula Science, volume 15, issue 2, 2007, Pages 187~195
This study is designed to evaluate the effects of an oriental herbal medication namely Danggwihwahyeolsan-gamibang and Gami-Jeonssibaekchulsan, on ulcerative colitis. Subject: A patient diagnosed ulcerative colitis who're not improved through western medication. Methods: The Clinical data was analyzed on a pastient with ulcerative clitis due to Changpung(腸風) resulted from Hanyeolchakjab(寒熱錯雜), whose symptoms were combined diarrhea, abdominal pain et al. The patient visited at the internal medicine department of Daegu Haany University affiliated Daegu Oriental Hospital on May 18. 2007 to June 25. 2007. The improvement of symptoms were checked by Seo Colitis Activity Index(AI).