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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Oriental Neuropsychiatry
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Journal DOI :
The Korean Society of Oriental Neuropsychiatry
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Volume & Issues
Volume 10, Issue 2 - Dec 1999
Volume 10, Issue 1 - Aug 1999
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Experimental studies on the anticonvulsion effect and mechanism of Samulanshintang
Kwon Bo-Hyung ; Gu Byung-Su ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 1~27
For experimental studies on the anticonvulsion effect and it was measured in mice that toxigenic effect, influence on the central nervous system, anticonvulsion effect, mechanism of anticonvulsion effect by change of GABA level and glutamic acid in brain, effect of the creation and degradation system of brain oxygen free radicals in convulsion. The results were obtained as follows: 1. Samulanshintang was perfect medicine without toxigenic effect. 2. Pretreatment of Samulanshintang did not influence on the central nervous system. 3. Pretreatment of Samulanshintang did not influence on maximal electric seizure(MES), strychnine, bicuculine and picrotoxin, but pentylenetrazol(PTZ)-induced convulsion significantly decreased. 4. Effect of Samulanshintang except for Jinsa on the PTZ-Induced convulsion decreased. 5. Effect of Samulanshintang fragrance(SMATF) and Samulanshintang distiled water(SMATW) on the PTZ-induced convulsion did not influence. 6. Decrease of brain GABA level in PTZ-induced convulsion was increased by pretreatment of Samulanshintang. 7. Decrease of brain glutathione content in PTZ-induced convulsion was increased by pretreatment of Samu- lanshintang. 8. GABA-T activity increased by PTZ-induced was controlled by the pretreatment of Samulanshintang. 9. Increase of brain lipid peroxide content in PTZ-induced convulsion was decreased by pretreatment of Samulanshintang. 10. Significant increase of brain xanthine oxidase and aldehyde oxidase activities in PTZ-induced was controlled by pretreatment of Samulanshintang. 11. Decrease of brain superoxide dismutase(SOD), catalase and glutathione peroxidase activities in PTZ-induced was decreased by pretreatment of Samulanshintang. From the above results, Samulanshintang was perfect medicine without toxigenic effect and was recognized anticonvulsion effect by decreasing brain glutamic acid level and increasing brain GABA level. Samulanshintang have an effect on creation and degradation system of brain oxygen free radicals in convulsion, thus it was considered that Samulanshintang could be applied in convulsive disorder as epilepsy, febrile seizure and spasm etc.
Effects of Jogihaeatag(調氣解瘀湯) on the Cerebral Cortex Neuron injured by XO/XA
Lee Yong-Keun ; Kang Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 29~45
As the average life span has been lengthened and the rate of senile population has been raised, chronic degenerative diseases incident to aging have been increased rapidly and become a social problem. With this social background, recently, oxygen radicals(OR) have toxic effects on Central Nervous System and Peripheral Nervous System and cause neuropathy such as Parkinson's Disease, Alzheimer Disease. The purpose of this study is to examine the toxic effects caused by Xanthine Oxidase(XO) and the effects of herbal extracts such as Jokihaeatang(JHT) on the treatment of the toxic effects. For this purpose, experiments with the cultured cell from the cerebrums of new born mice were done. The results of these experiments were as follows. 1. X0, an oxygen radical, decreased the survival rate of the cultured cells on NR assay, MTT assay and amount of neurofilaments and increased the amount of lipid peroxidation. 2. JHT have efficacy of increasing the amount of neurofilaments.
Effects of Peppermint Oil on Apoptosis of Astrocytes
Lee Sung-Ryull ; Kim Tae-Hun ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 47~57
Recently, essential oils are used for aromatherapy. Most essential oils are said to be anti-bacterial; some may be anti-viral or anti-fungal. I investigated the effects of peppermint pure essential oil on the heat shock-induced apoptosis in human astrocyte cell line CCF-STTGI. In previous studies, heat shock has been reported to induce the apoptosis or programmed cell death through the activation of caspase-3. We studied the heat shock-induced apoptosis through flow cytometry, DNA electrophoresis, and giemsa staining. Interestingly, these events were inhibited by pretreatment of peppermint pure essential oils in CCF-STTGl cells. Peppermint oil also inhibited the heat shock-induced apoptosis in primary cultured rat astrocytes. In addition, this Peppermint essential oil inhibited the heat shock-induced activation of caspase-3. These results suggest that peppermint pure essential oils may modulate the apoptosis through the activation of the interleukin-I -converting enzyme-like protease.
Studies on the anti-inflammatory action of steamed Rehmannia glutinosa in central nervous system
Jung Young-Sik ; Kang Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 59~70
We investigated whether an aqueous extract of Rehmannia glutinosa steamed root (RGAE) inhibits secretion of inflammatory cytolanes from primary cultures of mouse astrocytes. RGAE dose-dependently inhibited the
secretion by astrocytes stimulated with substance P (SP) and lipopolysaccharide (LPS). Interleukin-1 (IL-1) has been shown to elevate
secretion from LPS-stimulated astrocytes while having no effect on astrocytes in the absence of LPS. We therefore also investigated whether IL-1 mediated inhibition of
secretion from primary astrocytes by RGAE. Treatment of RGAE to astrocytes stimulated with both LPS and SP decreased IL-1 secretion to the level observed with LPS alone. Moreover, incubation of astrocytes with IL-1 antibody abolished the synergistic cooperative effect of LPS and SP. These results suggest that RGAE has an antiinflammatory activity on the central nervous system curing some pathological disease states.
The Effects of SUNGSIMJIHWANGTANG on the Blood Cell, Serum and Antioxidant Effects on Serum, Brain Tissue of Mouse
Kim Myung-Jin ; Lee Sang-Ryong ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 71~83
This study was to investigate the effects of SUNGSIMJIHWANGTANG(SSJHT) on the blood and brain tissues of aged rats. For the experiment, the aged rats were divided into three groups : Non treated group(NC), distilled water fed group(PC), SSJHT fed group(SSJHT). Each group was fed for ten days before administration of scopolamine. Then, we injected scopolamine intraperitoneally to PC and SSJHT group for 5 days. We observed the changes of their blood cell(WBC, RBC, platelet), blood serum(BUN, creatinine, glucose, uric acid), erythrocyte hemolysis, and the activities of cholinesterase and measured the amounts of malondialdehyde in the serum, catalase, and SOD in the brain tissue. The main results of this investigation are as follows. 1. In respect of the number of WBC, SSJHT group exhibited significant increase in comparison with PC. 2. In respect of the amount of creatinine and uric acid in the blood serum, SSJHT group exhibited significant decrease in comparison with PC. 3. In respect of erythrocyte hemolysis, SSJHT group exhibited significant suppression in comparison with PC. 4. In respect of the activity of cholinesterase in the serum, SSJHT group exhibited significant activation in comparison with PC. 5. In respect of the amounts of malondialdehyde in the serum, SSJHT group exhibited significant decrease in comparison with PC. 6. In respect of the activity of catalase in brain tissue, SSJHT group didn't exhibit significant change in comparison with PC. 7. In respect of the activity of SOD in brain tissue, SSJHT group exhibited significant activation in comparison with PC. As a result of this study, SSJHT is expected to have antiaging effect by suppressing the formation of free radicals, the accumulation of antioxidants and further study needs to be carried on about SSJHT.
The study on anticonvulsive effect of the fragrance of Magnoliae Flos in mice.
Shin Yong-Hyun ; Ku Byung-Su ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 85~103
In order to prove the anticonvulsive effect of the fragrance of Magnoliae Flos in convulsion-induced mice, experiments were performed on anticonvulsive effect, GABA level, glutamic acid level, GABA-T activity and GAD activity. The results were obtained as follows: 1. As far as anticonvulsive effect was concerned, on the convulsion induced by such as maximal electric seizure, strychnine, bicuculline, or picrotoxin it was not significant, but the convulsion induced by pentylenetetrazole it was significant comparing to the control group. 2. GABA level was increased significantly in mice. 3. Glutamic acid level was decreased significantly in mice. 4. GABA-T activity was decreased by the fragrance of Magnoliae Flos. 5. The fragrance of Magnoliae Flos was not effective in GAD activity. From above result, the fragrance of Magnoliae Flos had significant effects on convulsion induced by pentylenetetrazole, so it is expected to clinical application on convulsive diseases such as epilepsy.
The Effect of Sunghyangjungkisan on the Learning and memory of Nitric Oxide Synthase Inhibitor-treated rats in the Morris Water Maze.
Park Jung-Hyun ; Kim Jong-Woo ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 105~113
The purpose of this study was to investigate the effect of Sunhyangjungkisan on the learning and memory ability in rats. For this purpose we have evoked cerebral dysfunction in rats with NOS inhibitor and then performed the Morris water maze task for each rat. We have found that Sunghyangjungkisan have some improving effedts on impaired learning and memort ability in the NOS inhibitor treated rat. In these improving effects, memory effect was more evident then learning effect. This result implies that Sunghyangjungkisan may be one of useful prescriptions for treatment of vascular dementia after cerebral ischemia.
The effect of Woohwangchungsimwon on the learning and memory in NOS inhibitor treated rats in Morris water maze.
Baek Ji-Seong ; Kim Jong-Woo ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 115~126
This study was conducted to find out the effects of Woohwangchungsimwon on learning and memory in the NOS inhibitor treated rats. The Morris water maze was used in evaluating them. The result of the study was summarized as follows. 1. In the learning test, three groups have showed a gradual improvement of learning ability by repeating the trials in Morris water maze. WHCS group have showed statistical improvement than control group at 4,5,6 trial(p<0.05, p<0.01, p<0.01). 2. In the memory test, the first latency of WHCH group was statistically shortened than that of control group(p<0.05). 3. In the memory test, there was no statistical difference in the entry number between WHCH group and control. 4. In the memory test, there was no statistical difference in the memory score between WHCH group and control. The result of this experimental study presents that Woohwangchungsimwon has the improving effect on impaired learning and memory in NOS inhibitor treated rats, and implies that Woohwangchungsimwon may be one of the useful prescription for the treatment of vascular dementia after cerebral ischemia.
A Research of Relaxation therapy
Shin Yong-Cheol ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 127~133
In the study of the Relaxation therapy of Qi-gong, the results were as follows: 1. Although there are various ways to practice qigong, the following three elements should always be included. There are regulation of mind, body and respiration, among which regulation of mind is the most important one. Regulating the mind into a state of tranquility. is the most fundamental skill in qigong therapy. So smoothing the circulation of meridians, strengthened Essential-material(精), Qi(氣), Sprit(神). 2. The Qigong therapy makes the body and mind relaxed, and it is helpful of preventation of disease and mental health. And it treats neurosis, somatoform disease, and it uses resoluton of stress. As a result, The Qigong-therapy is preservation of health, raises the resistance of disease. 3. The Qigong therapy is more effective by application of music, aroma, taping-therapy.
<<영추(靈樞).본신편(本神篇)>>에 나타난 정비젼화(情志變化)와 신지상(神志傷)에 대(對)한 고찰(考察)
Jeong In-Cheol ; Lee Sang-Ryong ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 135~156
편두통(偏頭痛)의 중의진단(中醫診斷) 및 치험예(治驗例)에 대한 고찰(考察)
Hwang Seon-Mi ; Jeong Dae-Gyu ;
Journal of Oriental Neuropsychiatry, volume 10, issue 2, 1999, Pages 157~168