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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Oriental Neuropsychiatry
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Journal DOI :
The Korean Society of Oriental Neuropsychiatry
Editor in Chief :
Volume & Issues
Volume 14, Issue 2 - Nov 2003
Volume 14, Issue 1 - Jun 2003
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Effects of Hwangryeonhaedoktang on Depression and c-Fos Expression in Paraventricular Nucleus of the Brain in the Chronic Mild Stress Treated Rats
Chung, Sun-Yong ; Kim, Jong-Woo ; Lee, Jung-Ryun ; Jang, Hyun-Ho ; Kim, Hyun-Taek ; Whang, Wei-Wan ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 1~16
Objective : This study was designed to assess the protective effects of Hwangryeonhaedoktang on the animal model of depression, induced by chronic mild stress(CMS). Method : Male Sprague-Dawley rats were used for this experiment. The subjects were divided into 3 groups ( 1. CMS-drug: Hwangryeonhaedoktang administered during CMS treatment, 2. CMS-vehicle: water administered, 3. normal ). After 4 weeks of CMS treatment, they were executed forced swimming test(FST), open field test and c-Fos in paraventricular nucleus(PVN) were measured. Result : 1. In FST, immobility behavior decreased significantly in CMS-drug group. 2. There was no difference in the open field test between 3 groups 3. c-Fos expressed cell bodies in PVN were significantly less in CMS-drug than in CMS-vehicle group. Conclusion : These results suggest that Hwangryeonhaedoktang may have protective antidepressant effects in CMS model rats. And these effects could be explained by the elevated stress-copying behaviors which are related with PVN of hypothalamus.
A Study of Jowiseungchungtang in patients with mild Dementia of Alzheimer type
Cho, Seung-Hun ; Kim, Jong-Woo ; Kim, Hyun-Taek ; Chung, Kyung-Chun ; Whang, Wei-Wan ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 17~26
Objective : The clinical efficacy of Jowiseungchungtang(oriental herbal medication) over 6-month on the cognitive function in patients with mild Dementia of Alzheimer type(DAT) was investigated in this study. Method : The subjects for this study consisted of dementia patients who visited to the outpatient dementia department of Oriental Neuropsychiatry of the Kyunghee Oriental hospital. Patients were required to have at entry: a dignosis of mild DAT; Biochemical test, CBC, Urine analysis, Chest X -ray, EKG, Brain- MRI, Mini-Mental States-Korea(MMSE-K), Korean-Dementia Rating Scale(K-DRS), Samsung Dementia Questionaire(SDQ;to their caregiver). Patients(n=31) were assigned to treatment with Jowiseungchungtang (fourth/day for 6-month). The primary outcome measure was K-DRS. Result : 1. Patients' mean age was
years(range 59 to 86 years). 2. Patients' mean education was
years. K-DRS scores at baseline was
. K-DRS scores at 6-month was
. K-DRS scores at 6-month was not significantly different with K-DRS scores at baseline(t=.791 r=.435 p<.05). Conclusion : Treatment with Jowiseungchungtang for 6-month protected the cognitive function decline in patients with mild DAT.
The Effects of Whangryonhaedoktang on Morris Water Maze and Tyrosine Hydroxylase Expression in Ventral Tegmental Area and Locus Coeruleus of the Chronic Mild Stress Animal Model of Depression
Hong, Sung-Won ; Kim, Jong-U ; Kim, Eun-Ju ; Kim, Hyeon-Ju ; Kim, Hyeon-Taek ; Whang, Wei-Wan ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 27~44
Objective : The aim of this study was to assess protective effects of Whangryonhaedoktang on the chronic mild stress (CMS) animal model of depression. Method : Male Sprague-Dawley rats were used for this study. The subjects were divided into 3 groups (CMS-drug group: Whangryonhaedoktang was administered during CMS procedure, CMS-vehicle: water was administered during CMS procedure, normal control group: without CMS procedure). After 4 weeks of CMS procedure, Morris water maze (MWM) test and open field test were executed and tyrosine hydroxylase (TH) was measured in ventral tegmental area (VTA) and locus coeruleus (LC) of rat brain. Result : 1. CMS procedure induced defects of spatial learning in early period of MWM test. 2. CMS Whangryonhaedoktang group showed shorter escape latency in comparison with CMS control group in MWM test on the first day of the test. 3. CMS Whangryonhaedoktang group and CMS control group showed no significant difference of activities and emotional behaviors in comparison with normal control group in open field test. 4. CMS Whangryonhaedoktang group showed significant inhibition effects of TH expression in VTA and LC areas in comparison with CMS control group. Conclusion : These results suggest that Whangryonhaedoktang may have inhibition effects to early period defects of spatial learning and protective antidepressant effects in CMS model rats.
Effects of Morinda officinalis (MDOF) on Inhibition of Impairment of Learning and Memory, and Acetylcholinesterase in Amnesia Mice
Jung, In-Chul ; Lee, Sang-Ryong ; Kim, Hyun-Soo ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 45~58
Alzheimer's disease(AD) is progressive neurodegenerative disease, which is pathologically characterized by neuritic plaques and neurofibrillary tangles associated with the acetylcholinesterase, apolipoprotein E and butylcholinesterase, and by mutations in the presenilin genes PS1 and PS2, and amyloid precursor proteins (APP) overexpression. The present research is to examine the inhibition effect of MDOF on PS-1, PS-2 and APP overexpression by detected to Western blotting. To verify the effects of MDOF on cognitive deficits further, we tested it on the scopolamine-induced amnesia model of the mice using the Morris water maze tests, and there was ameliorative effects of memory impairment as a protection to scopolamine. MDOF only partially blocked the increase in blood serum level of acetylcholinesterase and Uric acid induced by scopolamine, whereas blood glucose level was shown to attenuate the amnesia induced by scopolamine and inreased extracelluar serum level compared with only scopolamine injection. In conclusion, studies of MDOF that has been know as anti-choline and inhibition ablilities of APP overexpression, this could also be used further as a important research data for a preventive and promising symptomatic treatment for Alzheimer's disease.
Effects of Cyperus rotundus (CPRT) on Inhibition of Impairment of Learning and Memory, and Acetylcholinesterase in Amnesia Mice
Jung, In-Chul ; Lee, Sang-Ryong ; Yun, Sang-Hak ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 59~74
Alzheimer's disease(AD) is a progressive neurodegenerative disease, which is pathologically characterized by neuritic plaques and neurofibrillary tangles associated with the acetylcholinesterase, apolipoprotein E and butylcholinesterase, and by mutations in the presenilin genes PS1 and PS2, and amyloid precursor proteins (APP) overexpression. The present research is to examine the inhibition effect of CPRT on PS-1, PS-2 and APP overexpression by detected to Western blotting. To verify the Effects of CPRT on cognitive deficits further, we tested it on the scopolamine-induced amnesia model of the mice using the Morris water maze tests, and there was ameliorative effects of memory impairment as a protection to scopolamine. CPRT only partially blocked the increase in blood serum level of acetylcholinesterase and Uric acid induced by scopolamine, whereas blood glucose level was shown to attenuate the amnesia induced by scopolamine and inreased extracellular serum level compared with only scopolamine injection. In conclusion, studies of CPRT that has been known as anti-choline and inhibition ablilities of APP overexpression, this could also be used further as a important research data for a preventive and promising symptomatic treatment for Alzheimer's disease.
Study on the Memory Enhancement of the Extract of Gongjadaesungjichimjung-bang(GDJB)
Kang, Yeon-Sug ; Chang, Mi-Kyung ; Kim, Geun-Woo ; Koo, Byung-Soo ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 75~84
Object : The present experiments were designed to study on the memory enhancement of the extract of Gongjadaesungjichimjung-bang(GDJB). Methods : The water extract of GCJB has been tested for its activities on memory enhancement by passive avoidance task in vivo and for its inhibitory effect on the acetylcholine esterase activity. Results : GDJB water extract significantly enhanced the memory at a concentration of 50mg/kg, but this effect did not proportionally increased at a dose of l00mg/kg and significantly inhibited the acetylcholine esterase activity in a dose-dependent manner in in vitro assay with IC50 value of 1.57mg/ml and also in in vivo assay. Conclusion : The extract of GDJB showed a memory enhancement as well as the inhibitory effect on acetylcholine esterase activity, which suggest that this prescription may be applied for the treatment of memory impairment.
Effect of acupuncture on behavior and dopamine release in the nucleus accumbens in rats sensitized to morphine
Kim, Jun-Han ; Kim, Tae-Heon ; Lyu, Yeoung-Su ; Kang, Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 85~106
Studies have shown that both the psychomotor stimulant effects and rewarding properties of addictive drugs, including morphine, are sensitized by repeated drug administration and it is suggested that both of these effects are mediated by the same or closely overlapping dopamine systems. Specifically, the mesolimbic dopamine system has been implicated in the reinforcing and sensitizing properties of morphine. In oriental medicine, Shenmen (HT7) point on the heart channel has been used to treat mental and psychosomatic disorders. This study was designed to investigate the effect of acupuncture on acute and repeated morphine-induced changes in extracellular dopamine levels using in vivo microdialysis and morphine-induced behavioral changes. In the morphine sensitization experiment, male Sprague-Dawley rats were treated twice a day for three days with increasing doses of morphine (10, 20 and 40 mg/kg, s.c.) or with saline. After 15 days of withdrawal, rats were challenged with morphine hydrochloride (5mg/kg, s.c.). Acupuncture was applied at bilateral Shenmen (HT7) points for 1 min after the morphine challenge. In the acute experiment, rats also received acupuncture for 1 min after an injection of morphine hydrochloride (5 mg/kg, s.c.). Results showed that acupuncture at the specific acupoint HT7, but not at control points (tail) significantly decreased both dopamine release and behavior induced by a systemic morphine challenge or a single sc morphine injection in the acute animals. These results suggest that reduction in sensitization may be one mechanism whereby acupuncture alleviates morphine craving in addicts.
The Antistress Effects of Semen Ziziphi Spinosae Extract
Lim, Dong-Seok ; Kim, Eun-Jung ; Cho, Su-In ; Lee, Dong-Won ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 107~116
The effects of Semen Ziziphi Spinosae extract were tested for the anti-stress action. 100g of crude drug of Semen Ziziphi Spinosae was extracted with pure water and the total extractive was evaporated under reduced pressure to give 10.7g. ICR male mice(
) were fed orally with the dose of 100mg/kg/day for five days. Foot shock was given to make experimental environment of physiological stress. Foot shock mice were placed individually in the foot shock compartments and sociopsychological mice were placed nonfoot shock compartment-the side of foot shock compartments. Mice were exposed to sociopsychological stress by restraining and seeing foot shock stressed mice for one hour for five days. Semen Ziziphi Spinosae extract administered group showed a significant decrease of serum corticosterone secretion compared with control group. Noradrenaline secretions in the dorsal cortex of brain were increased but not significant. Lipid peroxidation of the liver of mice were tested by measuring malondialdehyde, and Semen Ziziphi Spinosae extract had tendency of decreasing lipid peroxidation but not significant. But Semen Ziziphi Spinosae extract administration had the effect of decreasing serum level of aspartate aminotransferase and malondialdehyde. These results suggest that Semen Ziziphi Spinosae extract can effectively rid the sociopsychological stress and stress concerned diseases.
Symptom Checklist-90-Revision(SCL-90-R) in Inpatients on Tension headache and Insomnia
Shim, Sang-Min ; Koo, Byung-Soo ; Kim, Kyeong-Ok ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 117~131
SCL-90-R is a multidimensional self-report symptom inventory devoloped by Derogatis and his coworkers. Since it was standardized into Korean version in 1978 by Won and Kim et aI., but it has been rarely studies for the clinical groups. Objectives : This study sought to define a diagnotic character of SCL-90-R of tension headache and insomnia inpatients groups. Methods : We determined a diagnotic character of 17 tension headache and 23 insomnia patients by means of SCL-90-R, and compared with normal groups in order to characterize subscale of SCL-90-R in patients with tension headache and insomnia from Neurasthenia. Results : 1. Male tension headache group has significant difference in Somatization and Depression subscales, female group in Somatization, Obsessive-Compulsive, Depression and Hostility subscales. 2. Female insomnia group has significant difference in Anxiety subscale. Although there are a little significiant, many subscales such as Somatization, Obsessive-Compulsive, Depression and Hostility are higher than normal group. 3. There are significant difference in GSI and PDSI of Global index, which means that we use that for objective index of tension headache and insomnia from Neurasthenia. Conclusions : All of these results show that SCL-90-R is useful inventory to characterize and screening for Neurasthenia.
Clinical study on a case of a patient with a glossal tremor caused by a side effect of drugs
Kim, Geun-Woo ; Koo, Byung-Soo ; Kim, Hun-Il ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 133~139
The most common and unacknowleged something in the secondary parkinsonism is parkinsonism caused by drug abuse. Patient had a glossal tremor caused by a side effect of GIT regulators and antispasmodics taked for the purpose of cured cholecystitis. We thought that the cause of a glossal tremor is 'Pungdam(風痰)' and gave 'Chukdamtang(滌痰湯)'. As a result this patient was taken a quick turn for the better. This case is specific. Because parkinsonism is caused by GIT regulators and antispasmodics, and the symptom of side effect is a glossal tremor. We hope that this case arouse people's attention to a tremor caused by a side effect of drugs and is useful to medical cure and prognosis.
A case report on acquired torticollis
Won, Ho-Young ; Lee, Dong-Won ; Choi, Eun-Jung ; Kim, Kyong-Soo ; Kim, Eun-Jung ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 141~147
Objectives : The symptom of torticollis caused by abnormal contraction in cervical muscles, is easily found among those who get much stress physically and mentally in modern society. Due to this disease, the patients suffer not only from psychologic distress for appearance but also from functional disorder. Therefore, this case is to look for the effective treatment and understandings on the spasmodic torticollis. Methods : Herb medicine is used Guibi-tang(歸脾湯), Heosu-san(回首散), Hyangso-san(香蘇散) and Samul-tang(四物湯). Manipulation therapy is used stretching and meassage technique on cervical muscles. Self exercise of cervical and lumbosacral muscles, physical therapy with ultra sound carried out. Result and Conclusion : Acquired spasmodic torticollis effectively is treated with herb medicine, manipulation, exercise and physical therapy.
A case of Dizziness patient classified into 'Yeolhoon'
Lee, Dong-Won ; Kim, Eun-Jung ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 149~154
This is a case report about Dizziness patient classified into 'Yeolhoon(熱暈)' with 'Hyunghwangtang(荊黃湯)' prescription. Donguibogam(東醫寶鑑) says that taking a 'Hyunghwangtang' until one diarrhea, cures ‘Yeolhoon’ with flame and heat attacks a body, get thirsty. 'Hyunghwangtang' resulted from ‘Jangjahwabang(張子和方)’ is prescription that is based on ‘If disease is on the upper half of the body, treatment is done on the lower half of the body.’ We think that study and clinical examination about yeolhoon is considered, in the future.
The Case of regulation of Insomnia with Jahageo Herbal acupuncture
Jang, Hyun-Ho ; Doo, In-Sun ; Lee, Dae-Yong ; Lee, Seung-Hoon ; Min, Sang-Jun ; Kim, Tae-Heon ; Lyu, Yeoung-Su ; Kang, Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 155~160
The Common Symptoms of insomnia are to be hard to sleep, not to get deep sleep, often wake up at night, be easy not to fall asleep again after waking up. In serious conditions, an insomniac can never get to sleep overnight. Herbal acupuncture therapy is especially used for patients who cannot take an oral medication. Another advantage of herbal acupuncture therapy is immediate effect of the herbal potency which is not destroyed during digestion. One patient who have taken western drugs for long time, was treated with Jahageo herbal acupuncture at BaekRo and AnMyen. effectively his insomnia was regulated. So We consider that Jahageo herbal acupuncture is useful in regulation insomnia.
A Review of Attention Deficit Hyperactivity Disorder in Traditional Chinese Medicine
Lee, Tae-Ho ; Jang, In-Soo ; Kim, Jeong-Yun ; Kim, Lak-Hyung ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 161~174
Attention deficit hyperactivity disorder(ADHD) is one of the most common childhood-onset psychiatric disorders. It is distinguished by symptoms of hyperactivity, inattention, and impulsivity. The etiology of ADHD is unknown, and the disorder may several different causes. The pharmacotherapy most widely used for ADHD occasionally gives rise to ill effects. The studys of ADHD were approached from the viewpoint of medicine and pedagogics, but it is rare from the viewpoint of the Korean Medicine. So, we searched for the studies on ADHD of Chinese Traditional Medicine(TCM) in last eight years(1995-2002). In TCM, ADHD was placed under the category of 'wind(風)-one of the five pathogenic factors', 'insomnia(失眠)', 'forgetfulness(健忘)' and 'restlessness(躁動)', etc. Jang and Bu(the internal organs; 臟腑) related with the differentiations of syndrome about ADHD were liver(肝), heart(心), spleen(脾), kidney(腎) and gallbladder(膽). Among them, liver(肝), kidney(腎) and spleen(脾) were important. The herbal medicines used in ADHD had the effects of spirit-calming(安神), orifices-opening(開竅), Eumyang-balance(陰陽平衡). And acupuncture therapy, ear-acupuncture therapy and dietary treatment, etc. were used in the treatment of ADHD. We expect that this review about ADHD in TCM help the clinical study of ADHD in Korean Medicine.
A Case With Traffic Accident Related Post-traumatic Stress Disorder
Sim, Yun-Seub ; Kim, Sun-Hong ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 175~181
A lot of research have been done so far in terms of traffic accident sequela, but most of them have stressed simply on physical treatments, resulting in less attention to the psychological ones. This is a case report of a patient with post-traumatic stress disorder. Although that is simply following in the wake of past therapy, we were experienced an improved case of post-traumatic stress disorder patient treated by herbal medicine, acupuncture, mental therapeutics. This case effectively describes the characteristics of the post-traumatic stress disorder, and it also suggested one approach for the treatment of the disease. This report is for the better understanding of the disease, and also the search for the advanced treatments to it hereafter.
Differences in Depression between Over weight and Normal Group who visited to Obesity Clinic for Diet Therapy
Lee, Jeong-Hoon ; Park, Sang-Dong ; Park, Yong-Yup ; Park, Se-Jin ;
Journal of Oriental Neuropsychiatry, volume 14, issue 1, 2003, Pages 183~192
Objective : Obesity is related to psychological problems as well as physical problems. This study was designed to investigate the depression of over weight and normal group who visited to obesity clinic for diet therapy. Methods : 67 patients were selected(obesity group 42, normal group 25), they were treated medically in obesity clinic of Dong-Seo Oriental Hospital. We checked age, sex, education level, relative weight, BMI and Beck Depression Inventory(BDI) in two group. Results : The results were summarized as followed. 1. The ratio of Relative Weights are
in over weight group,
in normal group. 2. The ratio of BMI are
in over weight group,
in normal group. 3. The results of BDI score are
in over weight group,
in normal group. Conclusions : These results suggested that the patients who participated in diet therapy had mild depression and we should pay attention to psycological problem as well as the physical problem when we treat obesity.