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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Oriental Neuropsychiatry
Journal Basic Information
Journal DOI :
The Korean Society of Oriental Neuropsychiatry
Editor in Chief :
Volume & Issues
Volume 18, Issue 3 - Dec 2007
Volume 18, Issue 2 - Jul 2007
Volume 18, Issue 1 - Mar 2007
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A study on Oriental-medical Understanding of Tic Disorders (Within Dong yui bo gam Book)
Sim, Min ; Lee, Jong-Hwa ; Kim, Tae-Heon ; Lyu, Yeoung-Su ; Kang, Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 1~12
Objective : The aim of this study was to categorize tic disorders and introduce the treatments of tic disorders in oriental medicine. This article includes the report of successful treatment with oriental medicine. Methods : The author classifided the terms of oriental medicine in associated with tic disorders based on DSM-IV and then studied symptoms, etiological causes, and treatment through
Dong yui bo gam Book
. Results and Conclusions : 1. The concept of Tic disorders is similar to Mok-cha (目箚), Gun-chuck-youk-soon, Soon-dong, Mae-hack-gi (梅核氣) and etc, in oriental medical term. 2. In oriental medicine, tic disorders can be classified Gan-poong-nae-dong-zung (肝風內動證) type, Dam-hwa-yo-sin-zung (淡火擾神證) type, Bee-her-gan-wang-zung (脾虛肝旺證) type and Gan-sin-um-her-zung (肝腎陰虛證) type. 3. In oriental medicine, tic disorders are treated by much(so) various therapy such as herb medication, acupuncture and moxibustion, oriental psychotherapy and dirigation (Gi-Gong, 氣功) etc. 4. Tourette’s disorder is not easy to cure. When the treatment of occidental medicine and that of oriental medicine are mutually cooperated, more effective medical care might be expected. Therefore, it is necessary for further study to treat tic disorders by mutually cooperated therapy.
Inhibitory effect of Alzheimer's in APP-induced Neuro 2A cells by JangWonHwanGagambang(JWHG) water extract
Kim, Sang-Tae ; Lee, Jong-Hwa ; Kim, Tae-Hyeon ; Son, Hyeong-Jin ; Han, Pyeong-Leem ; Kang, Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 13~24
Objective : Recent studies indicate that the deposition of
) is related in the pathogenesis of Alzheimer's disease (AD), but the underlying mechanism is still not clear. Method : To investigate the potential cellular functions of APP and water extract of the JangwonHwangagambang (JWHG), we use as in vitro model, neuro 2A cells were treated with either JWHG or its oriental medicines, and the effect in APP expression was determined by MTT and LDH assay. JWHG have been shown to be neuroprotective in different model systems. We asked whether JWHG treatment would influence cell survival and AD-like pathology in APP-induced neuronal cells. Result : JWHG and water extracts of some oriental medicine has attenuated high cell death in vitro. JWHG-treated cells increased percentage of cell survival more longly than controls. JWHG had significantly increas neurite outgrowth in the as compared to control cells. Conclusion : These results suggest that JWHG prevent APP-induced neurotoxicity through attenuating oxidative stress, and may be useful as potential therapeutic agents for AD.
Changes of HRV according to Emotional Stimulus in Sasang Constitutional Groups
Lee, Gyung-Ro ; Shin, Dong-Yun ; Kim, Young-Won ; Yi, Ja-Hyeong ; Song, Jung-Mo ; Kim, Lak-Hyung ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 25~34
Objective : This study was done to investigate the differences of HRV(Heart Rate Variability) change as the response to the emotional stimulus in each Sasang constitutions. Method : We investigated 44 healthy volunteers consisted of 10 Soyangin, 14 Soeumin and 20 Taeumin. After diagnosing the Sasang constitution by specialist of Sasang medicine, we measured the baseline emotional state(100 sec) before the stimulus, the changing emotional state(100 sec) while fearful film was being played. And we rechecked the emotional state(100 sec) while taking a rest. At last, volunteers checked the questionnaire for emotional response. We analysed ECG data with HRV-time domain and frequency domain analysis. Results : (1) There were no significant difference in Mean-RR , SDNN between each groups. (2) LF of Taeumin group significantly increased by the emotional stimulation compared with other groups. (3) There was no significant difference in TP, HF, normalized LF, normalized HF, but the variation of each period in Taeumin group was bigger than those of other groups. (4) Soeumin group reported that they felt significant disgust-emotion in the questionnaire compared with other groups. Conclusion : Taeumin group showed significant emotional changes on HRV by fear stimulus film.
A Review of Attention Deficit Hyperactivity Disorder in Traditional Chinese Medicine
Park, Hyun-Chul ; Kang, Mun-Su ; Kim, Lak-Hyung ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 35~44
Objective : The purpose of this study is to take around the oriental medical treatment about Attention Deficit Hyperactivity Disorder in China. Method : We reviewed the 22 studies about ADHD which were published from 2005 to 2006. We selected those studies from CNKI (中國知識基礎設施工程 http://www.cnki.net). Result : We could find 22 studies about ADHD in CNKI from 2005 to 2006. DSM (III-R of IV) was used frequently in the diagnosis of ADHD. Herbal medicines, acupuncture, auricular therapy, moxibustion, chuna treatment, cupping therapy were used in the tre atments of ADHD. Differentiation of syndromes-Eum deficiency, heart and spleen deficiency, Damwha- was important in the diagnosis and treatments of ADHD in TCM. Jang and Bu(the internal organs; 臟腑) concerned in differentiation of syndromes about ADHD were Liver 肝, Kidney 賢, Heart 心, Spleen 脾. Most of studies reported very good results compared with western medicine treatment- Ritalin medication. Conclusion :There have been reported many ADHD clinical studies in China and these studies can be applied to the clinical practices in Korea.
Experimental Study on the Antidepressant Effect of Radix Curcumae
Lee, Jae-Youl ; Kim, Yong-Rae ; Whang, Moon-Je ; Koo, Byung-Soo ; Kim, Geun-Woo ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 45~55
Objective : The purpose of this study was to investigate the protective effects of Radix Curcumae on the animal model of depression induced immobilization stress. Method : 1) Male rats were used for this experiment. The subject were divided into 4 groups(1. normal 2. saline solution administered during immobilization stress treatment 3. Radix Curcumae of l00mg/kg administered 4. Radix Curcumae of 400mg/kg administered). 2) Immobilization stress was treated for 1 hours on day. During 2 days of immobilization stress treatment, they were executed forced swimming test, passive avoidance test, elevated plus maze test. Corticosterone in blood were measured. Results : 1) In EPM test, stress group showed significantly increased anxiety, Radix Curcumae of 400mg/kg group showed significantly decreased anxiety. 2) In forced swimming test, Radix Curcumae of 400mg/kg group showed significantly decreased immobilization. 3) In passive avoidance test, stress group showed significantly decreased learning execution, Radix Curcumae groups showed significantly increased learning execution. 4) Stress group showed significantly increase in serum level of corticosterone, Radix Curcumae of 400mg/kg group showed significantly decreased serum level of corticosterone. Conclusion : These results suggest that Radix Curcumae is effective in the treatment of depression.
Anti-obesity and Anti-hyperlipidemic Effects of Taeyeumjowee-tang and its modified prescription
Kim, Kil-Soo ; Lee, Dong-Ung ; Kim, Yong-Lae ; Hwang, Moon-Je ; Kim, Geun-Woo ; Koo, Byung-Soo ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 57~74
Objective : The purpose of this study was to investigate the anti-obesity and anti-hyperlipidemic Effects of Taeyeumjowee-tang and its modified prescription on the animal model of obesity and hyperlipidemia induced high-fat diet. Method : 1) The extracts of Taeyeumjowee-tang (TJT) and its modified prescription, Taeyeumjoweetang gagam-bang (TJGB) were evaluated for its inhibitory effects on obesity. 2) The body weight and feed weight were determined in the pre-treated and post-treated mice and the lipid profiles in the serum were analyzed in order to evaluate the anti-hyperlipidemia action of the extracts. 3) The effect of each extract was investigated for the influences on monoamine oxidase activity and HMG-CoA reductase activity. Results 1. TJT and TJGB extracts dose-dependently reduced the body weight and feed intake in normal mice. The effect of TJGB extract was better than that of TJT extract. 2. TJGB extract diminished the body weight increase and reduced the feed intake in the pre-treatment or post-treatment of the extract 3. TJGB extract decreased the amount of total cholesterol slightly and triglyceride potently after the pre-treatment or post-treatment, but HDL cholesterol exhibited no remarkable change compared with control. 4. TJGB extract weakly potentiated the monoamine oxidase activity, but its effect was better than that of TJT extract. 5. TJGB extract weakly inhibited the HMG-CoA reductase activity, but its effect was better than that of TJT extract. Conclusion : Taeyeumjowee-tang and its modified prescription can clinically be useful as anti-obesity drug and also for the improvement of hyperlipidemia.
Influence of Gigaltang on Alcohol Intake Amount in C57BL/6 mice
Byun, Soon-Im ; Kim, Sung-Gon ; Kim, Jong-Woo ; Whang, Wei-Wan ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 75~88
Objective : This study was designed to test the anti-craving effect of Gigaltang(extracts of Oriental medicinal herbs ; Hovenia dulcis and Puerariae flos) in C57BL/6 mice. Anti-craving effect was substituted by alcohol intake amount of C57BL/6 mice. Method : 60 C57BL/6 mice was randomized into vehicle(water) group and Gigaltang group. Only 39(vehicle group(21) and Gigaltang group(18)) was eligible for this study, and 21 C57BL/6 mice was dropped out. The procedure was composed of 5 days of adjustment period and 32 days of alcohol exposure and withdrawal period with limited access paradigm and 10 days of treatment period. Alcohol was offered only for 2 hours a day from 2 to 4PM and water was offered for 22 hours left. Food was offered for 24 hours a day. 1140mg/Kg/day of Gigaltang was administrated to 18 mice of Gigaltang group for 10 days whereas water to 21 mice of vehicle group. The amount of alcohol intake, water intake, food intake, body weight were measured every other day. Result : There weren't significant differences in 2 hours of alcohol intake, 22 hours of water intake, 24 hours of food intake and body weight for ten days between Gigaltang and vehicle group. Conclusion : Anti-craving effect of Gigaltang on C57BL/6 mice wasn't verified. To verify the anti-craving effect, further study with advanced animal model, various dose of Gigaltang and diverse period of drug administration should be taken.
The Study of Cognitive Functional Difference and EEG Spectrum Difference among Sasang Constitutions
Kim, Seok-Hwan ; Choi, Kang-Wook ; Lee, Sang-Ryong ; Jung, In-Chul ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 89~100
Objective : The purpose of this study is to examine relationship between cognitive function and sasang constitution by analyzing EEG status of company workers in Cheon-An. Method : 59 company workers were tested with cognitive assessment EEG program and questionaire for the Sasang Constitution Classification II. They were assorted by Sasang Constitutions, and we analyzed its correlation with cognitive assessment score and EEG data. Results : 1. According to mean active EEG rhythm of Alpha. H-Beta, Gamma wave, there were no significant difference among Sasang Constitution. 2. According to mean success, error, concentration, response, workload and left/right brain activity score, there were no significant difference among Sasang Constitution. 3. According to mean active EEG rhythm of Theta, SMR, M-Beta wave, Soyangin(少陽人)'s value was significantly higher than that of Taeumin(太陰人) 4. According to mean cognitive strenghth score, Soyangin(少陽人)'s value was significantly higher than that of Taeumin(太陰人). Conclusion : In conclusion, Sasang Constitutional difference has no relevance with cognitive abilities However, Soyangin(少陽人) showed higher mean active EEG rhythm of Theta, SMR, M-Beta wave than that of Taeumin(太陰人). In addition, Soyangin(少陽人) also showed higher mean cognitive strenghth score than that of Taeumin(太陰人).
The Effects of NogYongDaeBoTang,(NYDBT)on the Alzheimer's Disease Model Induced by CT-105 and
Seo, Gyoo-Tae ; Lee, Eun-Kyung ; Choi, Cheol-Hong ; Chung, Dae-Kyoo ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 101~132
Objective : This research investigates the effect of the NogYongDaeBoTang,(NYDBT) on Alzheimer's disease. Method : The effects of the NYDBT extract on (1)
, IL-6, and
mRNA of PC-12 cells treated with LPS; (2) acetylcholinesterase(AChE), amyloid precursor proteins(APP), and glial fibrillary acidic protein(GFAP) mRNA the AChE activity and the APP production of PC-12 cell treated with CT-105; (3) the behavior; (4) expression of
mRNA; (5) the infarction area of the hippocampus, and brain tissue injury in Alzheimer‘s diseased mice induced with
were investigated. Results : 1. The NYDBT extract suppressed the expression of
, IL-6 and
mRNA in BV2 microglia cell line treated with LPS. 2. The NYDBT extract suppressed the expression of
, IL-6, and
protein production in BV2 microglia cell line treated with LPS. 3. For the NYDBT extract group a significant inhibitory effect on the memory deficit was shown for the mice with Alzheimer's disease induced by
in the Morris water maze experiment, which measured stop-through latency, and distance movement-through latency. 4. The NYDBT extract suppressed the over-expression of
protein, MDA, and CD68/CD11b, in the mice with Alzheimer's disease induced by
. 5. The NYDBT extract reduced the infarction area of hippocampus, and controlled the injury of brain tissue in the mice with Alzheimer's disease induced by
. 6. The NYDBT extract reduced the Tau protein, GFAP protein, and presenilin1/2 protein (immunohistochemistry) of hippocampus in the mice with Alzheimer's disease induced by
. Conclusions : These results suggest that the NYDBT extract may be effective for the prevention and treatment of Alzheimer's disease.
A Case Report of Wi syndrome Treated by the Way of Reinforcing Weakness of the Spleen and Stomach(脾胃虛弱)
Yoo, Jong-Ho ; Koo, Byung-Soo ; Kim, Geun-Woo ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 133~142
Wi syndrome is the syndrome that reveals muscle relaxation without contraction and muscle relaxation occurs in the low or upper limb, in severe case leads to death. We experienced a 80year-old woman who had a Wi syndrome, and treated by the way of reinforcing weakness of the spleen and stomach(脾胃虛弱). After being treated, the patient showed that symptoms (gait disturbance, ptosis, dysphonia) was improved. This result suggests that oriental medical treatment has good effect on Wi syndrome.
A Case Report of the Herbal Medication Treatment and Counseling Therapy for the Chronic Idiopathic thrombocytopenic purpura Patient
Lee, Je-Kyun ; Kim, Ji-Hyung ; Ryu, Ki-Jun ; Kwon, Seung-Ro ; Lim, Myung-Jang ; Kang, Man-Ho ; Kim, Ha-Neul ; An, Keon-Sang ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 143~151
This study report the good reslut for chronic Idiopathic thrombocytopenic purpura(ITP) patient with Herbal medication treatment and Counseling therapy. The case was a 56 years old female who worried about small matters too much. This patient treated in western medicine, However, didn't see any improvement. So, the patient admitted in our hospital. We diagnosied this patient as 'The Defiency of the Spleen energy', caused by too much thinking and concern. Herbal medication(Nokyonggunbitang)and psychotherapy applied to this patient for hospitalized 22 days. The result showed that blood platelet increased at discharged moment(37,000 /
) compared with the admission time(19,000 /
). The present result indicated that Herbal medication treatment and psychotherapy may play a role elevate and maintain the number of blood platelet.
A Case Study of Pain Disorder Treated by Hypnosis
Kim, Ja-Young ; Ahn, Dea-Jong ; Lee, Ji-Young ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 153~162
This study is designed to assess the effect of hypnosis on the pain disorder patient. We treated a patient by using hypnosis as well as traditional oriental therapy-acupuncture, herbal medicine, Chu-Na therapy. We divide the pain into four parts and then we checked the intensities of them comparing with those of the first treatment. The pain worsened by psychic factor was decreased after treatment. Especially, after hypnosis, the intensity of the pain is highly changed. Psychotherapy in oriental medicine can be helpful to treat patients who have psychic and physical disorders.
Clinical Report of One Patient with the Vascular dementia by Sesimtang mixed Gujuntag
Jung, Myong-Suk ; Kang, Hee-Chul ; Lee, Seung-Gi ;
Journal of Oriental Neuropsychiatry, volume 18, issue 2, 2007, Pages 163~171
Dementia is a syndrome charaterized by a decline in multiple fields of cognitive domains. This is the case of a vascular dementia patient with disorientation, memory impairment and mental disorders. The patient was treated with herb medicine, Sesimtang mixed Gujuntang. As a result of herb medication, patient’s memory and disorientation were improved and the score of K-DRS(Korea-Dementia Rating Scale) and MMSE-K(Mini-Mental State Examination-K) was ascended.