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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Oriental Neuropsychiatry
Journal Basic Information
Journal DOI :
The Korean Society of Oriental Neuropsychiatry
Editor in Chief :
Volume & Issues
Volume 22, Issue 4 - Dec 2011
Volume 22, Issue 3 - Sep 2011
Volume 22, Issue 2 - Jun 2011
Volume 22, Issue 1 - Mar 2011
Selecting the target year
The effects of Sa-am Acupuncture Simpojeongkyeok Treatment on Hwa-byung : Randomized, patient-assessor blind, placebo-controlled acupuncture, pilot clinical trial
Choi, Woo-Jin ; Lee, Seung-Gi ; Son, In-Bong ; Sun, Seung-Ho ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 1~13
DOI : 10.7231/JON.2011.22.2.001
Objectives : The purpose of this research is to examine the effects of Sa-am acupuncture Simpojeongkyeok treatment on Hwa-byung. Methods : The study was performed through a patient-assessor blind, randomized, placebo-controlled trial in which the volunteers, data collector and analyst were unaware of individuals which were receiving the treatment. Fifty volunteers were divided into a trial and a control group, each of which consisted of 25 subjects. The trial group was treated with Sa-am acupuncture Simpojeongkyeok, while needle insertion at non-acupoints was given to the control group. The Likert scale for major symptoms of Hwa-byung was measured as the 1st evaluative instrument, and then a comparative analysis was conducted by comparing the results with those measured by of STAXI-K, STAI-K and BDI-K. Results : In the Likert scale comparison of major symptoms, total scores in both groups were decreased after treatment. However, a more significant decrease was found in those of trial group compared to those of the control group from a statistical perspective. The results measured by BDI scores also decreased significantly in the trial group after treatment. In comparison of STAXI and STAI scores, there were no significant differences found between the groups. Conclusions : The results suggest that Sa-am Acupuncture Simpojeongkyeok treatment is effective in the treatment of Hwa-byung.
Study on Correlation between Four Constitution Characteristics and Hwa-byung - Based on Hwa-byung Epidemiologic Study Data -
Suh, Hynu-Uk ; Chung, Sun-Yong ; Kim, Myoung-Geun ; Kim, Jong-Woo ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 15~25
DOI : 10.7231/JON.2011.22.2.015
Objectives : The aim of this study was to find correlations between characteristics of Four constitution and Hwa-byung. Methods : Clinical data were collected from Hwa-byung Epidemiologic study data. we selected 130 self-labelled Hwa-byung patients data and 83 of them were diagnosed as Hwa-byung by SCID. We used Hwa-byung SCID, Hwa-byung scale, CES-D, STAI, STAXI and Personality and Physiological Symptom Questionnaire(PPSQ) as evaluation tools. We performed statistical analysis of each 2 groups, self-labelled Hwa-byung group(N=130) and diagnosed Hwa-byung group(N=83). Results : 1. In self-labelled Hwa-byung group, Greater yin score showed significant negative correlation with 3 indices of Hwa-byung scale and significant positive correlation with 1 index. Lesser yin score showed significant positive correlation with 6 indices. In diagnosed Hwa-byung group, Greater yin score showed significant negaitive correlation with 5 indices. In both groups, Lesser yang score showed no significant correlation with any indices of Hwa-byung scale. 2. In self-labelled Hwa-byung group, Greater yin score showed significant negative correlation with both trait anger score and state anger score of STAXI. Lesser yin score showed significant positive correlation with trait anxiety score, state anxiety score and CES-D score self-labelled Hwa-byung group. Lesser yang score showed significant positive correlation with anger-out score of STAXI. But Lesser yin score showed significant negative correlation with same index diagnosed Hwa-byung group. Conclusions : 1. The higher Greater yin score, suppression or denial, psychological defense mechanism, become more stronger. 2. The higher Lesser yin score, anger-out tendency become more weakened and increased prevalence of Hwa-byung symptoms. 3. The higher Lesser yang score, anger-out tendency become more stronger.
Corelationship Study between Hwa-Byung and Type A Behavior Pattern, Cardiovascular Disease
Jeong, Ha-Ryong ; Koh, Sang-Baek ; Park, Jong-Ku ; Yu, Jun-Sang ; Kong, Kyung-Hwan ; Lee, Jae-Hyok ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 27~37
DOI : 10.7231/JON.2011.22.2.027
Objectives : The purpose of this research is to investigate the corelationship between Hwa-Byung and type A behavior pattern (TABP), cardiovascular disease. Methods : 637 people participated in the community based cohort study in Wonju City of South Korea from July 2nd to August 30th in 2006. Educated investigators checked up EKG and surveyed Hwa-Byung Diagnostic Interview Schedule(HBDIS), Framingham Type A Pattern Score(FTA score). Collected data were analyzed by the chi-square test & t-test. Results : 1. TABP, Hwa-Byung group was 24(70.6%), non Hwa-Byung group was 288(27.8%) p-value was 0.016. Difference of the two group was valid. 2. FTA score, Hwa-Byung group was
, non Hwa-Byung group was
, p-value was 0.002. Difference of the two group was valid. Conclusions : TABP ratio, FTA score was high in Hwa-Byung group compared with non Hwa-Byung group.
Two Case Reports of Cerebral Infarction Patients with Urinary Disturbance Treated by Gamigumguesingi-hwan
No, Dong-Jin ; Park, Jang-Ho ; Lyu, Yun-Sun ; Lee, Go-Eun ; Park, In-Sook ; Lyu, Yeoung-Su ; Kang, Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 39~47
DOI : 10.7231/JON.2011.22.2.039
Objectives : The purpose of this study is to examine the effect of Gamigumguesingi-hwan(Jiaweijinkuishenqi-wan) against urinary frequency. Methods : Gamigumguesingi-hwan(Jiaweijinkuishenqi-wan) is known as a useful herbal medication for urinary fequency. So we treat two patients with Gamigumguesingi-hwan(Jiaweijinkuishenqi-wan) three times a day. By investigating the frequency of urine, we can get some data. Results : One patient's nocturia frequency was counted 10 times to 3 times and voided volume was increased. The other patient's nocturia frequency was counted 10 times to 3~4 times. Conclusions : Gamigumguesingi-hwan(Jiaweijinkuishenqi-wan) is effective in urinary frequency and nocturia.
A Clinical Report of a Psychosomatic patient who has treated by Giungoroen-therapy based on Song Psychotherapy
Kim, Soo-Hyun ; Kim, Bo-Eun ; Chung, Dae-Kyoo ; Choi, Jung-Kyu ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 49~59
DOI : 10.7231/JON.2011.22.2.049
Objectives : This study was performed to report the effect of Giungoroen-therapy based on song psychotherapy in the treatment resistant patient with psychosomatic disease. Methods : A 43 year-old female patient suffered from headache, facial numbness, right upper and lower limb's numbness, ptosis, chest discomfort, dysarthria without identifiable physical cause. We diagnosed her as psychosomatic disease, and tried to apply Giungoroen-therapy with Korean traditional medical treatment. But she was resistant to Giungoroen-therapy. So we applied Giungoroen-therapy based on song psychotherapy. Results : After the Giungoroen-therapy based on song psychotherapy, the patient revealed her unrecognized hidden issues and got some insights about herself. Then the symptoms, such as headache, facial numbness, right upper and lower limb's numbness, ptosis, chest discomfort and dysarthria were reduced considerably. Conclusions : These results suggest that Giungoroen-therapy based on song psychotherapy can be effective on improvement of resistant psychosomatic disease.
A Clinical report on psychogenic torticollis
Ahn, Hyo-Jin ; Seo, Deok-Won ; Ryu, Ho-Sun ; Ko, In-Sung ; Lee, Su-Bin ; Park, Se-Jin ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 61~69
DOI : 10.7231/JON.2011.22.2.061
Objectives : The purpose of this study was to investigate the clinical application of Korean Traditional treatment to psychogenic torticollis patient who has panic disorder as underlying disease. Methods : Herb medicine used in this study are Heosu-san(Huishou-san) which is previously used for torticollis in several studies, Guibi-tang(Guipi-tang) and Gamiondam-tang(Jiaweiwendan-tang) which are frequently used for phychological disease. Also, physical therapy and aroma therapy were practiced which basically stretches and relaxes muscles around cervical muscles. Self exercise of cervical muscles was carried out during acupuncture. Results : After the comprehensive treatment, the clinical symptoms of the patient were improved. Conclusions : It is suggested that oriental medical treatment are effective in psychogenic torticollis.
A Case Report of The Delirium Accompained Wi syndrome(痿證) During The Treatment of Pneumonia
Kim, Soo-Jung ; Kim, Jin-Yi ; Ryu, Chun-Gil ; Seo, Joo-Hee ; Kim, Ji-Na ; Sung, Woo-Yong ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 71~83
DOI : 10.7231/JON.2011.22.2.071
Delirium is an acute syndrome of disorientaion caused by dysfunction of brain and has many various symptoms. The characteristic symptoms of delirium are conscious disturbance with disorientation, dysarthria and emotional disturbance. We experienced 84-year-old man who had Wi syndrome(痿證) as well as delirium during the treatment of pneumonia, and whose condition was improved through Oriental medical treatment. The patient was diagnosed as Yangmyeong Disease(陽明病) that was caused by heat in the stomach and stool in the colon, and was treated with Daeseungki-tang (Dachengqi-tang, 大承氣湯). We were able to improve the delirium caused by high fever infection through Oriental medical treatment.
Studies on the Nootropic and Anti-amnestic and Anxiolytic-like Effects of G.J.D-P.P.A. in Mice
Choi, Cheol-Hong ; Kim, Soo-Hyun ; Chung, Dae-Kyoo ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 85~105
DOI : 10.7231/JON.2011.22.2.085
Objectives : The purpose of this study was to characterize the neuroprotective effects and anxiolytic-like effects of Gongjin-dan and Polygala japonica, Polygala tenuifolia, Acorus gramineus mixed pills(G.J.D-P.P.A.). Methods : The neuroprotective effects of G.J.D-P.P.A. determined by the passive avoidance and Y-maze tasks and Morris water maze task, and the anxiolytic-like effects of the G.J.D-P.P.A. using an elevated plus-maze(EPM) in mice. Results : Drug-induced amnesia was induced by treating animals with scopolamine(1 mg/kg, i.p.). A single G.J.D-P.P.A.(400 and 800 mg/kg) administration significantly enhanced cognitive function and attenuated scopolamine-induced cognitive impairments as determined by the passive avoidance and Y-maze tasks(P < 0.05) and also reduced escape-latency on the Morris water maze task(P < 0.05). The administration of GJD-PPA(400 and 800 mg/kg) significantly increased the percentage of time spent in open arms and entries into the open arms of the EPM compared with saline-treated control group(P < 0.05). Moreover, there were no changes in the locomotor activity and myorelaxant effects in any group compared with saline-treated control group. Conclusions : These results suggest that GJD-PPA dramatically possesses the anti-amnestic and cognitive-enhancing activities related to the memory processes, and promotes the anxiolytic-like activity in mice.
The Effects of DoDamTanghapChongMungTang(Daotantanghecongmingtang) on LPS induced-Microglia and Memory Deficit Mice Model
Park, Dae-Myung ; Lee, Sang-Ryong ; Jung, In-Chul ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 107~128
DOI : 10.7231/JON.2011.22.2.107
Objectives : This experiment was designed to investigate the efficacy of DDTCMT hot water extract & ultra-fine powder on Alzheimer's Disease Model. Methods : The effects of the DDTCMT hot water extract on expression of IL-
, IL-6, TNF-
, COX-2, NOS-II, IL-10, IL-1 receptor antagonist mRNA and production of IL-
, IL-6, TNF-
in BV2 microglial cell line treated by lipopolysacchaide(LPS) were investigated. Expression of NO, ROS in BV2 microglial cell line treated by LPS and AChE activity in PC-12 cell treated by NGF were investigated. anti-AChE was observed through Western blot analysis. The effects of the DDTCMT hot water extract & ultra-fine powder on the behavior of the memory deficit mice induced by scopolamine were investigated. Results : 1. The DDTCMT hot water extract significantly decreased the production of mIL-6, mNOS-II, mTNF-
, and increased the production of mIL-10, mIL-1 receptor antagonist. 2. The DDTCMT hot water extract significantly suppressed the production of IL-
, IL-6, TNF-
in BV2 microglial cell line treated by LPS. 3. The DDTCMT hot water extract significantly suppressed the NO and ROS production in BV2 microglial cell line treated by LPS. 4. The DDTCMT hot water extract groups showed inhibition of AChE activity in NGF treated PC-12 cell line. 5. The DDTCMT hot water extract suppressed anti-AChE expression in NGF treated PC-12 cell line was observed by Western blot analysis. 6. The DDTCMT hot water extract & ultra-fine powder groups showed significantly inhibitory effect on the scopolamine -induced impairment of memory in the experiment of Morris water maze. Conclusions : These results suggest that the DDTCMT hot water extract & ultra-fine powder may be effective for the prevention and treatment of Alzheimer's disease.
Studies on the Behavioral Pharmacology of the Antidepressant Effect of Polygala japonica Houtt
Lee, Eun-Kyung ; Chung, Dae-Kyoo ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 129~146
DOI : 10.7231/JON.2011.22.2.129
Objectives : The purpose of this study was to characterize the putative antidepressant and antianxiolytic effects of the 70% ethanol extract of Polygala japonica(EEPJ) using animal's behavioral experiment in mice. Methods : The effect of EEPJ on the anxioty and depressive disorder was investigated via mice's behavioral experiment like Elevated plus-maze, Horizontal wire test, Open field test, Forced swimming test, Tail suspension test, and it was happen via any mechanism by WAY 100635, a 5-HT1A receptor antagonist and by Flumazenil, a GABAA antagonist Results : 1. In the EPM, single treatments of the EEPJ(200 and 400mg/kg) had usefully antianxiolytic effects versus vehicle, which was medicated via the serotonergic nervous system. 2. In the HWT, single treatments of the EEPJ were no changes in the myorelaxant effects versus vehicle. 3. In the OFT, single treatments of the EEPJ were no changes in the locomotor activity versus vehicle. 4. In the FST, single treatments of the EEPJ(50mg/kg) significantly reduced the immobility time versus vehicle. 5. In the TST, single treatments of the EEPJ(50mg/kg) significantly reduced the immobility time versus vehicle. Conclusions : These results indicate that EEPJ is an effective antidepressant and antianxiolytic activity in mice, and it might be usefully applied for prevention and treatment of depressive disorder through evolutive study like development of various experimental models.
The Effects of BunSimGiEumGami-Bang(Fenxinqiyinjiameifang) on Serotonin of P815 cell
Lim, Jae-Won ; Jung, In-Chul ; Lee, Sang-Ryong ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 147~162
DOI : 10.7231/JON.2011.22.2.147
Objectives : This experiment was designed to investigate the effect of the BSGE hot water extract on serotonin biosynthesis of depression model. Methods : The cytotoxicity of the BSGE hot water extract was analyzed by MTT assay on P815 cell. The antioxidant activity was measured by DPPH free radical-scavenging activity and SOD activity on P815 cell. The quantity of 5-HT and expression of TPH-1, AAADC and MAOa mRNA was measured by of HPLC profle Analysis on P815 cell. Results : 1. The BSGE hot water extract increased DPPH free radical-scavenging activity and SOD activity on P815 cell. 2. The BSGE hot water extract increased significantly the quantity of 5-HT. 3. The BSGE hot water extract increased the expression of TPH-1 mRNA. Conclusions : This experiment shows that the BSGE hot water extract might be effective for the prevention and treatment of depression. Investigation into the clinical use of the BSGE hot water extract for depression is suggested for future research.
Effects of Water-Extracts of Bambusae concretio silicae(BCS, 天竺黃) on the Expression of Neurotransmitter Receptors
Yoon, Jae-Hong ; Kim, Kyung-Min ; Kim, Kyung-Hun ; Shin, Gil-Cho ; Jeong, Seung-Hyun ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 163~176
DOI : 10.7231/JON.2011.22.2.163
Objectives : BCS(Bambusae concretio silicae) is used as a traditional medicine in Korea for the incipient stroke. Recent reports indicated that BCS has a neuroprotective effect by anti-convulsion effect. However, it's mechanism is not well studied. The purpose of this study was to investigate into the molecular mechanism of BCS for neuroprotection in normoxia of cultured rat hippocampal neurons. Methods : BCS (1.0, 2.5, 5.0, and
) was added to culture media (Neurobasal supplemented with B27) on DIV 0, given a normoxia, and the cell viability was measured by typical phase-contrast images of the cultures with 1.0, 2.5, 5.0, and
on DIV 21. Effects of BCS on the expression of various synaptic proteins (
R2, GlyR, PSD95) were observed by immunocytochemistry showing on DIV 3, 7 and 21. Results : Typical phase-contrast images of the cultures indicated that BCS has a protective effect of rat hippocampal cells in normoxia. The BCS upregulated
R1 after normoxia on DIV 7,
on DIV 21 and
R2 on DIV 21. And the BCS downregulated PSD95 after normoxia on DIV 7. Conclusions : The present study showed evidence for the efficacy of BCS in Typical phase-contrast images, upregulation of inhibitory neurotransmitter receptors(
R1) and downregulation of PSD95 which eventually protected neuronal cell death in normoxia.
The Literature Review on Medications of Insomnia in Chapter Mong(夢) of Donguibogam
Park, Bo-Ra ; Park, In-Sook ; Kang, Hyung-Won ; Lyu, Yeong-Su ;
Journal of Oriental Neuropsychiatry, volume 22, issue 2, 2011, Pages 177~198
DOI : 10.7231/JON.2011.22.2.177
Objectives : By analyzing and comparing indications, components and their doses of herb medicines, which were recorded in insomnia chapters of medical books, we examined historical changes and made clear documentary ground of medications. Methods : 1. 10 books which were noted in insomnia part of "The Eastern Medical Textbook of neuropsychiatry" and 13 books were mentioned in same part of "Uibujeonrok" were selected as reference. 2. We searched article database such as KISS, riss4U and journals issued by the Korean society of oriental neuropsychiatry. Finally, 39 books which were noted in 3 literature reviews, were chose as reference. 3. In reference books, we collected the herb medicines in chapters related to insomnia. 4. In case of no section associated with insomnia in books, we found prescriptions related to insomnia in whole chapters. 5. If the chief virtue of medication was not primarily for insomnia, we excluded applied or added herb medicines. 6. We classified prescriptions into small groups which had same name, and then rearranged them in chronological order. Results and Conclusions : 1. Banha-tang(banxiatang) of "Hwangjenaegyeong Youngchu" was the first-recorded prescription used for insomnia. 2. The chapter of insomnia appeared in "Chunkeumyobang" at first. 3. Ondam-tang(Wendantang) was most cited prescription in medical books. It was recorded totally 19 books from "Chunkeumyobang" to "Hyeoljeungron". 4. We suspects indications, components, dosage of medication of insomnia in Donguibogam were revised according to author's clinical experience and circumstances.