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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Oriental Neuropsychiatry
Journal Basic Information
Journal DOI :
The Korean Society of Oriental Neuropsychiatry
Editor in Chief :
Volume & Issues
Volume 24, Issue 4 - Dec 2013
Volume 24, Issue 3 - Sep 2013
Volume 24, Issue 2 - Jun 2013
Volume 24, Issue spc1 - Apr 2013
Volume 24, Issue 1 - Mar 2013
Selecting the target year
Literature Review of Randomized Clinical Trials Regarding Insomina
Park, Hye Joo ; Yoo, Jong Hyang ; Kwon, Ji Hye ; Lee, Si Woo ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 201~210
DOI : 10.7231/jon.2013.24.3.201
Objectives : To review the recent trend of randomized controlled clinical trials on insomnia and to provide information for future clinical trials. Methods : A total of 667 pieces of literature were searched using the key words `insomnia` and `randomized controlled trial` and using the title `insomnia` with the topic `trial or trials`, published from 2008 to 2012 through Web of Science. Studies including randomized controlled clinical trials were sorted from the search result and finally 104 pieces of the literature were selected and examined. Results : Besides 104 clinical trials, 14 trials related to CAM (Complementary and Alternative Medicine) were also reviewed. On average, 20 trials were annually conducted and they showed a growing trend. Participants were between 31 and 90 (34.6%), and were observed for less than 30 days (28.8%) in most trials. As intervention methods for clinical trials, non-pharmaceutical methods were used in 59 studies (56.7%), pharmaceutical drug in 43 studies (41.3%) and combinations in 2 studies (1.9%). In 60 studies, only insomnia without any underlying diseases was examined and other 44 studies involved other diseases. As diagnosis assessment tools, Sleep diary and Polysomnography were used. Conclusions : Randomized controlled trials relevant to insomnia were on the increase, but only a small number of clinical trials on Oriental Medicine have been performed. Larger scientific and well-founded randomized controlled trials are required for developing Oriental Medicine and establishing high-quality guideline going forward.
A Study on the System of Collaborative Practice between Korean Traditional Medicine and Western Medicine for Dementia based on a Case Study
Lee, Go-Eun ; Yang, Hyun Duk ; Jeon, Won Kyung ; Kang, Hyung-Won ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 211~228
DOI : 10.7231/jon.2013.24.3.211
Objectives : This report describes the diagnostic and therapeutic procedures of Collaborative Practice between Korean Traditional Medicine and Western Medicine for two dementia patients. Furthermore, through these cases, we suggest a model of collaborative practice between Korean traditional medicine and western medicine for the treatment of dementia. Methods : Two patients suffering from several symptoms related to dementia received collaborative practice between Korean traditional medicine and western medicine. Physicians of deparment which paient first visit interviewed patient and patient`s guardians, discussed the symptoms and the status of the patient. Since then, the medical team made a differential diagnosis based on the results of brain imaging, hematology, urine test. and apprehended the status of dementia by the neuropsychological test. Korean traditional physicians examined the physical symptoms and identified the pattern of dementia in Korean traditional medicine. Following this, they decided on the method of acupuncture, moxibustion, cupping and herbal treatment. Western physicians decided on the type of medication after consideration of the patient`s other medical conditions. Every intervention was decided by both Korean traditional physicians and western physicians after discussion. The medical team provided education on dementia and counseled the guardians. They also wrote the paper for using the long-term care insurance for the aged. Results : Two patients showed no improvement on the neuropsychologic and activity of daily living tests. However, the patients` subjective physical symptoms were improved. The collaborative practice between Korean traditional medicine and western medicine improved the patients` and guardians` satisfaction. Conclusions : Through these cases, we propose a model of collaborative practice between Korean traditional medicine and western medicine for dementia categorized diagnosis-test, treatment, prevention, management. More specifically, we supplement qigong and psychotherapy which was inadequate in these cases.
The Concept Analysis of Won-Buddhism`s Maumgongbu in Group Counseling based on Walker and Avant`s Strategy
Yang, Kyung Hee ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 229~244
DOI : 10.7231/jon.2013.24.3.229
Objectives : The purpose of this study was to provide information about Maumgongbu to meet the needs of people by analysing the concept of Maumgongbu in group counseling. Methods : This study was conducted using Walker and Avant`s Concept Analysis Strategy. Dictionaries, Wonbuddhism`s Kyunjions and literatures, and participants` journals were reviewed after enrolling in Onsarm maumgongbu group counseling. Results : The attributes of the Maumgongbu include emotion, object, self-reflection, attribution, and creativity. The antecedents of "Maumgongbu" are the conditions arising from negative emotions. The Maumgongbu helps people find the emotional causality of their inner self by self-reflecting, getting out of false belief, restoring positive emotions, maintaining healthy and warm relationships with oneself, family, friends and society. Above all, the Maumgongbu makes people experience tranquility and true happiness and activate their positive energy or power. Conclusions : If there is a clear indication of linkage to principles, attributions, precedents and consequences, and empirical referents to any of Maumgongbu programs, there is no doubt that our understanding of the human mind and lives will be greatly enriched. Furthermore, self-discipline and steadfast complements give us calmness, peacefulness and better quality of life.
Reconsideration of Psychasthenia- Two Cases
Lim, Hyun-Jung ; Kwon, Yong-Ju ; Lee, Jae-Eun ; Cho, Seung-Hun ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 245~250
DOI : 10.7231/jon.2013.24.3.245
Objectives : Psychasthenia is a psychological disorder that is characterized by phobias, obsessions, compulsions, or excessive anxiety. Their thoughts can be scattered and require significant effort to organize, often resulting in sentences that do not come out as intended, making little sense to others. Methods : Two Patients with psychasthenia are unable to resist specific actions or thoughts, regardless of their maladaptive nature and have insufficient control over their conscious thinking and memory, sometimes wandering aimlessly and/or forgetting what they were doing. Results : The constant mental effort induces physiological fatigue, which worsens the condition. Nevertheless, psychasthenia has become a forgotten disorder. We observed two cases that are worthy of the original definition of psychasthenia. Conclusions : It can be concluded that patients with psychasthenia complain of sinking because of a reduction in psychological tension or an effort to recover the reduction in tension.
A Case of Qigong-Induced Mental Disorder: a Differential Diagnosis
Kwon, Yongju ; Cho, Seung-Hun ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 251~256
DOI : 10.7231/jon.2013.24.3.251
Objectives : Qi gong is generally considered to be safe in most people when learned from a qualified instructor. But abnormal psychosomatic responses or mental disorder may be induced when Qigong is practiced inappropriately, excessively, or when practiced unguided in predisposed individuals. Here we reported a case of Qigong-induced Mental Disorder (QIMD). A woman who had not had a psychiatric disease, by chance started Qigong practice, and felt raising- Qisymptoms, including headache. Methods : We identified the unique characteristics of QIMD and discusses differences with other diseases such as somatoform disorder and schizophrenia. Results : To conclude, QIMD does not come under current somatoform disorder subtypes and schizophrenia. Conclusions : It has distinct characters that occurring after Qigong practice, symptoms of upper body, feeling that something to rise up.
Aripiprazole-Related Oculogyric Dystonia
Lee, Jae-Eun ; Cho, Seung-Hun ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 257~262
DOI : 10.7231/jon.2013.24.3.257
Objectives : Aripiprazole is unique drug among the SGA (Second generation antipsychotics) in its pharmacology and pharmacokinetics,but is similar in clinical efficacy. Aripiprazole acts as a partial agonist at dopamine D2 receptors, activating the receptor but eliciting a reduced response compared to the natural neurotransmitter. There are some side effects of aripiprazole, the most common side effects of aripiprazole are headache, nausea, vomiting, insomnia, tremor, constipation and EPS. Difficulty in opening eyes is not defined EPS yet, but it is a rare but important side-effect symptom of aripiprazole. Methods : This article is about a case of side-effect symptom of aripiprazole, 26-year-old single female suffering from schizophrenia had difficulty in opening eyes while she was taking antipsychotics. During the hospitalization, the relaxation therapy is helpful not only to reduce tension in the eyelids but also to headache. Results : It is important that early recognition of aripiprazole-induced oculogyric dystonia can prevent life-threatening complications. Education medical staff to this easily treatable reaction will improve overall quality of health care. Conclusions : This case notifies the need for awareness of the risk of acute oculogyric dystonia in adolescent female patients receiving aripiprazole.
Effects of Galgunhaejutang on Alcohol Consumption in C57BL/6 Mice
Cho, Seung-Hun ; Kim, Hyeun-Kyeung ; Kim, Jong-Woo ; Whang, Wei-Wan ; Kim, Sung-Gon ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 263~270
DOI : 10.7231/jon.2013.24.3.263
Objectives : Galgunhaejutang extract (GHT) is a Traditional Korean medical herbal mixture that has been tradtionally used to treat alcohol consumption. This study was preformed to evaluate the effects of GHT on alcohol consumption in C57BL/6 mice. Methods : Sixty three C57BL/6 mice were alcohol dependence-induced by limited access paradigm. Water, GHT 0.688 g/kg (GHT-L), or GHT 3.45 g/kg (GHT-H) were administrated for 10 days. The amounts of alcohol consumption for 2 hours, water consumption for 22 hours, food intake for 24 hours and body weight were measured. Results : There weren`t significant differences in 2 hours of alcohol consumption, 22 hours of water consumption, 24 hours of food intake and body weight for ten days between vehicle group and GHT-L or GHT-H group. Conclusions : Further studies employing multi-dose and long term administration of GHT (more than 10 days) might be of benefit.
The Involvement of AMPA Receptor in the Antidepressant-like Effects of the Portulaca Oleracea L. Extract in Mice
Park, Soo-Jin ; Choi, Min-Ji ; Chung, Sun-Yong ; Kim, Jong-Woo ; Cho, Seung-Hun ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 271~280
DOI : 10.7231/jon.2013.24.3.271
Objectives : The development of natural drugs with antidepressant effects is important and needed. This study was performed to investigate the antidepressant-like effects of the distilled water extract of Portulaca oleracea L. (POL) in a mouse model and to investigate the role of
-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects. Methods : The forced swim test (FST) and tail suspension test (TST) were used to investigate the behavioral anti-depressive-like effects of POL in mice. Additional behavioral experiments with 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione, an AMPA receptor antagonist, were undertaken to determine the involvement of the antidepressant-like properties of POL in AMPA receptor throughput. Results : Oral administration of the POL extract (100 mg/kg) 1 h prior to testing significantly reduced the immobility times in the FST and TST. The antidepressant-like effects of the POL extract were not increased in a dose-dependent manner. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the POL extract in the FST. Conclusions : The distilled water extract of POL has antidepressant-like effects, which may be related to AMPA receptor. Pre-treatment with NBQX significantly attenuates the reduction in immobility time induced by the POL extract in the FST.
Antidepressant-like Effects of the Gastrodia elata Bl Extract in Mice
Hong, Soon-Sang ; Cho, Seung-Hun ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 281~292
DOI : 10.7231/jon.2013.24.3.281
Objectives : A growing body of evidence has suggested that the dysfunction of glutamatergic systems plays a pivotal role in major depressive disorder (MDD). This study was performed to investigate the antidepressant-like effects of the ethanolic extract of Gastrodia elata Bl (GE) in mouse models and to investigate the role of
-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors in producing these antidepressant-like effects. Methods : The forced swim test (FST) and tail suspension test (TST) were used to investigate GE`s behavioral effects in mice. Additional biochemical and behavioral experiments with NBQX, an AMPA receptor antagonist, were undertaken to determine whether the antidepressant-like properties of GE are involved in AMPA receptor throughput. Results : Oral administration of GE extract (1,600 mg/kg) 1h prior to testing significantly reduced the immobility times in the FST and TST. These antidepressant-like effects of GE extract were increased dose-dependently. Pre-treatment with NBQX significantly attenuated the reduction in immobility time induced by the GE extract in the FST and TST. Conclusions : The ethanolic extract of GE may exert antidepressant-like effects with involvement of AMPA receptor.
The Anxiolytic, Anti-Depressive Effects Using Bambusae Caulis in Taeniam Extract in Rat Chronic Immobilization Stress Model
Lyu, Yun-Sun ; Park, Jong-Min ; Ko, In-Sung ; Kang, Hyoung-Won ; Lyu, Yeoung-Su ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 293~308
DOI : 10.7231/jon.2013.24.3.293
Objectives : The Bambusae Caulis in Taeniam has been used in traditional oriental medicine to treat a variety of mental disorders including anxiety and depression. The purpose of present study is to observe the changes which take place in the body in stressful situations and to compare the anti-depressive, anxiolytic and anti-stress effect of Bambusae Caulis in Taeniam in different doses. Methods : This study was performed to evaluate the effects of Bambusae Caulis in Taeniam in the immobilization stress model in rats. Twenty-five rats were divided into 5 groups of 5: control, stress, low dose administration (75 mg/kg), medium dose administration (150 mg/kg) and high dose administration (225 mg/kg). The four groups other than the control group were placed in an immobilization stress test, and distilled water (control) or Bambusae Caulis in Taeniam extract was administration orally for 2 weeks. After treatment, the despair and anxiety behavior of rats were measured by open field test, forced swimming test, weight gain, contents of 5-HT in raphe nucleus and adrenal gland weight. Results & Conclusions : As a result of evaluation by measuring five aspects, FST, OFT, weight gain, 5-HT contents and adrenal gland weight, Bambusae Caulis in Taeniam has significant antidepressant, anxiolytic, anti-stress effects.
The Mechanism of Lotus Root Extract (LRE) as Neuro-Protective Effect in Alzheimer Disease (AD)
Hong, Seung-Chul ; Lee, Chia-Hung ; Kim, Sang-Heon ; Lee, Jin-Hee ; Koo, Byung-Soo ;
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 309~320
DOI : 10.7231/jon.2013.24.3.309
Objectives : There is a possibility LRE as remedy in Alzheimer disease (AD), but it`s nerve protection effect and mechanism have to be elucidate. In this research, we applied LRE on
pre-treated SH-SY5Y cells, to find out the nerve protection effect and mechanism in AD cell model. Methods : We tried to confirm that effect by experimenting with 20, 50, and
concentration of LRE as a medicine. Next experiment, we assessed damage effect which induced
, known to cause AD, on SH-SY5Y cell. In addition, cellular viability test is executed under
treatment condition in a SH-SY5Y cell. Results : 1. In
treated SH-SY5Y cell, LRE exhibited an anti-phosphorylation effect about tau protein, JNK, and IKB. 2. LRE prevent nerve cell apoptosis, which indued
and oxidative stress, modify JNK engaged synaptic structure and
induced p75-neurotrophin receptor polymorphism. Conclusions : We found that LRE prevented oxidative stress-induced cellular destruction, for example, increased SOD activity of
treated SH-SY5Y cell and reduced toxicity of oxygen free radical. Consequently, the ingredients of LRE have a role as a catalyzer for
clearance and as scavenger for active oxygen free radical.
Journal of Oriental Neuropsychiatry, volume 24, issue 3, 2013, Pages 321~330
DOI : 10.7231/jon.2013.24.3.321
Voice Handicap Index and Voice-Related Quality of Life in Idiopathic Parkinson`s Disease 10.7231/jon.2013.24.2.155, The Differences of Learning Characteristics in Sasang Constitution 10.7231/jon.2013.24.2.163, A Preliminary Comparison of the Efficacy of Auricular Acupuncture, Transdermal Nicotine Patch and Combination Therapy for Smoking Cessation 10.7231/jon.2013.24.2.179, The Effects of OnDam-tang-Kami-bang (ODK) in Antioxidant and Serotonin Metabolism Testing on P815 Cell 10.7231/jon.2013.24.2.189