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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Oriental Neuropsychiatry
Journal Basic Information
Journal DOI :
The Korean Society of Oriental Neuropsychiatry
Editor in Chief :
Volume & Issues
Volume 9, Issue 2 - Dec 1998
Volume 9, Issue 1 - Aug 1998
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Effects of the Soyosan and Chyengansoyosan on the Regional Brain Monoamines Contents of Cold Swimming Stressed Mice
Lee Jeong-Ho ; Chung Dae-Kyoo ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 1~18
This study aimed to evaluate the anti-stress effects of soyosan and chyengansoyosan on the contents cold swimming stress.The experimental animals were forced cold swimming stress for 3 minutes, and administered 4㎎/10g of soyosan and chyengansoyosan extract for 7 days before stress. The monoamines contents were measured by HPLC method in various part of mouse brain. The following results were obtained :1. In frontal cortex, the contenrs of norepinephrine ans dopamine increased significantly in the group administered chyrngansoyosan compared with in the group administered non chyengansoyosan and soyosan(control group) of mice stressed by cold swiming.2. In hypothalamus, the content of norepinephrine increased with statistical significance in the group administered soyosan compared with control group of mice stressed by cold swimming. 3. The content of dopamine increased with statistical significance on the group administered chyenfansoyosan and compared with control group of mice stressed by cold swimming in hypothlaamus and hippocampus.4. The content of serotonin increased with statistical significance in the group administered soyosan and compared with control group of mice stressed by cold swimming in hippocampus and corpus striatum.5. In corpus striatum and hippocampus, the content of norepineohrine decreased with statistical significance in the group administered soyosan and chyengandoyosan compared with control group of mice stressed by cold swimming.Judgding from the above results, this sthdy reaches a conclusion that soyosan or chyengansoyosas has significant effects in reducing stress.
An experimental study of driental medicine on cure for dementia : the effect of Jowiseungcheongtang and Hyungbangjihwangtang on cure for aged rats
Park Soon-Kwen ; Lee Hong-Jae ; Kim Hyun-Taek ; Whang Wei-Wan ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 19~35
Some oriental medicine turned out to have a significant clinical effect on the cure for dementia. Therefore, thorough scientific tests for physiological effect of oriental medicne are needed. This study is aimed at doing experimental studies on the effects of two medicines, Jowiseungcheongtang and hyungbangjihwangtang, on the cure for dementia.For the demonstration of the effect of the two medicines on aged rats, we perfomed a radial arm medicines on aged rats, water maze task, known for their proper learning paradigm for behavior.Previous studies on aging and dementia show that aged rats displayed significant impariments in the learning of the radial arm maze task compared with younger rats. As in experiment 1, we found that the learning of the radial arm maze task compared with younger rats. As in experiment 1, we found that the learning deficits aged rats exhibit in radial arm maze task were improved with the application of each medicine. The resutls suggest that these two medicine can be effective to patients whose working or shortterm memory is impaired. In experiment 2 we studied the effect of the two medicines on the deficit of the aged rats with the Morris water maze task known for measuring long-tern memory. We did not find significant results between the performance of the ages rats and the younger ones. Considered the different results previous studies have reported, more thorough studies are needed to investigate the effect of the medicines on long-term memory.In conclusion, the results we found in experiment 1 and 2 suggest that Jowisengcheongtang and hyungbangjihwangtang can have useful effects for the cure of age-related memory (especially for short-term memory)deficits. Recent interests in dementia urges researchers concerned to explore the effect of oriental medicine on the disease. As there have been relatively few behavioral or scientific studies on dementia using oriental medicine to date, further studies are expected are expected to continue to elucidate 'what the wisdom of the oriental medicine tells about dementia'.
The Effects of Sahyangsohapwon on Learning and Memory of Rats in the Radial Arm Maze Task
Lee Jo-Hee ; Kim Jong-Woo ; Whang Wei-Wan ; Kim Hyun-Taek ; Lee Hong-Jae ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 37~44
Purpose: This study was conducted to find out the effects od Sahyangsohapwon on learning and memory of rats.Method: In the experiment, rats were divided two groups. One was control group which was adminstered Sahyangsohapwon and the other was sample group administered placebo. Numbers of each group were 13 rats. 8-arm radial maze task was used in it, and working memory test and retention(reference memory) test were done.Before the beginning of the test, the rats were deprived of water for 24hrs.In the frist test, each of eight arm was baited with water and a rat was permitted to remain on the maze until all eight arms were entered. A working memory error was defined as revisit of any previously entered arm. When a rat made an error not exceeding one time in consecutive 3 days-performance, it was regarded as learning criteria and the test was ended. The reference memory was evaluated with total days which it took rats to pass the learning crtirtia.The second test was performed after 24 hours when the first test was over. When a rat entered 4 arms, the entrance of arm was cut off during 30 seconds.Here the number if errors which was produced during a rat find remaining 4 tracks was regarded as the index of memory.This experiment compared the number of error at the control group with that of the sample group.Result: 1. In the first test, it was shown that the sample group took 7.69
1.11 days and the control group 9.31
1.97 days to pass the learning criteria.There was statistically significant reference mernory development at the sample group.2. In the second test, the frequency of errors made by the two groups were 0.92
1.32 times for the control group and 1.23
1.59 times for the Sahyangsohapwon group. There was no difference between the groups in frequency of errors.Conclusion: It is suggested that Sahyangsohapwon has effects on the improvement of learning and memory.
The Experimental Study on the Effects of Hangbujapalmultang on Enhancing Learning and Memory in Rats with Radial Arm Maze
Ryu Jae-Myun ; Kim Jong-Woo ; Whang Wei-Wan ; Kim Hyun-Taek ; Lee Hong-Jae ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 45~51
Purpose : This study has an experiment on finding how Hyangbujapamultang advanced the learning and memory of rat to find the method to improve the failure of memory which is the symptom of dementia.Method : In the experiment, rats were divided the control group (14 rat) which medicate the excipient into the sample group (17 rat) which medicates Hyangbujapalmutang. And the learning ability test and the memorv test was practiced to using the task of radial arm maze.The learning ability test had the presupposition that, when a rat which frequents 8 tracks makes am error not exceeding one time for 3 days without a break, it passes the test.First experiment compared total days when the control group passed the test with total days when the sample group it.The memory test practiced after 24 hours when the learning ability test was over. When a rat frequents 4 tracks, the gates is cut off during 30 seconds. Here the number of error at the control group with that of the sample group.Result: In the learning ability test, the sample group needed 5.82
0.37 days to pass the test and the control group needed 6.43
0.67 days. In the memory test, the sample group errored 0.29
0.37 times and the control group errored 1.86
0.78 times.Conclusion : In the learning ability test, the sample group passed the test earlier than the control group, but any statistical correlationship couldn't be found in it. In the memory test, the sample group had the pregnant reduction of the number of error in comparison with the control group.
The Effects of GAMIKWYBICHONGMUNGTANG on the Blood Cell, Serum and Antioxidant Effects on Serum, Brain Tissue of Mouse
Kim In-Jae ; Lee Sang-Ryong ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 53~69
This experiment was done to investigate the effects of GAMIKWYBICHONGTANG(GKCT) on the blood and brain tissues of aged rats. The experimental groups were divided into three groups and treated as follows for ten days before administration of scopolamine ; Non treated group(Normal), Distilled water feeding group (Control), GKCT feeding group(GKCT). After feeding them each, Control and GKCT were injected scopolamine for 5 days.We examined the changes of blood cell(WBC, RBC, platelet), blood serum(BUN, creatinine, glucose, uricacid), erythrocyte hemolysis, the activities of cholinesterase, and measured the amounts of malondialdehyde of the blood serum and checked the activities of catalase, SOD of the brain tissues.The results were as follows;1. GKCT showed significant increase of the number of WBC, but those of RBC and platelet didn't significantly changed in comparison with Control.2. GKCT showed significant decrease of BUN, creatinin, glucose, uric acid in blood serum in comparison with Control.3. Erythrocyte hemolysis were decreased significantly in GKCT in comparison with Control.4. About the activity of cholinesterase of blood serum, GKCT showed no significant increase in comparison with Control.5. In TBA reaction to measure the amount of MDA, oxidant material of blood serum of rats, GKCT showed significant decrease in comparison with Control.6. About the activity of catalase of brain tissue, GKCT showed no significant change in comparison with Control.7. About the activity of SOD of brain tissue, GKCT showed significant increse in comparison with Control.According to the above results, GKCT can reduce the formation of free radical and the accumulation of antioxidant materials, it is suggested that GAMIKWYBICHONGTANG(GKCT) has some effects on antiaging. It is also needed more following studies.
The Effects of GONGCHENGWHAN on the Blood Cell, Serum and Antioxidant Effects on Serum, Brain Tissue of Mouse
Chae Jong-Gul ; Lee Sang-Ryong ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 71~85
This study was to investigate the effects of GONGCHENGWHAN(GCW) on the blood and brain tissues of aged rats. For the experiment, the aged rats were divided into three groups : Non treated group (NC), distilled water feeding group(PC), GCW feeding group(GCW).Each group was treated as the procedure for ten days before administration of scopolamine. After this treating, we injected scopolamine to Pc and GCW group their blood cell(WBc, RBC, platelet), blood serum (BUN, creatinine, glucose, uric acid), erythrocyte hemolysis, and the activities of cholinesterase as well as measured the amounts malondialdehysde in the blood serum, catalase, and SOD in the brain tissue.The main results of this investigation are as follows.1. In respect of the number of WBC, GCW group exhibited the administrated incerase in comparison with PC. In respect of the number of RBC· and platelet, however, the changes was not administrated.2. In respect of the number of BUN, creatinine, glucose and uric and the blood, GCW group exhibited the administrated decrease in comparison with PC.3. In respect of erythrocyte hemolysis, GCW group exhibited the administrated repression in comparison with PC.4. In respect of the activity of cholinestease in the blood serum, GCW group exhibited the administrated improvement in comparison with PC.5. In respect of the amounts of malondialdehyde in the blood serum, GCW group exhibited the administrated dexrease in comparison with PC.6. In respect of the activity of catalase in brain tissue, GCW group didn't exhibit the administrated change in comparison with PC7. In respect of the activity of SOD in brain tissue, GCW group exhibited the administrated improvement in comparison with PC.Results of this study indicates that GCW improves the activities of cholinesterase and SOD, but represses the formation of the free radical and the accumulation of the antioxidant materials such as MDA. It implies that GCW has some effects on antiaging.
A Study on Effect of Soeuminsohabhyangwon on the Brain Serotonin contents of Stressed Mice
Kwen Soon-Ju ; Chung Dae-Kyoo ; Kim Yun-Sub ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 87~95
This study was aimed to evaluate the anti-stress effect of Soeuminsohabhyangwon on the mice in Cold and Swimming stress.In order to investigate the anti-stress effect of Soeuminsohabhyangwon in Cold and Swimming stressed mice, the serotonin contents were measured by HPLC method in various part of mouse brain The following results were observed. 1. In Cerebral Cortex of Frontal Lobe, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased in the SHW group as compared with Control group. 2. In hypothalamus, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased with statistical significance in the SHW group as compared with Control group. 3. In corpus striatum, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased with statistical significance in the SHW group as compared with Control group. 4. In hippocampus, the serotonin content was decreased in the Control group as compared with Normal group and the serotonin content was increased with statistical significance in the SHW group as compared with control group.Base on the above results, it may be concluded that Soeuminsohabhyangwon are effective to reduce stress.
A Study on the Clinical States in Hwabyung Patient used Anxiety, Depression & Anger Scale
Roh Jong-Yeong ; Kim Jong-Woo ; Whang Wei-Wan ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 97~109
This study was designed and undertaken to identify objectively the degree and relationship of anxiety, depression, & anger which are chief essential elements of emotional status in Hwabyung patients.The subjects in this study were 35 Hwabyung patients and 40 Non-Hwabyung persons, and for the assessment of anxiety, depression, & anger. We used Zung's Self-Rating Anxiety Scale(SAS), Zung's Self-Rating Depression Scale(SDS) & State-Trait Anger Expression Inventory(STAXI).The results of this study are as follows:1. There were significant differences in the 18 items of SAS among 20 items between Hwabyung patients and the control group(p＜0.05 respectively).2. There were significant differences in the 13 items of SDS among 20 items between Hwabyung patients and the control group(p＜0.05 respectively).3. There were significant differences in the mean scores of SAS and SDS between Hwabyung patients and the control group(p＜0.001 respectively).4. There were significant differences in the mean scores of State Anger, Trait Anger, Trait Anger/Temperament, Anger-in & Anger-out counted by STAXI between Hwabyung patients and the control group (p＜0.001, p＜0.01, p＜0.001, p＜0.001, p＜0.05 respectively).5. There were significant relationships between State Anger & Anxiety, Anger-out & Trait Anger/Temperament, Depression & Anxiety(r=.43, r=.37, r=.64).
동의보감(東醫寶鑑)에 나타난 기공(氣功)에 대한 고찰(考察)
Kim Gil-Su ; Gu Byeong-Su ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 111~130
신경정신과(神經精神科) 질환(疾患)과 연관(聯關)된 의안(醫案)의 연구(硏究)(Ⅱ) 중국(中國) 청(淸) 시대(時代) 의안(醫案)을 중심(中心)으로
Gwon Bo-Hyeong ; Gu Byeong-Su ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 131~160
The Clinical Analysis on 19 Cases of Anxiety Disorder
Jung In-Chul ; Lee Sang-Ryong ;
Journal of Oriental Neuropsychiatry, volume 9, issue 2, 1998, Pages 161~169
A clinical analysis was carried out for 19 patients who was treated in Dept. of Neuropsychiatry of Taejon Oriental Medicine Hospital from I aug. 1997 to 31 Jul. 1998 and was ruled out as anxiety disorder. The results were summarized as follows. 1. In the distribution of the sex, ratio between female and male was 1:2.8, distribution of the age was even each age, and the primary motive of the onset were psychological trauma, question of money, discord of a household. 2. As for the duration in disease, the duration from a week to a month had a majority of all, and the most duration of the addmission-treatment was a week. 3. The most common symptom were palpitation ·anxiety, headache·dizziness, chest discomfort, the cases of generalized anxiety disorder and atypical anxiety disorder was a large number. 4. In the aromatherapy of absorptive method, the sort of many used essential oil were Lavenda and Rosewood, in the massage, that were Peppermint and Rosemary. 5. The most used recipes were BUNSIMKIYEM(分心氣飮) HACHULBOSIMTANG(夏朮補心湯), CHUNGGANSOYOSAN(淸肝逍遙散), BANHABAEKCHUCHUNMATANG(半夏白朮天麻湯), CUIBIONDAMTANG(歸脾溫膽湯) etc. 6. In the judgement of efficacy, 9 cases showed good efficacy, 9 cases showed no change, 1 case showed excellent efficacy.