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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Marine Bioscience and Biotechnology
Journal Basic Information
Journal DOI :
The Korean Society for Marine Biotechnology
Editor in Chief :
Volume & Issues
Volume 5, Issue 4 - Dec 2011
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Beneficial Effects of Marine Bioactive Substances on Bone Health, via Osteoarthritis Inhibition and Osteoblast Differentiation
Nguyen, Minh Hong Thi ; Qian, Zhong-Ji ; Jung, Won-Kyo ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 1~7
Bone health is maintained by balance between bone resorption and bone formation, and bone homeostasis requires balanced interactions between osteoblasts and osteoclasts. Most of drugs and functional foods for bone health have been developed as bone resorption inhibitors, which maintain bone mass by inhibiting the function of osteoclasts. The recent studies have shown beneficial effects of marine natural products on bone health. Therefore, this review is aimed to study effects of marine-derived natural substances on osteoarthritis inhibition via attenuation of MMPs and osteoblastic differentiation via activation of alkaline phosphatase (ALP), osteoclacin (OC), bone morphogenic protein-2 (BMP-2) as an important factor for bone formation, and mineralization. The present review can provide new insights in the osteoblastic differentiation of marine natural products and possibility for their application in bone health supplement.
Recent Prospect of Compounds Derived from Marine Macroalgae for Medicinal Application of Anti-Inflammation for Chemoprevention of Cancer
Kim, Moon-Moo ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 8~14
Although marine living organism contains a numerious number of compounds, it is difficult to collect these compounds in a large scale for medicinal application. However, in recent years, several bioactive compounds isolated from marine macroalgae have been proved to be able to provide potential sources for development of medicinal products because they can be obtained in large amount from marine. A number of studies have reported a variety of effects of marine macroalgae but a few anti-inflammatory activity of marine macroalgae have recently been published. Herein, we reviewed novel anti-inflammatory compounds recently isolated from marine brown algae, green algae and red algae. From this survey, in particular, some compounds contained in edible macroalgae exert anti-inflammatory effects with inhibition on cyclooxygenase-2 (COX-2), inducible nitric oxide synthase(iNOS) and matrix metalloproteinases (MMPs) activity regulated by nuclear factor-kappa B transcription factor that play a key role in cancer as well as inflammation, demonstrating to be able to potentially apply to development of anti-inflammatory agent for chemoprevention of cancer. Furthermore, some macroalgae and their compounds with both excellent anti-inflammatory activity and very low toxicity can select a potential candidates capable of preventing or treating several chronic inflammation such as colitis, hepatitis and gastritis, leading to cancer.
Ecobiotechnology of Marine Sponges and Their Symbionts - Review and Present Status
Pallela, Ramjee ; Kim, Se-Kwon ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 15~25
Marine sponges are a rich source of highly diversified bioactive compounds. These medicinally valuable molecules represent extreme physiological and ecological functions in sponges, more presumably involving in the resistance to the feeding by other marine organisms like fish and fouling by barnacles, bacteria, fungi, etc. This feature of attaining resistance made sponges as successful poriferans that possess an impressive array of biological properties ranging from antimicrobial to anticancerous activities. The diversified bioactive principle of sponges might be due to their spacio-temporal distribution and although, the gateway for exploiting the sponges for isolating these distinct, potential molecules is open, suitable technical and methodological approaches are yet to be implemented in order to bring the sponges as successful pharmaceutical leads in the field of marine biotechnology. Despite of the identified difficulties of marine sponge research from past few decades, one should concentrate not only on the basic and applied technical/methodological considerations, but also on the novel strategies like in vitro sponge cell, fragment and whole sponge culture; sponge symbiont cell culture; in situ and ex situ sponge cultivation; and sponge bioreactors and metagenomic approaches, for the successful exploitation of marine sponges towards the novelty in sponge biotechnology. The present review narrates the pros and cons of the nowadays-marine sponge research by focusing on the suggestive ecobiotechnological approaches, based on the latest studies for feasible ecological exploitation and biotechnological application of sponges from the sea.
Potentiality of Green Fluorescent Protein (GFP) from Aequorea victoria - A Mini Review
Karagozlu, Mustafa Zafer ; Kim, Se-Kwon ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 26~32
Green fluorescent protein (GFP), a very important biological agent that involves shifting the color of bioluminescence from blue to green in luminous coelenterates and to increase the quantum yield of light emission. GFP discovered in medusa, Aequorea victoria is a key factor of various biotechnological and cell biological applications. Beside these applications, GFP of A. victoria is generally stable, which does not require co-factors for activity and can be functionally expressed in different bacterial species. This property of GFPs from A. victoria permits them to be a unique tool to monitor gene expression and protein localization in different organisms. The present review brings out the past milestones and future perspectives on GFPs, with an elaborative reviewing on its applications.
-glucosidase Inhibitory Activity of Jeju Seaweeds Using High Throughput Screening (HTS) Technique
Ko, Seok-Chun ; Lee, Seung-Hong ; Kang, Sung-Myung ; Ahn, Ginnae ; Cha, Seon-Heui ; Jeon, You-Jin ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 33~39
As a rapid and quick bioactive compound evaluation technique, we utilized an automatic system of high throughput screening (HTS) to investigate
-glucosidase inhibitory efficacy of seaweeds, collected from Jeju Island in Korea. In this study, different extracts with methanol at
from 23 species of brown seaweeds and 22 species of red seaweeds and 9 species of green seaweeds were subjected to HTS. Of the brown seaweeds tested, Myelophycus simplex (20B3), Ishige sinicola (20B5, 70B5), Colpomenia sinuosa, (20B14, 70B14), Hizikia fusiforme (20B21), Ishige okamurai (70B22) and Ecklonia cava (70B23) showed significantly high
-glucosidase inhibitory activity with 96.52%, 98.34%, 98.37%, 80.49%, 96.16%, 76.32%, 98.32% and 98.12%. Schizymenia dubyi (20R15), Gelidium amansii (20R16) and Polysiphonia japonica (70R22) amomng the red seaweeds showed remarkable
-glucosidase inhibitory activity more than 95%. On the other hand, the green seaweeds showed poor
-glucosidase inhibitory activities (less the10%) at 1 mg/ml.
Dynamics of Microalgae Along the Coastal Areas of Sooyoung Bay, Busan, South Korea
Prasad, Binod ; Thiyam, General ; Lee, Dong-Gyu ; Kim, Moo-Sang ; Cho, Man-Gi ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 40~45
Microalgae are one of the major, sustaining components of ecosystem processes and are responsible for biogeochemical reactions that drive our climate changes. Despite this, many marine microalgae are poorly described and little is known of their abundance and distribution along the coastal areas of Sooyoung Bay, Busan, South Korea. The present study has been conducted from November, 2011 to August, 2009 with the objective to provide an overview of the taxonomy diversity and abundance of microalgae along the coastal areas of the Sooyoung Bay. Water samples were collected from different sites, which were located by using a GPS tracker. Chlorophyll fluorescence of the water samples were measured by using ToxY-PAM dual-channel yield analyzer. The chlorophyll fluorescence values were relatively higher during the spring and summer and even in the region near to the sea port. Similarly the abundance of microalgae was higher near the port but diversity index had lower values. The temperature and pH values were same at all the sites. However, only the temperature varied during the sampling period, with higher values during summer and lower in winter. From the preliminary results, the following class of microalgae were found; Bacillariophyceae, Dinophyceae, Silicoflagellate and Cryptophyceae. With a future ongoing work, microalgae are being isolated to establish single cell culture and for identification using light microscopic observations, photography and molecular approaches.
수영만 지역의 미세조류로부터 ToxY-PAM을 이용한 조류 대번식 예측을 위한 에코-모니터링
Lee, Dong-Gyu ; Kim, Mu-Sang ; ; Jo, Man-Gi ;
Journal of Marine Bioscience and Biotechnology, volume 5, issue 4, 2011, Pages 46~50
Phytoplankton forms the base of sea ecosystems. Various environmental factors and anthropogenic pollution, primarily, affect the concentration and photosynthetic activity algal cells, and the changes in the phytoplankton photosynthesis influence other elements of aquatic ecosystems. The increase in anthropogenic pollution markedly damages natural aquatic ecosystems, particularly, in the coastal zones, where an intense blooming of microalgae occurs, including the release of highly dangerous ecotoxic substances of various chemical natures (red tides). In this study, we tried to apply as a parameter for the algal blooming prediction in the ocean from fluorescence values in the taken samples around Busan coastal area. F0 value was almost constant but Fv/Fm value showed the irregular pattern. We presume that these results are due to the changes of the ocean environment and climate. To predict or give early warning the algal blooming, we need to investigate the specific area or fixed area through real-time monitoring. Especially, algal blooming prediction or warning can be achieved via continuously monitoring and interpretation of fluorescence changes.