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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Korean Medicine Rehabilitation
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Journal DOI :
The Korean Academy of Oriental Rehabilitation Medicine
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Volume & Issues
Volume 25, Issue 3 - Jul 2015
Volume 25, Issue 2 - Apr 2015
Volume 25, Issue 1 - Jan 2015
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Antibacterial Effect of Haedokgeumhwa-san against Methicillin-Resistant Staphylococcus aureus
Lee, Ha-Il ; Lee, Su-Kyung ; Kwon, Young-Mi ; Song, Yung-Sun ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 1~13
DOI : 10.18325/jkmr.2015.25.2.001
Objectives Methicillin-Resistant Staphylococcus aureus (MRSA) is a human pathogen and a major cause of hospital-acquired infections. New antibacterial agents that have not been compromised by bacterial resistance are needed to treat MRSA-related infections. In this study, we investigated the antimicrobial activity ofethanol extract of Haedokgeumhwa-san (HGH) which prescription is composed of korean medicine against MRSA. Methods The antibacterial activity of HGH extract was evaluated against MRSA strains by using the Disc diffusion method, broth microdilution method (minimal inhibitory concentration; MIC), checkerboard dilution test, and time-kill test; its mechanism of action was investigated by bacteriolysis, detergent or ATPase inhibitors. The checkerboard dilution test was used to examined synergistic effect of ampicillin, oxacillin, ciprofloxacin, vancomycin, gentamicin and norfloxacin in combination with HGH ethanol extract. A time-kill assay was performed a survival curve which was obtained by plotting viable colony counts depending on time on bacterial growth. Results The minimum inhibitory concentration (MIC) of ethanol extract (HGH) ranged from 1,000 to
against all the tested bacterial strains, respectively. We are able to confirm that HGH extract has potentially strong antibacterial activity. In the checkerboard dilution test, fractional inhibitory concentration index of HGH in combination with antibiotics indicated synergy or partial synergism against S. aureus. A time-kill study showed that the growth of the tested bacteria was considerably inhibited after 8 hr of treatment with the combination of HGH with selected antibiotics. For measurement of cell membrane permeability, HGH
along with concentration of Triton X-100 (TX) and Tris-(hydroxymethyl) aminomethane (Tris) were used. In the other hand, N,N-dicyclohexylcarbodimide (DCCD) and Sodium azide (
) was used as an inhibitor of ATPase. TX, Tris, DCCD and
cooperation against S. aureus showed synergistic action. Accordingly, antimicrobial activity of HGH was affected by cell membrane and inhibitor of ATPase. Conclusions These results suggest that Haedokgeumhwa-san extract has antibacterial activity, and that HGH extract offers a potential as a natural antibiotic against MRSA.
Effects of Bujasasim-tang Ethanol Extract on Oxidative Stress, Inflammation and Osteoarthritic Rat Model
Woo, Chang-Hoon ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 15~35
DOI : 10.18325/jkmr.2015.25.2.015
Objectives This study was performed to investigate the effects of Bujasasim-tang ethanol extract (BST) on oxidative stress, inflammation and osteoarthritic rat model. Methods To ensure safety of BST, heavy metal levels were measured and cytotoxicity test was done. In vitro, To evaluate antioxidative effects of BST, total phenolic contents, 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2`-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activity, reactive oxygen species (ROS) levels were measured. Also, to evaluate anti-inflammatory effects of BST treated group, total nitric oxide (NO) and pro-inflammatory cytokines (IL-
, IL-6, TNF-
) levels were measured in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. In vivo, We injected MIA
(60 mg/ml) into knee joints of rats to induce osteoarthritis. Rats were divided into total 3 groups (normal, control, BST treated group, each n
Effects of Danggwisayeok-tang (Dangguisinitang) on MIA-Induced Osteoarthritis Rats
Yang, Doo-Hwa ; Woo, Chang-Hoon ; Kim, Jung-Min ; An, Hee-Duk ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 37~50
DOI : 10.18325/jkmr.2015.25.2.037
Objectives The purpose of this study was to know the effects of Danggwisayeok-tang (Dangguisinitang) extract (DGSYT) on monosodium iodoacetate (MIA)-induced rat osteoarthritis. Methods For this purpose, rats were divided into 5 groups. Normal group was not injected with MIA and orally administered any medication. Control group was injected with MIA and not orally administered any medication. DGSYT100 group was injected with MIA and orally administered 100 mg/kg of DGSYT. DGSYT300 group was injected with MIA and orally administered 300 mg/kg of DGSYT. JoinsT group was injected with MIA and orally administered 20 mg/kg of Joins tablet. DGSYT100 and DGSYT300 groups were orally administered DGSYT during a week before and 3 weeks after based on the day MIA injected. The changes of hepatotoxicity, nephrotoxicity, relative hind paw weight distribution, cytokine in serum, cytokine messenger ribonucleic acid (mRNA) in joint tissue and histopathological observation (Hematoxylin & Eosin and Safranin-O staining) were measured. Results Alanine aminotransferase (ALT) levels of DGSYT100, DGSYT300 and JoinsT groups were increased significantly, but these results were within normal range. Aspartate aminotransferase (AST) and creatinine levels of all groups were not changed significantly. In the change of relative hind paw weight distribution, DGSYT300 and JoinsT groups were decreased significantly 14 and 21 days after MIA injected. Interleukin-
) and Interleukin-6 (IL-6), Leukotriene
and Osteocalcin levels of DGSYT300 and JoinsT groups were decreased significantly. In measurement of IL-
and nitric oxide synthase-II mRNA relative quantitative of control, DGSYT100, DGSYT300 and JoinsT groups were decreased significantly. In measurement of TNF-
, IL-6 and Cyclooxygenase-2 mRNA relative quantitative of control, DGSYT300 and JoinsT groups was decreased significantly. In histopathological observation of knee, synovial tissue, cartilage and proteoglycan of DGSYT100, DGSYT300 and JoinsT were well preserved compared with control group. Conclusions According to the results, DGSYT has anti-inflammation and pain relief effects. So it should be suppressed progression of arthritis in MIA-induced osteoarthritis rat.
Effects of Gyejigabuja-tang on MIA-induced Osteoarthritis in Rats
Won, Je-Hoon ; Woo, Chang-Hoon ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 51~64
DOI : 10.18325/jkmr.2015.25.2.051
Objectives This study was carried out to investigate the effects of Gyejigabuja-tang extracts on the Monosodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of MIA into knee joint cavity of rats. Rats are divided into 4 groups (normal, control, positive comparison group, GBT group, each n
Identification of Novel Standard Compounds for Standardization of Sinbaro3 Pharmacopuncture
Lee, Jin-Ho ; Lee, Jae-Woong ; Kim, Min-Jeong ; Kim, Eun-Jee ; Lee, In-Hee ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 65~72
DOI : 10.18325/jkmr.2015.25.2.065
Objectives To investigate and validate potential standard compounds for standardization of Sinbaro3 pharmacopuncture prepared at OO Hospital of Korean Medicine. Methods Sinbaro3 pharmacopuncture was prepared by extraction, purification and hydrolysis of Harpagophytum procumbens, and various potential standard compounds were quantified through HPLC-UV and HPLC-MS analysis. Validation was examined by assessing specificity, linearity, precision, and accuracy. Results The retention time of harpagide and cinnamic acid were 15.2 min and 28.2 min, respectively, and both showed good linearity in analysis by concentration at 0.9999 and 0.9998, respectively. Intra-day variation of precision was 0.0015~0.0045% and 0.0058~0.1629%, while inter-day variation of precision was 0.0011~0.0243% and 0.0098~0.1629%, and that of accuracy was 99.53~99.89% and 99.50~99.91%, respectively. Conclusions Harpagide and cinnamic acid, which are hydrolyzates of harpagoside within Sinbaro3 pharmacopuncture, were both validated using HPLC-MS and HPLC-UV analysis, and Sinbaro3 pharmacopuncture contained 78.41 ug/ml harpagide, and 2.05 ug/ml cinnamic acid.
Single-dose Intramuscular Toxicity Studies of Shinbaro3 Pharmacopunture in Sprague-Dawley Rats and Beagle Dogs
Lee, Jin-Ho ; Lee, In-Hee ; Lee, Jae-Woong ; Kim, Eun-Jee ; Kim, Min-Jeong ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 73~80
DOI : 10.18325/jkmr.2015.25.2.073
Objectives To assess the safety of Shinbaro3 Pharmacopuncture by analyzing the potential single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture at various dose levels in SD (Spraque-Dawley) rats and Beagle dogs. Methods For evaluation of single-dose intramuscular toxicity of Shinbaro3 Pharmacopuncture, 40 SD rats (20 male and 20 famale) and 4 Beagle dogs (2 male and 2 female) were used. The rats were divided in four groups of 10 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.3, 0.6 and 1.2 mg/kg in distilled water, and distilled water as a vehicle control group, respectively. The Beagle dogs were divided into two groups of 2 each, and treated intramuscularly with Shinbaro3 Pharmacopuncture at doses of 0.15, and 0.3 mg/kg in distilled water, respectively, and signs of toxicity were observed. After a wash-out period of 3 days, the procedure was repeated with Shinbaro3 Pharmacopuncture at doses of 0.6, and 1.2 mg/kg in distilled water, respectively. Mortality, body weight changes, and necropsy findings were examined during the study period. Results There were no mortalities in either the SD rats or Beagle dogs. There were also no significant differences in adverse effects, body weight, or necropsy findings between the Shinbaro3 Pharmacopuncture and control groups. Conclusions There results suggest that the lethal dose 50 (
) and approximate lethal dose (ALD) value of the test substance Shinbaro3 Pharmacopuncture are higher than 1.2 mg/kg in SD rats and Beagle dogs.
Analysis of the Research Trends of Pelvic Malposition in Korean Clinical Research
Park, Jaehyeon ; Nam, Soohyeon ; Kim, Donghoo ; Kang, Jun-Hyuk ; Heo, Woo-Young ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 81~88
DOI : 10.18325/jkmr.2015.25.2.081
Objectives The purpose of this review was to analyze the research trends in clinical research related to pelvic malposition published in Korean medicine journals. Methods We searched articles in Korean databases (OASIS, NDSL, RISS, and KTKP), and sorted the articles by publishing date, pelvic malposition type, field of study, and measurement index. Results 1. 25 original articles and 9 case report articles were reviewed. 2. In recent years, this topic has been studied more frequently, with an increasing number of original articles published. 3. 16 articles analyzed pelvic malposition type. And half of the articles focused on ilium. 4. The original articles have figured out the correlation between pelvic malposition measurement indices and other measurement indices or diseases. 5. Treatment tools, such as chuna therapy, the mckenzie method, devices for correcting malposition, acupuncture were used in the case report articles. 6. 29 measurement indices, such as Ferguson`s angle, Ilium shadow measurement, and Iliac height difference were used. Conclusions According to the literature, pelvic malposition is related to other diseases and measurement indices, and manual medicine on pelvic malposition can be effective. However, due to the lack of sufficient empirical evidence from medical articles to support this, further clinical research should be conducted.
Trends of Chuna Manual Therapy on Traffic Accident in Korea from 2005 to 2014
Jeon, Yong-Tae ; Park, Sang-Hun ; Han, Kuk-In ; Lee, Jung-Han ; Ko, Youn-Seok ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 89~96
DOI : 10.18325/jkmr.2015.25.2.089
Objectives This study is to investigate domestic trends of chuna manual therapy on traffic accident for recent 10 years. Methods We searched the studies on chuna manual therapy for traffic accident in 6 Korean web databases. Consequently, 17 research papers were founded. We analyzed these papers according to their published year, the titles of journal, the type of study, the number of cases, the sites of injury, assessment scales of study, and ethics of research. Results 17 papers were published since 2005. The studies on chuna manual therapy about traffic accident were mainly published in the journal of korean society of chuna manual medicine for spine & nerves and the journal of korean medicine rehabilitation. All papers were clinical research include 2 case series, 2 non randomized controlled trials (NRCTs), 13 randomized controlled trials (RCTs). The most frequently occured symptom was neck pain. In assessment scales, visual analog scale (VAS) was mainly used. All clinical studies were not mentioned about approval of institutional review board (IRB). Conclusions In this study, we analyzed the trends of chuna manual therapy on traffic accident in Korea from 2005 to 2014. In reviewing published papers, we found several weak points in methods of research and quality of study protocol. It is needed to adjust these problems for development of future researches.
Acupuncture Treatment of Plantar Fasciitis: A Literature Review
Koh, Nak-Yong ; Kim, Chang-Gon ; Ko, Youn-Suk ; Lee, Jung-Han ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 97~110
DOI : 10.18325/jkmr.2015.25.2.097
Objectives Plantar fasciitis is one of the most common causes of heel pain. Plantar fasciitis can be managed with acupuncture, but the evidence for its effectiveness is uncertain. The aim of this review was to assess the effectiveness of acupuncture for plantar fasciitis. Methods I searched specific Korean and foreign electronic databases (KCI, RISS, NDSL, OASIS, KTKP, National Assembly Library, KMbase, PubMed, The Cochrane Library and China National Knowledge Infrastructure). The key search terms were `heel pain`, `plantar fasciitis` and `acupuncture`. Twenty-seven trials were included; eleven case reports, fourteen randomized controlled trials (RCTs) and two non-randomized controlled trials (NRCTs). Results Twenty-seven studies reported that acupuncture treatment reduced plantar fasciitis pain. However, the evidence provided by the case reports was regarded as weak because the methodological quality was poor, and the placebo effect of acupuncture was not accounted for in the RCTs and NRCTs. Overall, the methodological quality of the RCTs and NRCTs was weak. Conclusions There is some evidence for the effectiveness of acupuncture for plantar fasciitis. However, in order to reinforce the evidence for acupuncture`s effectiveness, additional placebo-controlled trials with well-designed methodologies are required.
A Study of Bi-Jeung in the Mid-Chosun Dynasty: Based on the Seungjeongwon Ilgi
Cho, Woo-Young ; Jung, Jae-Young ; Chung, Seok-Hee ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 111~118
DOI : 10.18325/jkmr.2015.25.2.111
Objectives Through the clinical records of Seungjeongwon Ilgi, we reviewed the usage of Bi-Jeung to know the concept of the word and studied therapeutic strategies for managing Bi-Jeung. Methods We investigated the clinical records of the mid-Chosun dynasty containing the key word "Bi" from electronic database (Seungjeongwon Ilgi). Results Of 4,039 records, 249 articles thought to have medicinal value were lastly selected. We subdivided the cases into 13 categories according to time, the connection of contents and the change of associated symptoms. "Bi" was not used alone but used in combination with body parts or other symptoms. Etiological causes of "Bi" involved dampness, phlegm, fire, heat and qi disorders. We suggested that "Bi" of the mid-Chosun dynasty meant a symptom group mainly of sensory impairment and additionally pain or motor disturbance. Among the 22 herbal medicine formulas used, 15 were based on internal medical pattern identifications and 7 were symptomatic treatments. Acupuncture and moxibustion therapy were primarily applied to adjacent acupoints. In addition, External therapies were used together, such as washing therapy, plaster therapy, cupping therapy and thermotherapy. Conclusions "Bi" principally indicated sensory impairment on limbs and the main etiological cause was considered to be dampness. Herbal medicine, acupuncture, moxibustion and external therapies were used to cure Bi-Jeung.
The Retrospective Medical Charts Review of 459 Neck Pain Inpatients in Korean Medicine Hospital
Huh, Gun ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 119~134
DOI : 10.18325/jkmr.2015.25.2.119
Objectives The purpose of this study was to investigate the characteristics of inpatients who were admitted to Korean medicine hospital due to neck pain. Methods Four hundred fifty nine neck pain patients who were admitted to Cheonan Korean Medicine Hospital, Dae-jeon University from 1st, January, 2013 to 31th, December, 2013 were retrospectively reviewed according to medical charts. Results In this study, people in their 30s, females, within 0~2 weeks after onset, motivated by traffic accident, diagnosed with neck sprain, with no medical history related to neck pain, underwent outpatient treatment at medical institutions, took the highest percentage from each category of patients who admitted to Korean Medicine Hospital due to neck pain. In most (78.77%) of the patients, symptoms were more than improved. Conclusions Neck pain inpatients in Korean medicine hospital, it is difficult to find tendency. This study suggests the characteristics of neck pain inpatients who were hospitalized in Koean medicine hospital.
Characteristics of 601 Low Back Pain Patients: A Korean Medicine Hospital Experience, Retrospective Chart Review
Nam, Dae-Jin ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 135~153
DOI : 10.18325/jkmr.2015.25.2.135
Objectives The purpose of this study was to investigate the characteristics of inpatients who were admitted to Korean medicine hospital due to low back pain. Methods The current study was designed as a retrospective chart review to investigate descriptive characteristics of LBP patients. The clinical records of 601 patients who were hospitalized for treatment of LBP in Cheonan Korean Medicine Hospital, Daejeon University from 1st, January, 2013 to 31th, December, 2013 were analyzed. Results 1. Most frequently given diagnosis was sprain and strain of lumbar (45.93%). 2. Female outnumbered male patients in all disease groups except fracture of lumbar spine. 3. In distribution according to age, sprain and strain of lumbar, HNP of L-spine and lumbago with sciatica were most frequent at 30s, fracture of lumbar spine was most frequent at 50s and spinal stenosis was most frequent at 70s. 4. The most frequently motive for low back pain was traffic accident (35.4%) 5. Patients with no related medical history were 76.95% 6. 0~1week interval between onset and visit to Korean Medicine Hospital was most frequent in all disease groups. 7. 50.85% of patients went through treatment at medical institutions before the admitting to Korean Medicine Hospital. 8. The average admission days of female was higher than male`s. And age goes up, average duration of admission was longer. 9. In most (74.59%) of the patients, symptoms were more than improved. 10. Most frequently prescribed examination was X-ray (65.13%). 11. Most frequently prescribed herb medicine was whal-lak-tang (Huoluo-tang). Conclusions In most (74.59%) of the patients, symptoms were more than improved, especially in sprain and strain of lumbar and lumbago with sciatica. But Patients with a local hospital statistic is not be representative of the incidence of the population. In order to obtain more accurate statistics, it is necessary to compare analysis collect statistics from other medical hospitals.
The Retrospective Review of 410 Shoulder Pain Inpatients in Korean Medicine Hospital
Lee, Jae-Eun ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 155~173
DOI : 10.18325/jkmr.2015.25.2.155
Objectives The purpose of this study is to investigate the characteristics of inpatients who were admitted to Korean medicine hospital due to shoulder pain. Methods Characteristics of four hundred ten shoulder pain inpatients of single institution from 2011 to 2013 were retrospectively reviewed through medical charts. Results Patients showed different characteristics in sex, age, motives, interval between onset and admission day, first occurrence or not, related medical history before admission, usage of west medication, admission days, treatment results, radiological examinations by shoulder pain disease groups. Accordingly, Korean medical treatment such as acupuncture, moxibustion, external treatment, cupping therapy, physiotherapy, herb-medication varied with the characteristics of shoulder pain disease groups. Conclusions Through retrospective medical charts review, characteristics of 410 single institution shoulder pain inpatients showed distinctive features and versatile Korean medicine treatments by disease groups. It is expected that this study would accelerate multi-institutional and large scale characteristic review of shoulder pain patients, which would raise reconsideration and expand boundary of Korean medicine.
A Case Report of Neck Pain Patient with Klippel-Feil Syndrome by Cervical Manipulation Treatment
Lee, Jong-Ha ; Kwon, Jeong-Gook ; Keum, Dong-Ho ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 175~180
DOI : 10.18325/jkmr.2015.25.2.175
The Klippel-Feil Syndrome (KFS) is characterized by congenital fusion of two or more vertebrae with hypermobile normal segment. According to this, a patient with KFS can be at risk of severe neurological symptoms after manipulation treatment. We had a KFS patient who suffered from neck pain and limited range of motion at cervical after manipulation treatment. The patient, 49-year-old woman was diagnosed as KFS through Cervical X-ray and MRI. The patient was treated by acupuncture therapy and SCENAR therapy. We measured neck pain by visual analog scale (VAS) and neck disability index (NDI) and checked range of motion at cervical before and after the treatments. After 8 times treatments, the patient`s pain decreased and the range of motion increased. From this case, we can recognize the risk of Chuna manipulation treatment for KFS patient. So, we suggest that radiological examination is needed before cervical Chuna manipulation treatment to avoid adverse reactions.
A Clinical Case Study of Operation-delayed Cauda Equina Syndrome Patient Improved by Korean Traditional Treatment
Jung, Hae-Chang ; Jeong, Su-Hyeon ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 181~187
DOI : 10.18325/jkmr.2015.25.2.181
Objectives The objective of this study is to report clinical effect of korean traditional treatments for Operation-delayed Cauda Equina Syndrome patient. Methods The patient was treated by korean traditional treatments including acupuncture, physical treatment, herbal medication. The improvement of the clinical symptoms was observed by Modified Visual analog scale (Modified VAS), SSCES (Scoring System for Cauda Equina Syndrome), function of urination and function of defecation. Results After treatments, Modified VAS, SSCES, function of urination and function of defecation were improved in this case. Conclusions On the basis of these results, we suggest that korean traditional treatment might be an effective method to improve the clinical symptoms of Operation-delayed Cauda Equina Syndrome patient.
The Clinical Study of Oriental Medicine on Spontaneous Osteonecrosis of the Knee
Lee, Sang-Wook ; Yang, Jae-Cheol ; Ok, So-Yoon ; Bang, Chan-Hyuk ; Shin, Woo-Suk ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 189~196
DOI : 10.18325/jkmr.2015.25.2.189
Objectives The purpose of this study was to report the effect of Oriental medicine on spontaneous osteonecrosis of the knee. Methods Patients received Oriental treatment such as Bee-Venom therapy and acupuncture & moxibustion. The improvement of the pain intensity and recovery of gait was observed. Results During five weeks of treatment, patient`s knee pain and gait disturbance were improved. Conclusions In this case, Oriental treatment on spontaneous osteonecrosis was effective to reduce pain and recover gait.
Deep Vein Thrombosis after Total Knee Replacement in a Patient undergoing Korean Medical Rehabilitation
Kim, Chang-Gon ; Koh, Nak-Yong ; Ko, Youn-Suk ; Lee, Jung-Han ;
Journal of Korean Medicine Rehabilitation, volume 25, issue 2, 2015, Pages 197~203
DOI : 10.18325/jkmr.2015.25.2.197
Objectives The objective of this study is to report the deep vein thrombosis (DVT) after total knee replacement (TKR) in a patient undergoing Korean medical rehabilitation. Methods A female patient who had total knee replacement (TKR) was treated by Korean medical rehabilitation with protocol. After fifteen days treatment, deep vein thrombosis (DVT) was suspected. Therefore, CT venography was performed. Results After Korean medical rehabilitation, pain was decreased. But also occurred deep vein thrombosis (DVT) as a complication. Conclusions We present a case of deep vein thrombosis (DVT) after total knee replacement (TKR) in a patient undergoing Korean medical rehabilitation. There is a limit that this study hasn`t sufficient number of cases. Further studies will be needed.