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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of Korean Medicine Rehabilitation
Journal Basic Information
Journal DOI :
The Korean Academy of Oriental Rehabilitation Medicine
Editor in Chief :
Volume & Issues
Volume 26, Issue 3 - Jul 2016
Volume 26, Issue 2 - Apr 2016
Volume 26, Issue 1 - Jan 2016
Selecting the target year
Influence of Galgeun-tang on Gene Expression in Diet-Induced Obese Mice
Ye, Sung-Ae ; Kim, Ho-Jun ; Ko, Seong-Gyu ; Song, Yun-Kyung ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 1~12
DOI : 10.18325/jkmr.2016.26.2.1
Objectives The purpose of this study was to evaluate anti-obesity effect of Galgeuntang (gegentang) and elucidate the effect of it on gene expression related to obesity. Methods The experiments were performed with the use of Diet-Induced Obese mice. They were grouped NC (normal control), HFD (high fat diet control), GGT (Galgeun-tang (gegentang), 700 mg/kg), ORL (Orlistat, 10 mg/kg). GGT was orally administered for 12 weeks. Body weight was measured every week. Real-time PCR was performed to investigate the effect of GGT on gene expression in liver tissue. Results GGT group and ORL group were reduced in body weight compared with HFD. HFD increased
, SREBP-1, Leptin, aP2, FATP1, FAS gene expression compared with NC. GGT increased FATP1 gene expression. But GGT reduced
& FAS gene expression in liver tissue of diet-induced obese mice compared with HFD. Conclusions These results suggest that GGT is supposed to have a certain impact on the treatment of obesity. But more study is needed in the future.
Anti-obesity Effects of Galgeun-tang in High Fat Diet Induced Obese Mice Model
Ki, Sung-Hoon ; Kim, Ho-Jun ; Ko, Seong-Gyu ; Song, Yun-Kyung ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 13~28
DOI : 10.18325/jkmr.2016.26.2.13
Objectives To investigate anti-obesity effects of Galgeun-tang, an herbal formula, in high fat diet induced obese mice model. Methods 24 Male C57Bl/6J mice were randomly assigned to normal group fed with normal research diet (NOR, n=6), high fat diet control group treated with water (HFD, n=6), high fat diet group treated with Orlistat (ORL, n=6, Orlistat 10 mg/kg), and high fat diet group treated with Galgeun-tang (GGT, n=6, Galgeun-tang 700 mg/kg). 12 weeks later, body weight, fat weight, liver weight, blood glucose, total cholesterol, triglyceride, HDL, ALT, AST, obesity related neuropeptides and adipokines, ratio of gut microbiota, and histopathology of liver were evaluated. Results In the GGT group, 1. body weight gain, liver weight gain, and total fat weight gain were significantly less than those in the HFD group. 2. blood glucose level was significantly lower and insulin level was significantly higher than in the HFD group. 3. total cholesterol level and triglyceride (TG) level were significantly lower and high density lipoprotein (HDL) level was significantly higher than in the HFD group. 4. appetite-promoting ARC neuropeptides such as Agrp and Npy were significantly less and appetite-inhibiting ARC neuropeptide, Cart was significantly more than in the HFD group in qRT-PCR analysis. 5. adiponectin level and visfatin level were significantly higher, and resistin level and leptin level was significantly lower than in the HFD group. 6. the relative level of Bacteroidetes was significantly higher, and the relative level of Firmicutes was significantly lower than in the HFD group. 7. the increase of adipose tissue was significantly more inhibited than in the HFD group. Conclusions The present study showed that Glageun-tang exerts anti-obesity effects in that it. 1. inhibited the increase in body weight, liver weight, and total fat weight. 2. decreased the level of TG, and increased the level of HDL. 3. influenced neuropeptides and adipokines that are important in regulating food intake and changes of body weight. 4. modified the beneficial quantitative changes in gut microbiota suppressing the tendency toward obesity.
The Effects of Gyejibokryeong-hwan (桂枝茯苓丸) for Wound Healing after Skin Suture
Jung, Hoon ; Lee, Eun-Jung ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 29~50
DOI : 10.18325/jkmr.2016.26.2.29
Objectives There is few Korean medicinal studies about post-operation wound healing despite much effort for minimizing wound or post-op scar. The aim of this study is to evaluate the wound healing effect of Gyejibokryeong-hwan (Guizhifuling-wan, GBH) after skin suture. Methods < In vitro > We observed anti-oxidative and anti-inflammatory effect by using lipopolysaccharide (LPS)-treated RAW 264.7 cells. For anti-oxidation, we mesured the total amount of polyphenol, flavonoid, DPPH scavenging ability, ABTS scavenging ability and the value of ROS production, and for anti-inflammation, we mesured the amount of NO and pro-inflammatory cytokines (
, IL-6). < In vivo > Thirty SD rats were divided into five equal groups (n=6, one normal, two controls and two experimentals). All groups except normal group were made a scar (around
) in the back by the depth of the fascia and then sutured by a thread and needle. Normal group rats received no treatment at all. Control group rats were fed distilled water, and positive control group rats were percutaneously applied terramycin once in 2 days. GBH 200 group rats were orally medicated GBH 200 mg/kg, and GBH 400 group rats were orally medicated GBH 400 mg/kg per day for two weeks. We analyzed the blood samples (WBC, neutrophil, lymphocyte, monocyte, eosinophil), and the serums (TIMP-1, MMP-2, MMP-2.
, VEGF), and examined the wounded skin tissue histopathologically. Results < in vitro > 1. DPPH and ABTS scavenging activity was increased concentration-dependantly, and ROS production was significantly increased in GBH treated cells (
). Therefore in this study, Gyejibokryeong-hwan appears to have the anti-oxidative. 2. NO production was significantly reduced in GBH treated cells (
production was significantly reduced in GBH treated cells (
and IL-6 did not show uneffective action. Therefore in this study, Gyejibokryeong-hwan did not show any significant effect on anti-inflammatory process. < in vivo > 1. Monocyte and neutrophil was significantly increased in GBH (200, 400) groups. WBC, lymphocyte and eosinophil did not show significant change. 2. TIMP-1, MMP-2, VEGF were significantly increased in GBH 400 group,
was significantly reduced in GBH 400 group.
was significantly increased in GBH (200, 400) groups, and MMP-9 was increased concentration-dependantly in GBH groups, but there was no significance. 3. In histopathological examinations, collagen was significantly increased and keratin was significantly decreased in GBH (200, 400) groups. Conclusions According to in vitro experiment, GBH appears to have the anti-oxidative effect and in vivo experiment, GBH stimulate the wound healing process hematologically and histopathologically. In conclusion, the results suggest that GBH promotes wound healing after skin suture.
Study on Long-Term Preservation of Hwangnyunhaedok-Tang Pharmacopuncture
Lee, Jin-Ho ; Ha, In-Hyuk ; Kim, Me-Riong ; Chung, Hwa-Jin ; Lee, Jae-Woong ; Kim, Min-Jeong ; Kim, Eun-Jee ; Lee, In-Hee ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 51~59
DOI : 10.18325/jkmr.2016.26.2.51
Objectives We studied long-term preservation in stability of a mixed preparation of distilled and 70% alcohol extracted Hwangnyunhaedok-tang pharmacopuncture to establish standards for expiration date and quality control. Methods Three lots of consecutively prepared Hwangnyunhaedok-tang pharmacopuncture were each tested in triplicate to a total 5 tests at 3 month intervals over a period of 12 months for analysis of appearance, pH, specific gravity, index component content, endotoxins, microbial sterility, residual organic solvents, heavy metals, and pesticides. Items with no difference by elapsed time were tested at the initial and final timepoints, and data of items with potential difference by elapsed time were analyzed for trends to establish individual quality control standards. Results All tested items were stable over the study period, and therefore the expiration date was set as 12 months. pH quality control standards were set as 3.66~5.69, and that of specific gravity as 0.802~1.203, respectively. In index component content standards, berberine was set at
, baicalin at
, and geniposide at
, respectively. Standards for other items with no difference by elapsed time were set according to general Korean herbal medicine standards in the Korean Pharmacopoeia. Conclusions Manageable expiration date and quality control standards were established through long-term preservation testing of Hwangnyunhaedok-tang pharmacopuncture, furthering standardization of Korean medicine pharmacopuncture.
A Review of Recent Studies for Treatment of TMD Using CNKI Database
Kim, Jung-Sup ; Kim, Dong-Eun ; Jung, Dong-Hoon ; Yu, Sun-Ae ; Cho, Sung-Woo ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 61~74
DOI : 10.18325/jkmr.2016.26.2.61
Objectives The purpose of this research is to investigate recent clinical studies of Temporomandibular Joint Disorder in China. Methods We investigated recent clinical studies of Oriental Medicine therapies in traditional Chinese medical journals for Temporomandibular Joint Disorder through CNKI search. 20 clinical articles published from 2010 to 2015 were analyzed. This study examined the authors, published years, types of study designs, criteria for diagnosis and evaluation, periods, purposes of study and classified articles by techniques of treatment. Results Most of articles were classified as RCT. TMD was diagnosed by symptoms in a high proportion of articles. The criteria for evaluation that most frequently used were grading scale, but there was a lack of objectivity. The techniques of treatment were Tuina, acupuncture, herb medicine, electrotherapy, splint, PNF, congnitive behavior therapy, laser therapy, magnetic therapy. Conclusions In order to develop treatment of TMD in the Korean medicine, clinical studies for various therapies on a high level and cooperative studies between medical communities are needed.
Effects of the Pharmacopuncture in Animal Models for Treatment of Osteoporosis: A Review of Animal Study Reports Published in Korea
Kim, Jung-min ; Choi, Soo-min ; An, Hee-Duk ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 75~83
DOI : 10.18325/jkmr.2016.26.2.75
Objectives This study is to review the effect of pharmacopuncture on treatment of osteoporosis in animal models reported in korean domestic journals. Methods The databases (Koreantk, KISS, NDSL) were searched with term as osteoporosis, and animal study reports on osteoporosis with pharmacopuncture were reviewed. Animal model, intervention, and osteoporosis indicator were extracted. Results 22 articles were reviewed. 11 studies used ddy mouse and 9 studies used SD rat. 20 studies used ovariectomy to induce osteoporosis. 21 studies used simple pharmacopuncture. Cervi pantotrichum cornu was most frequently used pharmacopuncture and Umgok (KI10) was most frequently used acupuncture point. Each study shows significant changes of osteoporosis indicators. Conclusions Pharmacopuncture is expected to be a positive effect on osteoporosis.
Thermographic Study on Effectiveness of Acupuncture, Electro-Acupuncture and Acupuncture with Pulsed Electromagnetic Therapy on Upper Extremity of Healthy and Hemiplegic Group
Lee, Jong-Ha ; Song, Mi-Young ; Keum, Dong-Ho ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 85~96
DOI : 10.18325/jkmr.2016.26.2.85
Objectives This study was performed to evaluate the effects of acupuncture, electro-acupuncture and acupuncture with pulsed electromagnetic therapy on upper extremity of healthy people and hemiplegic patients by D.I.T.I.. Methods 20 healthy people and 20 hemiplegic patients caused by stroke were selected. They have been treated three different types of treatment; acupuncture, electro-acupuncture and acupuncture with pulsed electromagnetic therapy. And skin temperature of upper extremity has been measured before and after each treatment by D.I.T.I.. The thermographic data was analyzed by 'Independent T-test' and 'Repeated measures ANOVA test'. Results 1. In healthy group, there was very statistical significant difference (p<0.001) of the amount of thermal change by each treatment, and the amount of change was arranged in descending order; acupuncture with pulsed electromagnetic, acupuncture and electro-acupuncture. 2. In hemiplegic group, the skin temperature of hemiplegic side was
cooler than non-hemiplegic side. 3. Skin temperature of all hemiplegic patients was increased after acupuncture treatment. 4. In hemiplegic group, there was statistical significant difference (p<0.05) of the amount of thermal change by each treatment, and the amount of change was arranged in descending order; acupuncture with pulsed electromagnetic, acupuncture and electro-acupuncture. Conclusions The results indicate that acupuncture, electro-acupuncture and acupuncture with pulsed electromagnetic therapy had good effect on the change of skin temperature by stimulating sympathetic nervous system.
Effect of an Aqueous Extract of Poncirus trifoliate (L.) Raf. in Stroke Patient with Constipation
Moon, Hyo Jeong ; Lee, Su Kyung ; Noh, Se Eung ; Joo, Min Cheol ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 97~103
DOI : 10.18325/jkmr.2016.26.2.97
Objectives To evaluate the effects and safety of the aqueous extract of the dried, immature fruit of Poncirus trifoliate (L.) Raf. (Rutaceae) (PF) in stroke patients with constipation. Methods A total of 22 patients were recruited. Patients were interviewed about the clinical informations, constipation score and Bristol stool form scale at twice, before intake PF and after intake PF 2 weeks. The total and segmental colon transit time (CTT) were measured by using radio-opaque markers (Kolomark
). The degree of stool retention was evaluated by the plain abdominal radiography and was scored by Leech score. Results Before intake PF, constipation scores ranged from 3 to 12, average
and Bristol stool form scale ranged from 1 to 6, average
. CTTs were
in the right, left, rectosigmoid and total colon, respectively. Stool retention score was
in the right, left, rectosigmoid and total colon, respectively. After 2 weeks, constipation scores ranged from 2 to 8, average
and Bristol stool form scale ranged from 1 to 6, average
. CTTs were
hours in the right, left, rectosigmoid and total colon, respectively. Stool retention score was
in the right, left, rectosigmoid and total colon, respectively. There were statistically significant difference in the total and rectosigmoid colon CTT and constipation score, Stool retention score in right and rectosigmoid colon (p<0.05) after PF therapy. Conclusions These results suggest potential for PF therapy in stroke patient with constipation.
The Study on Correlation between the Degree of Herniated Intervertebral Lumbar Disc at L4~5 Level and Improvement of Low Back Pain Treated by Korean Medicine Therapy
Yoo, Hyung-jin ; Lee, Hyun-ho ; Jeong, Seong-hyun ; Jo, Kyeong-sang ; Lee, Gie-on ; Lee, Dong-hyun ; Kim, Sang-min ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 105~121
DOI : 10.18325/jkmr.2016.26.2.105
Objectives The purpose of this study was to compare the effects between the degree of herniated intervertebral lumbar disc (HIVD) at L4-5 level and improvement of low back pain treated by Korean Medicine therapy. Methods 567 patients who received inpatient treatment from May 2014 to December 2015 in the Daejeon-Jaseng of Korean Medicine Hospital were divided into 6 groups by the degree of HIVD at L4-5 level confirmed with a Lumbar spine magnetic resonance imaging. All patients received a combination of treatment including acupunture, chuna manual therapy, pharmacopunture, herbal medication. They were compared and analyzed on the basis of improvement between measuring Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), EuroQol-5 Dimension Index (EQ5D Index) as they were hospitalized and as they were discharged. The statistically significance was evaluated by SPSS 23.0 for windows. Results After treatment, Normal stage on Intervertebral Lumbar Disc at L4-5 level group's Numeric Rating Scale (NRS), Oswestry Disability Index (ODI), EuroQol-5 Dimension Index (EQ5D Index) improvement was
respectively. Bulging group's improvement was
respectively. Spinal canal occupying ratio (SOR) less than 20 group's improvement was
respectively. SOR 20 to less than 40 stage group's improvement was
respectively. SOR 40 to less than 60 group's improvement was
respectively. Surgery group's improvement was
respectively (p<0.03). But there was no statistically significance between 6 group's improvement after treatment (p>0.05). Conclusions After inpatient treatment by Korean Medicine therapy, Most patient's pain, disability and Health Related Quality of Life was improved significantly. But there was no statistically correlation between the degree of HIVD at L4-5 level and improvement of low back pain. So We think that future research of higher quality and correct statistics shall be necessary.
Pilot Study on Characterization of Patients with Low Back Pain: Multi-center, Prospective, Observation Study
Park, Chang-Hyun ; Jang, Bo-Hyoung ; Ko, You-Me ; Park, Dong-Su ; Kim, Soon-Joong ; Park, Won-Hyung ; Cha, Yun-Yeop ; Ko, Seong-Gyu ; Song, Yun-Kyung ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 123~132
DOI : 10.18325/jkmr.2016.26.2.123
Objectives The aim of this study done as pilot study is to analyze the current state of patients who have low back pain through registry. Methods This study is done under approval of Gil Oriental Medical Hospital of Gachon University, Oriental Medical Hospital of Sangji University, Jecheon Oriental Medical Hospital of Se-Myung University IRB. Among subjects who signed the consent form by their own will, we decided whom to register as subjects of this study by the standard of selection and exception. We collected the sociological investigation, character of low pack pain, degree of symptom which they felt before and after the hospitalization from registered subjects. Results 1. The number of the subjects is 16. The average age is 41.0. 9 of them are female, 7 of them are male. Most of the subjects have history illness which has connection with low pack pain. 2. According to the patient's free description of the back pain, 6 of them suffered throbbing pain. And 8 of the patients have chronic pain, 6 of them have intermittent pain of back pain analysing the character of the low back pain. They answered the pain lasted for 47.6 minutes on average. 3. About the change on the average R.O.M. of L-spine, R.O.M. of Lateral bending, Extension, Flexion, Rotation has increased after leaving the hospital compared with before hospitalization. 4. The amount of discomfort or strength of pain, which was checked by VAS on the day of leaving the hospital, has decreased than they were before the hospitalization. And there was the improvement on the dysfunction score and EQ-5D. Conclusions Through this study, we specifically analyzed the symptoms of the low back pain by accumulating the analysis about the symptoms using several indicators and description which is freely spoken by patients about their symptoms. Further research is expected to complete multi-center registry by building registry and by using it, to get various epidemiologic informations about low back pain.
The Influential Factors Associated with Hospitalization Period of Patients from Traffic Accident by Groups: A Korean Medicine Hospital Experience, Respective Chart Review
Jeon, Dong Hwi ; Lee, Eun Jung ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 2, 2016, Pages 133~144
DOI : 10.18325/jkmr.2016.26.2.133
Objectives This study was designed to find out influential factors associated with Hospitalization of the patients from traffic accident by Groups. Methods Based on the medical charts, we analyzed statistical study of 486 patients putting them into two groups to identify the factors associated with the duration of hospitalization involving age, sex, elapse day (Interval between time of injury and visit to hospital), and the types of accident. Patients in group A were diagnosed with a mere 'sprain', and patients in Group B had other symptoms accompanied by 'sprain'. Results 1. In group A, cervical sprain was the most and male patients with the symptom outnumbered female patients. In group B, headache was most where female patients had the symptom 1.7 times more than male patients. 2. Female patients in group B were found to stay for a longer period of time in the hospital than the male counterparts (p<0.05). 3. Both group A and B have positive correlation between length of hospital stay and age though group B exhibited stronger correlation. 4. Patients who had accident while riding bus in group A and those who were pedestrians in group B were found to stay in the hospital for a significantly longer period of time than those who had any other types of accident (p<0.05). Conclusions We noticed that hospital stay lengthened when the patients were older and when they had accidents while riding bus in Group A whereas in Group B, patients stayed longer when they were females and older as well as when they were pedestrians in accidents.