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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of Korean Medicine Rehabilitation
Journal Basic Information
Journal DOI :
The Korean Academy of Oriental Rehabilitation Medicine
Editor in Chief :
Volume & Issues
Volume 26, Issue 3 - Jul 2016
Volume 26, Issue 2 - Apr 2016
Volume 26, Issue 1 - Jan 2016
Selecting the target year
Effects of Seungseup-tang on MIA-induced Osteoarthritis Rats
Lee, Jong-Hoon ; Woo, Chang-Hoon ; Kim, Young-Jun ; Ahn, Hee-Duk ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 1~15
DOI : 10.18325/jkmr.2016.26.3.1
Objectives This study was designed to evaluate the anti-inflammatory effects of Seungseup-tang (SST) on the monosodium iodoacetate (MIA)-induced osteoarthritis rats. Methods Osteoarthritis was induced by injection of MIA (
with 80 mg/ml) into knee joint cavity of rats. Rats were divided into 4 groups (normal group, control group, indomethacin treated group, SST treated group, each n=6). Normal group was not injected with MIA and taken normal diet. Control group was injected with MIA and taken with distilled water. Indomethacin treated group was injected with MIA and taken indomethacin 5 mg/kg by oral administration. SST treated group was injected with MIA and taken SST 200 mg/kg by oral administration. We examined the weight-bearing ability of hind paw, biomarkers related to oxidative stress in serum, inflammatory proteins and inflammatory mediators and cytokines. Moreover, histopathological examination of knee joint structure was also performed by Hematoxylin & Eosin (H&E), Safranin-O staining method. Results In the present study, SST treated group showed a similar inhibitory effects alike indomethacin treated group, in most of the studied parameters of inflammation. The increased oxidative stress biomarker such as reactive oxygen species (ROS) and peroxy nitrite (
) in the serum were reduced with SST. Especially, the level of
compared with control group significantly suppressed. Also, the expression of inflammatory mediators and cytokines induced by nuclear factor-kappa B (NF-
) activation was modulated through inhibition of IkBa phosphorlation. In addition, histological analysis revealed that cartilage damage by MIA repaired markedly in SST treated group. Conclusions According to the results, Seungseup-tang may be effective for preventing the progression of osteoarthritis.
Analgesic Effects of ChondroT in Collagenase-induced Osteoarthritis Rat Model
Won, Jeong-Yoon ; Jeong, Ji-Won ; Na, Chang-Su ; Kim, Seon-Jong ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 17~30
DOI : 10.18325/jkmr.2016.26.3.17
Objectives The purpose of this study was to find out the effects of ChondroT on arthralgia of the Collagenase-induced osteoarthritis in rats. Methods Osteoarthritis was induced into rat by injecting Collagenase in its knee joint. Rats are divided into a total of 8 groups (n=6). Normal group was not induced for osteoarthritis whereas control groups were induced for osteoarthritis by Collagenase. Positive-A (Indomethacin) was injected with Collagenase and after 8 days, 2 mg/kg of Indomethacin was medicated. Positive-B (JOINS TAB) was injected with Collagenase and after 8 days, 20 mg/kg of JOINS TAB was medicated. Experimental groups (Chondro T) at three dose levels (50, 100 and 200 mg/kg) were injected with Collagenase and after 8days they were medicated with 10 ml/kg. Indomethacin, JOINS TAB and ChondroT were medicated each substances once a day for 10 days. Thereafter, the changes in plantar withdrawal response of osteoarthritis rats by dynamic plantar aesthesiometer were observed and then RT-PCR analysis was done to investigate the expression of related proteins. Results 1. ChondroT significantly decreased withdrawal response of mechanical allodynia compared with control group in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 2. ChondroT significantly reduced Bax/Bcl-2 ratio in all of the experimental groups (ChondroT-A, ChondroT-B, ChondroT-C). 3. ChondroT significantly reduced the expression of INF-
compared with control group in group ChondroT-B, ChondroT-C. Conclusions This results suggest that ChondroT may be meaningful for suppressing the pain of osteoarthritis. Further study is needed to conduct a rigorous clinical research.
Effects of Joaguihwan (JGH, 左歸丸) Extract on Changes of Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and on Factors Related with Bone Metabolism in Skull Fractured Rat
Li, Yu Chen ; Oh, Min-seok ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 31~49
DOI : 10.18325/jkmr.2016.26.3.31
Objectives The study was designed to evaluate the healing effects of Joaguihwan (JGH) extract on Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells and factors related with bone metabolism in skull fractured Rat. Methods The fracture healing effect of JGH was measured by scavenging activities of1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) and nitric oxide (NO) in RAW 264.7 cells. The inhibitory effect against the production of inflammatory mediators including interleukin-
), interleukin-6 (IL-6), tumor necosis factors-
) expression was inhibited in RAW 264.7 cells was experimented using JGH. The effects of JGH on healing fractured rats was measured by osteocalcin, calcitonin, CTXII, TGF-
, BMP-2, Insulin, ALP in the serum. and was checked every 3 weeks from 0 week to 6week using x-ray. Results 1. DPPH free radica and ABTS scavenging activity of JGH were increased according to concentration of JGH in RAW 264.7 Cells. 2. In the experiment, NO, IL-
, IL-6, TNF-
all showed decrease, in general. Especially NO and IL-
showed significantly decrease at a concentration of 10, 100 (
). 3. In the production of osteocalcin in the serum, JGH 200, 400 mg/kg experimental group showed significant increased effect at 2 weeks. 4. In the production of calcitonin in the serum. JGH 200 mg/kg experimental group showed significant increased effect at 4, 6 weeks. JGH 400 mg/kg experimental group showed significant increased effect at 2, 4, 6 weeks. 5. In the production of CTX, TGF-
, BMP-2 in the serum, experimental group showed increased effect. but no significant effect. 6. In the production of insulin in the serum. JGH 200, 400 mg/kg experimental group showed significant decrease effect at 2, 4, 6 weeks. 7. In the production of ALP in the serum. JGH 200 mg/kg experimental group showed significant increased effect at 2, 4, 6 weeks. JGH 400 mg/kg experimental group showed significant increased effect at 4, 6 weeks. 8. In the change of X-ray, the experimental group showed better healing effects on skull fractured rats than control group. Conclusions From above results, JGH showed healing effect on Anti-oxidation, Anti-inflammatory in RAW 264.7 Cells, factors related with bone metabolism in the serum of skull fractured rat and x-ray, which is expected to be applied in clinics.
Anti-Oxidative and Anti-Inflammatory Effects of Cheongajihwang-Tang Extract on RAW264.7 Cells
Yoon, Jeong-won ; Kim, Soon-Joong ; Park, Dong-Su ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 51~58
DOI : 10.18325/jkmr.2016.26.3.51
Objectives This study was designed to investigate whether the Cheongajihwang-Tang (CT) has an inhibitory effect association with oxidation or inflammation in RAW264.7 cells. Methods Cytotoxic activity of CT extract on RAW264.7 cells was evaluated by using 3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) solution. Nitric oxide production was measured using Griess reagent system. The total phenolic contents and 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity was measured to evaluate the anti-oxidative effects of CT. Dichlorofluorescin diacetate (DCFH-DA) has been used as a substrate for measuring intracellular oxidant production. Results Cheongajihwang-Tang does not impair the cell viability in tested concentration. CT showed anti-oxidative effects in vitro by decreasing electron donating ability, and also showed anti-inflammatory effects suppressing NO and ROS expression in LPS induced RAW264.7 activation. CT inhibited the generation of intracellular ROS production as dose dependant manner. Conclusions CT has anti-oxidative effects and anti-inflammatory activities. These results indicate that CT extract has an anti-inflammatory activities via anti-oxidative effects.
Domestic Research Trend of the Ossicification of the Posterior Longitudinal Ligament in Korean Medicine
Ahn, Min-Youn ; Lim, Hyung-Ho ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 59~65
DOI : 10.18325/jkmr.2016.26.3.59
Objectives The purpose of this review is to analyze domestic research trend of the ossification of posterior longitudinal ligament in Korean medicine. Methods We searched articles in Korean databases such as OASIS, RISS, NDSL and sorted the articles by journals, published year, institutions and research type. Results 9 suitable theses were reviewed. They were published between 2002 till 2011. Most of the theses were published in The Acupuncture, the journal of Korean Acupuncture & Moxibustion Medicine Society. There were 6 case reports, 2 case series and single disease review. Conclusions There were only 9 studies about the ossification of posterior longitudinal ligament in Korean medicine and most of them were case reports. To reinforce the evidence of effectiveness of Korean medicine, additional studies are required and well designed studies such as randomized controlled trials need to be carried out.
Systematic Review of Bee Venom Therapy for Traumatic Injury
Lee, Jae-Eun ; Lee, Chi-Ho ; Lee, Eun-Jung ; Lee, Jung-Min ; Oh, Min-Seok ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 67~77
DOI : 10.18325/jkmr.2016.26.3.67
Objectives To evaluate the evidence supporting the effectiveness of Bee Venom therapy for traumatic injury. Methods We conducted search across 3 electronic databases (Pubmed, CAJ and Oasis) to find clinical trials that used Bee Venom therapy as treatment for traumatic injury. The methodological quality of RCTs (Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias (RoB) tool, while NRCTs (Non-Randomized controlled clinical trials) were assessed using the Cochrane Risk of Bias Assessment tool for Non-randomized Study (RoBANS) tool. Results Among 87 articles that were searched, 10 RCTs and 19 NRCTs were finally selected. Among 19 selected studies, all studies showed that Bee Venom therapy has significant effect on traumatic injury. Conclusions Our systematic review found encouraging but limited evidence of Bee Venom therapy for traumatic injury. We recommend clinical trials which compare the effectiveness of Bee Venom therapy with other pharmacopuncture therapies to clarify the effectiveness of Bee Venom therapy from other pharmacopuncture therapies.
Chuna Manual Therapy for Primary Insomnia; A Review of Clinical Study
Hwang, Man-Suk ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 79~84
DOI : 10.18325/jkmr.2016.26.3.79
Objectives To evaluate the evidence supporting the effectiveness of Chuna manual therapy for primary insomnia. Methods The researcher conducted search across the 3 electronic databases (Pubmed, CAJ and Oasis) to find all of randomized controlled clinical trials(RCTs) that used Chuna manual therapy as a treatment for primary insomnia. Results Four RCTs met inclusion criteria. The meta-analysis showed positive results for the use of Chuna manual therapy in terms of the PSQI when compared to medication treatments alone. Positive results were also obtained, in terms of the PSQI, when comparing Chuna manual therapy combined with acupuncture therapy to acupuncture therapy alone, but was not statistically significant. Conclusions The review found encouraging but limited evidence of Chuna manual therapy for primary insomnia. We recommend clinical trials which compare the effectiveness of Chuna manual therapy with usual care to obtain stronger evidence without the demerits of trial design.
A Study on Research for Utilization Acupuncture Treatment in Military Medicine
Choi, Hee-seung ; Cha, Yun-Yeop ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 85~95
DOI : 10.18325/jkmr.2016.26.3.85
Objectives Military medicine is the study of research which includes health, sanitation, clinic, and quarantine in military personnel. This study is focused on research the acupuncture treatment of military medicine. Methods The study on acupuncture research for Military Medicine was referred from via KoreaMed, OASIS, The Journal of Korean Military Medical Association, KMbase, KAMJE, NDSL, KISS, KISTI, PubMed, MEDLINE, EMBASE, and The Cochran library. As a result, 18 research papers were found and they were analyzed according to the year of publishment, the titles of journals, the nation of research center, the types of study, the purpose of study, the outcome of measurement, the type of acupuncture, and the assessment of acupuncture effect. And then assessed the risk of bias about RCT, NRCT, prospective cohort studies, and before and after studies. Results The number of the published research papers on acupuncture was increased since 2013. The studies were mainly published in the USA and eight out of 18 were RCT. The purpose of study is mostly for musculoskeletal and psychological disease and medical decision for acupuncture. The type of the acupuncture used is not only traditional acupuncture but also the auricular acupuncture. Even though the research results about the effect of acupuncture were excellent and positive, some of studies had a high risk of bias. Conclusions The studies state about acupuncture treatment as mostly positive and effective, however, further clinical studies are required to obtain objective clinical evidence of acupuncture treatment. Furthermore, future trials would be needed to find out effective acupuncture treatments on military duty.
Effectiveness of Korean Medicine Treatment on Lumbar Intervertebral Disc Herniation Patients' Fear-Avoidance Belief
Choi, Young-Jun ; Moon, Byung-Heon ; Ju, Yeung-Guk ; Kim, Kil-Hwan ; Song, Seong-Bae ; Shin, Dong-Jae ; Chung, Jai-Hyeon ; Lee, Chi-Ho ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 97~108
DOI : 10.18325/jkmr.2016.26.3.97
Objectives This study is planned to classify effectiveness of Korean medicine treatment on lumbar intervertebral Disc herniation patients' fear-avoidance belief. Methods We measured 84 patients with lumbar intervertebral disc herniation in Jaseng Korean Medicine Hospital. We used numeric rating scale, oswestry disability index, fear-avoidance belief questionaire for evaluating effectiveness of oriental medicine treatment on lumbar intervertebral disc herniation. And We used Magentic Resonance Imaging(MRI) for classifying the patient who has lumbar intervertebral disc or not. Results 1. There was statistical effectiveness of korean medicine treatment on lumbar intervertebral disc herniation patients' fear-avoidance belief (p<0.01).
(r=0.587) was Most statistically correlative.
had a little of statistically correlation (r=0.313).
has no statistically correlation (r=0.145). Conclusions This study suggests that screening for the korean medicine treatment reduces fears and negative belief of patients with the lumbar disc herniation and prevents chronic physical symptoms that come from them so that it can be a great help to controlling patients' pain clinically.
The Correlation between Cross-sectional Area of Lumbar Paraspinal Muscles and Walking Ability in the Patients with Lumbar Spinal Stenosis
Kim, Min Chul ; Seo, Young Hoon ; Lee, Sang Min ; Kim, Yu Jong ; Hong, Je Rak ; Yoo, Do Hyun ; Kim, Ji Su ; Kim, Tae Gyu ; Choi, Jae Young ; Kim, Tae-Hun ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 109~117
DOI : 10.18325/jkmr.2016.26.3.109
Objectives The purpose of this study was to investigate the correlation between walking ability of lumbar spinal stenosis patients and the cross-sectional area (CSA) of lumbar paraspinal muscles. Methods This study was carried out on 62 lumbar spinal stenosis patients who had limited walking abilities because of neurogenic claudication (NC). All patients received more than 2 weeks of complex treatment at Mokhuri Neck&Back Hospital. CSA of lumbar paraspinal muscles was measured from axial T2-weighted MRI and divided by CSA of adjacent vertebral body to avoid influence of body statues (RCSA-Relative CSA). Pain Free Walking Distance and Numerical Rating Scale (NRS) was measured before and after treatment. Results The Pain Free Walking Distance had significantly increased in patients who had bigger RCSA of psoas muscle (r=0.313, p<0.05). Conclusions The psoas muscle can be a predictive factor for restoring walking ability of lumbar spinal stenosis patients who have limitations walking.
Effect of E10 on Relief of Cervical Myalgia; One Group Pre-Post, Pilot Trial Study
Jung, Dong-Hoon ; Kim, Hye-Jung ; Kim, Jung-Sup ; Lee, Gui-Sun ; Park, Won-Hyung ; Cha, Yun-Yeop ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 119~128
DOI : 10.18325/jkmr.2016.26.3.119
Objectives The purpose of this study is to investigate the efficacy of E10 on the relief of cervical myalgia. Methods This study is a one group pre-post, pilot trial test. After the approval of institutional review board (IRB), we have recruited 25 patients suffering from cervical myalgia. 23 patients (2 patients dropped out) was treated by using E10 on the cervical muscle and acupuncture points, three times a week for a total of two weeks from February 2016 to April 2016. Evaluations of VAS for bothersomeness of neck pain (VASB), VAS for pain intensity (VASP), NDI, SF-36, X-ray, thermography, etc. before and 1 week after treatment were carried out. The primary outcome measure was the VASB, measured 1 week after the end of the therapy. Results VASB scores was significantly decreased from
. VASP scores was significantly decreased from
. Results showed significant improvements in VASB, VASP, NDI, SF-36 from the baseline. However, in X-ray, thermography, there was no singnificant difference. Conclusions This study demonstrates the effectiveness of E10 treatment for relieving cervical myalgia.
Selection of Manageable Diseases for Quality Assessment in Korean Medicine by Delphi Method
Park, Chang-Hyun ; Lim, Hyung-Ho ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 129~141
DOI : 10.18325/jkmr.2016.26.3.129
Objectives As awareness of the public about Korean medicine health care and the social demand about improvement for quality of health care service is constantly rising, the quality evaluation of Korean medicine health care service is needed to improve the quality. Through trial of Delphi method, we tried to set the priority in short, medium, long term among the disease which is the subject of quality assessment. Methods Carrying out the delphi survey to 50 experts of korean medicine who were recommended by the 41 member societies of Korean medicine and related organizations, we selected final candidates for quality assessment. It is composed with total 2 rounds, and we investigated the priority in three aspects; the importance of the matter, possibility quality assessment, potential about if there's any chance of improvement. Results By delphi method, we set the priority of quality assessment. Base on the result of the second round, we classified importance of the questions into above average, average, below average, and categorized items as short, medium, long term according on the final priority. We classified of musculoskeletal diseases and diseases of connective tissues and musculoskeletal injury as short term and cerebrovascular disease and disease of nerve system and malignant neoplasm as medium term, disease of digestive organs and diseases, symptoms and abnormal findings in clinical field or inspections which are not categorized as long term. Conclusions We set the subjects of quality assessment by delphi survey by experts, and classified into short, medium, long term. Further research is necessary for execution the Quality Assessment to each of the candidate. Also, we can send feedback to medical institution base on the result of Quality Assessment. then it would be able to induce the improvement in quality of medical institution by itself.
A Case Report of Complex Korean Medical Treatment for Cervical Spinal Cord Injury and Neurogenic Bladder
Song, Min-Yeong ; Jo, Hee-Guen ; Kim, Tae-Gwang ; Choi, Jin-Bong ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 143~151
DOI : 10.18325/jkmr.2016.26.3.143
A 57-year-old male patient was diagnosed as Incomplete cervical spinal cord injury and Neurogenic bladder after falling accident and suffered from tetraplegia and urinary retention. The patient was hospitalized and treated with Complex Korean Medical treatment such as acupuncture, electro-acupuncture, bee venom pharmacopuncture and herbal medication for 13 weeks. International Standard for Neurological Classification of Spinal Cord Injury (ISNCSCI) was adopted to evaluate the functional recovery and Korean version of Modified Barthel Index (K-MBI) was adopted to evaluate the recovery of activities of daily living (ADL). After treatment, Total scores of ISNCSCI and K-MBI were improved. Also patient's micturition reflex was recovered and symptoms of neurogenic bladder were improved. This result shows that Korean Medical treatment may be an effective treatment option for spinal cord injury and neurogenic bladder patients. Further clinical studies are needed to clarify the effect of Korean Medical treatment on spinal cord injury.
A Rehabilitation for Total Hip Replacement in Korean Medicine: A Report of Three Cases
Ha, Won-Bae ; Lee, Jong-Ha ; Ko, Youn-Seok ; Lee, Jung-Han ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 153~164
DOI : 10.18325/jkmr.2016.26.3.153
The objective of this study was to propose a rehabilitation protocol for total hip replacement in Korean medicine and to report its effectiveness. Three patients who had undergone total hip replacement were treated using the rehabilitation protocol in Korean medicine. We evaluated the outcome evaluating physical examination findings of the hip joint, numeric rating scale, pain disability index, Harris hip score, and walking state. After the treatment, we observed that hip movement and muscular strength improved. Moreover numeric rating scale, pain disability index, Harris hip score, and walking state of patients improved. A rehabilitation in Korean medicine can be effectively used for total hip replacement patients. The limitation of this study was the insufficient number of cases. Further studies are needed to design a rehabilitation protocol in Korean medicine.
The Clinical Reaction Study on 64 Cases with Essential Bee Venom Treatment
Jeon, Yong-Tae ; Go, Ung ; Kim, Sung-Moon ; Jeong, Hae-Chan ; Han, Kuk-In ; Shin, Seon-Ho ; Ko, Youn-Seok ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 165~170
DOI : 10.18325/jkmr.2016.26.3.165
Objectives The purpose of this study was to observe clinical reactions (itching, pain, etc.) after Essential Bee Venom (EBV) treatment. Methods This study was conducted 64 patients who had been injected with EBV in Korean Medicine Hospital of Woosuk University and Haeundae Ja-Seng Hospital of Korean Medicine from October 5, 2015 to February 20, 2016. We checked clinical reactions of treatment region. Results 8 patients (12.5%) complained of localized itching and 4 patients (6.3%) complained of localized pain after EBV injection. In itching reaction of patients, 2 patients (15.4%) occurred itching in head and neck, 4 patients (12.9%) occurred in lumbar and back. In pain reaction of patients, 2 patients (6.5%) occurred pain in lumbar and back, 1 patient (11.1%) occurred pain in upper limb. All clinical reactions were happened within 7 treatment times. Conclusions This study suggested EBV treatment can cause clinical reaction like itching and pain. Clinical reactions were more common in inpatients than outpatient, and all reactions were happened within 7 treatment times. Doctors should recognize physical reaction caused by EBV and explain to patient. Further studies are needed to more improved treatment.
The Case Report of Chronic Ankle Sprain Improved with Hominis Placenta Pharmacopuncture Treatment
Lee, Dong-eun ; Park, Won-hyung ; Cha, Yun-yeop ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 171~181
DOI : 10.18325/jkmr.2016.26.3.171
Objectives The purpose of this study is to investigate and report the effectiveness of Hominis Placenta pharmacopuncture treatment for chronic ankle sprain. Methods 2 patients are treated at Dept. of Korean Medicine, the Armed Forces Busan Hospital, diagnosed as thinning of anterior talofibular ligament (ATFL), suggestive of partial tear and anterior tibiofibular ligament partial tear. They are treated with Hominis Placenta pharmacopuncture. Each cases are measured and assessed by ankle hindfoot scale (AHS), visual analgue scale (VAS), cumberland ankle instability tool (CAIT) scores. Results 2 patients of chronic disease of ankle sprain have a different kind of diagnoses they have. After treatment of Hominis placenta pharmacopuncture, spontaneous pain is decreased and ankle instability, ankle functions are increased significantly. Conclusions Hominis placenta Pharmacopuncture has a effect on chronic ankle sprain.
A Case of Therapeutic Laser for Suggested Drug Induced Liver Injury Patient during Treatment of Korean Medicine
Lim, Kyeong-Tae ; Shin, Byung-Cheul ; Hwang, Eui-Hyoung ; Heo, In ; Kim, Byung-Jun ; Heo, Kwang-Ho ;
Journal of Korean Medicine Rehabilitation, volume 26, issue 3, 2016, Pages 183~189
DOI : 10.18325/jkmr.2016.26.3.183
A 84 year old male patient with amyotrophic lateral sclerosis (ALS) was treated by Jeungsonbaekchulsan and Gakbyeongyeonsu-tang for ten days. In the course of treatments, this patient was evaluated with Roussel Uclaf Casusality Assessment Method (RUCAM), showing results of drug induced liver injury. Herb medicine was immediately discontinued, followed by therapeutic laser treatments once a day for one week combined with 2 weeks of GODEX
administration. Transaminase results were lowered and changes in blood test results were time-effective changes. Therapeutic laser therapy could be considered effective on drug induced liver injury with further studies.