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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Journal of Pediatrics of Korean Medicine
Journal Basic Information
Journal DOI :
The Association of Korean Oriental Pediatrics
Editor in Chief :
Volume & Issues
Volume 22, Issue 3 - Dec 2008
Volume 22, Issue 2 - Aug 2008
Volume 22, Issue 1 - Apr 2008
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An Experimental Study on the Anticonvulsive Effects of Jisungbomuyngtan
Lee, Hee-Sung ; Kim, Deog-Kon ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 1~11
Objectives In order to investigate the anticonvulsive effects of Jisungbomuyngtan, the experiments were done in mice. Methods After solid extracts of Jisungbomuyngtan was orally administered to mice, four types of convulsion were induced in mice by ECT, strychnine, picrotoxin, caffein. Each of the time to convulsion and death was measured. Results 1. The solid extracts of Jisungbomuyngtan showed a remarkable effect in delaying the onset of convulsion induced by ECT 2. In case of convulsion induced by strychnine, the solid extracts of Jisungbomuyngtan revealed a slight, but not statistically significant effect. 3. Considerable prolongation of time to death was observed in convulsion induced by picrotoxin due to the anticonvulsive effect of Jisungbomuyngtan. 4. The anticonvulsive effect of Jisungbomuyngtan was not found in convulsion induced by caffein. Conclusions Jisungbomuyngtan effect remarkably in delaying the onset of convulsion induced by ECT. But slightly effect by strychnine. And Jisungbomuyngtan effect in prolonging time to death in convulsion induced by picrotoxin, but not found in convulsion induced by caffein.
Traditional Chinese Medicine in the Treatment of Mental Retardation;A Review Study
Im, Jeong-Gyun ; Kim, Lak-Hyung ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 13~24
Objectives This study was designed to analyze the clinical studies on Mental retardation(MR) in traditional Chinese medicine(TCM). Methods For this study, we searched the clinical studies on MR, which had been published from 2003 to 2007, through web site CNKI(中國知識基礎設施工 http://www.cnki.net). There were 17 clinical studies and we focused on those studies. Results 1. In those Chinese studies, they used following words to describe Mental retardation; 小人弱智(
). 2. There were many kinds of TCM treatment methods for MR, such as herbal medicine, acupuncture, electroacupunture, acupoint injection, Chuna therapy, and special education. And those TCM treatments methods showed higher efficacies in the treatment of MR compared with Western medicine. 3. Mental retardation was related with the deficiency of heart, kidney, liver, spleen(心虛, 腎虛, 肝虛, 脾虛) and the pathological mechanism of Phlegm(絹) and Blood stasis(慫沂)in the studies about the Bian Zheng-the types of differential diagnosis- of MR. 4. Most of studies used Intelligence Quotient(IQ) to assess the efficacy of TCM treatment of MR. And the duration of treatment, the degree of illness, the age of patient, and the cause of illness affected the prognosis of MR. Conclusions These results suggest that traditional medicine could be one of the useful treatments on MR. And these results could be used in the clinical practices and studies on MR in Korea.
Clinical Investigation of Survey and Test in Korean Oriental Pediatrics
Hwang, Young-Jun ; Kim, Ki-Bong ; Min, Sang-Yeon ; Kim, Jang-Hyun ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 25~34
Objectives The purpose of this study is to investigate whether Korean oriental pediatrics hospitals are using their feedback surveys to improve their medical conditions. Methods We selected 24 oriental medicine university hospitals and sent surveys to investigate. 15 of those surveys were analyzed. Results The results were classified as follows; Only 9 of university hospital said that they are currently using their feedback surveys to improve their services. Question for asking the purpose of doing their feedback surveys, 58.3% of hospital responded to get some information for diagnosis, 25% of them said to see the progress of treatment of specific disease, and 16.7% answered for using their data to the further studies. The question about the reason why hospital were need to make these feedback surveys, 46.2% of them answered to apply better service, 38.4% of them said to post medical journal. The question for asking what do oriental medical hospitals check from feedback surveys, 40% of them said they check Ryodoraku, 33.3% was pulse diagnostic apparatus, EAV(Electro-puncture According to Voll) was 26.7%. The classification according to purpose of test resulted as follows; information for diagnosis was 48.1%, the progress of a disease was 37.3%. In addition oriental medical test there were blood test, radiological test, brain waves test, Hair Tissue Mineral Analysis(HTMA), ultrasonic test, body composition analysis. Conclusions Further clinical research is necessary for improvement of using the feedback survey effectively.
Case Study of the Effects of Saenghyeoryunbueum on Atopic Dermatitis
Yu, Hyeon-Yeong ; Kim, Ki-Bong ; Min, Sang-Yeon ; Kim, Jang-Hyun ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 35~48
Objectives The purpose of this study is to report the clinical effects of herbal medicine on atopic dermatitis. Methods This nine clinical studies were done by those people who were visited the Oriental Hospital and all of them were diagnosed as atopic dermatitis. We treated the atopic dermatitis patients with herbal medicine(Saenghyeoryunbueum), and we checked SCORAD score and observed the wounds those patients had. Results The patients' wounds were improved and SCORAD score was decreased. Conclusions Herbal medicine(Saenghyeoryunbueum) is an effective in the treatment of atopic dermatitis, and it helped to improve regenerating the skin in the body. The further studies might be also needed.
Study on Dan Dong Ten Lessons (Dan Dong Exercise) among Healthcare Qi Gong Methods for Children
Jeon, Chun-San ; Kim, Jang-Hyun ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 49~57
Objectives As children are physiologically and pathologically sensitive and likely to have trouble developing respiratory and the digestive system, it is necessary for them to improve and adapt to their digestive and respiratory capacity slowly. Although they desperately need to practice Healthcare Qi Gong as they get older, few studies have been conducted about that. While collecting materials on child Healthcare Qi Gong, In order to study more about Dan Dong Ten Lessons, medical researchers and children's parent should be more concerned to these studies. The purpose of this study was to understand Dan Dong Ten Lessons through research on children's healthcare Qi Gong. Methods This study was prepared through collecting data from past oriental medicine studies. Through the examination of Chinese medicine books and scientific studies about Dan Dong Ten Lessons and healthcare Qi Gong, Dan Dong Ten Lessons was classified and systemized. Results Dan Dong Exercise among the contents of children's healthcare Qi Gong was classified through the classification and theorization of Dan Dong Ten Lessons, although the classification and development of children's Qi Gong methods should have been carried out in the area of korean medicine, but it was not easy to find the references. Conclusions Dan Dong Ten Lessons is a song and Qi Gong therapy for children. It also teaches children how to live their life, guides them in the right direction for their life. Therefore, it should be developed academically and practically, so that it can pass down to the next generation as traditional heritage.
A Case Report of Traumatic Cerebral Infarction
Lee, Nam-Yeol ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 59~67
Objectives This study is to investigate the effects of oriental medical treatment for traumatic cerebral infarction. Methods We treated the patients with herbal medicine, acupuncture, aroma therapy, rehabilitation, and we evaluated these cases with Activity Index. Results There are some improvements in each patients, such as manual muscle power, finger apraxia after oriental medical treatments. Conclusions We report a change for the better effect of oriental medical treatment on this case. The more clinical studies of oriental medical treatment for traumatic cerebral infarction are needed.
Effect of Kami-kanghwalsan (KKHS) on Atopic Dermatitis-like Skin Lesions Induced in NC/Nga Mouse by Mite Antigen Stimulation
Kim, Yun-Hee ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 69~93
Objectives The purpose of this study is to investigate the effect of KKHS on atopic dermatitis in an in-vivo experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to this condition in humans. Methods To investigate the effect of KKHS on atopic dermatitis (AD), we evaluated atopic dermatitis-like skin lesions by clinical skin index and analyzed immunological parameters in peripheral blood mononuclear cells(PBMCs), splenocytes, draining lymph node(DLN) and performed skin histology in ears and dorsal skin of atopic dermatitis of NC/Nga mouse in vivo. Results In vivo, clinical skin severity score was significantly lower in the KKHS group than in the control group. IgE, IL-6, TNF-
, IgM, IgG2a and IgG2b levels in serum decreased remarkably in the KKHS group than in the control group, and the level of IFN-
production which is secreted from Th1 cell was increased by KKHS. After this experiment we analyzed immunological cells (
) by flow cytometry. It results that the total absolute number of
cells were recovered as much as normal state, and the level of
in isolated DLN and PBMCs were significantly decreased, and total absolute number of
in dorsal skin of NC/Nga mouse were decreased by KKHS. We analyzed ear, DLN, and neck-back skin after biopsy and dyeing by hematoxyline/eosin(H&E), toluidine staining (mast cells marker). KKHS were very effective to the histological symptoms which are in dermal and epidermal thickening, hyperkeratosis and inflammatory cell infiltration. Ear thickness was significantly decreased compared with the control group and the size of inflammatory lymphocytes cells (ILC) and plasma cells (PC) in DLN were also decreased. Conclusions KKHS on atopic dermatitis in an in-vivo experiment using an NC/Nga atopic dermatitis mouse was very effectiveness to the atopy dermatitis treatment.
Anti-allergic Effects of Cheonmaec-tang in RBL-2H3 Cell
Kim, Yong-Hyeon ; Lee, Seung-Yeon ; Kim, Won-Il ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 95~102
Objectives The purpose of this study was to examine the anti allergic reaction with Cheonmaec-tang. Methods We examined Cell Viability,
, IL-4 secretion from RBL-2H3 cell after pretreatment with 2 ㎎/ml, 4 ㎎/ml of Cheonmaec-tang. Results We observed that Cheonmaec-tang is reduced to
, IL-4 secretion in RBL-2H3 cell. Conclusions These results indicate that Cheonmaec-tang has anti-histamic effect and controls TNF-
, IL-4 secretion on allergic reaction.
The Comparative Study on the Difference of Anti-allergic Effects Based on Different Form of Seunggal-tang
Lee, Seung-Yeon ; Kang, Kyung-Hwa ; Lee, Hai-Woong ; Lyu, Sun-Ae ; Kim, Hong-Bae ; Lyu, Ji-Hyo ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 103~111
Objectives Seunggal-tang is one of the prescriptions of oriental herbal medicine, which has been applied to several allergic diseases such as atopic dermatitis. This study was planned to compare differences of anti-allergic effects based on different form of Seunggal-tang by manufacturing differently. Methods Two types herb medicine products were used; aqueous extract (SG-T, Seunggal-Tang) and powder (SG-S, Seunggal-San) which were made from the same mixed formula of Seunggal-tang. To investigate in vitro anti-allergic activities, rat basophilic leukemia (RBL-2H3) cells were treated with SG-T and SG-S for 1 hour, and then stimulated with the phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187. We examined the release of beta-hexosaminidase, as a marker of degranulation, and the releases of tumor necrosis factor (TNF)-alpha and interleukin (IL)-4, as proinflammatory cytokines. Results SG-T and SG-S didn't have effects on cell viabilities in concentrations under 2㎎/㎖. In additionto that, SG-T more inhibited releasing
and IL-4 than SG-S. Conclusions These results indicate that SG-T is more effective against mast cell-mediated allergic reactions than SG-S.
Induction of Mitochondria-mediated Apoptosis by Solanum Nigrum in Leukemia Cells
Chang, Gyu-Tae ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 113~121
Objectives In human myeloid leukemia cells, there are no specific features of apoptosis compared with apoptosis in other cell types. Solanum nigrum L.(SNL) is a deciduous tree, which is widely distributed in Korea with reported anti-tumor, anti-inflammatory and non-specific immune-enhancing properties. Although the plant has been clinically used for treating a variety of diseases, its bioactive ingredients are unknown and its mode of action potential has never been investigated. Thus anti-tumor property of methanol extract was investigated. Methods In this study, anti-tumor property of methanol extract was investigated by determining its in vitro growth-inhibitory effects on human myeloid leukemia cells. XTT proliferation assay, DNA fragmentation, immunoblot analysis, densitometric analysis were used. Results 1. The methanol fraction of the extracts of SNL induced mitochondria-mediated apoptosis in human myeloid leukemia cells. 2. The methanol fraction exhibited relatively higher cytotoxic activity in a dose-dependent manner than chloroform, and hexane fraction. 3. Typical ladder profile of Oligonucleosomal fragments were appeared. 4. The secreted cytosolic cytochrome C level was increased by treatment of methanol fraction. Conclusions Methanol fraction of SNL is capable of inducing apoptosis in human myeloid leukemia cells.
The Effect of Ikhwang-San on Immune Suppression Induced by Methotrexate in SD Rats
Park, Yu-Boo ; Yun, Hye-Jin ; Baek, Jung-Han ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 123~147
Objectives This study is to investigate how dose Ikhwang-San can be effective on SD rats which deteriorated immunity caused by methotrexate. Methods The test sample were dosed once a day for 14 days by gastric gavage at the beginning of dosage 1000, 500 and 250㎎/㎏/10㎖ from 2 days after last MTX-dosing, and the changes of the body and spleen weight, total number of blood leukocytes, total number of lymphocytes, the percentage of B-cell, T-cell, CD3+CD4+ T-cell, CD3+CD8+ T-cell and CD4+/CD8+ T-cell ratios in the blood and spleen were observed. Results The changes of the body and spleen weight, the total number of blood leukocytes, the total number of lymphocyte in the blood and spleen were significantly increased in IHS Extracts groups comparing with the control group. The percentage of B-cell, T-cell, CD3+CD4+ T-cell in the blood and spleen were significantly increase in IHS groups and comparing with the control group. The ratio of CD4+/CD8+ T-cell in blood and spleen was significantly increased in IHS Extracts groups comparing with the control group. Conclusions According to those results, Ikhwang-San has good immunostimulating effect on SD rats which had deteriorated immunity caused by methotrexate.
The Cause of Motion Sickness in Oriental Medicine
Han, Yun-Jeong ; Jang, Gyu-Tae ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 149~162
Objectives The purpose of this study is to investigate that causes of motion sickness in oriental medicine. Methods The internal and external studies about motion sickness were searched Results and Conclusions The motion sickness is induced by conflict of balance system including vestibular, visual and proprioceptive system. The motion sickness is more common in female and in children between 2 and 12 years old. In western medicine, antihistamine and anticholinergic has been used for treatment of motion sickness, but these anti-motion sickness drug turn out to be not a perfect solution and have several side effects. On the other hands, In oriental medical terminology, there is no words equivalent to the "motion sickness", but we consider the motion sickness as state with dizziness, nausea and vomiting. The motion sickness can be induced by either internal or external causes and the internal causes can thought to be a constitutional factor of an individuals, and the general transportation can be an external cause. The important internal cause is a dysfunction of the spleen, stomch(脾胃不調), retention of phlegm and fluids(痰飮), and deficiency of the kidney jing(腎精不足). The wind(風) and fire(火) in the upper part of the body, especially in the head, also can be an important cause of the motion sickness.
The Study for Precocious Puberty in Recent Journals of Traditional Chinese Medicine
Lee, Min-Jeong ; Chang, Gyu-Tae ; Han, Yun-Jeong ;
The Journal of Pediatrics of Korean Medicine, volume 22, issue 1, 2008, Pages 163~187
Objectives The aim of this study was to investigate the treatment of precocious puberty in current traditional Chinese medical journals. Methods To figure out diagnosis methods, treatment methods, treatment effects of oriental medicine about precious puberty, Chinese medical journals from China National Knowledge Infrastructure (CNKI) which was published from 1999 to 2007 were analyzed and precocious puberty was also been searched. Results 82 articles were selected. 1. Yin and purging Fire(滋陰瀉火) from traditional Chinese Medicine was usually used. 2. The herbs were almost used such as Rehmannia glutinosa(地黃), Anemarrhena asphodeloides (知母), Phellodendron amurense(黃柏), Thesium chinense(夏枯草), Paeonia suffruticosa Andrews(牧丹皮), Alisma canaliculatum(澤瀉), Testudinis Plastrum(龜板), Paeonia japonica(白芍藥), Bupleurum falcatum(柴胡), Genianae Scabrae Radix(龍膽草). 3. The total improvement rate was 72.50 to 100% Conclusions The oriental medical treatments for precocious puberty were presumed to be effective, but more studies are still needed.