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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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The Journal of Pediatrics of Korean Medicine
Journal Basic Information
Journal DOI :
The Association of Korean Oriental Pediatrics
Editor in Chief :
Volume & Issues
Volume 23, Issue 3 - Dec 2009
Volume 23, Issue 2 - Aug 2009
Volume 23, Issue 1 - Apr 2009
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The Effect of Li Zhong Tang on the Suppression of Th2 Differentiation by
Response in IgE Hyperproduction and Atopic Dermatitis-like Skin Lesions Induced NC/Nga Mouse
Seo, Hui-Yeon ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 1~22
Objectives The purpose of this study is to investigate the effect of Li Zhong Tang(LZH-T) on atopic dermatitis by using NC/Nga atopic dermatitis mouse. Methods First, in vitro, we isolated B cells from NC/Nga mouse which induced atopic dermatitis-like skin for 18 weeks. We analyzed FACS by intracellular staining of
, GATA-3+ and also analyzed cytokines by using real-time PCR. Secondly, in vivo, after administration of LZH-T to the 12 weeks old mouse with atopic dermatitis. We analyzed serum IgE,
level and observed the changes of activated cell. Results In vitro, LZH-T decreased the levels of CD4+/
and increased the levels of CD4+/GATA3+. In vivo, serum IgE levels were decreased and
levels were increased in LZH-T group compared to the control group. In PBMCs, the percentage of activated cell - granulocytes, CD3+, CD3+CD4+, B220+CD23+, and CCR3+ were decreased and CD19+, CD3+CD8+ were increased in LZH-T group compared to the control group. Conclusions This study demonstrates immunological activity of GPJST on atopic dermatitis-like model mice.
Effects of Kakamsodokum (KKSDU) on Atopic Dermatitis-like Skin Lesions in NC/Nga Mouse
Song, Hyun-Jee ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 23~35
Objectives The purpose of this study is to investigate the effect of Kakamsodokum (KKSDU) on atopic dermatitis in an in-vitro experiment using an NC/Nga atopic dermatitis mouse, which has histological and clinical similarities to the condition in humans. Methods We evaluated
, IL-10 mRNA, CD4+/
, and CD4+CD25+foxp3+ in B and T cells of NC/Nga atopic dermatitis mouse by real-time PCR and intracellular staining in vitro. Results KKSDU medicines supressed
mRNA and increased IL-10 mRNA in B cells. CD4+/
and CD4+CD25+foxp3+ in T cells were increased by KKSDU. Conclusions KKSDU on atopic dermatitis might be very effective to the atopic dermatitis treatment.
Effects of Atopy Cream-combined with Jawoongo Ointment on the Development of Atopic Dermatitis-like Skin Lesions in NC/Nga Mouse
Yeo, Eui-Ju ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 37~72
Objectives The purpose of this study is to investigate the suppressive effects of Atopy cream-combined with Jawoongo ointment (A-J), on the development of atopic dermatitis-like skinlesions in NC/Nga mouse. Methods We evaluated clinical skin score, hematology and Serum total IgE and IgG1 of NC/Nga atopic dermatitis mouse, analyzed the cytokine level, total cell number, Immunohistochemical staining and Histological features of axillary lymph node(ALN), draining lymph node(DLN), peripheral blood mononuclear cells(PBMCs) and dorsal skin tissue in NC/Nga mouse. Results A-J decreased the clinical skin score, total cell number of WBC, platelet, neutrophils, eosinophils in blood, Serum total IgE & IgG1, IL-5, IL-13. Also, total cell number of ALN and dorsal skin tissue, Absolute cell number of
in ALN, PBMCs, Absolute cell number of
in dorsalskin tissue, Eotaxin2 mRNA, CCR3 mRNA in dorsal skin tissue and gene expression of IL-5 mRNA, IL-13 mRNA in ALN decreased significantly. Furthermore, thickness of epidermis, infiltrated inflammatory immune cell and mast cell in dermis, histologic infiltration of mast cell, the size of inflammatory lymphocytes cells and plasma cells in ALN and histologic infiltration of CD4+ & CCR3+ in ALN and dorsal skin tissue decreased significantly. However, total cell number of DLN, absolute cell number of
increased significantly. Conclusions A-J was the successful treatment of atopic dermatitis in a NC/Nga mouse model.
A Case Report of Systemic Type Juvenile Rheumatoid Arthritis with Fever and Eruption
Yoo, Chang-Kil ; Lee, Yun-Ju ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 73~83
Objectives This study is to report a case that has an important meaning as a result of treating Juvenile Rheumatoid Arthritis. We investigated a patient who had to maintain his life with western medicines such as DMARDs, NSAIDs and steroids for a long time. The patient has recovered from all symptoms and his ESR, CRP has been back to normal range with oriental medicine treatment. Methods The patient had fever, especially repeated fever during the afternoon, pain and swelling of joints, generalized skin eruption, anorexia, delayed growth, weight loss, fatigue. So we treated him with herbal medicine and reduced his western medicine. The aim of treatment was recovery from Juvenile Rheumatoid Arthritis after discontinuance of all western medicine. Results The symptoms of systemic type Juvenile Rheumatoid Arthritis was vanished and the patient maintains his condition with oriental medicine treatment after stopped all DMARDs such as MTX(methotrexate) and NSAIDs. His ESR and CRP levels were back to the normal range. After this treatment the patient's height and weight has been increased which showed a significant meaning in growth to the child. Conclusions This study showed that oriental medicine can elevate the Juvenile Rheumatoid Arthritis patient's quality of life with continuous health care and treatment for major problem. For more accurate studies, further studies would be needed with more cases.
A Case Report of Symptomatic Epilepsy
Kim, Yoon-Young ; Min, Sang-Yeon ; Kim, Jang-Hyun ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 85~93
Objectives The purpose of this study is to report a case which gave various remarkable epilepsy treatment results by using oriental medicine. Methods We treated the patient with acupuncture as a main treatment and herbal medicine. We also recommended to the patient and patient's parents to continue oriental medical treatment for 2 years from now because symptomatic epilepsy is a type of disease which needs long term care. Results The epileptic seizure has been well controlled for 12 months so far, and the results was recorded by EEG. The EEG level was in normal range. Conclusions Even though this is only one case of the study but this case has an important meaning because the epilepsy was treated by oriental medicine, especially acupuncture treatment. The control of the symptomatic epileptic seizure was effective by means of increasing patient's quality of life. Further studies about effective treatment of symptomatic epilepsy would be needed with more various cases.
The Effects of Moschus and Herbal Combination with Moschus by Oral Administration at Memory and Activation of Brain Ability on Rats
Chung, Hyun-Ju ; Lee, Yu-Kyung ; Chae, Jung-Won ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 95~113
Objectives This study was investigated to find how the orally administrated Moschus, herbal combination with Moschus, and herbal combination improves the rats' memory and rats' liver. These medications are generally known asthe memory improvement. Methods This study used the Sprague Dawley rats. They were divided into two groups - SD rats and orally administrated Saline(Control group). 0.473 mg/kg Moschus(HM-A), 153.9 mg/kg herbal composition without Moschus(HM-B), and 165.95 mg/kg herbal composition with Moschus combined(HM-C) Control, saline were orally administered. Each group was trained in the eight-arm radial maze task at the conditions of before oral administrated, and also right after third, sixth, and eighth by oral administration. Lastly, these animals were killed and were tested for brain tissue and serum AST/ALT level to measure how the medications were effected to the liver function. Results The result of radial eight-arm maze task test, the HM-B and HM-C groups showed significant decrease in mistakes from the fourth day of testing. Whereas, the HM-A group showed increasing in the error rate. HM-A and HM-C group of rats had significantly increased amount of acetylcholinesterase in the CA1 region of hippocampus, compared to the control group. Whereas, HM-B and HM-C group had increased level of ChAT compared to the control group. On the other hand, each experimental group did not show any significant difference to the level of serum AST/ALT and the weight ratio of the liver to the body. Conclusions This study provided evidences that the orally administered memory improvement herbal medication, and Moschus were effective to improve memory.
The Study on Treatment of Attention Deficit Hyperactivity Disorder by Oriental Medicine Music Therapy
Lee, Seung-Hyun ; Kim, Yeo-Jin ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 115~126
Objectives The purpose of this study is to introduce oriental medicine music therapy related to the treatment of ADHD. Methods This study observed ADHD from the oriental medical point of view and tried to treat this disease with the oriental medicine music therapy. Results ADHD is caused by excess of Yang energy, flaming-up of fire, blood deficiency of the heart and the spleen, deficiency of the kidney essence, and instability of emotions. The ADHD patients with the case of excess of Yang energy and flaming-up of fire, patients were played Fire-Gi rhythm as a treatment, and they listened to Metal-Gi music. Whereas, the ADHD patient with blood deficiency of the heart and the spleen, invigoration of vital energy music therapy can be used. Another case of ADHD patients with deficiency of the kidney, Water-Gi rhythm and replenishing vital essence music therapy can be used. According to the patients' seven modes of emotions, the proper music should be chosen. Conclusions Oriental medicine music therapy can be a new type of treatment for ADHD patients.
Pre-study of Validation of the Children's Eating Behaviour Questionnaire in Korean Children
Lee, Min-Jeong ; Chang, Gyu-Tae ; Han, Yun-Jeong ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 127~140
Objectives In this study, we obtained Korean version of CEBQ (Children's Eating Behaviour Questionnaire) and verify whether it is reliable or not. Methods Total 106 parents completed this questionnaire, and we gathered children's BMI data and examined the relationship between children's BMI and mean scale scores. Results 1. This study results confirmed the theorectical factor structure, with acceptable internal reliability and between-subscale correlations. 2. There are significant mean scale scores difference between anorexia group and control group. 3. There are significant relations between children's BMI and mean scale scores. Conclusions The results support the use of the CEBQ as a phsychometrically sound tool for assessing children's eating behaviours in Korean children.
The Effect of KyungOcGogamibang on the Growth of the Rats
Jung, Bong-Kyun ; Yun, Hye-Jin ; Lee, Yu-Jin ; Kang, Mi-Sun ; Baek, Jung-Han ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 141~158
Objectives The purpose of this study is to find out the effect of KyungOcGogamibang(KOGE) on the growth of rats. Methods First of all, we divided male Sprague-Dawley rats into 4 groups(KOGE1, KOGE2, KOGE3 and control group). Then KOGE1, KOGE2 and KOGE3 groups were administered with KOGE water extracts once a day at a dosage of 250, 500, 1,000mg/kg respectively for 3 weeks. The control group was administered with normal saline in the same manner. We measured the rat's body weight, amount of body weight increased, length of femur, serum GH, serum IGF-Ⅰ, serum TSH and serum testosterone after each week of administration. Results 1. There were significant changes of the rat's body weight, the length of the femur, the level of GH, IGF-Ⅰand TSH in KOGE1 groups. 2. There were significant changes of the rat's body weight, the length of the femur, the level of IGF-Ⅰand TSH in KOGE2 groups. 3. There were significant changes of the rat's body weight, the length of the femur, the level of IGF-Ⅰand TSH in KOGE3 groups. Conclusions According to the results above, rat in KOGE group have been increased their body weight, length of femur, serum GH, serum IGF-1 compared to the control group. This study shows that groups of KOGE have an effect on promoting the growth, thus it is expected to treat growth problems for children.
Inhibitory Effect of Coicis Semen Extract(CSE) on Pro-inflammatory Mediatory
Yun, Hye-Jin ; Lee, Yu-Jin ; Kang, Mi-Sun ; Baek, Jung-Han ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 159~171
Objectives This study was evaluated the effects of CSE the regulatory mechanism of NO and cytokines in the LPS-stimulated Raw 264.7 cells. Methods The Coicis Semen MeOH extract dissolved in EMEM for 1 hour prior to the addition of LPS(1
). The cell viability was measured by MTT assay, and Nitric Oxide production was monitored by measuring the nitrite content in culture medium. The levels of cytokine and PGE2 were analyzed by sandwich immunoassays. Results CSE inhibited the production of NO (0.03 and 0.1 mg/ml),
(0.03 and 0.1 mg/ml),
(0.03 and 0.1 mg/ml), IL-6 (0.03, 0.1 mg/ml) and PGE2(0.03 and 0.1 mg/ml) in Raw 264.7 cells activated with LPS(lipopolysaccharide). Conclusion According to the results above, Coicis Semen can produce anti-inflammatory effect, which may play a role in adjunctive therapy in Gram-negative bacterial infections.
The Relationship Between Zema 21 and Inbody Based on the Sasang Constitutional Differences of Children
Seo, Jung-Min ; Lee, Yu-Jin ; Yun, Hye-Jin ; Kang, Mi-Sun ; Baek, Jung-Han ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 173~193
Objectives The purpose of this research is to find out the relationship between Zema 21 and in body based on the Sasang Constitutional difference of children. Methods We collected 1050 children from 5 years old to 15 years old who had been tested for both Zema21 and Inbody in OO oriental hospital from the period of September 1, January 1999 to August 31, 2008. This research investigated the Constitutional differences based on the relationship between Zema21 and Inbody. Results 1. It turned out that the children's height does not have a significant relationship between their age and gender. 2. Generally, Taeumin's weights were significantly high than those of Soyangin's and Soumin's in certain ages in children over 9 years old and in all genders. 3. The percentage of the body fat in Taeumin were significantly high than Soyangin and Soumin in certain ages in children over 10 years old and in all genders. 4. Waist-Hip ratio in Taeumin were significantly high than Soyangin and Soumin in male over 10 years old and in female over 13 years old of children. On the other hand, there was no relationship to the Soyangin and Soumin. 5. The obesity degree in Taeumin were significantly high in all female and male who were over 10 years old. Soyangin were the next highest group and Soumin follows. 6. Body Mass Index in Taeumin were significantly high in all genders who were over 10 years old. The second is Soyangin, and the lowest groupis Soumin. 7. The Basal Metabolic Rate resulted as significant in all age, although this does not have any relationship between age and gender. 8. Abdomen out in Taeumin were significantly high in ages over 10 and genders. The second is Soyangin and the lowest is Soumin. 9. Hip circumference Abdomen out in Taeumin were significantly high in ages over 10 and genders. Specially, Taeumin shows highest value, then the second is Soyangin, and the lowest is Soumin who were over 12 years old. Conclusions The results of Inbody were not significant to the children who were under 9 years old. Taeumin became significantly fat after over 10 years old. The results of Body Composition except height and Basal Metabolic Rate(MBR) were the highest in Taeumin, and Soyangin and Soumin were the second, and the third respectively.
The Effects of Sobieum on Decrease of Body Mass Index (BMI) and Obesity Index of Obese Children
Lee, Dong-Hyung ; Kim, Deog-Gon ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 195~203
Objectives The purpose of this study is to evaluate the effects of Sobieum on decrease of BMI and obesity index of obese children. Methods 66 children (33 boys, 33 girls) were involved in this study. We measured height and weight for each time their visit, and calculated BMI and obesity index. Results After medication, BMI level and obesity index were significantly reduced (p<0.001). Conclusions We speculate that Sobieum is effective in the treatment of childhood obesity, and further controlled studies are needed with clinical cases of hematological evaluation.
A Literature Study on Acupuncture for Cerebral Palsy -Based on the Current Traditional Chinese Medical Journals-
Ha, Su-Yun ; Min, Sang-Yeon ; Kim, Jang-Hyun ;
The Journal of Pediatrics of Korean Medicine, volume 23, issue 1, 2009, Pages 205~228
Objectives The purpose of this study is to investigate the current acupuncture therapy of cerebral palsy. Methods We investigated the Chinese clinical papers which were published in the last 10 years(from 1999 to 2008). We found these papers from the oriental medical library in university and we also used the China National Knowledge Infrastructure(CNKI) through the internet and selected 32 papers for analyzing. Results Most papers were described the effect of acupuncture or acupoint-injection. This is more effective way to treat than the general rehabilitation treatment such as the physical therapy, the occupational therapy, and the speech therapy. Acupuncture or acupoint-injection has overall
of rehabilitation rate. The younger the children were, the longer the treatment period was, and the more successful in treatment. The acupuncture was often used with the general acupuncture and scalp acupuncture. Commonly used major acupuncture points were sishencong(四神聰), bohui(百會), zusanli(足三里), yundongqu(運動區), pinghengqu(平衡區), quchi(曲池), and sanyinjiao(三陰交). Commonly used main meridian pathways were bladder, governor vessel, gallbladder, large intestine, stomach, small intestine meridian. Head is the common site for acupuncture. The main acupoint-injection points were zusanli(足三里), dazhui(大椎), shenshu(腎兪), yamen(啞門), neiguan(內關), and fengchi(風池). For the injection, brain activator, ganglioside M1, cerebroprotein hydrolysate, cytidine diphosphate choline, Vit B1, Vit B12, the salviae root, the safflower were commonly used. Conclusions Acupuncture and acupoint-injection have been shown as an effective treatment on cerebral palsy. The acupuncture was used often the general acupuncture and scalp acupuncture all together. Commonly used main acupuncture points were sishencong, bohui, zusanli, yundongqu, pinghengqu, quchi, sanyinjiao.