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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
The Journal of Pediatrics of Korean Medicine
Journal Basic Information
Journal DOI :
The Association of Korean Oriental Pediatrics
Editor in Chief :
Volume & Issues
Volume 25, Issue 3 - Dec 2011
Volume 25, Issue 2 - Aug 2011
Volume 25, Issue 1 - Apr 2011
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Therapeutic Effects of Yijungtang on Atopic Dermatitis-like Skin Lesions of NC/Nga Mouse Induced by Mite Antigen
Seo, Hui-Yeon ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 1~27
DOI : 10.7778/jpkm.2011.25.1.001
Objectives: The purpose of this study is to investigate the effects of Yijungtang(YJT) on atopic dermatitis in an in-vitro and in-vivo experiment using a RBL-2H3 mast cells and a NC/Nga atopic dermatitis mouse. Methods: In-vitro experiment, IL-4, IL-13 mRNA expression were evaluated by a real-time PCR, IL-4, IL-13 production by ELISA and transcription factor as GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-kB by western blotting. In-vivo experiment, clinical skin score we evaluated by, hematology and Serum total IgE and IgG1 of NC/Nga atopic dermatitis mouse, cytokine level, total number of cell, Immunohistochemical staining and Histological features of auxiliary lymph node(ALN), draining lymph node(DLN), peripheral blood mononuclear cells(PBMCs) and dorsal skin tissue in NC/Nga mouse. Results: YJT decreased IL-4, IL-13 mRNA expression, IL-4, IL-13 production and prominently decreased the expression of mast cell specific transcription factors including GATA-2, NF-AT2, c-Fos and NF-kB. YJT oral administration reduced the levels of skin severity scores. It also decreased the level of inflammatory cytokines such as IL-5, IL-13, histamine and IgE in the serum. It elevated IFN-gamma level in the spleenocyte culture supernatant but decreased.
in the PBMCs,
in the ALN,
in the ALN and
in the dorsal skin. Histological examination showed that infiltration levels of immune cells in the skin of AD-induced NC/Nga mice were much improved by YJT oral administration. Conclusions: The anti-allergic activities of YJT may be mediated by down-regulation of Th2 cytokines, such as IL-4 and IL-13, through the regulation GATA-2, NF-AT2 and NF-kB transcription factors in mast cells. YJT would be regulate molecular mediators and immune cells which are functionally associated with atopic dermatitis induced in NC/Nga mice, and may play an important role in recovering AD symptoms.
Suppressive Effect of SaengRyoSaMulTang on Activated RBL-2H3 Mast Cells
Son, Mi-Ju ; Han, Jae-Kyung ; Kim, Yun-Hee ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 28~39
DOI : 10.7778/jpkm.2011.25.1.028
Objectives: SaengRyoSaMulTang is a herbal formula in Oriental Medicine, known anti-allergens. However, its mechanism and cellular targets have not been found yet. Thus the study has developed to investigate the suppressive effect of SaengRyoSaMulTang. Methods: In the study, cellular viability, IL-4, IL-13 mRNA expression, IL-4, IL-13 production, manifestations of GATA-1, GATA-2, NF-AT1, NF-AT2, AP-1 and NF-
B p65 transcription factors were examined by Real-Time PCR, ELISA analysis and western blotting. Results: As a result of treating with SaengRyoSaMulTang extract(SRSMT), the study has shown that the amount of Th2 cytokines, which include PI induced IL-4 and IL-13, plays a significant role in suppressing effect. RBL-2H3 mast cells significantly suppressed the PI-induced Th2 cytokine production including IL-4 and IL-13 in a dose dependent manner. PI-induced IL-4 and IL-13 production was significantly suppressed by SRSMT intervention. Western blot analysis of transcription factors involving IL-4 and IL-13 expression also revealed a prominent decreases of mast cell's specific transcription factors including GATA-1, GATA-2, NF-AT2, c-Jun and c-Fos, but NF-
B p65. Conclusions: The study suggests that the anti-allergenic activities of SRSMT may regulate the transcription factors GATA-1, GATA-2, NF-AT2, c-Jun and c-Fos inhibiting Th2 cytokines IL-4 and IL-13 in mast cells.
The Effects of Gonjadaesungchimjoongbang on Learning Ability and Memory after Ischemic Brain Injury in Rats
Ryu, Su-Hyang ; Chae, Jung-Won ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 40~48
DOI : 10.7778/jpkm.2011.25.1.040
Objectives: The purpose of this study is to evaluate the effect of Gonjadaesungchimjoongbang on spatial learning abilities and memories in ischemic brain injury. Methods: Rats were separated into three groups; (1) Normal, (2) Saline medication after ischemic brain injuries (control), (3) Gonjadaesungchimjoongbang medication after ischemic brain injuries (experiment). Ischemic brain injuries was induced by MCA occlusion and reperfusion. Morris water maze test was conducted for spatial learning and memory tests. Then, the change of BDNF in the hippocampus(
day) was examined by immunohistoche- mistry. Results: In Morris water maze test, spatial learning abilities and memory functioning were considerably increased in the experiment group as oppose to control group on
day(p<0.01). Moreover, immunohistochemistric response of BDNF in the hippocampus indicated that the more increased immune reaction was found in the experiment group as oppose to the control group on
day. Conclusions: Gonjadaesungchimjoongbang can improve the learning abilities and memories in ischemic brain injury.
Herbal Medicine Promotes Growth of Children
Lee, Yu-Jin ; Baek, Jung-Han ; Ko, Min-Jung ; Seo, Jung-Min ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 49~62
DOI : 10.7778/jpkm.2011.25.1.049
Objectives: The purpose of this study is to evaluate the effect of the herbal medicine in children's growth. Methods: 67 of the children in the age from 3 to 16 were participated in this study(31 of boys and 36 of girls). Department of the pediatrics,
university oriental medical hospital, and the participants were measured their body composition and their bone age, the height percentile of the first and the last visit were measured, and those were compared by the Korean Association of Pediatrics' Growth Statistics Curve. Results: 1. Generally, total children's average height and weight were significantly increased after the herbal medical treatment. The comparison between the height and the average height, the weight and the average weight were significantly decreased after the herbal medical treatment. 2. Total children's average soft lean mass, body fat mass, BMI, basal metabolic rate, abdominal circumference and hip circumference were also significantly increased after the herbal medical treatment. 3. The mean height percentile of the children showed 0.88 percentile upwardly. The mean weight percentile of children showed 1.84 percentile upwardly. 4. The height percentile was increased in the group of boys younger than 13, and a group of girls older than 12 year old. Other than a group of boys older than 14, every group showed increasing weight percentile. Conclusions: The herbal medical treatment helped children with growth retardation.
A Case Report of Delayed Healing in Femoral Shaft Fractured Child
Sung, Hyun-Kyung ; Kim, Jang-Hyun ; Min, Sang-Yeon ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 63~71
DOI : 10.7778/jpkm.2011.25.1.063
Objectives: The purpose of this study is to report the clinical effects of oriental medical treatment on delayed healing in femoral shaft fractured child. Methods: We treated the patient with herb medicine named Kamiboatang and Pyritum. Child took Kamiboatang and Pyritum for 2 months, and Kamiboatang for 1 month. After 3 months treatments, we examined the case with radiological findings. Results: The patient's delayed femoral shaft fracture was improved after 3 months oriental medical treatment. Conclusions: This case showed that oriental medical treatment on delayed healing in femoral shaft fractured child was effective. To prove the effectiveness of Kamiboatang and Pyritum, the more clinical study of Oriental medical treatment for this case might be also needed.
Pilot Research about Influential Factors and Efficacy Judgement of Acupoint Sticking in Dog-Days
Lee, Sun-Haeng ; Kim, Cho-Young ; Chang, Gyu-Tae ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 72~81
DOI : 10.7778/jpkm.2011.25.1.072
Backgrounds: Sticking warm and hot herbs to acupoint in Dog-Days where the strongest Yangqi takes place, Acupoint sticking in Dog-Days is one of Oriental medical treatment to cure winter diseases in the summer. This treatment is widespread in China and Taiwan, and is becoming popular in South Korea nowadays. Objectives: The research has been conducted to evaluate the influencial factors and efficacy in Acupoint sticking in Dog-Days. Methods: We visited one kindergarten in Dog-Days of 2010, and attached pills which are made of Sinapis Semen(白芥子), Corydalis Tuber(玄胡索), Asari Herba Cum Radix(細辛), Juice of Zingiber Officinale(薑汁) to BL-13(肺兪), BL-15(心兪), BL-17(膈兪) of 56 children for 4-6 hours(34 boys, 22 girls,
months, 19-78 months). Exacerbating effect or non-significant changes in respiratory symptoms before and after the treatment were ified.. The influentialfactors of efficacy were analyzed by Pearson's
-test and Fisher's exact test. In addition, the efficacy and satisfaction among once, twice, and three times treatment groups were verified by ANOVA. Results: 27 children (48.2%) were effective, but efficacy felt by parents is 45 cases (80.4%). Sex, perspiration, stool, urine, sleep, cold of hands and feet, cold sensitivity, and frequency of Acupoint sticking in Dog-Days has no relation to efficacy(p>0.05). However, the efficacy is poor in 1 and 2 age(p=0.030). Difference among efficacy of once, twice, and three times treatment groups is not significant(p=0.069), whereas there are linear association in frequency of Acupoint sticking in Dog-Days and efficacy(p=0.030). 36 parents (64.3%) are satisfied with Acupoint sticking in Dog-Days, and we observed significant difference among once, twice, three times treatment groups(p=0.041). 19 parents (33.9%) had been known about Acupoint sticking in Dog-Days, but 53 parents (94.6%) wanted repetition, and 41 parents (73.2%) intended to recommend it to acquaintance. Side effects are minor itching in two cases. Twenty seven participants showed positive effect, and forty five people (80.4%) felt beneficial. Sex, perspiration, stool, urine, sleep, cold hands and feet, sensitivity in cold, and frequency of Acupoint sticking in Dog-Days has no relation to the efficacy(p>0.05). Though the efficacy was poor in one and two year old infants, it was linearly correlated with the frequency count and responses from the treatment (p=0.030). Thirty six participants (64.3%) satisfied with the treatment, and so did the first, second, and third participant groups (p=0.041). Even though, only nineteen participants (33.9%) were familiar with Acupoint sticking in Dog-Days, fifty three participants (94.6%) preferred to repeat the treatment, and 41 parents were preferable to recommend the treatment to others. Side effects of minor itching has been reported in a couple cases. Conclusions: Acupoint sticking in Dog-Days is effective in children older than three year old. The effect would be greater when going through the treatment three times. Based on significant satisfaction, intention of repetition and recommendation, strong promotion on Dog-Days are needed to make a better use of Acupoint sticking in Dog-Days for the effective treatment.
Percentile of Body Fat Percentage for Diagnose Obese Among Selected Number of Preschool Children in Yangsan
Jeong, Min-Jeong ; Yun, Young-Ju ; Kim, Bong-Hyun ; Kim, Ki-Bong ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 82~89
DOI : 10.7778/jpkm.2011.25.1.082
Objectives: This study was designed to regulate the percentile of body fat percentage by Bioelectrical Impedence Analysis (BIA) in order to detect overweight and obesity in preschool children. Methods 1301 three to six year old children's height, weight, and body fat percentage using BIA was measured. Results: The percent of the boys with 85th percentiles of the body fat percentage were 22.3%(3years), 23.4%(3.5years), 23.9%(4years), 24.8%(4.5years), 22.8%(5years), 24.6%(5.5years) and 23.8%(6years). The percent of the girls with 95th percentiles of the body fat percentage were 24.9%(3years), 27.5%(3.5years), 27.3%(4years), 28.6%(4.5years), 28.1%(5years), 33.3%(5.5years) and 32.7%(6years). For the girls, the percent of girls with 85th percentiles of body fat percentage were 23.3%(3years), 24.4%(3.5years), 23.6%(4years), 23.7%(4.5years), 24.7%(5years), 26.0%(5.5years) and 28.1%(6years). And the 95th percentiles of the body fat percentage were 28.6%(3years), 27.3%(3.5years), 25.4%(4years), 28.0%(4.5years), 31.7%(5years), 33.5%(5.5years) and 36.4%(6years). Conclusions: The 85th percentiles of body fat percentage to classify as overweight and the 95th percentiles of body fat percentage to classify as obesity were accord with the Body Mass Index (BMI) criteria by the Korean pediatrics society in 2007.
A Survey on Parent's Recognition and Utilization Patterns of Oriental Medical Care of Preschool Students in Seong-Dong district
Park, You-Jin ; Lee, Seul-Ji ; Yoon, Ji-Yeon ; Myoung, Sung-Min ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 90~110
DOI : 10.7778/jpkm.2011.25.1.090
Objectives: The purpose of this study is to examine the parental recognition and utilizing patterns of oriental medical care in children who live in Seong-Dong district. Methods 802 day-care center children's parents participated in the survey on recognition and utilizing patterns of oriental medical care, and 702 of the surveys were analyzed. Results: 1. 38.33% has received previous oriental medical treatments and most were received at the children's age under 12-24 months. Majority of the treatments took place in the clinical settings. By recommendation, some also received their treatment at the medical centers. One of the reasons why they receive oriental medical treatments was that they prefer to balance their treatment with the orental medical treatments along with the western's. 2. 53.85% of those who received oriental medical treatments were satisfied with their treatments. The effective treatment results were the major reason for the satisfaction. 3. 49.56% of those who had oriental medical treatments chose specific oriental medical facilities for the children's ailment. Most specific oriental medical facilities were local oriental medical clinics. Reputation fame were the main reason in choosing the clinics. 4. In 2009, 55.26% had received care in the specific oriental medical clinics for the diseases, such as respiratory symptoms, systemic symptoms, gastrointestinal symptoms, skin problems, neurological and psychiatric disease for infants, and respiratory symptoms, gastrointestinal symptoms, systemic symptoms, skin problems, neurological and psychiatric symptoms, urinary symptoms and musculoskeletal symptoms for toddlers. 5. The average duration of herbal treatment were 7-14 days, preferably 4-6 days, and preferred number of medical visits were once a week on Saturdays and preferred day for night cares were on Friday nights. Average treatment fee per treatment was less than 10,000 won which coincided with the preferred treatment fee per visit. 6. The very first medical institutions chosen by parents once their children are ill are the following; Western medical institutions, western medical clinics, pharmacies, oriental medical clinics, health centers, and lastly, oriental medical institutions. The major concerns in receiving oriental medical cares include pesticides in herbs and hazardous substances in heavy metals. Preferred form of oriental medicine was decoction, the negative feedback of oriental medicine was mostly due to the bitter taste of the oriental herbal decoctions. Preferred frequency of intake was twice a day with less than 10cc~20cc per single intake. Conclusions: Taken all together, we conclude that the growing recognition of Oriental Pediatric medicine is needed among parents.
Study to Examine the Awareness of the Parents, whose Children are Attending an Elementary School in Gyeonggi-do, on Herbal Medication and Health Functional Food
Kim, Mi-Ki ; Jung, Ji-Ho ; Min, Deul-Le ; Lee, Hai-Ja ; Park, Eun-Jung ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 111~118
DOI : 10.7778/jpkm.2011.25.1.111
Objectives: The purpose of this study is to examine the different preferences between herbal medicine and health functional food, and analyze the reasons for the preferences to figure out the better way of promoting herbal medicine. Methods: 500 questionnaires has been handed out to the parents having elementary school students in Gyeonggi-do province, and 331 questionnaires has been collected and evaluated for this study. Results: Among the 331 responses, 58.4% were female, and 41.6% were male. The percentages of the subjects who consume health supplements and that of herbal medicines were 67.4% and 59.2% respectively. The preference rate for the health supplements was 57.6%, and for herbal medicines was 42.4%. The major reason of taking the health supplements was that they were convenient to consume(54%). The major reason for choosing herbal medicines was that people 'expect them to be more effective'(72.7%). However, the problem with Herbal medicine was their consumptions were inconvenient (39.8%), and their tastes was unfavorable. The most preferable form of herbal medication was pills(50.6%), followed by syrup(22.9%). Pertinent price for herbal medication, the participants were favorable to pay 30,000 within a week. For the question on when to start taking the herbal medication, 18 months after was the popular answers from the participants. Conclusions: Among the 331 subjects, the percentage of consuming the health supplements (67.4%) was higher than that of consuming the Herbal Medicine (59.2%). Also the preference was higher than the Herbal Medicine. The reason why the participant preferred health supplements was that they were 'easy to take', The reason for subjects' great preference in herbal medicine was based on their conception that herbal medicines were highly effective. When taking herbal medicine, participants addressed inconvenience in consuming, and unfavorable taste as the biggest problems. Also they thought that pills would be most convenient form of herbal medicine to consume. For the proper price, they were willing to pay less than 30000won, lower than a market price, per a week for the herbal medicine. Most parents thought that proper age of taking herbal medicine is ' 18 month after the birth'. Taking these into account, different perspectives on herbal medicine is necessary at the very moment.
A Study for the Parent's Recognition of the Oriental Medical Treatment and the Expectation of Children's Growth
Yoon, Hye-Joon ; Lee, Jin-Yong ; Kim, Deog-Gon ;
The Journal of Pediatrics of Korean Medicine, volume 25, issue 1, 2011, Pages 119~127
DOI : 10.7778/jpkm.2011.25.1.119
Objectives: The purpose of this study is to evaluate the parents' awareness on the oriental medical treatment and their expectation on children's growth. Methods: The survey was conducted on 78 Health Kids Fair visitors, and 87 children's height and weight were measured in this study. Results: 1. Compare to other treatment, 62.82% of the parents responded that herbal medicine is relatively effective in treating weakness, followed by 'Allergic disease'(46.15%) 'Growth disturbance'(26.92%) 'Obesity'(26.92%) 'Respiratory disease'(26.92%) 'Digestive disease'(19.23%) 'Precocious puberty'(8.97%) 'Neurologic & psychologic disease'(6.41%) 'Urogenital disease'(3.85%). 2. Parents recognize that 'Oriental medicine have an effect on children's height mostly'(25.64%) 'Oriental medicine have an effect on children's height partially'(64.10%) 'Oriental medicine have no effect on children's height'(10.26%) 25.64% of the parents responded that herbal medicine would be helpful in increasing height, 64.10% of the parents said they would be helpful to the certain extent, and 10.26% said they would not play any roles. 3. Expected average weight, height, and BMI score for the boys were 71.8kg, 179.6cm and 22.10. For the girls, however, they were 53.4kg, 168.7, and 18.74. 4. Survey on parents' awareness on benefits of different treatments for challenged growth, Herbal medicine'(48.72%) 'Acupuncture'(7.69%), 'Moxibustion'(3.85%), 'Electronic acupuncture and Aqua acupuncture'(1.28%), 'Massage on acupuncture point'(19.23%), 'Consultation of eating habits'(61.54%), 'Consultation of exercise'(47.44%) were measured. Conclusions: Considering the collected results, we realized that the parents' expected height on their children was, in fact, higher than the standard height. In addition, for treatments for their children's growth improvement, parents expected that 'Herbal madicine' 'Massage on acupuncture point' 'Consultation of eating habits' 'Consultation of exercise would be beneficial.