Go to the main menu
Skip to content
Go to bottom
REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
> Journal Vol & Issue
Journal of the Society of Cosmetic Scientists of Korea
Journal Basic Information
Journal DOI :
Society of Cosmetic Scientists of Korea
Editor in Chief :
Volume & Issues
Volume 37, Issue 4 - Dec 2011
Volume 37, Issue 3 - Sep 2011
Volume 37, Issue 2 - Jun 2011
Volume 37, Issue 1 - Mar 2011
Selecting the target year
Anti-Inflammatory Effects of Volatile Flavor Extract from Herbal Medicinal Prescriptions Including Cnidium officinale Makino and Angelica gigas Nakai
Leem, Hyun-Hee ; Kim, Eun-Ok ; Seo, Mi-Jae ; Choi, Sang-Won ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 199~210
This study was conducted to develop functional sources of herbal cosmetics for treatment of skin aging and inflammatory disorders using volatile flavor extracts of four different herbal medicinal prescriptions including Cnidium officinale Makino (COM), Angelica gigas Nakai (AGN), Mentha arvense L. (MAL), Artemisiae argyi Folium (AAF), Paeonia lactiflora Pall (PLP), Rehmanniae Radix Preparata (RRP), Scutellaria baicalensis Georgi (SBG), Panax ginseng C.A. Meyer (PGM), Glycyrrhiza uralensis Fisch (GUF). The volatile flavor extracts of four different herbal medicinal prescriptions (HH-1: COM, AGN, PLP, RRP, HH-2: COM, AGN, PLP, RRP, SBG, PGM, GUF, HH-3: COM, AGN, MAL, AAF, HH-4: COM, AGN, MAL, AAF, SBG, PGM, GUF) were extracted using SDE and their antioxidant and anti-inflammatory effects were measured by using DPPH radical and SLO, respectively. As a result, HH-2 showed moderate DPPH radical scavenging activity (68.24 %) and the strongest SLO inhibitory activity (83.96 %) at 100
/mL. Moreover, HH-2 of four different prescriptions significantly inhibited NO production on LPS-stimulated RAW 264.7 cells in a dose-dependent manner without considerable cell cytotoxicity at range of 2.0 ~ 50
/mL. Additionally, HH-2 also effectively suppressed the production of
and IL-6, which are responsible for promoting the inflammatory process. Major volatile components of HH-2 were identified as eugenol, paeonol, butyl phthalide,
-eudesmol and butylidene dihydrophthalide by GC-MS analysis. Thus, these results suggest that HH-2 may be useful as a potential source of anti-inflammatory agents in herbal medicinal cosmetics.
Effect of Kenpaullone, a Specific Inhibitor of GSK3
, on Melanin Synthesis in B16 Melanoma and Human Melanocytes
Kim, Hae-Jong ; Lee, You-Ree ; Nguyen, Dung Hoang ; Lee, Hyang-Bok ; Kim, Eun-Ki ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 211~218
Effects of Kenpaullone, a specific inhibitor of GSK3
, on melanin synthesis in B16 melanoma cells and human melanocytes were investigated. Kenpaullone showed a melanogenesis stimulation activity in a concentrationdependent manner in murine B16 melanoma cells and human melanocytes without any significant effects on cell proliferation. Tyrosinase activity was increased 48 h after treatment of B16 cells with Kenpaullone. The protein expression level of tyrosinase was dose-dependently enhanced after the treatment with Kenpaullone. At the same time, the expression level of tyrosinase mRNA was also increased after addition of Kenpaullone. The stimulatory effect of Kenpaullone mainly resulted from increased expression of tyrosinase. These findings suggest that the application of GSK3
inhibitors may be a potential therapeutic agent for the treatment of hypopigmentation disorder.
Study on Biological Activities of Adventitious Roots Cultured from Echinacea angustifolia
Park, Chang-Min ; Joung, Min-Seok ; Ko, Du-Jin ; Paek, Kee-Yoeup ; Choi, Jong-Wan ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 219~226
The Echinacea, which has been commonly known as a species of composite herb of dicotyledonous plant, has been used in native American traditional medicine for the treatment of diseases like colds or other infections in North America. We artificially cultured the adventitious roots of Echinacea angustifolia using the bioreactor culture system from Echinacea angustifolia and evaluated the efficacy as a cosmetic ingredient for skin care. Several studies previously have reported neogenesis, wound healing and inflammatory inhibition effect of Echinacea angustifolia but other efficacies were not well known. In the present study, we investigated the cosmetic efficacy to know applicable value of adventitious roots cultured from Echinacea angustifolia as a cosmetic ingredient. The adventitious roots extract of Echinacea angustifolia has superior anti-oxidant effect and matrix metalloproteinase-2 inhibitory effect, compared to natural Echinacea angustifolia. These results indicate that the adventitious roots extract cultured from Echinacea angustifolia presents a new possibility of being applicable to skin care and anti-wrinkle products as a cosmetic ingredient.
Photostability Evaluation of a New Sunscreen Agent, Methoxycinnamidopropyl Polysilsesquioxane
Jung, Taek-Kyu ; Kim, Young-Back ; Yoon, Kyung-Sup ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 227~236
The new sunscreen agent, methoxycinnamidopropyl polysilsesquioxane, is manufactured as polymeric particles with an organic/inorganic hybrid composition. We have already reported the manufacturing method, physical properties, and sunprotection effects of methoxycinnamidopropyl polysilsesquioxane. In this study, we evaluated the photochemical properties and photostabilities of methoxycinnamidopropyl polysilsesquioxane that has the same functional group as a typical organic sunscreen agent, ethylhexyl methoxycinnamate (EHMC). Using the correlation of UV absorbance and fluorescence, we studied photostabilizers to enhance the photostability of methoxycinnamidopropyl polysilsesquioxane. Finally, we confirmed that octocrylene, ethylhexyl methoxycrylene, and bis-ethylhexyloxyphenol methoxyphenyl triazine were good photostabilizers for methoxycinnamidopropyl polysilsesquioxane.
Effect of Inonotus obliquus Extract on the Expression MMPs and HAS-2
Lee, So-Hun ; Park, Sun-Hee ; Lee, Kang-Hyuk ; Park, Soo-Jin ; Kim, Young-Heui ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 237~245
In order to investigate the possibility of Inonotus obliquus extract as an active ingredient for wrinkle-care cosmetics, we prepared 70 % ethanolic extract of Inonotus obliquus and measured its DPPH radical scavenging activity and elastase inhibitory activity. We also evaluated the effect of Inonotus obliquus extract on expression of MMPs and HAS-2 in fibroblast and HaCaT cell, respectively. Inonotus Obliquus extract showed DPPH radical scavenging activity and elastase inhibitory activity in a dose-dependant manner (
/mL). Inonotus obliquus extract inhibited the expression of MMP-1 mRNA 50 ~ 79 % at concentrations of 5 ~ 25
/mL, and reduced the expression of MMP-2 around 20 % at a concentration of 10
/mL. And it also reduced the expression of MMP-9 54 ~ 70 % in tconcentrations of 5 to 25
/mL. Furthermore, Inonotus obliquus extract increased HAS-2 mRNA expression in a dose-dependent manner in concentrations of 5 to 25
/mL without cytotoxicity. These results suggested that Inonotus Obliquus extract could be useful as an active ingredient for wrinkle-care cosmetics.
Embryo-Fetal Developmental Toxicity Study of Methoxycinnamidopropyl Polysilsesquioxane
Hong, Jeong-Sup ; Lim, Jeong-Hyeon ; Kim, Kang-Hyun ; Park, Myeong-Kyu ; Jo, Ki-Yeon ; Park, Gil-Jong ; Jung, Taek-Kyu ; Kim, Ja-Young ; Yoon, Kyung-Sup ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 247~256
Existing organic UV protection materials seem to be problematic due to their penetration and irritation to skin. Inorganic UV protection materials are also at issue for safety of their nano-type transformation. Therefore, the recent studies of UV protection materials have been focused not only on the effectiveness but also on their safety. One of the UV protection materials in study which have higher safety is the organic-inorganic conjugation type UV protection material. Previously, we have reported the manufacturing process, physical property and UV protection efficiency of methoxychinnamidoprophy poloysilsesquixan as a new cross-linked polymer type UV protection material. In this study, we have evaluated the effect of the methoxychinnamidoprophy poloysilsesquixan on embryo-fetal development in SD rats. This study is expected to show some definite information related to the effect on pregnancy or embryo-fetal abnormality in case of the clinical exposure of the methoxychinnamidoprophy poloysilsesquixan.
Study on the Antioxidative Activities and Anti-Inflammatory Effect of Kaempferol and Kaempferol Rhamnosides
Lee, Keun-Ha ; Cho, Young-Long ; Joo, Chul-Gue ; Joo, Yeon-Jeong ; Kwon, Sun-Sang ; Ahn, Soo-Mi ; Oh, Su-Jin ; Rho, Ho-Sik ; Park, Chung ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 257~264
In this study, to evaluate the antioxidative activities and anti-inflammatory effects of kaempferol and its rhamnosides, we performed the free radical scavenging assay, ROS inhibition assay and TARC (thymus and activation-regulated chemokine) assay. Also, we studied physiological activity of kaempferol and its rhamnosides (
-rhamnoisorobin, afzelin, kaempferitn) by structure-activity relations. The free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activities were determined with kaempferol (62.5
) but afzelin and kaempferitrin did not show free radical scavenging activities. Kaempferol showed a 97.5, 57.8, 47.8 % inhibition of ROS (reactive oxygen species) generated at concentrations of 10, 50 and 100
, compared to control (100 %).
-rhamnoisorobin showed a 93.1, 59.1 and 41.4 % inhibition of ROS at the same concentration. We investigated the inhibitory effects of kaempferol and its rhamnosides on TARC expression. Kaempferol showed a 48.8, 5.5 and 4.4 % inhibition of TARC generated at 10, 50 and 100
, compared to control.
-Rhamnoisorobin showed a 88.1, 19.0 and 1.0 % inhibition of TARC generated at the same concentration. In conclusion, these results indicate that kaempferol and
-rhamnoisorobin have good antioxidative activities and anti-inflammatory effects that could be applicable to new functional cosmetics for anti-aging and anti-inflammation.
Antioxidative and Inhibitory Activities on Tyrosinase of Hippophae rhamnoides Leaf Extracts
Kim, Jung-Eun ; Chae, Kyo-Young ; Park, Soo-Nam ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 265~273
In this study, the antioxidative and inhibitory effects on tyrosinase and elastase of Hippophae rhamnoides (H. rhamnoides) leaf extracts were investigated. The ethyl acetate fraction of H. rhamnoides extracts showed more effective free radical (1,1-diphenyl-2-picrylhydrazyl, DPPH) scavenging activity (
/mL). Reactive oxygen species (ROS) scavenging activity (
) of the aglycone fraction in the luminol-dependent
system was 0.19
/mL. The aglycone fraction exhibited more prominent cellular protective effects (
, 133.3 min at 10
/mL) in the
-induced photohemolysis of human erythrocytes. The inhibitory effect (
) of the aglycone fraction on tyrosinase was 54.86
/mL, and more effective than arbutin known as whitening agent. These results indicate that fractions of Hippophae rhamnoides extract can be used as antioxidants in biological system, particulaly skin exposed to UV radiation by quenching and/or scavenging
and other ROS, and protecting cellular membranes against ROS.
Whitening Efficacy Study of Natural Compounds-Peptide Derivatives via cAMP Signaling Pathway
Lee, Hye-Suk ; Shin, Kyong-Hoon ; Ryu, Geun-Seok ; Jee, Kyung-Yup ; Cho, In-Shik ; Kim, Han-Young ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 275~282
Novel whitening agents were prepared using peptide-Natural origin compound derivatives. The peptide could be an antagonist of MC1R and Natural origin compound were well-known material as a Tyrosinase inhibitor. We also suggest the new assay method which could evaluate the Antagonistic effectiveness to MC1R using cAMP signaling pathway. 24 candidates were synthesized and 11 peptide derivatives were selected by cAMP assay method. To evaluate cAMP assay, the selected peptide derivatives were assayed to evaluate their melanogensis inhibitory activity. At this work, we could know that the sequences which include -RW- have a melanogensis inhibitory activity, and cAMP assy could use as a evaluating method of MC1R antagonist. But, to evaluate the whitening activity of some material, cross-checking with melanin inhibitory assay method was recommended.
Skin Brightening Effect of Gel Essence Containing High Concentrated-Marine Minerals in Silicon Copolyol Network Film in vivo
Kim, Sun-Kyong ; Kim, Young-So ; Joo, Kyung-Mi ; Kim, Eun-Joo ; Lee, Ji-Eun ; Chae, Byung-Gun ; Cho, Jun-Cheol ; Han, Sang-Hoon ;
Journal of the Society of Cosmetic Scientists of Korea, volume 37, issue 3, 2011, Pages 283~288
Since minerals are in ionic forms in aqueous phase (like deep sea water), it is very hard to incorporate concentrated minerals in gel like cosmetic formulations which are generally composed of carbomer or acrylates polymer. In this study, we invented a salt-resistant network formulation made of silicon copolyol. It was found that the network formulation traps minerals (especially from marine) in a mesh-like silicone copolyol structure. Since the mineral-containing formulation makes a very thin film on the skin, minerals could be easily absorbed into stratum corneum. In 6 weeks in vivo test, it was found that the novel mineral formulation increased the amounts of amino acids, major components of natural moisturizing factors (NMFs), as well as levels of minerals. It was also found that the moisture contents and the brightness of the skin increased.