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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of the Korean Magnetic Resonance Society
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Korean Magnetic Resonance Society
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Volume & Issues
Volume 10, Issue 2 - Dec 2006
Volume 10, Issue 1 - Jun 2006
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Quantification of Metabolic Alterations of Dorsolateral Pre-Frontal Cortex in Depression SD Rat by MR Spectroscopy
Hong, Sung-Tak ; Choe, Bo-Young ; Choi, Chi-Bong ; Park, Cheong-Soo ; Hong, Kwan-Soo ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 126~140
Purpose: Contrary to the human study, it has rarely investigated metabolic alterations in the dorsolateral prefrontal cortex (DLPFC) of depressed rats versus age and sex-matched controls using proton magnetic resonance spectroscopy (MRS). Thus, the purpose of this research was to verify the feasibility of metabolic differences between the normal rat and the depression model rat. Materials and Methods: A homogeneous group of 20 SD male rats was used for MRI and in vivo 1H MRS. To induce a depressed status in SD rats, we performed the forced swimming test (FST). Using image-guide, water suppressed in vivo 1H MRS with 4.7 T MRI/MRS system, NAA/Cr and Cho/Cr ratios were mainly measured between depressed rats and normal subjects. Results: In depressed rats, increased Cho/Cr ratio was measured versus control subjects. However, no significant group effect for NAA/Cr was observed between case-control pairs. Discussion and Conclusions: The present 1H MRS study shows significant brain metabolic alterations of dorsolateral prefrontal cortex with experimental depressed status of SD rat induced by FST compared to normal subjects. This result provides new evidence that in vivo 1 H MRS may be a useful modality for detecting localized functional neurochemical markers alterations in left DLPFC in SD rats.
Synthesis and Spectroscopic Characterization of Vanadium incorporated V-AlMCM-41 Molecular Sieves
Back, Gern-Ho ; Yu, Jong-Sung ; Lee, Hye-Young ; Lee, Yong-Ill ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 141~154
A solid-state reaction of
with AlMCM-41 followed by calcinations generated
species in the mesoporous materials. Dehydration results in the formation of a vanadyl species,
, that can be characterized by electron spin resonance (ESR). The chemical environment of the vanadium centers in V-AlMCM-41 was investigated by XRD, EDX, diffuse reflectance UV-VIS, ESR,
NMR. It was found that the vanadium species on the wall surface and inside the wall of the hexagonal tubular wall of the V-AlMCM-41 were completely oxidized to tetrahedral
and transformed to square pyramidal by additional coordination to water molecules upon hydration. The oxidized
species on the wall surfaces and inside the wall were also reversibly reduced to
species or lower valences by thermal process.
Chmical Shift Variation of Bovine Angiogenin Upon Binding with Phosphate ions
Baek, Sun-Hee ; Kang, Dong-Il ; Lee, Jee-Young ; Shin, Hang-Cheol ; Kim, Yang-Mee ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 155~162
Angiogenin is unique among angiogenic molecules in that it is a member of the pancreatic ribonuclease superfamily and, in fact, is a ribonucleolytic enzyme. Its enzymatic activity is extremely weak compared to that of the digestive RNases but is critical for its capacity to induce neovascularization. In this study, we completed the backbone resonance assignment of bovine angiogenin using triple resonance NMR experiments of
isotope labeled protein and investigated the chemical shift variation upon binding with inhibitor phosphate ion and determine the phosphate binding site.
NMR Studies of Zinc-binding Luteinizing Hormone Releasing Hormone
Kim, Dae-Sung ; Lee, Mi-Sun ; Lee, Chang-Jun ; Won, Ho-Shik ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 163~174
Luteinizing Hormone Releasing Hormone(LHRH) is a decapeptide neurotransmitter known to be regulated by metal ions in the hyperthalamus. Zn-binding LHRH complex was systhesized, and zinc-LHRH complex was studied to understand what kinds of structural modifications would be critical in the LHRH releasing mechanism. Both nonexchangeable and exchangeable
signal assignments were accomplished by pH-dependent and COSY NMR experiments. In addition,
chemical shift changes of a-proton and peptide NH NMR signals at different pH condition, and
signal differences between metal free and metallo-LHRH complex was monitored. NMR signals exhibit that primary metal-binding sites are nitrogens donor of imidazole ring and Arg, and peptide oxygen of Pro-His in the sequence. Structure obtained in this study has a cyclic conformation which is similar to that of energy minimized, and exhibits a specific a-helical turn with residue numbers
out of 10 amino acids.
Binding Interactions of TMAP to Triple- and Double Helical DNA
Kim, Nan-Jung ; Yoo, Sang-Heon ; Huh, Sung-Ho ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 175~187
Binding interactions between a positively charged porphyrin derivative TMAP(meso-tetra(p-trimethylanilinium-4-yl)porphyrin) and triple helical
, as well as double helical
have been studied with NMR, UV and CD spectroscopy to obtain the detailed information about the binding mode and binding site. UV melting studies showed both DNA duplex and triple helix represented very similar UV absorption patterns upon binding TMAP, but the presence of third strand of triple helical
, inhibited improvement in thermal stability in terms of melting temperature,
. In addition, the TMAP molecule is thought to bind to the major groove, according to CD and NMR data. But absence of the clear isosbestic point in UV absorption spectra represented that binding of TMAP to DNA duplex as well as DNA triplex did not show a single binding mode, rather complex binding modes.
Preliminary Structure Determination of the theonellapeptolide Ie from the marine sponge Theonella swinhoei Using NMR Methods
Oh, Sun-Kwan ; Kim, Eun-Hee ; Cheong, Hae-Kap ; Rho, Jung-Rae ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 188~196
A known theonellapeptolide Ie, previously reported in other research group, was isolated from the methanolic extract of the Philippine sponge Theonella swinhoei. The planar structure of this compound was determined on the basis of NMR methods including HMBC and selective HMBC experiments. This is fast and efficient for the dereplication of natural products compared with the MS studies of fragments obtained from complete and partial hydrolysis. The sequence of thirteen amino acids including six N-methyl amino acids in the compound was clearly determined from correlations of extensive HMBC experiments.
] Nuclear Magnetic Resonance Study of Spin Structures in Terbium Tetraboride
Mean, B.J. ; Kang, K.H. ; Kim, J.H. ; Hyun, I.N. ; Lee, Moo-Hee ; Cho, B.K. ;
Journal of the Korean Magnetic Resonance Society, volume 10, issue 2, 2006, Pages 197~202
] nuclear magnetic resonance (NMR) measurements were performed on the single crystals of
to investigate local electronic structure and 4f spin dynamics.
NMR spectrum, Knight shift, spin-lattice and spin-spin relaxation rates were measured down to 4K at 8T.
NMR shift and linewidth are huge and strongly temperature dependent due to the 4f moments. In addition, both are proportional to magnetic susceptibility, indicating that the hyperfine field at the boron site originates from the 4f spins of Tb. Below
, the single broad resonance peak of
NMR splits into several peaks reflecting the local magnetic fields due to antiferromagnetic spin arrangements. The longitudinal and the transverse relaxation rates,
, independent of temperature above
, decreases tremendously confirming huge suppression of spin fluctuation below