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REFERENCE LINKING PLATFORM OF KOREA S&T JOURNALS
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Journal of the Korean Magnetic Resonance Society
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Korean Magnetic Resonance Society
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Volume & Issues
Volume 11, Issue 2 - Dec 2007
Volume 11, Issue 1 - Jun 2007
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An NMR Study of Unequal Site Exchange of 9-Methyl Group in Triptycene by Spin-Lattice Relaxation and 2D-EXSY Experiments
Cho, Jang-Geun ; Ahn, Sang-Doo ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 1~9
An unequal site exchanging system induced by restricted rotation of 9-methyl group in 1,8-dichloro-9-triptycene has been studied by spin-lattice relaxation and 2D-EXSY experiments. The exchange rate obtained from relaxation studies is very well coincident to the result of line shape analysis, and the difference of the relaxation times (
) in two different sites has an important role to analyze 2D-EXSY experimental data.
NMR Structural Studies on Novel Disintegrin, Saxatilin from Gloydius saxatilis Venom
Shin, Joon ; Lee, Dong-Hee ; Hong, Sung-Yu ; Chung, Kwang-Hoe ; Kim, Doo-Sik ; Lee, Weon-Tae ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 10~23
A new disintegrin protein named saxatilin was purified from Korean snake venom (Gloydius saxatilis). Saxatilin is a 73 residue small ploypeptide, which has a primary recognition motif in extracellular matrix, Arg-Gly-Asp (RGD) sequence. Data from inhibition activity assay for the
integrin showed that saxatilin showed about 5000-fold higher activity than those of RGD peptides, suggesting that RGD sequence may not be sufficient to induce full cellular function of this site. The solution structures calculated from NMR data were well converged for backbone atoms except RGD loop. The structure revealed that most of tight turns are stabilized by medium range NOE contacts and the RGD motif is located far from the rigid core of the C-terminal domain. The three-dimensional fold and biological function of saxatilin are discussed with those of salmosin, which is a disintegrin protein derived from Agkistrodon halys brevicaudus.
The Solution Structure of 18 residue YH motif Peptide within the Second fas-1 domain of
Han, Kyung-Doo ; Son, Woo-Sung ; Kim, Won-Je ; Lee, Bong-Jin ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 24~29
] is an extracellular matrix protein that mediates cell adhesion through interaction with integrins. The 18 residue YH motifs within each fas-1 domain are known to be responsible for the interaction with the
integrin, and the synthetic YH motif peptides are known to inhibit endothelial tube formation and reduces the number of blood vessels, and so expected to be an effective inhibitor of angiogenesis. In this study, we solved the 3D structure of the 18 residue YH motif peptide (EALRDLLNNHILKSAMCA; D2 peptide) within the second fas-1 domain of
using NMR. The Peptide has
structure at the C terminal region but the N terminal region is flexible. The present structural information may be helpful for developing more effective peptide drug candidate for the treatment of diseases dependent on angiogenesis.
Molecular Dynamics of the C-Terminal Domain Mouse CDT1 Protein
Khayrutdinov, Bulat I. ; Bae, Won-Jin ; Kim, Jeong-Ju ; Hwang, Eun-Ha ; Yun, Young-Mi ; Ryu, Kyoung-Seok ; Cheong, Hae-Kap ; Kim, Yu-Gene ; Cho, Yun-Je ; Jeon, Young-Ho ; Cheong, Chae-Joon ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 30~41
The backbone molecular dynamics of the C-terminal part of the mouse Cdt1 protein (tCdt1, residues 420-557) was studied by high field NMR spectroscopy. The Secondary structure of this protein was suggested by analyzing of chemical shift of backbone atoms with programs TALOS and PECAN, together with NOE connectivities from 3D
data. Measurement of dynamic parameters
and NOE and limited proteolysis experiment provided information for domain organization of tCdt1(420-557). Analysis of the experimental data showed that the C-terminal part of the tCdt1 has well folded domain for residues 455-553. The residues 420-453 including
(432-441) are flexible and probably belong to other functional domain in intact full length Cdt1 protein.
Structural Studies of Hydrotalcite Compounds Calcined with Different Temperatures by
Solid-state NMR Spectroscopy
Park, Tae-Joon ; Kim, Yong-Ae ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 42~47
Several hydrotalcite compounds calcined with different temperature for applications in a chlorine resistant textile were prepared, and its structural changes in dependence on the temperature were studied by using
solid-state nuclear magnetic resonance(NMR) spectroscopy. We found that the Al coordination was partly lowered from octahedral to tetrahedral site as the calcined temperature goes up. And we also investigated the hydrotalcite-treated textile for chlorine resistance by using
solid-state NMR spectroscopy.
Heme proton resonances assignments based on nuclear Overhauser effect
Li, Chun-Ri ; Kim, So-Sun ; Lu, Ming ; Park, Jang-Su ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 48~55
NMR signals of two hemes were assigned to particular hemes in the crystal structures by nuclear Overhauser effect experiments. The results showed that the hemes with the highest and lowest redox potentials in the one-electron reduction process correspond to the hemes I and IV in the crystal structure.
The in vitro antioxidant activities of the bromophenols from the red alga Tichocarpus crinitus and phenolic derivatives
Lee, Ji-Hye ; Lee, Taek-Kyun ; Kang, Rae-Seon ; Shin, Hee-Jae ; Lee, Hyi-Seung ;
Journal of the Korean Magnetic Resonance Society, volume 11, issue 1, 2007, Pages 56~63
A series of bromophenols and corresponding debrominated phenolic compounds was prepared by isolation from red alga Tichocarpus crinitus and by structural modification of natural bromophenols. Their structures were determined by extensive NMR analysis and the antioxidant activities were established through the determination of their abilities to inhibit free radicals using DPPH as the stable radical. The most active free radical scavengers were the debrominated phenolic derivatives 3,4-dihydroxybenzyl alcohol and 3,3',4,4'-tetrahydroxydiphenylmethane.